Mina míasrɔ̃ nu tso Parathyroid Cancer ŋu. Mègavɔ̃ o, na míaƒo nu!

Mí katã míekpɔa tɔtrɔ suesuesuewo kple vevesese le míaƒe ŋutilã me ɣeaɖewoɣi, alo? Ðewohĩ enye ƒu sue aɖe si le kɔ me, alo ate ŋu anye nane abe ɖeɖiteameŋu ƒe seselelãme le susu aɖeke manɔmee, alo tsikɔwuame ɣesiaɣi ene. Togbɔ be nu siawo ƒe akpa gãtɔ menye nusiwo ŋu woatsi dzi ɖo o hã la, le go siwo mebɔ o me la, woate ŋu anye dɔléle aɖe ƒe dzesi vevitɔwo. Egbea míele nu ƒom tso kansa ƒomevi aɖe si mebɔ vie o ŋu, gake ele vevie ŋutɔ be mí katã míanɔ ŋudzɔ. Emae nye kansa si dona le parathyroid glands me, si woyɔna le atikewɔwɔ me be parathyroid cancer , alo `(Parathyroid Carcinoma)`.

Nukae Nye Parathyroid Kansa?

Kpuie ko la, parathyroid cancer nye kansa ƒomevi aɖe si mebɔ kura o si dona le wò parathyroid glands ƒe lãkusiwo me. Zi geɖe la, wò parathyroid glandwo nɔa thyroid gland si le abe kpakpaluʋui ene si le wò kɔ ƒe ŋgɔgbe la megbe.

Womedea parathyroid kansa ɖe akpa ene me (``afɔɖeɖe ene ƒe ŋkɔyɔyɔ ƒe ɖoɖo``) abe kansa ƒomevi bubuwo ene o. Ke boŋ ɖɔktawo ma kansa la ɖe ƒomevi vevi etɔ̃ me:

• Teƒe si wòle: Esia fia be wò parathyroid gland me koe kansa la le. Ɣeaɖewoɣi la, ate ŋu akaka vie ɖe lãkusi siwo ƒo xlãe me. Esia fia be kansa la gakpɔtɔ le teƒe ɖeka ko.
• Metastatic: Esia nye ne kansa la kaka ɖe wò ŋutilã ƒe akpa bubuwo, abe ʋukawo, aklã, lãkusi, ƒuwo, alo dɔgbo ene. Ame siwo ŋu parathyroid cancer le la dometɔ 10% va ɖo 30% ƒe kansa kaka (metastatic) le ɣeyiɣi si me wokpɔe. Teƒe siwo bɔ wue nye lãkusi, ƒuwo, alo aklã.
• Egbugbɔna: Esia nye ne kansa la gatrɔna va le atikewɔwɔ gbãtɔ megbe – zi geɖe la, ne woɖe kansa ƒe lãkusia ɖa to amekoko me vɔ megbe. Kansa sia ƒomevi axɔ amesiwo ŋu parathyroid cancer le la dometɔ siwo wu afã. Zi geɖe la, kansa la gatrɔna gbɔna le ƒe eve va ɖo atɔ̃ me tso esime wowɔ dɔ nɛ zi gbãtɔ. Ke hã, ate ŋu atrɔ ava ɣeaɖewoɣi le ƒe 20 megbe.

Nukae nye parathyroid lãkusi siawo?

Parathyroid gland ene siwo lolo abe pea ene le mía dometɔ akpa gãtɔ si. Abe alesi míegblɔe va yi ene la, esiawo le lãkusia megbe. Abe thyroid gland ene la, parathyroid glands nye wò lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe akpa aɖe. Ɣeaɖewoɣi la, parathyroid gland siawo ate ŋu anɔ wò nuɖuɖutome alo wò akɔta gɔ̃ hã. Woyɔa esia be ectopic.Woyɔa parathyroid glands be parathyroid glands, si fia be womele afisi wòle be woanɔ le dzɔdzɔme nu o.

