Ua noʻonoʻo paha ʻoe pehea e hoʻololi ai ko mākou kino i nā leka liʻiliʻi e hakakā i nā maʻi a kōkua kekahi i kekahi? Aia nā ʻāpana o ko mākou kino e hana ana e like me nā ʻelele huna liʻiliʻi. ʻO
nā Cytokines kahi hui o nā kemika e hana ana i kahi hana kūikawā. I kēia lā, e kamaʻilio mākou e pili ana i kēia mau ʻelele liʻiliʻi akā koʻikoʻi loa.
He aha maoli nā cytokines?
I ka ʻōlelo maʻalahi, he ʻano protein nā cytokines. Ua like lākou me nā ʻelele kemika e hoʻolaha i ka ʻike i loko o kā mākou
ʻōnaehana pale . E noʻonoʻo i kā mākou ʻōnaehana pale e like me kahi pūʻali koa e pale aku i kahi ʻāina. He
mau lālā like ʻole kēia pūʻali koa, nā koa. ʻO wai ka mea e hoʻouna i kēia mau koa (ʻo ia hoʻi nā cell immune) i nā leka e like me, "Eia mai ka ʻenemi!" "E hele mai a kaua!" "E pale iā ʻoe iho penei!"? ʻO ia ka hana a kēia mau
cytokines . Ke komo
nā pathogens e like me nā germs, viruses, bacteria, a i ʻole allergens i loko o ko mākou kino, haʻi kēia mau cytokines i kā mākou mau cell immune e "e hana, e hakakā i kēia mau mea hoʻouka kaua." ʻAʻole wale ia, akā kōkua kēia mau cytokines i ka mālama ʻana i kā mākou ʻōnaehana pale e hana pono a me ka laulima ʻana me kekahi i kekahi, ʻoiai ʻaʻohe hoʻoweliweli i ko mākou kino. E like me ka hoʻololi ʻia ʻana o nā leka e hoʻomau i ka holo pono ʻana o kā mākou keʻena.
He aha nā ʻano cytokine i loaʻa?
Nui nā ʻano like ʻole o nā lālā o kēia ʻohana o nā ʻelele i kapa ʻia ʻo cytokines. Hōʻike lākou a pau i nā pūnaewele pale i kahi e hele ai a me ka mea e hana ai. Akā aia kekahi mau ʻano, ma muli o kā lākou mau hana kikoʻī. E nānā kākou i kekahi o nā ʻano nui.
- Nā Chemokines: ʻO kēia nā "alakaʻi." Ua like lākou me GPS. ʻO lākou nā mea e alakaʻi i nā pūnaewele pale i kahi o kahi maʻi, e haʻi ana iā lākou, "E hele mai ma kēia ʻaoʻao."
- Nā Interferon: ʻO ka inoa ponoʻī o kēia mau mea ʻo ia hoʻi "e hoʻopilikia." He aha ke ʻano o ka hoʻopilikia? Hana lākou ma ka hoʻōki ʻana i nā virus mai ke komo ʻana i loko o kā mākou mau cell a hana i nā virus hou aʻe ('replicating'). Ua like ia me ke kau ʻana i kahi hōʻailona no nā virus e ʻōlelo ana, "ʻAʻole e hele hou ma aneʻi!"
- Interleukins: Ua loaʻa ka inoa mai nā huaʻōlelo "inter" (ma waena) a me "leukocyte" (kele koko keʻokeʻo). Ua manaʻo mua ʻia e kamaʻilio wale ana kēia mau kemika ma waena o nā kele koko keʻokeʻo. Eia naʻe, ua ʻike ʻia i kēia manawa ua hana ʻia lākou e nā kele ʻē aʻe a ke kamaʻilio pū nei lākou ma waena o nā kele koko ʻaʻole keʻokeʻo.
- ʻO Tumor Necrosis Factor (TNF): He ʻano ʻino iki kēia inoa, ʻeā? ʻO kāna hana nui kaHoʻomalu ia i ka mumū , ʻo ia hoʻi ka pehu a me ka ʻulaʻula. Hōʻailona pū ia i nā pūnaewele pale e luku i nā pūnaewele tumor .
