Ðe tɔmelã ƒe ʋeʋẽ hã le ŋuwòa? Mina míasrɔ̃ nu tso Trimethylaminuria (TMAU) ŋu!

Ɣeaɖewoɣi le míaƒe agbe me la, nu wɔnukuwo dzɔna, alo? Èse nɔnɔme aɖe si me ame aɖe ƒe ŋutilã, fifia, gbɔgbɔ, alo aɖuɖɔ ʋẽna abe tɔmelã gbegblẽ ene kpɔa? Eɖi nusi wɔ nuku, alo? Gake, nɔnɔme sia tɔgbe li vavã. Esiae nye nɔnɔme si ŋu míele nu ƒom tsoe egbea, Trimethylaminuria, alo `(TMAU)` kpuie. Ame aɖewo hã yɔnɛ be ``Fish Odor Syndrome``.

Nukae nye trimethylaminuria (TMAU)?

Kpuie ko la, trimethylaminuria (TMAU) nye lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔléle . Fifia ɖewohĩ ànɔ nusi nye lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔléle ŋu bum. Le míaƒe ŋutilã me la, atikewo ƒe dɔwɔwɔ, alo lãmenugbagbeviwo ƒe dɔwɔwɔ , dzɔna be woatrɔ nuɖuɖu siwo míeɖuna wòazu ŋusẽ eye woawɔ nusiwo míaƒe ŋutilã hiã. Enzyme siwo le míaƒe ŋutilã me kpena ɖe nuwɔna siawo ŋu be wodzɔna nyuie. Eyata le nɔnɔme sia si woyɔna be trimethylaminuria me la, le tɔtrɔ si va le enzyme aɖe ƒe dɔwɔwɔ me ta la, womate ŋu agbã atike siwo wowɔna le ŋutilã me dometɔ aɖewo nyuie o. Esia tae tɔmelã ƒe ʋeʋẽ madzeameŋu ma dona tso fifia, gbɔgbɔ, aɖuɖɔ, kple aɖuɖɔ me ɖo.

Ðewohĩ èse ɖɔktawo yɔa nɔnɔme sia be `(TMAU)` alo `(Fish Odor Syndrome)`. Womekpɔ atike blibo aɖeke na esia haɖe o . Gake, mègatsi dzi o. Àte ŋu aɖe dzesi siawo dzi akpɔtɔ ŋutɔ ne ètrɔ nusiwo nèɖuna kple nunono, adzalẽ kple atike aɖewo zazã, kple wò nuteɖeamedzi dzi ɖuɖu .

Nukae nye `(TMAU)` ƒe ƒomevi veviwo?

Trimethylaminuria ƒomevi vevi eve li:

1. Trimethylaminuria Gbãtɔ : Esiae nye ƒomevi si wodzina . Esia fia be tɔtrɔ aɖewo (`(Domenyiŋusẽfianu ƒe tɔtrɔ)`) le domenyiŋusẽfianu (`(Domenyiŋusẽfianu)`) siwo ƒe dome wonyi tso vidadaa kple fofoa siaa gbɔ gbɔe nɔnɔme sia tsona.

2. Trimethylaminuria evelia : Esia dzɔna le eƒe tsitsime . Atikewɔwɔ ƒe nɔnɔme aɖewo alo nuɖuɖu kpeɖeŋutɔ aɖewo ate ŋu ahe tɔmelã ƒe ʋeʋẽ sia vɛ.

Aleke gbegbee nɔnɔme sia bɔe?

Le nyateƒe me la, TMAU nye dɔléle si mebɔ kura o . Numekuku aɖe ɖee fia be ame ɖeka le ame 200,000 va ɖo miliɔn ɖeka me koe wòdzena le le xexeame godoo. Gake wogblɔ hã be nyɔnuwo ate ŋu axɔe vie wu ŋutsuwo.

Ke hã, numekula aɖewo xɔe se be ɖewohĩ ame siwo ŋu `(TMAU)` le la asɔ gbɔ le hadomegbenɔnɔ me wu alesi akɔntabubu siawo ɖee fia. Elabena ame geɖe susuna be esia nye yewo ŋutɔ yewoƒe dzadzɛnyenye ƒe kuxi . Eyata womegblɔnɛ na ame aɖeke alo yia ɖɔkta gbɔ le ŋukpe ta o. Eyata, womexɔa dɔléle ŋuti dzesi (`(Diagnosis)`).

