Ðe wònye nulɔdɔ aɖe ko? Alo ɖe esia nye Mast Cell Activation Syndrome (MCAS)?

Ðe nèdzea ʋuʋu gɔme zi ɖeka, wò ŋutigbalẽ biãna eye wògbãna abe ʋuʋudedi enea? Alo ɖe nèsena le ɖokuiwò me zi ɖeka be yeƒe dɔgbo le dɔ lém eye wòdi be yeaɖe aɖuɖɔa? Ɣeaɖewoɣi la, nusiawo dzɔna le ami ʋeʋĩ aɖe zazã vɔ megbe, alo le nuɖuɖu aɖe ɖuɖu vɔ megbe, eye ɣeaɖewoɣi la, woate ŋu adzɔ le susu aɖeke ta kura o. Ne mète ŋu kpɔ susu aɖeke si tae wòle alea ɖo o, eye dzesi vovovowo le ŋuwò le ɣeyiɣi vovovowo me la, ate ŋu adzɔ be menye nulɔdɔ koe wònye o. Egbea míele nu ƒom tso nɔnɔme mawo dometɔ ɖeka ŋu, si nye Mast Cell Activation Syndrome (MCAS).

Nukae Nye Lãmenugbagbeviwo ƒe Dɔwɔwɔ ƒe Dɔléle (MCAS)?

Kpuie ko la, MCAS nye nɔnɔme si me lãmenugbagbevi ƒomevi aɖe si le míaƒe ŋutilã me si woyɔna be ‘mast cells’ va zua nusi mehiã o eye wòwɔa dɔ wògbɔa eme, si wɔnɛ be atike gbogbo aɖewo siwo le wo me la dona ɖe ŋutilãa me.

Azɔ mina míalé ŋku ɖe nusiwo nye mast cell siawo ŋu. Bu lãmenugbagbevi siawo be wonye ame kukua ƒe dedienɔnɔdzikpɔlawo. Wonye míaƒe dɔlélenutsiŋutete ƒe akpa aɖe. Woƒe dɔ vevitɔe nye be woawɔ avu kple dɔlékuiwo. Gake lãmenugbagbevi siawo gbɔe nulɔdɔ hã tsona. Zi geɖe la, ne nane si gblẽa nu le mía ŋu, le kpɔɖeŋu me, nulɔdɔ aɖe ge ɖe ŋutilã me la, mast cell siawo wɔa dɔ eye woɖea atike siwo woyɔna be ‘mediators’ dona. Atike siawoe nana míaƒe ŋutilã ƒe nulɔdɔwo wɔa nu ɖe ​​ame ŋu. Le ame si le lãmesẽ me gome la, ɖoɖo sia nye be wòakpɔ mía ta.

Gake, le amesi ŋu MCAS le gome la, mast cell siawo sea veve ŋutɔ . Dzi dzɔa wo akpa ɖe nu suetɔ kekeake gɔ̃ hã ŋu eye woɖea atike gbogbo aɖewo ɖe go zi ɖeka. Ele abe aʋakɔ blibo aɖe tsɔtsɔ vɛ be woalé fiafitɔ sue aɖe ene. Atike siawo siwo míedi o ye hea dzesi siwo mebɔ o, siwo ɖea fu na ame, siwo ŋu míeƒo nu tsoe va yi la dometɔ geɖe vɛ.

Zi geɖe la, nu geɖe li siwo ate ŋu aʋã mast cell siawo:

• Dɔlékuiwo
• Atike aɖewo
• Aɖi si tso nudzodzoewo ƒe ɖuɖu me
• Ʋeʋẽ lililiwo
• Nuteɖeamedzi
• Kamedede
• Nuɖuɖu aɖewo
• Dzoxɔxɔ ƒe tɔtrɔ kpata

Ðe MCAS kple Mastocytosis nye nu vovovo evea?

Ẽ, mègatɔtɔ ame eveawo o. Togbɔ be nɔnɔme eveawo siaa lɔ mast cells ɖe eme hã la, woto vovo.

Nukawoe hea MCAS vɛ?

Woate ŋu ama MCAS ɖe hatsotso vevi etɔ̃ me le nusi gbɔ wòtso nu.

1. MCAS Gbãtɔ: Kuxi aɖe si le mast cells ŋutɔ ŋu gbɔe esia tsona. Zi geɖe la, domenyiŋusẽfianu ``(KIT)`` ƒe tɔtrɔ nana lãmenugbagbevi siawo wɔa nu le mɔ si mesɔ o nu. Mastocytosis ye nye nɔnɔme vevitɔ le ƒomevi sia me.

2. MCAS evelia: Esia dzɔna ne gotagome nu bubu aɖee ʋã mast cells. Le kpɔɖeŋu me, esia ate ŋu atso nulɔdɔ sesẽ aɖe, dɔlékui si nɔa anyi didi, alo atikewɔwɔ ƒe nɔnɔme bubu aɖe gbɔ.

3. Idiopathic MCAS: "Idiopathic" gɔmee nye "womate ŋu akpɔ nusi gbɔ wòtso o." Esia ƒomevi le MCAS dɔnɔ akpa gãtɔ ŋu. Esia fia be susu aɖeke koŋ meli si tae mast cell siawo le nu wɔm le mɔ si mesɔ o nu ɖo o. Dzesiwo ate ŋu adze le nu yeyewo ŋu ɣesiaɣi.

Nukawoe nye MCAS ƒe dzesi siwo ate ŋu anɔ ame ŋu?

Kuxi gãtɔ siwo le MCAS ŋu dometɔ ɖekae nye be dzesiawo to vovo ale gbegbe eye woate ŋu akpɔ ŋusẽ ɖe ŋutilã ƒe dɔwɔwɔ geɖe dzi zi ɖeka.

