Ðe Alzheimer dɔlélea le wò lɔlɔ̃tɔ, ɖewohĩ dawò, fofowò, mamawò alo tɔgbuiwò, ŋua? Mí katã míenya blanuiléle kple kpekpeɖeŋumanɔamesi si dona tso ŋkuɖoɖonudzi vivivi kple mo nyanyɛwo ŋlɔm be me. Le nyateƒe me la, Alzheimer dɔlélea nye nɔnɔme si ate ŋu ana ame naɖo ŋku nu dzi, ahɔhɔ̃a nagblẽ eye wòaku gɔ̃ hã. Togbɔ be womekpɔ atike na dɔléle sia o hã la, atike aɖewo li siwo ate ŋu ana dɔléle sia nagbɔdzɔ eye wòana gbɔdzɔe aɖe dɔnɔa. Egbea míele nu ƒom tso atike vɔ̃ɖiwo ƒe hatsotso tɔxɛ mawo dometɔ ɖeka ŋu. Emae nye NMDA Receptor Antagonists . Togbɔ be ŋkɔa sesẽ vie hã la, mina míase egɔme bɔbɔe.
Atikeŋutinunya ŋutinya sue aɖe si dzɔna le ahɔhɔ̃a me
Míaƒe ahɔhɔ̃ nye teƒe wɔnuku aɖe. Lãmetsiŋusẽ ƒe lãmenugbagbevi biliɔn geɖe, alo `ahɔhɔ̃mekawo` le eme. Lãmenugbagbevi siawo wɔa nyatakakawo ŋudɔ, ɖoa ŋku nyatakakawo dzi, eye wogblɔa nusi woawɔ na ŋutilã ƒe akpa bubuwo to elektrikŋusẽ kple atike ƒe dzesiwo ɖoɖo ɖe wo nɔewo yiyi kple megbe me.
Míeyɔa dɔla siwo tsɔa atike ƒe dzesi siawo be `neurotransmitters`. Dɔla mawo dometɔ ɖekae nye `glutamate` .
Ðeko nàbu glutamate be enye tɔdziʋu si tsɔa gbedasi tso lãmeka ɖeka me yia bubu gbɔ. Tɔdziʋu sia hiã melidzeƒe tɔxɛ aɖe be wòate ŋu ayi gaxɔ si kemɛa me eye wòaɖo tɔdziʋudzeƒea. Tɔdziʋudzeƒe mae nye nusi míeyɔna be NMDA xɔla (`N-methyl-D-aspartate` xɔla. Ne tɔdziʋu si woyɔna be glutamate kpe ɖe NMDA melidzeƒe sia ŋu la, eɖoa nu vevi bubu si woyɔna be `calcium` ɖe lãmenugbagbevi la me. Calcium siae wua gbedasi ma nu eye wòkpena ɖe mía ŋu míesrɔ̃a nu eye wòɖoa ŋku nane dzi. Esia nye nuwɔna si sɔ le ahɔhɔ̃ si le lãmesẽ me me.
Eyata nukae dzɔna le Alzheimer-dɔlélea me?
Le amesi ŋu Alzheimer-dɔléle le ƒe ahɔhɔ̃menugbagbeviwo me la , glutamate si sɔ gbɔ akpa dzea wɔwɔ gɔme . Nusi dzɔnae nye be calcium si sɔ gbɔ akpa sina yia lãmeka mawo me. Bu nusi adzɔ ne ètsɔ tsi geɖe yɔ tsigoe me ŋu kpɔ? Eyɔ fũ. Nenema kee ne calcium sɔ gbɔ akpa ƒo ƒu ɖe lãmenugbagbeviawo me la, lãmenugbagbevi mawo tea gbegblẽ. Nu gbegblẽ siae nana Alzheimer-dɔlélea ƒe dzesiwo dzina ɖe edzi vivivi.
Alesi NMDA Receptor Antagonists kpena ɖe ame ŋue nye esi
Atikewo ƒe hatsotso si woyɔna be NMDA receptor antagonists wɔa dɔ to teƒe siwo tɔdziʋu mawo siwo me glutamate sɔ gbɔ ɖo ate ŋu atɔ ɖo le NMDA receptor la dzi ɖeɖe kpɔtɔ me. Eyae nye be atike la xea melidzeƒe aɖewo. Gake nu vevitɔ kekeakee nye be atike siawo ɖea mɔ gbedasi veviwo sina . Eyae nye be ɖeko woɖua calcium ƒe gege ɖe eme si gblẽa nu dzi evɔ womehea tɔtɔ gã aɖeke vɛ na ahɔhɔ̃a ƒe dɔwɔwɔ nyuie o. Esia ɖea nusiwo gblẽna le lãmekawo ƒe lãmenugbagbeviwo ŋu dzi kpɔtɔna eye wòkpɔa dɔlélea ƒe duƒuƒu dzi.
Le Alzheimer ƒe dɔlélea dada me la, zi geɖe la, ɖɔktawo zãa atike siwo tɔa ŋku ahɔhɔ̃mekawo ƒe dɔlékui bubu si woyɔna be acetylcholine. Gake NMDA receptor antagonists nye atike vevi aɖe si wɔa dɔ le mɔ bubu nu.