Nukae nye trimethylaminuria ƒe dzesiwo?

Dzesi vevitɔ si dze ƒã wue nye tɔmelã ƒe ʋeʋẽ si dona tso ŋutilã, gbɔgbɔ, kple fifia me . Ʋeʋẽ sia te ŋu mevivina ɣeaɖewoɣi o ale gbegbe be ate ŋu ana ame natsi dzodzodzoe. Le ame aɖewo gome la, ate ŋu akplɔe hã kple gbɔgbɔtsixe ƒoƒo (`(Halitosis)`) kple ʋeʋẽ sesẽ si dona tso aɖuɖɔ me.

Ɣeaɖewoɣi la, amesi ŋu `(TMAU)` le sea ʋeʋẽ sia wu ne wole fifia alo ne wole nuteɖeamedzi me. Gake le ame aɖewo gome la, ʋeʋẽ sia nu sẽna ale gbegbe be ne woge ɖe xɔ aɖe si me wole me, tsi tre ɖe kplɔ̃a ƒe go kemɛ dzi le fiase aɖe me, alo wobɔbɔ nɔ bɔs alo keteke ƒe akpa ɖeka hã la, ame bubuwo ate ŋu ase eƒe ʋeʋẽ kokoko. Bu ale si gbegbe ema sesẽe ŋu kpɔ.

Nukae nye nusiwo gbɔ `(TMAU)` tsona?

Trimethylaminuria dzɔna ne enzyme aɖe si woyɔna be `(FMO3)` ƒe dɔwɔwɔ le míaƒe ŋutilã me gblẽ. `(FMO3)` tsi tre ɖi na Flavin- si me monooxygenase 3. Enzyme sia ƒe dɔ vevitɔe nye be wòakpɔ atike si woyɔna be `( Trimethylamine )` si wowɔna le míaƒe ŋutilã me dzi. Trimethylamine sia gbɔe tɔmelã ƒe ʋeʋẽ ma tsona. Trimethylamine sia dona ne nuɖuɖu aɖewo siwo míeɖuna, le kpɔɖeŋu me, tɔmelã, gbe, kple azi, ɖu.

Nusi dzɔna zi geɖe enye esi: Ne trimethylamine ƒo ƒu ɖe míaƒe ŋutilã me la, enzyme `(FMO3)` va dona eye wògbãnɛ, si trɔna wòzua atike si meʋẽna o. Emegbe togbɔ be etoa míaƒe nuɖuɖumeŋusẽ me yia míaƒe ʋukawo me hã la, meʋẽna o.

Gake, nukae adzɔ ne `(FMO3)` enzyme ma mewɔ dɔ nyuie o? Trimethylamine ma si ʋẽna lilili la ƒoa ƒu ɖe míaƒe ŋutilã me. Ne eƒo ƒu la, edona mlɔeba le fifia, gbɔgbɔ, aɖuɖɔ, kple aɖuɖɔ me, eye tɔmelã ƒe ʋeʋẽ ma dona. Èse egɔmea?

Ame siwo ŋu trimethylaminuria gbãtɔ (`(TMAU gbãtɔ)`) le la va xɔa nɔnɔme sia elabena wonyia domenyiŋusẽfianu siwo wɔa `(FMO3)` enzyme (`(Abnormal FMO3 genes)`) ƒe kɔpi siwo mesɔ o ƒe dome tso wo dada kple wo fofo siaa gbɔ.

Le trimethylaminuria evelia (`(Secondary TMAU)`) me la, wò `(FMO3)` enzyme mete ŋu gblẽa trimethylamine me o le susu bubu aɖe ta. Esia ate ŋu atso:

• Ne dɔléle aɖe le ŋuwò, abe aklã ƒe dɔmawɔmawɔ nyuie alo dɔlékui ƒe aklãdɔ ene la , ate ŋu ado kplamatse enzyme la ƒe dɔwɔwɔ eye wòaxe mɔ nɛ be wòagagbã trimethylamine o.
• Ne wò dɔgbo me nugbagbevi suesuesuewo meda sɔ o, si fia be dɔlékui nyui kple gbegblẽ siwo le wò dɔgbo me meda sɔ o la, trimethylamine si sɔ gbɔ akpa ate ŋu aƒo ƒu. Ekema enzyme (FMO3) mate ŋu aɖe ʋeʋẽ mawo katã ɖa o.
• Ne èno atike siwo me choline alo carnitine le la, nunyiame siawo kpena ɖe ame ŋu be trimethylamine dona.

