Míenya be lãmenugbagbevi triliɔn geɖe ye le míaƒe ŋutilã me. Zi geɖe la, míebua lãmenugbagbevi siawo dometɔ ɖesiaɖe be domenyiŋusẽfianu ŋuti nyatakaka ɖeka le wo si, abe nɔnɔmetata ɖeka ƒe kɔpi geɖe ene. Gake ɣeaɖewoɣi la, esia ate ŋu ato vovo vie. Tsɔe be lãmenugbagbevi aɖewo le wò ŋutilã me ƒe domenyiŋusẽfianu ƒe nɔnɔmetata ɖeka, eye lãmenugbagbevi aɖewo ƒe domenyiŋusẽfianu ƒe nɔnɔmetata to vovo vie. Emae nye nusi míeyɔna be mosaicism le atikewɔwɔ me.
Kpuie ko la, nukae nye Mose-subɔsubɔ?
Kpuie ko la, Mose-subɔsubɔ nye lãmenugbagbevi ƒe hatsotso eve alo esi wu nenema ƒe anyinɔnɔ le ame ɖeka ƒe ŋutilã me le domenyiŋusẽfianu me. Esia le abe mosaic-nutata ene. Abe ale si ko tile sue siwo ƒe amadede kple nɔnɔme to vovo la ƒoa ƒu wɔa nɔnɔmetata dzeani aɖe ene la, nusi dzɔna le afisiae nye be lãmenugbagbevi siwo ƒe domenyiŋusẽfianu to vovo la va ƒoa ƒu wɔa ŋutilã ɖeka.
Esia ƒe kpɔɖeŋu nyui aɖee nye vovototo si le domenyiŋusẽfianu ƒe xexlẽme me. Dzɔdzɔmenugbagbevi 46 ye le ame si le lãmesẽ me la me le lãmenugbagbevi ɖesiaɖe me. Gake le amesi ŋu mosaicism le gome la, domenyiŋusẽfianu 46 ye le lãmenugbagbevi aɖewo me, evɔ lãmenugbagbeviwo ƒe hatsotso bubu ya ƒe xexlẽme ate ŋu ato vovo, abe domenyiŋusẽfianu 47 alo 45 ene. Domenyiŋusẽfianu ƒe vovototo sia ate ŋu ahe lãmesẽkuxi aɖewo vɛ le vidzidzi me, eye ɣeaɖewoɣi la, kuxiwo ate ŋu ado mo ɖa le eƒe tsitsime.
Dɔléle kawoe woate ŋu atsɔ asɔ kple mosaicism?
Mosaic-nuɖuɖu ate ŋu ahe dɔléle vovovowo vɛ. Gake nusi esia gblẽna le ame ŋu la toa vovo ŋutɔ tso ame ɖeka gbɔ yi bubu gbɔ. Enɔ te ɖe lãmenugbagbevi siwo mesɔ o ƒe alafa memamã si le ŋutilãa me kple ŋutinu siwo me lãmenugbagbevi mawo le dzi. Na míalé ŋku ɖe dɔléle vevi aɖewo siwo do ƒome kple esia ŋu.
