Ðe dzesi wɔnuku siawo hã le ŋuwòa? Mina míaƒo nu tso Plasmacytoma ŋu

Vevesese si womate ŋu aɖe o le ŋutilã ƒe akpa vovovowo, ɣeaɖewoɣi ƒu ƒe kuxi siwo womate ŋu asusu o, alo lãmeka falɛfalɛ siwo mesɔ o le teƒewo abe kɔ kple ta ene... Esiawo ate ŋu anye nusiwo ŋu míeléa ŋku ɖo boo o ɣeaɖewoɣi. Gake le go siwo mebɔ o me la, esiawo ate ŋu anye dɔléle aɖe si mebɔ o si woyɔna be Plasmacytoma hã ƒe dzesiwo. Mègatsi dzi o, esia menye dɔléle si dzea ame geɖe dzi o. Gake ele vevie ŋutɔ be nànya esia.

Nukae nye plasmacytoma sia? Mina míase egɔme bɔbɔe ŋutɔ.

Kpuie ko la, Plasmacytoma nye dɔléle si ɖi Multiple Myeloma, gake mebɔ kura o. Lãmenugbagbevi ƒomevi aɖe le mí katã si le míaƒe ŋutilã me si woyɔna be Plasma cells . Ame aɖewo hã yɔa lãmenugbagbevi siawo be B lãmenugbagbeviwo. Esiawo nye míaƒe dɔlélenutsiŋutete ƒe akpa vevi aɖe. Plasma lãmenugbagbevi siwo le lãmesẽ me wɔa dɔlékuiwutikewo, alo dɔlélenutsiŋutete, siwo kpena ɖe míaƒe ŋutilã ŋu wòwɔa avu kple dɔléle.

Gake ɣeaɖewoɣi la, ʋumenugbagbevi dzĩ siawo siwo le lãmesẽ me la va zua nusiwo mesɔ o eye wodzea mama kple dzidziɖedzi gɔme kabakaba akpa. Emegbe lãmenugbagbevi siawo siwo mesɔ o la ƒoa ƒu hewɔa dɔdzẽ. Dɔdzẽ siawo ate ŋu adzɔ le míaƒe ƒuwo me, le ta kple kɔ ƒe lãkusi falɛfalɛwo me, alo le ŋutinu ɖesiaɖe, abe tsinyegoe, lãkusi, alo ayiku ene me.

Aleke Plasmacytoma kpɔa ŋusẽ ɖe nye ŋutilã dzii?

Abe alesi míeƒo nu tso eŋu va yi ene la, kuxi sia dzea egɔme ne ʋumenugbagbevi dzĩ siwo le lãmesẽ me va zu nusi mesɔ o. Plasma lãmenugbagbevi siawo siwo mesɔ o la dzina ɖe edzi eye wowɔa dɔlékuiwutike ƒomevi aɖe si mesɔ o si woyɔna be M proteins . Ne M protein siawo dzi ɖe edzi la, ʋumenugbagbevi dzĩ ŋutɔŋutɔ siwo le lãmesẽ me siwo kpena ɖe mía ŋu ŋutɔŋutɔ be míakpɔ mía ta tso dɔléle me ƒe xexlẽme dzi ɖena kpɔtɔna. Esia fia be míaƒe dɔlélenutsiŋutete ate ŋu agbɔdzɔ.

Plasmacytoma ƒomevi vevi eve li, le ŋutilã ƒe akpa siwo wògblẽa nu le nu:

1. Solitary Plasmacytoma of Bone (SPB): Esiae nye esime ʋumenugbagbevi dzĩ siwo mesɔ o wɔa dɔdzẽ le ƒu ɖeka me le wò ŋutilã me. Bu eŋu be enye akɔtaƒu ɖeka ko le wò akɔta, alo teƒe ɖeka ko le wò akɔta. SPB sia ate ŋu ana ƒuwo nagblẽ eye wòase veve. Ame siwo ŋu SPB le la dometɔ siwo ade 50% ava xɔ multiple myeloma mlɔeba.