Nukawoe nye nɔnɔme sia ƒe kuxiwo?

Alesi nɔnɔme aɖe si woyɔna be trimethylaminuria kpɔa ŋusẽ ɖe wò agbenɔnɔ dzii(`(Agbe ƒe nyonyome)`) ate ŋu agblẽ nu le ame ŋu ŋutɔ. Numekukuwo ɖee fia be zi geɖe la, amesiwo ŋu dɔléle sia le ƒoa asa na ƒomedodo, dɔwɔɖui, kple hadomenuwɔnawo le esi wovɔ̃na be ame bubuwo ade dzesi ʋeʋẽ si mevivina o ta. Le esia ta la, ame siwo ŋu dɔléle sia le ate ŋu axɔ susumedɔléle vovovowo. Le kpɔɖeŋu me:

• Dzimaɖitsitsi (`(Dzimaɖitsitsi)`) .
• Teteɖeanyi
• Dzimaɖitsitsi kple vɔvɔ̃ si me susu mele o (`(Paranoia)`) .

Togbɔ be ƒã ŋutɔ hã la, wogblɔ be ame aɖewo siwo ŋu TMAU le la ƒe susu nɔa wo ɖokui wuwu ŋu (`(Suicidal behavior)`). Esia ɖe alesi gbegbe nɔnɔme sia ate ŋu akpɔ ŋusẽ ɖe susu dzii la fia.

Aleke wokpɔa dɔléle si nye trimethylaminuria?

Ðɔktawo dea dzesi TMAU to trimethylamine ƒe agbɔsɔsɔ si le wò aɖuɖɔ me dzidzedze me . Zi geɖe la, wowɔa esia to aɖuɖɔ dodokpɔ me . Tsɔ kpe ɖe eŋu la, wò ɖɔkta ate ŋu aɖo aɖaŋu be nàwɔ domenyiŋusẽfianu ƒe dodokpɔwo atsɔ anya nenye be gbãtɔ (i.e., congenital) alo evelia (i.e., acquired) ƒe nɔnɔme le ŋuwò.

Nukawoe nye trimethylaminuria ƒe atikewo?

Wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nu vovovowo nakpe ɖe ŋuwò nàɖe TMAU ƒe dzesiwo dzi akpɔtɔ.

• Nuɖuɖu: Wokafui be woaɖe nuɖuɖu aɖewo siwo nana atike si hea dɔlélea vɛ (TMAU) ƒe wɔwɔme dzina ɖe edzi le ŋutilãa me la ɖa.
• Adzalẽ kple atike tɔxɛwo: Wokafui be woazã adzalẽ kple ami tɔxɛ siwo kpena ɖe ame ŋu be tɔmelã ƒe ʋeʋẽ si dona le ŋutigbalẽa me dzi naɖe akpɔtɔ.
• Atikewo: Ɣeaɖewoɣi la, woate ŋu aŋlɔ atikewo hã na ame.
• Susu ƒe lãmesẽnyawo gbɔ kpɔkpɔ ƒe kpekpeɖeŋu: Woate ŋu aɖo aɖaŋu na wò hã be nàdi susuŋutinunyalawo ƒe aɖaŋuɖoɖo be wòakpe ɖe ŋuwò nànɔ te ɖe nuteɖeamedzi si nɔnɔme sia hena vɛ nu.

Nuɖuɖu kawo ƒomevie wòle be woaɖe ɖa?

Ne trimethylaminuria le ŋuwò la, zi geɖe la, ɖɔktawo gblɔna na wò be nàɖo seɖoƒe na nuɖuɖu siwo gbɔna alo nàƒo asa na wo keŋkeŋ:

• Tɔmelã kple ƒumelã bubuwo (vevietɔ tɔmelã siwo le dzetsi me) .
• Azi (vevietɔ azi tutu) .
• Aklã kple lãwo ƒe ŋutinu bubu siwo le ememe
• Mɔliwo abe soya, chickpeas, kple lentils ene
• Amagbe siwo wotsɔ atitsoga wɔe abe kabɔb, broccoli, seƒoƒotsihe, kple Brussels sprouts ene
• Akɔɖu
• Notsi kple nyinotsibabla (na ame aɖewo) .
• Nuɖuɖu kple nunyiame siwo me choline kple L-carnitine sɔ gbɔ ɖo

Vevietɔ: Menye amesiamee hiã be wòaɖe nuɖuɖu siawo katã ɖa o. Anyo wu be nàƒo nu kple ɖɔkta alo nuɖuɖuŋutinunyala be nànya nuɖuɖu siwo sɔ na wò.