| Nᴐnᴐme | Ŋusẽkpɔɖeamedzi kple nusiwo bɔ |
|---|---|
| Mosaic Down ƒe dɔléle si nye Mosaic Down ƒe dɔléle | Esia nye Down ƒe dɔléle ƒomevi aɖe . Ate ŋu ana susu nazu nuwɔametɔ, lãmekawo ƒe gbɔdzɔgbɔdzɔ, kple mo si le gbadzaa. Dzidɔ, nuɖuɖumeŋusẽ ƒe kuxiwo, kple lãkusi me kuxiwo hã ate ŋu anɔ ɖevi aɖewo ŋu. |
| Pallister-Killan ƒe mosaic ƒe dɔléle | Le nɔnɔme sia gɔ̃ hã me la, wokpɔa lãmekawo ƒe gbɔdzɔgbɔdzɔ, susu ƒe heheɖemegbe, taɖa ƒe ƒuƒu, ŋutigbalẽ ƒe amadede si mesɔ o, kple vidzidzi ƒe gbɔdzɔgbɔdzɔ bubuwo. |
| SOX2 ŋkumeʋuʋu ƒe dɔléle | Esia nye nɔnɔme si mebɔ kura o si ate ŋu ahe kuxi sesẽwo abe vidzĩa dzidzi ŋkumanɔmee, alɔ̃madɔmadɔ, ahɔhɔ̃ ƒe tsitsi ƒe kuxiwo, kple ŋutilã ƒe tsitsi ƒe megbetsitsi ene vɛ. |
| Trisomy 18 (Mosaic) . | Esia nye nɔnɔme si me vidzĩa ƒe tsitsi tsia megbe le vidzidɔa me. Woate ŋu adzi vidzĩa kple ta si le sue wu alesi wòle dzɔdzɔmee, dzi ƒe dɔmawɔmawɔ nyuie, kple ŋutinu bubuwo ƒe gbɔdzɔgbɔdzɔ. Nublanuitɔe la, vidzĩ geɖe siwo ŋu dɔléle sia le menɔa agbe wu woƒe ƒe gbãtɔ o. |
Tsɔ kpe ɖe eŋu la, mosaicism ate ŋu ado ƒome kple domenyiŋusẽfianu ƒe dɔmawɔmawɔ nyuie bubuwo, abe Turner ƒe dɔléle ene, kple kansa ƒomevi aɖewo, vevietɔ ʋumekansa.
Nukatae nɔnɔme sia dzɔna ɖo?
Le nyateƒe me la, esia dzɔna zi geɖe le vome. Menye ame aɖeke ƒe vodada gbɔe esia tso o. Bu eŋu kpɔ, ne vidadaa ƒe azi to vifofoa ƒe tsinyenye me vɔ la, lãmenugbagbevi gbãtɔ (zygote) si dzɔna la dzea mama gɔme. To mɔ sia dzi la, ne lãmenugbagbevi ɖeka ma ɖe eve, eve, ene, ene, enyi, kple bubuawo me la, fugboea tsina.
Le lãmenugbagbeviwo ƒe mama sia me la, ele be lãmenugbagbevi yeye ɖesiaɖe naxɔ lãmenugbagbevi gbãtɔa ƒe domenyiŋusẽfianu ƒe kɔpi pɛpɛpɛ. Gake ƒã ŋutɔ be vodada ate ŋu adzɔ le kɔpiwɔwɔ sia me. Vodadaa ate ŋu ana lãmenugbagbevi yeyea ƒe domenyiŋusẽfianu ƒe xexlẽme nato vovo. Ne lãmenugbagbevi si gblẽ la yi edzi le mamam la, ŋutilãa wɔa lãmenugbagbevi siwo ƒe domenyiŋusẽfianu mesɔ o ƒe dzidzime. Lãmenugbagbevi gbãtɔ siwo le lãmesẽ me hã yia edzi le mamam, ale be mlɔeba la, lãmenugbagbevi eve va nɔa ŋutilãa me.
- Mosaicism si de ŋgɔ: Ne nɔnɔme madeamedzi sia dzɔ le fugboe ƒe tsitsi ƒe gɔmedzedze ŋutɔ la, lãmenugbagbevi siwo mesɔ o ƒe alafa memamã gã aɖe (50% alo esi wu nenema) kaka ɖe ŋutilã bliboa me.
- Mosaicism si mebɔ o: Ne nusi gblẽ le eŋu la dzɔ le eƒe tsitsi ƒe akpa aɖe megbe la, lãmenugbagbevi siwo ŋu wògblẽ nu le ƒe xexlẽme le sue.
Ðe mosaic-ƒoƒo ƒomevi vevi aɖewo lia?
