Atike yeye aɖe si woatsɔ ada CAH dɔlélea! Nusi wòle be nànya tso eŋu (Congenital Adrenal Hyperplasia) .

Ðe lãmetsiŋusẽdɔléle aɖe le wò ƒomea me, vevietɔ ɖevi aɖe, si wodzina? Ðewohĩ ènya kuxiwo abe tsitsi ƒe dɔmawɔmawɔ nyuie, sɔhɛmenɔɣi kaba, kple nyɔnuwo ƒe dzinukpɔkpɔ edziedzi. Domenyiŋusẽfianu ƒe nɔnɔme si mebɔ o si ate ŋu ahe nusiawo vɛ la woyɔna be ‘Congenital Adrenal Hyperplasia’. Míayɔe be CAH kpuie. Egbea, míaƒo nu tso esia kple atike yeye aɖe si va nɛ ŋu kpuie.

Kpuie ko la, nukae nye CAH?

CAH nye domenyiŋusẽfianu ƒe nɔnɔme si xea mɔ na adrenal glands, si nye lãkusi sue eve siwo le ayiku tame, be woagawɔ cortisol, si nye lãmetsi si le vevie na míaƒe agbe o.

Bu míaƒe ŋutilã abe dɔwɔƒe ene. Ne atike siwo le dɔwɔƒe sia dometɔ ɖeka (cortisol) vɔ la, ahɔhɔ̃a dzikpɔƒe (pituitary gland) doa dziku eye wòɖoa dzesiwo (ACTH) ɖe adrenal glands be woawɔ dɔ sesĩe wu. Le dzideƒoname sia si gbɔ eme ta la, togbɔ be cortisol wɔwɔ medzina ɖe edzi o hã la, edzea ŋutsu ƒe lãmetsi geɖe siwo woyɔna be ‘androgens’ wɔwɔ gɔme boŋ.

Lãmetsiŋusẽ ƒe masɔmasɔ sia ate ŋu ahe kuxi geɖe vɛ:

• Nyɔnu vidzĩwo: Le wo dzidzi me la, gotagome vidzinuwo ate ŋu anɔ abe ŋutsuvi ene.
• Le akpa evea siaa gome la: kuxiwo abe tsitsi ƒe megbetsitsi, sɔhɛmenɔɣi kaba, kple vidzidzimakpɔmakpɔ ate ŋu ado mo ɖa le eƒe tsitsime.

Tsɔ kpe ɖe eŋu la, ate ŋu anye be CAH dɔnɔ aɖewo hã ƒe lãmetsi vevi bubu si woyɔna be aldosterone ƒe wɔwɔ dzi ɖe kpɔtɔ. Ne lãmetsi sia meli o la, CAH ate ŋu asẽ ŋutɔ, si ana ame natsi dzodzodzoe, atsi alɔ̃ me, alo aku gɔ̃ hã.

Ƒe 70 ƒe atikewɔwɔ kple mɔkpɔkpɔ yeye

Ƒe bla nanewoe nye sia la, atike ɖeka kolia si wozãna ɖe CAH ŋue nye be woatsɔ steroid , abe hydrocortisone ene, ƒe agbɔsɔsɔ gbogbo aɖe aɖɔli lãmetsi si nye cortisol si mesɔ gbɔ le ŋutilãa me o. Gake steroid agbɔsɔsɔme siawo nono ɣeyiɣi didi ate ŋu ahe nugbegblẽ le ame ŋu geɖe vɛ. Esiawo dometɔ siwo bɔ wue nye lolo, ʋusɔgbɔdɔ, ƒu siwo gbɔdzɔ, kple ɖeviwo ƒe tsitsi ƒe tsitsi.

Aleke atike yeye sia (Crinecerfont) wɔa dɔe?

Esiae nye nu vevitɔ kekeake. To vovo na atike xoxoa la, atike yeye sia wɔa dɔ le mɔ bubu kura nu.

‘Crinesurfont’ metsɔa lãmetsiŋusẽ siwo tso egodo kpena ɖe eŋu o. Ke boŋ atike sia yia ahɔhɔ̃a ƒe dziɖuƒe (pituitary gland) tẽ eye wòxea mɔ na dzesi si womedi o (ACTH) si doa ŋusẽ adrenal glands la ƒe dodo.

Kpuie ko la, esia le abe ɖoɖo aɖe si mehiã o ƒe ‘switch’ tsitsi ene. Esia kpɔa ŋusẽ ɖe ŋutilãa ƒe ‘androgen’ lãmetsi siwo mehiã o wɔwɔ dzi.