Nukae nye atike siwo wonana na `(TMAU)`?

Wò ɖɔkta ate ŋu aŋlɔ atikewo abe esiawo ene be wòaɖe TMAU ƒe dzesiwo dzi akpɔtɔ:

• Dɔlékuiwutikewo kple probiotics : Atike siawo kpena ɖe ame ŋu be dɔlékui siwo le wò dɔgbo me dzi ɖena kpɔtɔna, si wɔnɛ be trimethylamine ƒe wɔwɔ dzi ɖena kpɔtɔna.
• Activated charcoal : Esia le abe ƒumebɔbɔ ene. Exɔa trimethylamine le ŋutilã me eye wòkpena ɖe eŋu wòdona le aɖuɖɔ me.
• Blanuilélenutsitikewo kple dzimaɖitsitsinutsitikewo : Wonaa atike siawo tsɔ daa susumedɔléle siwo ame aɖewo siwo ŋu TMAU le doa goe.

Wò ɖɔkta ate ŋu aɖo wò ɖe susumedɔlélewo gbɔ kpɔƒe hã . Nuƒoƒo kple susuŋutinunyala alo aɖaŋuɖola le vevie ŋutɔ ne èle avu wɔm kple bubudede ɖokuiwò kple ŋutilã ƒe nɔnɔme ŋuti nyawo. Tagbɔdɔdada ate ŋu akpe ɖe ŋuwò nàsrɔ̃ alesi nàwɔ anɔ te ɖe wò nɔnɔmea nu ahaɖu nuteɖeamedzi dzi.

Nukae ame si ŋu trimethylaminuria le ate ŋu akpɔ mɔ na?

Trimethylaminuria nye dɔléle si nɔa anyi didi . Esia fia be womate ŋu adae keŋkeŋ alo ahaya le eɖokui si o. Gake abe alesi míegblɔe va yi ene la, atikewɔmɔnu kple nu aɖewo li nàte ŋu awɔ atsɔ aɖe TMAU ƒe dzesiwo dzi akpɔtɔ eye nàɖe ŋusẽ si nɔnɔmea kpɔna ɖe wò agbe dzi dzi akpɔtɔ.

Aleke malé be na ɖokuinye?

Ðokuidzikpɔkpɔ le vevie ŋutɔ ne èle TMAU gbɔ. Nu aɖewo siwo ŋu wòle be nàbu lae nye esi:

• Ame ŋutɔ ƒe dzadzɛnyenye : Adzalẽ kple atike siwo ƒe asixɔxɔ mede `(pH)` o zazã ate ŋu akpe ɖe ŋuwò nàɖe wò ŋutilã ƒe ʋeʋẽ dzi akpɔtɔ. Bia wò ɖɔkta be `(pH)` ƒe asixɔxɔ kae sɔ na wò kple atike siwo nyo wu hã.
• Kpɔ nyuie le nusi nèɖuna ŋu : Nuɖuɖu geɖe ate ŋu ana trimethylaminuria nagado gã ɖe edzi. Ƒo nu kple nuɖuɖuŋutinunyala aɖe be wòawɔ ɖoɖo ɖe wò nuɖuɖu kple nuɖuɖu tiatia ŋu ale be nunyiame siwo nèhiã la nasu asiwò.
• Dzra nuteɖeamedzi dzi : Nuteɖeamedzi ƒe dzidziɖedzi ate ŋu ana TMAU ƒe dzesiwo nadzi ɖe edzi. Eyata bia wò ɖɔkta tso mɔ siwo dzi nàto akpe ɖe ŋuwò nàɖe wò nuteɖeamedzi dzi akpɔtɔ ŋu. (e.g., ŋugbledede, yoga, gbɔgbɔtsixe ƒe kamedede)
• Di kpekpeɖeŋu : Trimethylaminuria nye dɔléle si mebɔ o, eyata àte ŋu ase le ɖokuiwò me be yetsi akogo eye yeɖe ye ɖokui ɖe aga. Eyata ate ŋu anye kpekpeɖeŋu gã aɖe be nàdo ka kple kpekpeɖeŋunaha siwo me woate ŋu akpɔ ame bubu siwo ŋu nɔnɔme ma ke le le .