Lé ŋku ɖe nu ŋu etɔxɛe: Anaphylactic Shock

Dzesi siwo dzena le anaphylaxis ŋu:

• Yagbɔgbɔ sesẽ, sese le ɖokuiwò me be yeƒe ŋɔti xaxa
• Nuyi, aɖe, alo mo ƒe vuvu
• Dzi ƒe tsotso kabakaba ŋutɔ.
• Ʋu ƒe sisi ƒe ɖiɖi kpata
• Taɖuame sesẽ kple alɔ̃madɔmadɔ
• Aɖuɖɔtoe kple aɖuɖɔtoe
• Dzobibi kple ʋuʋudedi kpata le ŋutilã bliboa ŋu

Ne èkpɔ dzesi siawo dometɔ ɖeka alo esi wu nenema la, mègahe ɖe megbe o. Yɔ dɔnɔdzikpɔʋu enumake alo yi kɔdzi si te ɖe ŋuwò ƒe Dɔwɔƒe si Kpɔa Nudzɔdzɔ Kpatawo Gbɔ (ETU).

Aleke mawɔ anya ne MCAS le ŋunye?

MCAS didi ate ŋu asesẽ vie elabena dzesiawo to vovo ale gbegbe. Zi geɖe la, wò ɖɔkta adi nu etɔ̃ koŋ.

1. Dzesiwo: Dzesi siwo gbugbɔna, siwo ɖi nulɔdɔ si nɔa anyi didi ƒe anyinɔnɔ le ŋutilã ƒe ɖoɖo eve alo esi wu nenema me (e.g., ŋutigbalẽ kple dɔgbo).

2. Dodokpɔwo: Ʋu alo aɖuɖɔ si woɖe ne dzesiawo dze la ɖea atikewo abe ``tryptase'' kple ``histamine'', siwo mast cells ɖena ɖe go la ƒe agbɔsɔsɔ si dzi ɖe edzi fiana.

3. Alesi wowɔa nui ɖe atikewɔwɔ ŋu: Dzesiwo dzi ɖena kpɔtɔna ne wona atike siwo xea mɔ na mast cell ƒe dɔwɔwɔ, abe antihistamines ene.

Ne woɖo dzidzenu etɔ̃ siawo katã gbɔ la, ɖɔktaa ate ŋu asusui be MCAS. Ɣeaɖewoɣi la, nɔnɔme aɖe si woyɔna be ``(POTS)`` - Postural Orthostatic Tachycardia Syndrome kpena ɖe MCAS ŋu. Esiae nye esime dzi ƒe tsotso dzina ɖe edzi le mɔ si mesɔ o nu ne wotsi tre.

Aleke wowɔa atike nɛ?

Atike aɖeke meli na MCAS haɖe o. Gake woate ŋu aɖu dzesiawo dzi nyuie eye woate ŋu anɔ agbe si sɔ. Taɖodzinu vevi eve le atikewɔwɔ ŋu.

1. Ƒo asa na nusiwo hea wò dɔlélea vɛ: Nu vevitɔe nye be nànya nusi hea wò dzesiwo vɛ eye nàƒo asa na wo.

2. Dzesiwo dzi ɖuɖu to atikewo zazã me: Ðɔktaa aŋlɔ atike vovovowo na wò.

• H1 kple H2 antihistamines: Atikewo abe Cetirizine, Loratadine, Famotidine ene.
• Mast Cell Stabilizers: Atike siwo xea mɔ na atike siwo dona le mast cells me.
• Leukotriene Mɔxenuwo: Atikewo abe Montelukast ene.
• Le nɔnɔme kpatawo gome: Ne afɔku le anaphylaxis me la, ɖɔktawo ɖo aɖaŋu be nàna auto-injector (abe EpiPen ene) si me `(epinephrine)` le la nanɔ teƒe si te ɖe ŋuwò ɣesiaɣi.

Nusiwo ŋu wòle be woabu ne wole agbe kple MCAS

Agbenɔnɔ kple MCAS ate ŋu asesẽ, gake ne èkpɔ egbɔ nyuie la, àte ŋu anɔ agbe kple nɔnɔmea dzidzedzetɔe.

• Nuɖuɖu: Nuɖuɖu aɖewo ate ŋu ahe MCAS vɛ. Kpɔ nyuie vevietɔ le nuɖuɖu siwo me histamine sɔ gbɔ ɖo (cheese si wofli, tɔmelã si wotsɔ gaze me, tomatos, aŋanyi, tsokolet) ŋu. Anyo wu be nàbia wò ɖɔkta eye nàkpɔ nuɖuɖuŋutinunyala aɖe be wòawɔ nuɖuɖu ŋuti ɖoɖo si sɔ na wò.
• Nuteɖeamedzi dzi ɖuɖu: Nuteɖeamedzi nye nu vevi aɖe si hea MCAS vɛ. Eyata ele vevie ŋutɔ be nàna wò susu naɖe dzi ɖi. Nuwo abe ŋugbledede, yoga, kple gomekpɔkpɔ le modzakaɖeɖe si nèlɔ̃na me ene ate ŋu akpe ɖe ŋuwò.
• Di kpekpeɖeŋu: Ƒo nu tso wò nɔnɔmea ŋu na ƒometɔwo kple xɔlɔ̃wo. Ate ŋu aɖe vi hã be nàge ɖe kpekpeɖeŋunahawo me kple amesiwo le nɔnɔme mawo tɔgbe me tom.
• Dzeɖoɖo kple wò ɖɔkta edziedzi: Ðo dze kple wò ɖɔkta edziedzi eye nàtrɔ asi le wò atikewɔwɔ ƒe ɖoɖoa ŋu ne ehiã.