2. Extramedullary Plasmacytoma (EMP): Le EMP me la, dɔdzẽ ɖeka si me ʋumenugbagbevi dzĩ siwo mesɔ o le la gblẽa nu le lãmeka falɛfalɛwo ŋu . Lãmetsi falɛfalɛwoe nye lãkusi si ƒo xlã míaƒe ŋutinuwo kple ƒuwo, doa ka kple wo nɔewo, eye wòléa wo ɖe te. Le kpɔɖeŋu me, esia lɔ míaƒe lãmekawo, lãkusiwo, ŋutigbalẽ, ami, kple lãkusiwo ɖe eme. EMP ate ŋu adzɔ le ŋutilãa ƒe lãkusi falɛfalɛ ɖesiaɖe me, gake ebɔ wu le gbɔgbɔtsixe ƒe akpa si le etame.. Eyae nye be, le teƒewo abe ŋɔti, ŋɔti, ŋɔti, kple ŋɔti ene. Gake ate ŋu adzɔ le ŋutinu ɖesiaɖe me. Ame siwo ŋu EMP le dometɔ siwo ade 15% ate ŋu axɔ multiple myeloma emegbe.

Amekae xɔa plasmacytoma sia? Aleke gbegbe wòbɔe?

Zi geɖe la, wokpɔa ʋumenugbagbeviɣidɔ le amesiwo xɔ tso ƒe 55 va ɖo ƒe 60. Wokpɔe hã be ŋutsuwo ate ŋu axɔ dɔléle sia wu nyɔnuwo.

Le nyateƒe me la , plasmacytoma nye dɔléle si mebɔ kura o . Ame yeye siwo ade 450 koe ɖɔktawo kpɔna le SPB dɔlékui yeye siwo ade 450 kple ame yeye siwo ade 300 siwo ŋu EMP le ƒe sia ƒe. Gake ame aɖewo siwo le avu wɔm kple multiple myeloma ɣeyiɣi didi aɖe hã ate ŋu axɔ plasmacytoma.

Nukae nye SPB ƒe dzesiwo?

Solitary Plasmacytoma of Bone (SPB) nye ƒumeŋuɖui si ƒe dzesi enye ƒu ƒe vevesese alo ƒu ƒe gbagbã . Le kpɔɖeŋu me, àte ŋu ase akɔtave zi ɖeka le susu aɖeke manɔmee, alo akɔta nase veve. SPB ƒe dzesi bubuwoe nye:

• Vevesese alo gbagbã le teƒewo abe wò akɔta, akɔta ƒe akɔtaƒu, afɔkpodzi, kple akɔta ene .
• Akɔta ƒe gbagbã siwo wotsɔa nutete ƒoa ƒui . Esia ate ŋu agblẽ nu le wò aklã alo lãmekawo ƒe kewo ŋu. Ne edzɔ alea la, àte ŋu ase veve sesẽ si aƒo wò, si azɔ to wò afɔwo dzi age ɖe wò akɔta.
• Ƒã hafi ne SPB gblẽ nu le taɖu ŋu la, ate ŋu ahe taɖui, taɖuame, kple ŋku ƒe kuxiwo vɛ .

Eyata nukawoe nye EMP ƒe dzesiwo?

Extramedullary Plasmacytoma (EMP) ƒe dzesiwo dzena ne dɔdzẽa te ɖe lãmeka falɛfalɛwo ŋu, si na be vevesese kple ŋutilã ƒe dɔwɔwɔ tɔtɔ.