Ɣekaɣie wòle be makpɔ nye ɖɔkta?

Ne wò dzesiwo meva nyo ɖe edzi o le tɔtrɔ siwo nèwɔ le wò nuɖuɖu kple nuteɖeamedzi dzi ɖuɖu me vɔ megbe gɔ̃ hã la, kpɔ egbɔ be yeyi ɖɔkta gbɔ. Ate ŋu adzro atikewɔwɔmɔnu bubu siwo ŋu nàte ŋu abu la me.

Nya kawoe wòle be mabia nye ɖɔkta?

Esi wònye be trimethylaminuria nye dɔléle si mebɔ kura o ta la, ɖewohĩ mànya nu geɖe tso eŋu o. Nya aɖewo siwo nàte ŋu abia wò ɖɔktae nye esi:

• Nukatae meva ge ɖe nɔnɔme sia me?
• Atikewɔwɔ nyuitɔ kawoe nèkafu nam?
• Àte ŋu akafu kpekpeɖeŋunaha alo ɖoɖo aɖe si me mate ŋu axɔ kpekpeɖeŋu lea?

Ðe amesiwo ŋu trimethylaminuria le ate ŋu ase ʋeʋẽa?

Esia hã nye kuxi na ame geɖe. Ẽ, zi geɖe la, míesea mía ŋutɔwo ƒe fifia kple ŋutilã ƒe ʋeʋẽ, eye amesiwo ŋu `(TMAU)` le ate ŋu ase woawo ŋutɔ ƒe ʋeʋẽ. Gake ɣeaɖewoɣi la, ne wonya zu numame na woawo ŋutɔ ƒe ʋeʋẽ ko la, ɖewohĩ womade dzesii vevie abe ame bubuwo ene o. Azɔ hã, menye amesiamee ate ŋu agblɔ be yemesea eƒe ʋeʋẽ o; ɖewohĩ ame aɖewo made dzesii gɔ̃ hã be ʋeʋẽ si mebɔ o le yewoƒe ŋutilã ŋu o.

Mlɔeba la, gbedasi vevitɔ kekeake

Trimethylaminuria nye dɔléle si ate ŋu ana ame nagate ŋu awɔ naneke kura o ŋutɔŋutɔ, menye le ŋutilã me ɖeɖeko o, ke le susu hã gome . Ne mehe ŋutilã me veve o hã la, ate ŋu ana ame nase veve vevie eye abi nanɔ susu me. Ame aɖewo siwo ŋu nɔnɔme sia le la ɖea wo ɖokui ɖe aga tso hadomegbenɔnɔ gbɔ eye wodzea agbagba be yewoanɔ yewo ɖokui si, le vɔvɔ̃ be yewoanye fuɖename na ame bubuwo ta. Le woƒe nuɖuɖu tɔtrɔ kple aɖaŋuɖoɖo bubuwo dzi wɔwɔ vɔ megbe gɔ̃ hã la, ame aɖewo siwo ŋu `(TMAU)` le sena le wo ɖokui me be egahiã kokoko be yewoaɖe yewoƒe agbenɔnɔ ɖa tso ame bubuwo gbɔ. Amewo ɖeɖe ɖe aga le hadome alea ate ŋu ana nuwo abe blanuiléle kple dzimaɖitsitsi ene nadze dziwò.

Ðo ŋku edzi be menye wò ɖeka koe o . Ne nɔnɔme sia le fu ɖem na wò la, taflatse mègakpe ŋu alo nàvɔ̃ be yeabia kpekpeɖeŋu wò ɖɔkta o. Woate ŋu ase nusiwo me tom nèle gɔme eye woate ŋu agblɔ ɖoɖo kple dɔwɔna siwo ate ŋu akpe ɖe ŋuwò la na wò. Wò susu ƒe lãmesẽ le vevie abe alesi wò ŋutilã ƒe lãmesẽ le vevie ene. Eyata kpɔ egbɔ be yebu eŋu hã.

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