Viɖe gãtɔ kekeake si le esia ŋue nye be esi wònye be wokpɔa androgen ƒe agbɔsɔsɔ dzi ta la, woate ŋu aɖe steroid ƒe agbɔsɔsɔ si hiã be woalé lãmetsiŋusẽ ƒe dadasɔ me ɖe asi dzi akpɔtɔ ŋutɔ . Esia fia be woate ŋu aɖe nusiwo steroid-tikewo hena vɛ hã dzi akpɔtɔ ŋutɔ.

Amekae atike sia sɔ na wu?

Woda asi ɖe ‘Crinesurfont’ dzi fifia na CAH dɔnɔ siwo xɔ wu ƒe 4 . Menye steroid teƒee wònye o, ke boŋ enye kpeɖeŋutɔ na steroid.Atikewɔwɔ si wotsɔ kpe ɖe eŋu.

• Le ɖeviwo gome: Esi ɖeviwo gakpɔtɔ le tsitsim ta la, steroid zazã fũ ate ŋu akpɔ ŋusẽ gã aɖe ɖe woƒe tsitsi dzi. Eyata atike sia si ate ŋu aɖe steroid ƒe agbɔsɔsɔ dzi akpɔtɔ ate ŋu aɖe vi na wo ŋutɔ. Esia le vevie ŋutɔ le ƒewuiwo me, esime wòsesẽna be woaɖu lãmetsiŋusẽwo dzi.
• Le ame tsitsiwo gome: Atikewɔwɔ sia ate ŋu ana gbɔdzɔe ame tsitsi siwo steroid nono ɣeyiɣi didi ƒe nugbegblẽ le ame ŋu hã, alo esesẽna na wo be woalé lãmetsiŋusẽ ƒe agbɔsɔsɔ si li ke me ɖe asi.

Srɔ̃ nu tso eƒe nugbegblẽ le ame ŋu kple dedienɔnɔ ŋu

Le dɔdamɔnu dodokpɔwo me la, atike sia ƒe nugbegblẽ le ame ŋu suesuesue ʋɛ aɖewo siwo nɔa anyi ɣeyiɣi kpui aɖe koe wogblɔ.

• Le ame tsitsiwo gome la: ɖeɖiteameŋu, taɖuame, taɖuame, ƒunukpeƒeveame.
• Le ɖeviwo gome la: taɖuame, dɔgbo ƒe vevesese, ɖeɖiteameŋu, ŋɔti ƒe ʋuʋu.

Vevietɔ la, dzesi siawo ƒe akpa gãtɔ menɔa bɔbɔe o, eye dɔnɔ siwo wòle be woadzudzɔ atikeawo nono ƒe xexlẽme mesɔ gbɔ kura o.

Nuxlɔ̃ame Tɔxɛ: Nya nyuie le Adrenal Crisis ŋu!

Ne èle atike sia nom la, ele vevie ŋutɔ be nànya nɔnɔme sesẽ aɖe si woyɔna be ‘adrenal crisis’. Kpuie ko la, nɔnɔme sia ateŋu adzɔ ne ŋutilãa mexɔ ‘cortisol’ agbɔsɔsɔme si hiã le nuteɖeamedzi sesẽɣi (e.g., dɔlékui sesẽ, amekoko, afɔku).

Aleke mawɔ anya ne atike sia sɔ na nye/vinye?

Ele be nàwɔ nyametsotso sia ne èƒo nu kple wò ɖɔkta, vevietɔ lãmenugbagbeviwo ƒe dɔwɔwɔ ŋuti nunyala . Wò ɖɔkta abu nu geɖe ŋu, siwo dometɔ aɖewoe nye wò ʋudodokpɔ me tsonu, tsitsi ƒe agbɔsɔsɔme, wò kpekpeme, ʋu ƒe sisi, kple lãmetsiŋusẽ ƒe agbɔsɔsɔ si li fifia, be yeanya ne atike sia sɔ na wò.

Esia menye CAH ƒe atike o, gake mɔkpɔkpɔ gã aɖe li be akpe ɖe dɔnɔwo ƒe agbenɔnɔ ŋu wòanyo ɖe edzi, aɖe steroid ƒe nugbegblẽ le ame ŋu dzi akpɔtɔ, eye wòana lãmetsiŋusẽ zazã nanɔ bɔbɔe wu.