Le kpɔɖeŋu me, ne EMP le wò ŋɔti me la, àte ŋu ase le ɖokuiwò me abe ɖe nane tsi wò ŋɔti me ene, eye ate ŋu asesẽ be nàgbɔ ya to wò ŋɔti me. Togbɔ be EMP ateŋu adzɔ le ŋutilã ƒe akpa ɖesiaɖe hã la, 80% va ɖo 90% dzɔna le ta kple kɔ ƒe akpa dzi. Dzesi siwo bɔ ɖe EMPwo ŋu dometɔ aɖewoe nye:

• Taɖuame
• Tsi si dona le ŋɔti me
• Nu mimi sesẽ (Dysphagia) .
• Kɔmeve alo dɔlékui (Pharyngitis) .
• Ʋu si dona le ŋɔti me (Epistaxis) .

Ƒã hafi ne EMP la gblẽ nu le wò lãkusi (gbe ƒe aɖaka) ŋu la, àte ŋu akpɔ dzesiwo abe:

• Gbeɖiɖi ƒe ɖiɖi
• Yaƒoƒomɔ̃ si xe mɔ na
• Ʋuʋudedi

Le veviẽ:Zi geɖe la, plasmacytoma ƒe dzesi siawo sɔ kple dɔléle bubu siwo mesẽ boo o ƒe dzesiwo. Eyata mègatsi dzodzodzoe ne èkpɔ nane si le abe esia ene o. Gake ne dzesi siawo gakpɔtɔ li wu kwasiɖa eve alo wova le sesẽm ɖe edzi la, ele be nàyi ɖɔkta gbɔ godoo.

Nukatae plasmacytoma sia dzɔna? Nuka gbɔe wòtso?

Le nyateƒe me la, míenya azɔ be ʋumenugbagbevi dzĩ siwo le lãmesẽ me trɔna zua lãmenugbagbevi siwo mesɔ o eye wodzina ɖe edzi le mɔ si dzi womate ŋu aɖu o nu gbɔe plasmacytoma tsona. Gake numekulawo menya nusi tututu he tɔtrɔ sia vɛ haɖe o. Eyae nye be womekpɔ nusi koŋ gbɔ wòtso haɖe o.

Aleke ɖɔktawo wɔa anya Plasmacytoma?

Ðɔktawo zãa dodokpɔ geɖe tsɔ dea dzesi plasmacytoma ƒomeviwo eye ne ele wo me la, wozãa alesi EMP ƒe dɔlélea le.

Dodokpɔ mawo dometɔ aɖewoe nye esi:

• CT scan (Computed Tomography - CT scan): Esia zãa X-ray kple kɔmpiuta tsɔ wɔa wò lãkusi falɛfalɛwo kple ƒuwo ƒe nɔnɔmetata si le akpa etɔ̃ (3D). Ðɔktawo zãa CT-dɔdamɔnu tsɔ dia ƒu ƒe gbegblẽ si plasmacytomas hena vɛ.
• MRI scan (Magnetic Resonance Imaging - MRI): Dodokpɔ sia ate ŋu aɖe wò ŋutilã ƒe foto tsitotsito keklẽŋusẽ mazãmazãe. MRI ate ŋu akpe ɖe ame ŋu woada lãmeka falɛfalɛ siwo EMP gblẽ le ame ŋu la akpɔ.
• Ʋu kple aɖuɖɔ dodokpɔ: Wozãa dodokpɔ siawo tsɔ dzidzea M protein mawo siwo ŋu míeƒo nu tsoe ƒe agbɔsɔsɔ.
• Nasal endoscopy: Ne wosusu be EMP ƒe nɔnɔme aɖe le ame ŋu la, woate ŋu azã mɔnu sia atsɔ ado mɔ siwo to ŋɔti me kple ʋuka siwo le ŋɔti me la akpɔ. Esia bia be woatsɔ mɔ̃ aɖe si me fotoɖemɔ̃ sue aɖe le la ayi ŋɔti me.
• Fine-needle biopsy: Woate ŋu azã mɔnu sia atsɔ axɔ lãkusi kple tsi ƒe kpɔɖeŋu tso lãkusi falɛfalɛ siwo ŋu EMP gblẽ nu le me.
• Biopsy: Wowɔa esia hã be woatsɔ axɔ lãmenugbagbevi alo tsi aɖe atsɔ ado ʋumenugbagbevi dzĩwo kpɔ. Esia nye be woatsɔ aɖo kpe edzi nenye be lãmenugbagbevi aɖewo siwo mesɔ o li.