Dɔ vevitɔ si wò parathyroid glands wɔnae nye be wòakpɔ calcium agbɔsɔsɔme si le wò ʋu me dzi to parathyroid hormone (PTH) wɔwɔ me . Ɣeaɖewoɣi la, wò parathyroid gland ɖeka alo esi wu nenema dzea parathyroid hormone (PTH) sia ƒe akpa gãtɔ wɔwɔ gɔme. Woyɔa nɔnɔme sia be Primary Hyperparathyroidism (pHPT) . Ne PTH sɔ gbɔ akpa la, calcium ƒe agbɔsɔsɔ si le wò ʋu me dzina ɖe edzi. Woyɔa nɔnɔme sia be hypercalcemia .

Vovototo kae le parathyroid cancer kple parathyroid adenoma dome?

Parathyroid adenoma nye tsitsi si mewɔa dɔ nyuie o, si me kansa mele o le parathyroid gland me. Gake parathyroid cancer nye lãmenugbagbevi vɔ̃ɖi siwo menye kansa o ƒe tsitsi le wò parathyroid lãkusi me. Le dɔléle siwo do ƒome kple parathyroid glands dome la, parathyroid adenoma bɔ wu parathyroid kansa sã.

Gake nu vevitɔe nye esi: Le nɔnɔme siawo evea siaa, siwo nye parathyroid cancer kple parathyroid adenoma me la, wò parathyroid gland ate ŋu awɔ dɔ akpa eye wòawɔ parathyroid hormone (PTH) geɖe akpa. Emegbe abe alesi míegblɔe va yi ene la, hypercalcemia dzɔna. Calcemia si gbɔ eme sia ate ŋu agblẽ nu le wò ŋutilã kple lãmesẽ ŋu. Eyata atike si wozãna wu na parathyroid kansa, kpakple parathyroid adenomas, enye be woawɔ dɔ na parathyroid gland si wɔa dɔ akpa la ɖa.

Le ɖɔktawo gɔ̃ hã gome la, ate ŋu asesẽ be woanya enumake nenye be parathyroid adenoma alo parathyroid carcinoma ye. Esi wònye be wo ame evea siaa ƒe lãmenugbagbeviwo ate ŋu aɖi wo nɔewo ta la, ne woɖe parathyroid gland si le dɔ wɔm akpa la ɖa vɔ la, ehiã be woagawɔ dodokpɔ bubuwo atsɔ aɖo kpe edzi nenye be adenoma alo carcinoma ye.

Nukae nye hypercalcemia? Aleke wòdo ƒome kple parathyroid kansa?

Hypercalcemia nye ne wò ʋu me calcium sɔ gbɔ wu alesi wòle be wòanɔ. Zi geɖe la, amesiwo ŋu parathyroid kansa le la xɔa hypercalcemia. Esia le alea elabena kansa la nana wò parathyroid gland la wɔa dɔ akpa eye wòwɔa parathyroid hormone (PTH) fũ akpa. Parathyroid hormone (PTH) ɖɔa calcium ƒe agbɔsɔsɔ si le wò ʋu me ɖo. Eyata ne parathyroid hormone (PTH) sɔ gbɔ ɖe lãme na wò akpa la, wò ʋu me calcium adzi ɖe edzi.

Calcemia fũ ate ŋu agblẽ nu le wò lãmesẽ kple ŋutilã ŋu. Eyata ele vevie ŋutɔ be woada hypercalcemia si parathyroid cancer hena vɛ kpakple kansa ŋutɔ hã.

Ðe parathyroid kansa ƒomevi vovovowo lia?

Ẽ, parathyroid kansa ƒomevi vevi eve li.

1. Ƒomevi si bɔ wu: Le go sia me la, kansa lãmenugbagbeviwo nana wò parathyroid gland la wɔa parathyroid hormone (PTH) fũ akpa eye wòɖea asi le eŋu yia ʋua me. Esia wɔnɛ be calcium ƒe agbɔsɔsɔ si le wò ʋu me dzina ɖe edzi.