- Nā Kumu Hoʻoulu Koloni (CSF): Ua like kēia me nā "luna hoʻokele o ka hale hana cell" i loko o ko kākou kino. No ka mea, aia kekahi ʻano cell kūikawā i kapa ʻia ʻo nā cell kumu koko (HSC) . Hiki i kēia mau cell ke hana i nā ʻano cell koko āpau e like me nā cell koko keʻokeʻo, nā cell koko ʻulaʻula, a me nā platelets. Kōkua ʻia kēia " CSF " e kēia "CSF", ʻo ia hoʻi, haʻi ia i nā cell kumu e "hana i kēia ʻano cell". No ka laʻana, kōkua ʻo " G-CSF " i ka hana ʻana i kahi ʻano cell koko keʻokeʻo i kapa ʻia ʻo "Neutrophil" . He mea nui loa kēia mau neutrophils i ke kaua ʻana i nā maʻi.
Ua kapa ʻia kekahi mau cytokine ʻē aʻe ma muli o ke ʻano o ke kelepona e hana ana iā lākou.
- Lymphokines: No ka mea, ua hana ʻia lākou e kahi ʻano keʻokeʻo koko i kapa ʻia ʻo lymphocytes.
- Monokines: No ka mea, ua hana ʻia lākou e kahi ʻano keʻokeʻo koko i kapa ʻia ʻo monocytes.
He aha ke kōkua a nā cytokines e hāʻawi ai i ko mākou kino?
Ke kamaʻilio mākou e pili ana i nā cytokines, manaʻo ka hapa nui o ka poʻe i
ka mumū . Ke noʻonoʻo mākou i ka mumū, manaʻo mākou i ka pehu hoʻonāukiuki a me ka ʻulaʻula e kū mai ana i ka wā maʻi a i ʻole nā maʻi ʻaleka. Akā ʻo ka mumū he hōʻailona maoli ia e hakakā ana nā ʻōnaehana pale o ko mākou kino i nā mea hoʻouka kaua a i ʻole e ho'ōla ana i nā ʻiʻo i hōʻeha ʻia.
E noʻonoʻo i ka wā e ʻoki ai ʻoe i kou manamana lima, pehu a ʻulaʻula ka wahi, ʻeā? ʻO ia ka mumū. ʻO ia hoʻi, ua hoʻouna ʻia nā cytokines i laila, me ka ʻōlelo ʻana, "Aia kahi pilikia ma ʻaneʻi, e hele mai e nānā, a ho'ōla i ka ʻeha," a lawe ʻia mai nā pūnaewele pili a hoʻomaka e hana.
No laila, ua like nā cytokines me nā ʻelele kemika e haʻi i nā cell "pehea e hana ai." Hōʻailona nui lākou i nā mea e like me:
- Hoʻāla ʻana o ke kelepona: Hōʻike i nā kelepona i kahi e hele ai a me ka mea e hana ai. No ka laʻana, kuhikuhi ia i nā kelepona pale i kahi o kahi maʻi e hakakā i nā germs ma laila. Hōʻailona pū ia e hoʻonui a hoʻemi paha i nā kaʻina hana e pili ana i ka mumū.
- Ka hoʻokaʻawale ʻana o nā pūnaewele:Ua like kēia me ke kula hoʻomaʻamaʻa. Lawe lākou i nā ʻōpū palupalu a hoʻomaʻamaʻa iā lākou e lilo i "ʻo kēia ke ʻano o ke ʻōpū āu e makemake ai ke ulu ʻoe." Eia kekahi laʻana, lawe lākou i kahi ʻōpū ʻōpiopio a hoʻolilo iā ia i ʻōpū koko keʻokeʻo e hiki ke hakakā i ka maʻi.
- Ka hoʻonui ʻana o nā pūnaewele: ʻO ke ʻano kēia "e hoʻonui i nā kānaka e makemake iā ʻoe." Ua like ia me ka hana ʻana i kahi kope. No ka laʻana, ke pono ʻoe i nā hunaola koko keʻokeʻo hou aʻe e hakakā i kahi maʻi, hōʻailona ʻoe i kāu mau hunaola koko keʻokeʻo e "hoʻonui i nā kānaka e makemake iā ʻoe."
ʻAʻole wale kēlā, akā i kekahi manawa hōʻailona pū nā cytokines i nā cell o ko mākou kino e "hana i nā cytokines hou aku." A laila hoʻonui hou aku ka pane mumū.
He aha ka ʻokoʻa ma waena o nā cytokine pro-inflammatory a me nā anti-inflammatory?
Ke hana pono nei kā mākou ʻōnaehana pale, hoʻoulu nā cytokines i ka mumū i ka wā e pono ai e hakakā i nā mea komo hewa a ho'ōla i nā ʻiʻo. A laila, ʻōlelo lākou, "ʻAe, ua lawa kēlā, ʻo ia wale nō," a hōʻemi lākou a hoʻōki i ka mumū. Ua like ia me
ka mea hoʻolalelale (pedal kinoea) a me ka paleki ma ke kaʻa.