Ẽ, woate ŋu ama Mose-subɔsubɔ ɖe hatsotso vevi geɖe me. Esia gɔmesese ate ŋu akpe ɖe ŋuwò nàse nɔnɔmea ƒe nɔnɔme gɔme nyuie wu.
| Woƒe hatsotsowo me toto | Numeɖeɖe bɔbɔe |
|---|---|
| Le lãmenugbagbevi ƒomevi si ŋu wògblẽ nu le nu | |
| Somatic Mosaic-nufiafia | Le afisia la, ŋutilãa ƒe lãmenugbagbevi siwo sɔ (somatic cells) koe domenyiŋusẽfianu ƒe tɔtrɔa le. Eyae nye lãmenugbagbevi siwo le ŋutinuwo abe ŋutigbalẽ, ahɔhɔ̃, kple dzi ene me. Vevietɔ la, nɔnɔme sia mekpɔa ŋusẽ ɖe vidzidzi lãmenugbagbeviwo (azi kple tsinyenye) dzi o, eyata womenyie tso dzilawo gbɔ na viwo o. |
| Dɔlékuiwo ƒe Mosaic-nufiafia | Dɔlékui ƒe lãmenugbagbeviwo me koe domenyiŋusẽfianu ƒe tɔtrɔa le, si fia be azi alo tsinyenye me. Eyata ne dzesi aɖeke mele dzilawo ŋu o hã la, wo viwo le afɔku me be wonyi domenyiŋusẽfianu ƒe nɔnɔme sia ƒe dome. |
| Le alesi kaka ɖe ŋutilãa me nu | |
| Mose-subɔsubɔ ƒe Nufiafia Gbãtɔ | Le afisia la, lãmenugbagbevi siwo mesɔ o le ɖevia ƒe ŋutilã bliboa me. |
| Mose-subɔsubɔ si Woxe Mɔ Na | Le afisia la, womekpɔa lãmenugbagbevi siwo mesɔ o le ŋutilã bliboa me o, ke boŋ ŋutinu alo lãkusi aɖe koŋ, abe ahɔhɔ̃, dzi, alo aklã ene koe wokpɔna. Le kpɔɖeŋu me, nɔnɔme aɖe li si woyɔna be Confined Placental Mosaicism, si nye vidzidɔa ɖeɖeko. |
Aleke ɖɔktawo wɔa dea dzesi dɔléle siae?
Ele be woado domenyiŋusẽfianu ƒe dodokpɔ tɔxɛwo atsɔ anya mosaicism.
- Do Ŋgɔ Na Vidzidzi: Ne ɖikeke aɖe li be Mosaicism le vidzĩ ŋu le fufɔɣi la, ɖɔktawo ate ŋu aɖo aɖaŋu be woawɔ dodokpɔ tɔxɛwo. Amniocentesis (dodokpɔ le vidzidɔ me tsi si ƒo xlã vidzĩa) kpleChorionic Villus Sampling (CVS) (si nye lãkusi sue aɖe si le vidzidɔa me me dzodzro) nye dodokpɔ mawo dometɔ ɖeka.
- Dodokpɔ le vidzidzi megbe: Ne wodzi vidzĩa vɔ la, woate ŋu akpɔ dɔlélea to ʋudodokpɔ, ŋutigbalẽ ƒe lãmenugbagbeviwo ɖeɖe, kple bubuawo me Ɣeaɖewoɣi la, ahiã be woado lãkusi ƒomevi vovovo eve akpɔ be woaɖo kpe nɔnɔmea tututu dzi.
Vevietɔ le mɔnuwo abe vidzidzi le vidzidɔ me (IVF) ene me la, woate ŋu ado domenyiŋusẽfianu ƒe gbɔdzɔgbɔdzɔwo kpɔ to dodokpɔ si woyɔna be Preimplantation Genetic Screening (PGS) me hafi woatsɔ fugboea ade vidadaa ƒe vidzidɔ me.
Ðe atike aɖe li na mosaic-ƒoƒoa?
Esia nye kuxi si le ame geɖe ŋu. Le nyateƒe me la, fifia la, mɔ aɖeke meli si dzi woato atrɔ domenyiŋusẽfianu ƒe nɔnɔme si gbɔ wòtso si woyɔna be Mose-subɔsubɔ alo adae o. Eyae nye be manya wɔ be woaɖe lãmenugbagbevi siwo mesɔ o ɖa eye woatsɔ lãmenugbagbevi siwo sɔ aɖo wo teƒe o.
Gake, vevietɔ wu la, mɔ vovovowo li siwo dzi woato akpɔ lãmesẽkuxiwo kple dzesi siwo Mose-subɔsubɔ hena vɛ gbɔ ahada wo.