2. Parathyroid carcinoma si mewɔa dɔ o: Wogayɔa esia be ``non-secreting parathyroid carcinoma''. Esia to vovo na ƒomevi bubuawo. Elabena, amesiwo ŋu kansa sia ƒomevi le la mekpɔa parathyroid hormone (PTH) alo calcium ƒe agbɔsɔsɔ si dzi ɖe edzi le woƒe ʋu me o. Esia ƒomevi mebɔ kura o, edzɔna le parathyroid kansa dɔnɔ siwo mede 10% o me .

Ne wonya kpɔ parathyroid kansa ko la, wogawɔa dodokpɔ bubuwo tsɔ nyaa nenye be ele teƒe ɖeka , ekaka ɖe teƒe bubuwo , alo gbugbɔna . Abe alesi míegblɔe va yi ene la, womezãa afɔɖeɖe ene ƒe hatsotso si wozãna na kansa bubuwo na esia o.

Amekae ate ŋu axɔ parathyroid kansa wu?

Kansa sia gblẽa nu le nyɔnuwo kple ŋutsuwo ŋu sɔsɔe. Zi geɖe la , wokpɔnɛ le amesiwo xɔ wu ƒe 30 ŋu .

Aleke gbegbee dɔléle sia bɔe?

Parathyroid cancer nye dɔléle si mebɔ kura o. Bu eŋu kpɔ ko, kansa katã ƒe 0.005% koe wònye. Azɔ hã, parathyroid cancer nye dɔléle siwo katã do ƒome kple parathyroid gland ƒe 0.5% va ɖo 1% . Eyata, esia mebɔ ŋutɔŋutɔ o.

Nukawoe hea Parathyroid Cancer vɛ?

Le nyateƒe me la, womekpɔ nusi koŋ gbɔ parathyroid cancer tsona haɖe o.

Gake wobua domenyiŋusẽfianu ƒe nɔnɔme siwo mebɔ o (i.e., siwo ƒe dome wonyi tso ƒome me) siwo gbɔna be wonye afɔku na kansa sia:

• Dɔlékuiwutike geɖe ƒe dɔdzẽ ƒomevi I (MEN1) .
• Ƒome ƒe ʋumenugbagbeviɣidɔ si woɖe ɖe aga (FIHP) .
• Hyperparathyroidism-aɖuɖɔtoe me dɔdzẽ ƒe dɔléle

Tsɔ kpe ɖe eŋu la, ne wozã keklẽŋusẽdɔdamɔnu na wò ta alo kɔ va yi la, ate ŋu ana nàxɔ parathyroid cancer hã nadzi ɖe edzi.

Nukae nye Parathyroid Cancer ƒe dzesiwo?

Zi geɖe la, parathyroid cancer ƒe dzesiwo nyea hypercalcemia ƒe dzesi siwo dona tso eme. Dzesiwo kple dzesi siwo dzena le ʋumenugbagbeviɣidɔ me ate ŋu anye:

• Ehiã be nàɖe aɖuɖɔ zi geɖe wu alesi wònɔna ɖaa (aɖuɖɔtoe enuenu) .
• Tkɔkɔwuame wu alesi wònɔna ɖaa
• Aɖuɖɔtoe kple ʋuʋudedi
• Abe alesi wònɔna ɖaa eneDɔwuame ƒe seselelãme manɔmee
• Miléle
• Sese le eɖokui me be ɖeɖi te ye ŋu ŋutɔ
• Sese le ɖokuiwò me be yelé blanui
• Nuŋlɔɖi be alo ŋkuɖoɖonudzi ƒe dɔmawɔmawɔ nyuie
• Lãmetsiwo ƒe vevesese, gbɔdzɔgbɔdzɔ, kple/alo lãmekawo ƒe ʋuʋu

Dzesi bubu siwo ate ŋu anɔ parathyroid cancer ŋu:

• Kplu aɖe ƒe amesinɔnɔ le kɔ me
• Gbe ƒe tɔtrɔ alo gbeɖiɖi ƒe ɖiɖi
• Nuɖuɖu mimi sesẽ

Ne dzesi siawo dometɔ ɖeka alo esi wu nenema le ŋuwò la, mègavɔ̃ be yeasusui be parathyroid cancer ye godoo o. Woate ŋu akpɔ dzesi siawo le nɔnɔme bubu geɖewo hã me. Gake ne nane si le abe esia ene gakpɔtɔ li la, anyo wu be nàyi ɖɔkta gbɔ aɖaɖo aɖaŋu na wò.

Aleke wowɔna dea dzesi Parathyroid Cancer?

Parathyroid cancer didi ate ŋu asesẽ vie ɣeaɖewoɣi. Susu ɖekae nye be parathyroid adenoma si menye kansa o ƒe lãmenugbagbeviwo kple parathyroid cancer tɔ ate ŋu adze ɖeka.

Zi geɖe la, wokpɔa parathyroid kansa ne woɖe wò parathyroid gland si mesɔ o, si le dɔ wɔm akpa la ɖa (`parathyroidectomy`), eye wogado lãkusia kpɔ. Ɣeaɖewoɣi la, amekolaa te ŋu dea dzesi parathyroid kansa le amekokoa me.

Dodokpɔ kawoe wowɔna tsɔ dea dzesi dɔlélea?

Abe alesi míegblɔe va yi ene la, zi geɖe la, wokpɔa parathyroid kansa le esi wokpɔe be primary hyperparathyroidism , le ŋuwò vɔ megbe, eye wowɔa dɔ na parathyroid gland si mesɔ o, si wɔa dɔ akpa la ɖa. Ɣeaɖewoɣi la, amekolaa ate ŋu akpɔ parathyroid kansa le amekokoa me.

Hafi woawɔ dɔ na wò be woaɖe wò parathyroid gland si le dɔ wɔm akpa la ɖa la, woate ŋu awɔ dodokpɔwo abe esiawo ene:

• Ʋu me calcium dodokpɔ
• Ʋu me PTH dodokpɔ
• Parathyroid scan - Zi geɖe la, esia nyea radioactive sestamibi scan kple/alo CT scan.

Ne wokpɔe be parathyroid kansa le ŋuwò la, wò ɖɔkta ate ŋu aɖe gbe be woawɔ nɔnɔmetatawo dodokpɔ abe esiawo ene atsɔ akpɔe ɖa be kansa la kaka (kaka) ɖe wò ŋutilã ƒe akpa bubuwo hã:

• CT scan (computerized tomography scan): CT scan zãa X-ray kple kɔmpiuta tsɔ wɔa wò ŋutilã ƒe nɔnɔmetata geɖe siwo le akpa etɔ̃ (3D).
• MRI scan (MRI - magnetic resonance nɔnɔmetatawo ɖeɖeɖa):MRI scan zãa magnet gã aɖe, radio ƒe ƒutsotsoewo, kple kɔmpiuta tsɔ wɔa wò ŋutilã ƒe nɔnɔmetata tsitotsito. Mezãa X-ray (kekeli) o.

Nukawoe nye parathyroid kansa ƒe atikewo?

Atike vevitɔ si woate ŋu azã na parathyroid cancer enye amekoko be woaɖe parathyroid gland si me kansa le la ɖa (`en bloc resection`). Ne parathyroid cancer kaka (ekaka ɖe teƒe bubuwo) la, ahiã be wò amekola hã naɖe lãkusi siwo ƒo xlã wò parathyroid gland alo kansa ƒe lãkusiwo ɖa le wò ŋutilã ƒe akpa bubuwo.