- ʻO nā cytokines pro-inflammatory: ʻO kēia nā "pedals kinoea." ʻO kēia nā kāne e hōʻailona ana i ka mumū e hoʻomaka a hoʻonui. Ke komo mai kahi ʻenemi i loko o ko mākou kino, ʻōlelo lākou, "E nā kānaka a pau, e mākaukau no ke kaua!"
- ʻO nā cytokine anti-inflammatory: ʻO kēia nā "brake". ʻO kēia nā mea e hōʻailona ai e hoʻōki a hōʻemi i ka mumū . No ka mea, inā piʻi nui ka mumū, hiki iā ia ke hōʻino i nā ʻiʻo maikaʻi i loko o ko mākou kino. ʻO kēia nā mea e pale ai i kēlā.
I ka pololei, ʻo ka hoʻōki ʻana i ka mumū he mea nui ia e like me ka hoʻomaka ʻana. ʻO ka nui o ka mumū hiki ke alakaʻi i nā hōʻailona ʻoluʻolu ʻole, nā maʻi lōʻihi, a i kekahi manawa, inā ʻaʻole mālama ʻia, hiki ke hoʻoweliweli i ke ola.
Pehea e hana ai kēia mau cytokine?
Hana ʻia kēia ma ke ʻano maʻalahi loa. E noʻonoʻo i kahi cytokine ma ke ʻano
he kī , a aia
kahi 'mea loaʻa' ma ke kelepona e kūlike ana i kēlā kī. Ke hele ka cytokine (ke kī) a kūpono i loko o kēlā 'mea loaʻa' ma kēlā kelepona, loaʻa i kēlā kelepona ka leka "He aha ka mea e hana ai?". A laila hana kēlā kelepona e like me kēlā leka. E nānā kākou i kahi laʻana. Inā ʻike kekahi o kā mākou mau kelepona pale i kahi mea ʻino, e like me ka maʻi, i loko o ke kino, hoʻokuʻu kēlā kelepona i kahi cytokine. Hele kēia cytokine ma ke kahe koko a i ʻole ma o nā ʻiʻo a loaʻa i kahi kelepona nona kahi 'mea loaʻa' e kūlike ana me ia. Ke hoʻopaʻa ka cytokine i kēlā 'mea loaʻa', loaʻa i ke kelepona e loaʻa ana i kēlā leka ke kuhikuhi. Malia paha e hele kēlā kelepona i kahi o ka maʻi a hoʻomaka e hoʻouka iā ia. A i ʻole, e hoʻoikaika ia i kona mau pale e pale aku i ka maʻi mai ke komo ʻana. Hiki i nā Cytokines ke hoʻouna i nā leka i ke kelepona nāna i hoʻokuʻu iā lākou, i nā kelepona kokoke, a i ʻole i nā kelepona mamao loa.
- Ke hoʻouna nei i nā leka i kāna kelepona ponoʻī (`Autocrine signaling`):Hoʻopaʻa ka cytokine i kahi mea loaʻa ma ke kele i hoʻokuʻu iā ia.
- Hōʻailona paracrine: hoʻopaʻa i nā mea loaʻa ma nā pūnaewele kokoke.
- Hōʻailona Endocrine: Hoʻopaʻa nā Cytokines i nā mea loaʻa ma nā pūnaewele mamao loa mai ke kelepona i hoʻokuʻu iā lākou.
Aia nā pūnaewele ma ko kākou kino a pau i loaʻa nā 'mea hoʻokipa' cytokine. ʻO kaʻoiaʻiʻo, he nui nā ʻōkana i loko o ko kākou kino i loaʻa nā pūnaewele i loaʻa kēia mau 'mea hoʻokipa'. ʻO ia ke kumu e hiki ai ke loaʻa ka mumū ma nā wahi āpau.
Mai hea mai nā cytokine? ʻO wai ka mea hana iā lākou?
ʻO nā cytokines maʻamau i loko o ko mākou kino e hana ʻia
e nā pūnaewele pale , ʻo ia hoʻi nā pūnaewele koko keʻokeʻo (leukocytes). ʻO kekahi o kēia mau mea:
- Nā Macrophage
- Nā pūnaewele dendritic
- Nā Lymphocytes (nā lymphocytes T a me B)
- Nā monocyte
- Nā Neutrophils
- Nā Basophil
- Nā Eosinophils
- Nā pūnaewele mast
Akā, ʻaʻole wale nā pūnaewele pale kino, hiki i nā ʻano ʻē aʻe o nā pūnaewele i loko o ko mākou kino ke hana i nā cytokines. Eia kekahi mau laʻana:
- Nā pūnaewele Endothelial: Nā pūnaewele e hoʻopaʻa ana i loko o ko mākou mau kīʻaha koko.