Nukawoe nye EMP ƒe afɔɖeɖewo?

Ðɔktawo bua nusiwo gbɔna ŋu be woatsɔ anya afisi Extramedullary Plasmacytoma (EMP) le:

• Afɔɖeɖe I: Dodokpɔwo ɖee fia be dɔdzẽ ɖeka koe le teƒe ɖeka le wò ŋutilã ŋu.
• Afɔɖeɖe II: Dodokpɔwo ɖee fia be EMP lãmenugbagbeviwo hã le wò ʋukawo me.
• Afɔɖeɖe III: Dodokpɔwo ɖee fia be EMP dɔdzẽ wu ɖeka.

Nukawoe nye Plasmacytoma ƒe atikewo?

Nu nyuitɔ kekeakee nye be, atikewo li na dɔléle sia. Ðɔktawo tsɔa keklẽŋusẽdɔdamɔnu daa ƒu ƒe ʋumenugbagbeviɣidɔ (SPB) si woɖena le ame ɖeka ko me.Ɣeaɖewoɣi la, ne protein (M protein) mawo siwo mesɔ o le ame aɖe ƒe ʋu alo aɖuɖɔ me eye plasmacytoma hã le eŋu la, ɖɔktawo azã atike siwo woatsɔ ada multiple myeloma hã.

Woate ŋu atsɔ amekoko kple/alo atikewɔmɔnu alo dɔlélenutsiŋutete ƒe dɔdamɔnu ada ƒunukpeƒetetedɔ (EMP) . Wò ɖɔkta anɔ te ɖe wò nɔnɔmea dzi atso nya me le atikewɔwɔ si sɔ wu ŋu.

Ðe woate ŋu axe mɔ ɖe plasmacytoma ƒe dzɔdzɔ nua?

Le nyateƒe me la, abe multiple myeloma ene la, mɔ aɖeke meli si wonya si dzi woato axe mɔ ɖe plasmacytoma ƒe dzɔdzɔ nu o. Esi womenya nusi tututu gbɔ wòtso o ta la, esesẽna be woagblɔ alesi woawɔ axe mɔ ɖe enu.

Ɣeyiɣi didi kae nàte ŋu anɔ agbe kple Plasmacytoma?

Esia nye kuxi na ame geɖe. Ame siwo ŋu SPB le la dometɔ siwo ade 60% gakpɔtɔ le agbe ƒe atɔ̃ le dɔlélea kpɔkpɔ vɔ megbe. Ame siwo ŋu EMP le la dometɔ siwo ade 82% gakpɔtɔ le agbe ƒe atɔ̃ le dɔlélea kpɔkpɔ vɔ megbe. Akɔntabubuwo koe esiawo nye, esia ate ŋu ato vovo tso ame ɖeka gbɔ yi bubu gbɔ.

Nublanuitɔe la, plasmacytoma ate ŋu atrɔ ava ɣeaɖewoɣi , alo adze le ŋutilãa ƒe akpa bubu. Azɔ hã, ame aɖewo siwo ŋu SPB alo EMP le ate ŋu axɔ multiple myeloma emegbe. Esia ate ŋu akpɔ ŋusẽ ɖe ɣeyiɣi didi si woanɔ agbe dzi.

Aleke malé be na ɖokuinye? Nukae wòle be mawɔ?

Esi wònye be dɔléle aɖe si woyɔna be plasmacytoma ate ŋu ava zu multiple myeloma ta la, ne plasmacytoma le ŋuwò la, ahiã be woakpɔ egbɔ le wò agbemeŋkekewo katã me ne wowu atikewɔwɔa nu gɔ̃ hã. Esia le vevie ŋutɔ.