Woate ŋu azã amekokomɔnu siwo gbɔna na parathyroid kansa:

• En bloc resection: Le dɔ sia wɔwɔ me la, amekolaa ɖea wò parathyroid gland bliboa kple capsule si ƒo xlãe la ɖa. Ɣeaɖewoɣi la, woate ŋu aɖe lãkusi si le axa ɖeka kple lãkusi si me kansa le ƒe afã hã ɖa, tsɔ kpe ɖe lãkusi, lãmeka, kple lãmeka siwo ƒo xlãe ŋu.
• Tumor debulking: Le dɔ sia wɔwɔ me la, amekolaa ɖea tumor la ƒe akpa gãtɔ ɖa alesi wòate ŋui. Ðewohĩ womate ŋu aɖe dɔdzẽ aɖewo ɖa keŋkeŋ o.
• Metastasectomy: Le esia me la, amekolaa ɖea kansa ɖesiaɖe si kaka (si kaka) ɖe wò ŋutilã ƒe lãkusi bubuwo kple/alo ŋutinu bubuwo me, le kpɔɖeŋu me, lãkusiwo me.

Ðe woawɔ atike alo keklẽŋusẽdɔdamɔnua?

Zi geɖe la, womezãa atikewɔmɔnu kple keklẽŋusẽdɔdamɔnu tsɔ daa parathyroid kansa o. Wò ɖɔkta atso nya me nenye be atikewɔmɔnu kple/alo keklẽŋusẽdɔdamɔnu nye tiatia si sɔ na wò.

Ðe atike aɖe li na parathyroid kansaa?

Fifia la, atike aɖeke meli koŋ na parathyroid kansa o. Ame geɖe siwo ŋu parathyroid cancer le la dzea hypercalcemia ƒe dzesiwo fiana. Esi wònye be ʋumenugbagbeviɣidɔ ate ŋu agblẽ nu le ŋuwò ta la, wò ɖɔkta ate ŋu aŋlɔ ʋumenugbagbeviɣidɔtike siwo gbɔna la dometɔ ɖeka alo esi wu nenema na wò:

• Cinacalcet (Cinacalcet - Sensipar®) ƒe dɔlékuiwutike .
• Bisphosphonates ƒe atikewo
• Denosumab (Denosumab - XGEVA®) ƒe lãmesẽnyawo gbɔ kpɔkpɔ.

Ne ʋumenugbagbeviɣidɔ ƒe dzesi sesẽwo le ŋuwò la, wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nàxɔ kɔdzi enumake eye nàdze tsi dodo ɖe ʋuka me (IV) kple atikewɔwɔ bubuwo gɔme.

Ðe nye parathyroid kansa ate ŋu atrɔ ava?

Ẽ, amesiwo ŋu wokpɔ parathyroid kansa le la dometɔ siwo wu afã ate ŋu axɔ kansa la ake.Zi geɖe la, kansa trɔna gbɔna le ƒe ʋee aɖewo megbe – zi geɖe la, enɔa ƒe eve va ɖo atɔ̃ dome. Gake le go aɖewo me la, ate ŋu adzɔ ƒe bla nanewo (ƒe 20 alo esi wu nenema) le wò dɔlélea kpɔkpɔ zi gbãtɔ kple atikewɔwɔ vɔ megbe.

Ðe kansa sia ate ŋu akaka (akaka) ɖe ŋutilã ƒe akpa bubuwoa?

Ẽ, parathyroid kansa ate ŋu akaka (akaka) ɖe wò ŋutilã ƒe akpa bubuwo. Ame siwo ŋu parathyroid cancer le la dometɔ 10% va ɖo 30% ƒe kansa kaka xoxo (metastatic) le ɣeyiɣi si me wokpɔe. Le nɔnɔme siawo me la, zi geɖe la, kansa la kakana ɖe wò lãkusi, ƒuwo, alo aklã me. Gake ate ŋu akaka ɖe wò ʋukawo alo dɔgbo me hã.

Nukae nye parathyroid kansa ƒe ŋgɔdonya?