Atikewɔwɔ ƒe tiatia nɔ te ɖe nɔnɔme si gblẽa nu le ame ɖesiaɖe ŋu dzi. Le kpɔɖeŋu me, ɖevi si ŋu Mosaic Down ƒe dɔlélea le ate ŋu aɖe vi tso nuƒoƒo ƒe atikewɔwɔ kple ŋutilãmedɔdada me be wòakpe ɖe wo ŋu woatu woƒe ŋutetewo ɖo ahawɔ wo ŋudɔ nyuie wu. Ne dzidɔ aɖe li la, wowɔa atike be woatsɔ akpɔ nusi gbɔ wòtso gbɔ. Esia fia be menye Mose ƒe nufiafiaa ŋue wotsɔ atikewɔwɔ ɖo o, ke boŋ nɔnɔmea me tsonuwo ŋue woɖoe ɖo. Ele vevie be nàƒo nu kple wò ɖɔkta tso atikewɔwɔ ƒe ɖoɖo nyuitɔ kekeake si nàwɔ na wò alo viwòa ŋu.
Aleke etsɔme anɔ le nɔnɔme sia me?
Esesẽna be woagblɔ amesi ŋu mosaic-dɔlékui le ƒe nyagblɔɖi ɖi, elabena enɔ te ɖe nu geɖe dzi. Wo dometɔ vevitɔwo dometɔ aɖewoe nye:
- Lãmenugbagbevi siwo mesɔ o ƒe alafa memamã nenie? (Lãmenugbagbevi siwo mesɔ o ƒe alafa memamã) .
- Ŋutinu/lãmeka kawoe wògblẽa nu le?
- Nɔnɔme si do ƒome kplii ƒe sesẽme.
Ame si ƒe lãmenugbagbevi siwo mesɔ o ƒe alafa memamã si le sue ŋutɔ (mosaicism si mebɔ o) ate ŋu anɔ agbe le lãmesẽ me keŋkeŋ dzesi aɖeke manɔmee. Kuxi suesuesuewo ate ŋu anɔ ame bubu ŋu. Ne lãmenugbagbevi siwo mesɔ o ƒe alafa memamã sɔ gbɔ eye wògblẽ nu le ŋutinu veviwo abe ahɔhɔ̃ kple dzi ene ŋu la, kuxiawo ate ŋu adzi ɖe edzi.
Eyata le esi teƒe be nàvɔ̃ na esia madzemadzee la, ele vevie ŋutɔ be nàkpɔ eŋutinunyala bibi aɖe, axɔ domenyiŋusẽfianu ŋuti aɖaŋuɖoɖo , eye nàse viwò alo viwò ƒe nɔnɔme tɔxɛa gɔme nyuie.
Gbedasi si Wotsɔ Yi Aƒeme
- Mosaicism nye lãmenugbagbeviwo ƒe hatsotso siwo to vovo wu ɖeka ƒe anyinɔnɔ le ame ɖeka ƒe ŋutilã me.
- Esia menye ame aɖeke ƒe vodada o, ke boŋ vodada si dzɔna le vome si dzɔna le lãmenugbagbeviwo ƒe mama me le fugboe ƒe tsitsi ƒe gɔmedzedze.
- Nusiwo mosaic-nuwɔnawo gblẽna le ame ŋu la toa vovo ŋutɔ tso ame ɖeka gbɔ yi bubu gbɔ. Ðewohĩ magblẽ nu le wo dometɔ aɖewo ŋu o, evɔ lãmesẽkuxi sesẽwo ate ŋu adze ame bubuwo dzi.
- Togbɔ be womekpɔ atike aɖeke na dɔléle sia o hã la, atikewɔmɔnu siwo wɔa dɔ ŋutɔ li siwo dzi woato akpɔ dzesiwo kple lãmesẽkuxi siwo dona tso eme gbɔ.
- Ne ɖikeke alo nyabiase aɖe le wò ƒomea me alo le wò ƒomea me le Mose-subɔsubɔ ŋu la, nu nyuitɔ si nàwɔe nye be nàdzro eme kple wò ɖɔkta gaglãa .
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