What happens if the body stops or stops producing a special enzyme that helps keep our bones and teeth strong? It's actually not as simple as you might think. Hypophosphatasia (HPP) is a rare genetic condition. So, a special vaccine that is given to treat this condition is called Asfotase Alfa. Today, we will talk about this medicine, how to use it, what to be careful about, and everything else in a very simple way.
What really happens with this medicine?
Simply put, this is enzyme replacement therapy . Think about it, for something in our body to work properly, it needs to have an enzyme that it needs. A person with HPP has a deficiency of this enzyme that helps build strong bones and teeth. So, what the Asfotase Alfa injection does is to give the body the enzyme that is lacking from outside. This is like putting oil in a car when it runs out of gas. The enzyme from this injection helps the body build strong bones and teeth again. This medicine is also available in the market under the brand name Strensiq.
Things you need to tell your doctor before taking medicine
Before starting this treatment, for your own safety, there are a few things you should clearly inform your doctor about. Be sure to mention these.
- Allergies : If you have any allergies to this Asfotase Alfa medicine, any other medicine, food, preservatives, or dyes, please tell us first.
- Pregnancy : If you are pregnant, or planning to have a baby soon, tell your doctor about it.
- If you are a breastfeeding mother: If you are a breastfeeding mother, you must also inform the doctor.
Providing this information to your doctor will greatly help him treat you more safely and accurately.
How is this vaccine used?
This vaccine is given by subcutaneous injection . But there is no reason to be afraid of this. You will be taught how to prepare this vaccine and how to inject yourself correctly. The doctor or nursing staff will give you clear instructions about this.
- Take the medicine you receive exactly as directed on the label, in the correct dosage, and at the correct time.
- Continue using this medicine until your doctor tells you to stop.
- Read the instructions that come with the medicine carefully. If you have any questions, don't hesitate to ask your doctor.
How do you dispose of used needles and syringes?
This is very important. Never throw used needles and syringes in the trash. Doing so can be dangerous to others. You should use a special container for these, called a 'sharps container.' If you don't have one, ask your doctor about how to get one.
What to do if the dose of the medicine increases?
If you think you have taken an overdose, go to the nearest hospital Emergency Department (ETU) without delay . Alternatively, call the National Poisons Information Centre at the Colombo National Hospital. This is an emergency and it is important to act quickly.
What if I miss a dose of medicine?
Don't worry. If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed dose.
Things to be careful about when taking medicine
It is very important to maintain a close relationship with your doctor throughout this treatment.
- Regular check-ups: Talk to your doctor regularly to see if your symptoms are improving or decreasing, and how your body is responding to treatment. Attend clinics on the dates he or she prescribes.
- Medical tests : While you are taking this medicine, your doctor may need to do blood and urine tests to check how well your kidneys are working and to monitor other things. Do not skip these tests.
- Vision Check : Your vision may be checked before and during treatment. If you notice any changes in your vision (such as blurred or decreased vision), tell your doctor immediately.
- Patient Registry: You may be invited to join a long-term registry of patients with HPP. This will help to collect data to better understand the disease and its treatment. You can ask your doctor for more information.
What are the possible side effects?
Like any medicine, this medicine can cause some side effects. But not everyone gets them. Let's break these down into two categories.
| Side effect | Description and what to do |
|---|---|
| Serious side effects that should be reported to the doctor immediately | |
| Allergic reactions | Seek immediate medical attention if you experience symptoms such as skin rash, itching, swelling of the face, lips, tongue, or throat, or difficulty breathing. |
| Kidney stones | Blood in the urine, pain or difficulty urinating, pain in the lower back or groin. Tell your doctor if you have any of these. |
| Vision loss or change | If you notice any sudden changes in your vision, inform your doctor immediately. |
| Things that are usually not dangerous, but should be reported to the doctor if they persist | |
| Changes in the injection site | Pain, redness, itching, or skin discoloration may occur at the injection site. |
| Lipodystrophy | Thickening, hardening, or scarring of the tissue under the skin at the injection site. If this persists, inform your doctor. |
How should I store the medicine?
It is very important to store this medicine correctly.
- Keep away from children and pets.
- Store in the fridge. But do not put in the freezer. Do not let the medicine freeze.
- Protect from light. Therefore, keep in the original packaging until use.
- After removing from the refrigerator, administer the vaccine within 3 hours .
- Dispose of expired medications. Ask your doctor for advice on how to safely dispose of expired or no longer needed medications.
Take-Home Message
- Asfotase Alfa is an enzyme replacement vaccine that treats the genetic condition Hypophosphatasia (HPP).
- Tell your doctor about all your allergies and health conditions before starting treatment.
- Learn how to inject the vaccine correctly and safely dispose of used needles.
- Seek immediate medical attention if you experience any severe side effects such as facial swelling, difficulty breathing, or changes in vision.
- Do not skip the tests and clinic dates prescribed by the doctor.
- Always store the medicine in the refrigerator, protected from light, and in the original packaging.
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