Parathyroid kansa ƒe ŋgɔdonya nɔ te ɖe alesi amekoko si wowɔ be woaɖe parathyroid gland la awu enu ne wokpɔ dɔlélea le ŋuwò zi gbãtɔ dzi, elabena atikewɔwɔ evelia abe keklẽŋusẽdɔdamɔnu kple atikewɔmɔnu ene mesɔ gbɔ o.

Le amesiwo ŋu parathyroid cancer le siwo woɖe en bloc resection eye woƒe vovototowo menyo o gome la, agbetsitsi ƒe agbɔsɔsɔme sɔ gbɔ va ɖo 90% le ƒe atɔ̃ le amekoko gbãtɔ megbe. Agbetsitsi ƒe agbɔsɔsɔme hã sɔ gbɔ va ɖo 67% le ƒe ewo le amekoko gbãtɔ megbe.

Ame siwo ŋu wokpɔ parathyroid kansa le eye wowɔ dɔ na wo be woaɖe lãkusia ɖa la dometɔ siwo wu afã akpɔ kansa la ake. Le nɔnɔme siawo me la, zi geɖe la, kansa la gatrɔna le ƒe eve va ɖo atɔ̃ me tso esime wowɔ dɔ nɛ zi gbãtɔ. Ke hã, ate ŋu atrɔ ava le ƒe bla nanewo megbe.

Ðe woate ŋu axe mɔ ɖe Parathyroid Cancer nua?

Nublanuitɔe la, mɔ aɖeke meli si wonya si dzi woato axe mɔ ɖe parathyroid kansa nu o. Azɔ hã, mɔ aɖeke meli si dzi woato aɖe dɔléle sia xɔxɔ ƒe afɔkua dzi akpɔtɔ o. Ne parathyroid gland dɔléle aɖe nɔ wò ƒomea me la, anyo be nàƒo nu kple wò ɖɔkta.

Nya kawoe wòle be mabia nye ɖɔkta?

Ne parathyroid cancer le ŋuwò la, àte ŋu abia nya siawo abe esiawo ene na wò ɖɔkta:

• Ðe kansa la kaka yi ŋgɔ wu nye parathyroid gland la?
• Nukae nye atike nyuitɔ kekeake na parathyroid kansa?
• Afɔku kple nugbegblẽ kawoe le atikewɔwɔa me?
• Ðe nye ƒomea le afɔku me be woaxɔ parathyroid cancer?
• Ðe mate ŋu agaxɔ parathyroid kansa akea?
• Ðe mele afɔku me be kansa ƒomevi bubuwo nadze dzinyea?
• Beléle si akplɔm ɖo kae mahiã le atikewɔwɔ vɔ megbe?
• Ðe wòle be manya kuxi siwo dona tso eme ƒe dzesiwoa?

Mlɔeba la, nu siwo dzi wòle be woaɖo ŋkui

Ne wokpɔ kansa le ŋuwò la, ate ŋu anye nusi dzi ŋɔ ŋutɔ. Gake ɖo ŋku edzi be, .Wò atikewɔlawo ƒe ƒuƒoƒoa le afisia be yewoakpe ɖe ŋuwò eye yewoafia atikewɔwɔmɔnu nyuitɔ kekeake wò. Togbɔ be amekoko koe nye parathyroid kansa dada fifia hã la, numekuku kple kansa dada le nyonyom ɖe edzi ɣesiaɣi. Ðewohĩ dɔdamɔnu dodokpɔ aɖe gɔ̃ hã li si me nàte ŋu akpɔ gome le Eyata mègavɔ̃ be yeabia nya wò ɖɔkta tso wò parathyroid kansa ŋu o. Kpɔ egbɔ be woɖe nusianu me le mɔ si gɔme nèse nu.

` Parathyroid Cancer, Parathyroid Glands, Hypercalcemia, Parathyroid Hormone, PTH, Kansa ƒe Dzesiwo, Kansa ƒe Dɔdamɔnu, Amekoko