NMDA xɔla ƒe mɔxenu vevitɔ si dzi woda asi ɖo fifia be woatsɔ ada Alzheimer ƒe dɔléleae nye memantine (si ƒe ŋkɔe nye `Namenda XR`). Zi geɖe la, ɖɔktawoe ŋlɔnɛ na dɔlélea ƒe akpa siwo le titina va ɖo esiwo nu sẽ. Ɣeaɖewoɣi la, wonaa memantine kpena ɖe `cholinesterase inhibitors` siwo míeyɔ va yi ŋu, siwo dzia acetylcholine ƒe agbɔsɔsɔ ɖe edzi. Esia ate ŋu ana nu nyuiwo nado tso eme le dɔnɔ aɖewo ŋu.
Gake ɖo ŋku edzi be atike siawo mewɔa dɔ ɖekae na amesiame o.
Mina míanya nu tso eƒe nugbegblẽ le ame ŋu hã ŋu.
Abe atikewo katã ene la, esia hã ate ŋu agblẽ nu suesuesuewo.
- Taɖuamee nye dzesi si bɔ wu.
- Tsɔ kpe ɖe eŋu la, nuwo abe taɖuame kple dɔmeɖui ene hã ate ŋu adzɔ.
- Ƒã ŋutɔ hafi wòate ŋu atɔtɔ le ahɔhɔ̃a me .
Ne wò ŋutɔ alo wò dɔnɔa to nusiawo dometɔ aɖe me la, ele be nàna wò ɖɔkta nanya enumake . Manyo gbeɖe be nàdzudzɔ atikewo nono alo atrɔ atikeawo ƒe agbɔsɔsɔme le ɖokuiwò si o.
Atike bubu siwo le ƒome sia me kple wo zazã
Atike bubuwo hã le ƒome sia me siwo woyɔna be NMDA receptor antagonists. Wo dometɔ aɖewo míekpɔna le gbesiagbegbenɔnɔ me. Wo dometɔ aɖewo nye esiwo me afɔku le vie wu, eye wozãa wo le mɔ gbegblẽ nu abe atike vɔ̃ɖiwo ene. Dzɔdzɔmeŋutinunyalawo le numekuku wɔm tso viɖe siwo le atike ƒomevi sia ŋu na ahɔhɔ̃medɔ bubuwo abe Parkinson ƒe dɔléle kple ALS (amyotrophic lateral sclerosis) ene hã ŋu.
Mina míasrɔ̃ nu geɖe tso eŋu le kplɔ̃ si le ete la dzi.
| Atike Vɔ̃ɖiwo ƒe Ŋkɔ | Zãzã vevitɔ | Nya veviwo kple afɔku siwo le eme |
|---|---|---|
| Dextromethorphan ƒe atike | Enɔa kɔdzitikewo me. | Zi geɖe la, mele dedie o, gake ate ŋu anye afɔku ne wonoe le agbɔsɔsɔ gã me. |
| Ketamine ƒe atike | Atike si naa alɔ̃dɔdɔ (na amegbetɔwo kple lãwo). | Wozãnɛ tsɔ ɖea vevesese dzi kpɔtɔna le amekoko me. Gake wowɔ ŋlɔmi le eŋu abe "club drug" ene. Ate ŋu ana woakpɔ susumenuwo eye woase le wo ɖokui me be yeɖe ye ɖokui ɖa tso ŋutilãa gbɔ. Wole numekuku wɔm tso eŋudɔwɔwɔ na nɔnɔmewo abe blanuiléle ene ŋu. |
| Phencyclidine (PCP) ƒe atike . | Wozãnɛ ɖe mɔ gbegblẽ nu abe atike vɔ̃ɖi ene. | Woto esia vɛ gbã abe atike si naa alɔ̃dɔdɔ ame ene, eye woɖe asi le eŋu le eŋudɔwɔwɔ me le eƒe nugbegblẽ sesẽwo (susumekpɔkpɔ, tɔtɔ) ta. Atike si me afɔku le si woyɔna be "Angel Dust". Do ƒome kple ŋutasẽnuwɔwɔ. |
Gbedasi si Wotsɔ Yi Aƒeme
- Togbɔ be womate ŋu ada Alzheimer ƒe dɔlélea keŋkeŋ o hã la, atike siwo tsia tre ɖe NMDA ƒe dɔlékuiwo ŋu abe memantine ene ate ŋu akpe ɖe ame ŋu woakpɔ dɔlélea ƒe akpa siwo le titina va ɖo esiwo nu sẽ gbɔ to nusiwo gblẽ le ahɔhɔ̃mekawo ŋu dzi ɖeɖe kpɔtɔ me.
- Atike siawo wɔa dɔ to lãmekawo ƒe lãmenugbagbeviwo takpɔkpɔ tso glutamate si sɔ gbɔ ɖe ahɔhɔ̃a me si me.
- Abe alesi wòle le atike ɖesiaɖe gome ene la, nugbegblẽ le ame ŋu abe taɖuame ene ate ŋu ado mo ɖa. Dzro nya sia me kple wò ɖɔkta ɣesiaɣi. Mègatrɔ atikeawo ƒe agbɔsɔsɔme alo adzudzɔ atikeawo nono le ɖokuiwò si gbeɖe o.
- Wozãa atike vɔ̃ɖiwo ƒe hatsotso sia abe Ketamine kple PCP ene le mɔ gbegblẽ nu abe atike muamewo ene eye afɔku le wo me ŋutɔ. Vovototo gã aɖe le esiawo kple atike siwo woŋlɔ na Alzheimer-dɔlélea dome.
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