Zi geɖe la, beléle sia si wotsɔ kplɔa ame ɖo la lɔ ʋudodokpɔ edziedzi kple nɔnɔmetatawo dodokpɔ (abe CT kple MRI ene) ɖe eme. Ðɔkta siawo alé ŋku ɖe ŋuwò be màkpɔ dzesi siwo nye multiple myeloma hã. Ne plasmacytoma le ŋuwò la, bia wò ɖɔkta be beléle si ƒomevi wòle be yeakpɔ mɔ na be yeakplɔ ye ɖo hã.

Plasmacytoma nye ʋumenugbagbeviɣidɔ si mebɔ kura o si ɖi multiple myeloma. Dzɔgbenyuietɔe la, ɖɔktawo ate ŋu ada plasmacytoma ƒe akpa gãtɔ dzidzedzetɔe, si ana dɔdzẽa naɖe akpɔtɔ eye wòaɖe dzesiawo dzi akpɔtɔ. Gake ne wokpɔe be plasmacytoma le ŋuwò la, efia be ele be nànɔ agbe kple atikewɔwɔ ƒe kplɔkplɔ ɖo le wò agbemeŋkekewo katã me. Mele bɔbɔe be woanɔ agbe kple dɔléle si nu yina keŋkeŋ gbeɖe o. Ne èle agbe kple plasmacytoma la, bia wò ɖɔkta tso mɔ siwo dzi wòato akpe ɖe ŋuwò nànɔ te ɖe dɔléle sia si nɔa anyi didi nu ŋu. Adzɔ dzi na wo be yewoakpe ɖe ŋuwò.

Mlɔeba la, nusiwo dzi wòle be woaɖo ŋkui (Take-Home Message) .

Enyo, eyata mina míagbugbɔ aƒo nu tso nusiwo dzi wòle be nàɖo ŋkui tso nusiwo ŋu míeƒo nu tsoe me la dometɔ aɖewo ŋu:

• Plasmacytoma nye dɔléle si mebɔ o si tsoa dɔdzẽ siwo dona le mɔ si mesɔ o nu tso ʋumenugbagbevi dzĩwo me gbɔ .
• Esia ƒomevi vevi eve li: SPB, si gblẽa nu le ƒuwo ŋu , kple EMP, si gblẽa nu le lãkusi falɛfalɛwo ŋu .
• Dzesiawo ate ŋu anye ƒu ƒe vevesese, ƒu ƒe gbagbã, taɖuame, ŋɔti me sisi, kple nu mimi sesẽ . Ne dzesi siawo gakpɔtɔ li alo gagblẽ ɖe edzi la, di atikewɔlawo ƒe aɖaŋuɖoɖo.
• Womeke ɖe nusi koŋ gbɔ esia tso ŋu haɖe o , eyata mɔ aɖeke meli si dzi woato axe mɔ ɖe enu o.
• Atikewɔwɔmɔnu aɖewo li abe keklẽŋusẽdɔdamɔnu, amekoko, atikewɔmɔnu, kple dɔlélenutsiŋutete ƒe dɔdamɔnu ene .
• Agbemeŋkekewo katã ƒe kplɔkplɔ ɖo le atikewɔwɔ vɔ megbe le vevie ŋutɔ, elabena esia ate ŋu ava zu multiple myeloma alo atrɔ ava.
• Agbenɔnɔ kple nɔnɔme sia ate ŋu asesẽ. Ƒo nu kple wò ɖɔkta eye nàxɔ kpekpeɖeŋu si nèhiã.

Mele mɔ kpɔm be nyatakaka sia aɖe vi na wò. Nɔ lãmesẽ me!

` plasmacytoma, kansa, ʋudɔ, ƒumeŋuɖui, lãmeka falɛfalɛwo ƒe kansa, multiple myeloma