- Nā pūnaewele Epithelial: Nā pūnaewele e hoʻopili ana i ko kākou mau kino.
- Nā Fibroblasts: Nā pūnaewele i loaʻa i loko o nā ʻiʻo pili.
- Nā pūnaewele Stromal: ʻO kekahi ʻano pūnaewele i loaʻa i loko o nā ʻiʻo pili.
- Nā pūnaewele Schwann: Nā pūnaewele e hoʻopuni ana i nā pūnaewele nerve (neurons).
Hiki ke hana ʻia ke ʻano like o ka cytokine e nā ʻano cell like ʻole.
He aha nā maʻi e hiki ke pili me nā cytokines?
He mea nui nā cytokines i kā mākou ʻōnaehana pale kino, a ua pili lākou i nā maʻi he nui a mākou e hiki ai ke hoʻomohala. ʻO ka maʻamau, kōkua nā cytokines i ka mālama ʻana iā mākou mai nā maʻi. Eia nō naʻe, i kekahi manawa hiki i kā mākou ʻōnaehana pale kino ke hana i nā cytokines he nui loa. Hiki i kēia ke pane i kahi maʻi a i ʻole ma ke ʻano he ʻāpana o kahi lāʻau lapaʻau e like me
ka immunotherapy . Ua kapa ʻia kēia he
cytokine release syndrome (CRS) a i ʻole
cytokine storm . Hiki i kēia ke hana i nā ʻano hōʻailona like ʻole e hoʻopilikia i nā ʻōnaehana he nui o ko mākou kino. Inā ʻaʻole mālama ʻia, hiki i kēia kūlana ke hoʻoweliweli i ke ola. Ke nui nā cytokines, piʻi ka pane mumū. Hiki i kēia mumū nui ke hōʻino i nā ʻiʻo, e alakaʻi ana i nā maʻi e like me:
- Nā maʻi Autoimmune: ʻO kēia ka manawa e hoʻouka hewa ai kā mākou mau hunaola ponoʻī i kā mākou mau hunaola olakino ponoʻī.
- Nā maʻi metabolic:Nā pilikia e pili ana i ka metabolism, ke kaʻina hana e hoʻololi ai ko mākou kino i ka meaʻai i ikehu a hoʻoneʻe i nā ʻōpala.
- Ka maʻi ʻaʻai
- Sepsis: ʻO kēia ka manawa e lilo ai ka pane mumū o ke kino i mea koʻikoʻi a emi iho ke kahe o ke koko i nā ʻōpū nui. He pilikia olakino ka Sepsis hiki ke make.
Akā, mai hopohopo. Inā ua hoʻonui ʻia nā pae cytokine o kou kino a ua hana nui kāu ʻōnaehana pale, hiki i kāu kauka ke kuhikuhi i nā lāʻau lapaʻau e hōʻemi i kēlā mumū.
He aha ka panela cytokine?
Hiki i nā kauka ke ʻike inā nui a liʻiliʻi paha nā cytokines e hana ana kou kino. Hana lākou i kēia me kahi mea i kapa ʻia
he cytokine panel . He hoʻāʻo koko maʻalahi kēia. Lawe lākou i kahi hāpana o kou koko a nānā i nā pae o nā cytokines e pili ana me ka mumū. Inā kiʻekiʻe nā pae cytokine, ʻo ia hoʻi ua hoʻonui ʻia ka mumū. A laila, hiki ke hoʻomaka ʻia nā lāʻau lapaʻau e pono ai.
ʻO nā mea nui a mākou e hoʻomanaʻo ai mai kēia moʻolelo, ʻo ia
No laila, ua maopopo paha iā ʻoe i kēia manawa ke koʻikoʻi o nā cytokines no kahi ʻōnaehana pale olakino i loko o ko mākou kino. E like me nā mea āpau, ʻo
ke kaulike ke kī.
Ke kūpono ka nui o ka hōʻailona cytokine a ma ke ala kūpono, hiki iā ia ke pale iā mākou mai ka maʻi. Eia nō naʻe, inā kiʻekiʻe loa nā pae cytokine, hiki i ka mumū nui ke lilo i mea ʻino inā ʻaʻole mālama ʻia.
No laila, he mea nui loa ia e makaʻala i kēia kamaʻilio kupaianaha e hana ʻia ana i loko o ko kākou kino. Inā he mau nīnau a kānalua paha kāu e pili ana i kēia, mai kānalua e kamaʻilio me ke kauka.
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