E kamaʻilio kākou e pili ana i kēia ʻano maʻi kanesa 'clear cell' e ulu ana i loko o ka puʻupaʻa (Clear Cell Renal Cell Carcinoma - ccRCC) i kēia lā?

ʻO nā puʻupaʻa kekahi o nā ʻōkana koʻikoʻi loa i loko o ko kākou kino. ʻO kēia mau ʻōkana liʻiliʻi ʻelua e kānana ana i ko kākou koko i kēlā me kēia lā a hoʻokuʻu aku i nā mea pono ʻole e like me ka mimi, ua like lākou me ʻelua mau kānana i loko o ko kākou kino. Eia nō naʻe, hiki i kēia mau puʻupaʻa ke hoʻomohala i nā maʻi like ʻole. I kēia lā, e kamaʻilio kākou e pili ana i kahi ʻano maʻi ʻaʻai puʻupaʻa he ʻano koʻikoʻi iki, akā he mea nui loa ia e makaʻala. ʻO kēia ka `(Clear Cell Renal Cell Carcinoma)`, ma ka pōkole `(ccRCC)`.

He aha ke ʻano o ka 'clear cell renal cell carcinoma' (ccRCC)?

I ka ʻōlelo maʻalahi, ʻo kēia `(Clear Cell Renal Cell Carcinoma - ccRCC)` he ʻano maʻi ʻaʻai puʻupaʻa. Ke kamaʻilio mākou e pili ana i ke kanesa puʻupaʻa, ʻōlelo pinepine mākou `(Renal Cell Carcinoma - RCC)`. ʻO kēia `(ccRCC)` kekahi o kona ʻano.

Ua ʻike anei ʻoe he mau kahawai liʻiliʻi ko loko o ko kākou mau puʻupaʻa, e like me ke kānana? ʻO kēia nā mea e kānana i nā huahana ʻōpala i loko o ke koko a hoʻopuka iā lākou ma ke ʻano he mimi. Hoʻomaka kēia maʻi kanesa i loko o nā pūnaewele e hoʻopili ana i kēlā mau kahawai. Māhelehele a hoʻonui koke kēia mau pūnaewele `(ccRCC)`, e hana ana i hoʻokahi a ʻoi aku paha nā puʻupuʻu. ʻO ka maʻamau, hoʻopilikia ia i hoʻokahi puʻupaʻa, akā i kekahi manawa hiki ke hoʻopilikia i nā puʻupaʻa ʻelua.

He aha nā hōʻailona o kēia maʻi?

I ka hapanui o nā hihia, i nā pae mua o kēia `(ccRCC)`, ʻaʻohe hōʻailona nui. ʻO ia ka mea e hopohopo iki ai. No ka mea, ʻaʻole paha ʻoe e ʻike he maʻi kou. Akā i ka holomua ʻana o ka maʻi, hiki iā ʻoe ke ʻike i nā mea e like me:

• Koko i loko o ka mimi. I kekahi manawa he ʻulaʻula, poni, a ʻeleʻele paha ka mimi. Kāhea nā kauka i kēia "hematuria".
• ʻO ka luhi ka manaʻo o ka luhi loa, ʻaʻohe mea nui ka nui o kāu hiamoe. Hiki iā ʻoe ke manaʻo i ka luhi i ka lā a pau.
• Ke kuni e hele mai me ke kumu ʻole. Inā loaʻa iā ʻoe ke kuni me ka ʻole o kekahi maʻi ʻē aʻe, he mea nō hoʻi ia e makaʻala ai.
• Ua like ia me kahi puʻupuʻu i hiki ke ʻike ʻia i loko o ka puʻupaʻa i hoʻopilikia ʻia .
• ʻO ka ʻeha ma ka ʻaoʻao o ka puʻupaʻa, ʻo ia ka ʻeha ma ka ʻaoʻao o ka puʻupaʻa . Hiki i kēia ʻeha ke mau a hele mai a hele aku.
• ʻO ka pohō kaumaha i wehewehe ʻole ʻia. Inā ʻoe e pohō ana i ke kaumaha me ka ʻole o ka ʻai ʻana a i ʻole ka hoʻoikaika kino ʻana, he mea ia e nānā ai.

No ke aha e hana ʻia ai kēia `(ccRCC)`? He aha nā kumu?

ʻO kaʻoiaʻiʻo, ʻaʻole ʻike ʻia ke kumu pololei o ka hapa nui o nā maʻi kanesa puʻupaʻa, me kēia `(ccRCC)` . Eia nō naʻe, ua ʻike ʻia kekahi mau mea e hoʻonui ai i ka pilikia o ka loaʻa ʻana. E nānā kākou he aha lākou?

• Ka hoʻohana ʻana i nā huahana paka : ʻAʻole wale kēia e pili ana i ka puhi paka akā ʻo ka vaping pū kekahi. Hiki i nā kemika ʻino i loko o ka paka ke hōʻino i nā puʻupaʻa.
• ʻO ka Index Mass Body (BMI) ma luna o 25 : I ka ʻōlelo maʻalahi, ʻo ke kaumaha nui/momona. Hiki i ka momona ke hoʻololi i nā hormonal a me nā pilikia ʻē aʻe e hiki ke hoʻonui i ka pilikia o ka maʻi kanesa.
• Ke koko kiʻekiʻe (hypertension): ʻO kēia ka manawa e piʻi ai kou koko. Hiki ke loaʻa kēia pilikia no ka mea ua hōʻino ke koko kiʻekiʻe i nā puʻupaʻa.
• Pono e hana i ka dialysis ma muli o ka maʻi puʻupaʻa lōʻihi : Loaʻa i ka poʻe ma ka dialysis ka pilikia o ka loaʻa ʻana o ka maʻi ʻaʻai puʻupaʻa.
• Ka ʻike ʻia ʻana i kekahi mau kemika ʻawahia ma ka wahi hana : No ka laʻana, ʻo ka poʻe i ʻike ʻia i nā mea hoʻoheheʻe e like me ka trichloroethylene, asbestos, a me ka cadmium e piʻi aʻe ana ka pilikia.
• Ka hoʻohana lōʻihi ʻana i nā lāʻau hoʻomaha ʻeha : ʻO kekahi mau lāʻau hoʻomaha ʻeha, e like me ka acetaminophen (Tylenol®), ʻaʻole maikaʻi iā ʻoe inā ʻoe e lawe mau a keu paha.

ʻO wai ka mea hiki ke hoʻomohala nui i kēia `(ccRCC)`?

ʻOiaʻiʻo, hiki i kekahi ke loaʻa i kēia maʻi, i kapa ʻia ʻo ``(ccRCC)``. Eia nō naʻe, ua ʻike ʻia he ʻelua ka nui o ka loaʻa ʻana o kēia maʻi i nā kāne ma mua o nā wahine . Eia kekahi, ʻoi aku ka maʻamau i waena o ka poʻe ma waena o 50 a me 70 mau makahiki.

Wahi a ka American Cancer Society, ʻoi aku ma mua o 81,000 mau kānaka ma ʻAmelika Hui Pū ʻIa i ʻike ʻia me ke kanesa puʻupaʻa i kēlā me kēia makahiki. Ma waena o kēia mau mea, ʻo ke ʻano maʻamau o ke kanesa puʻupaʻa i kapa ʻia ʻo ccRCC .

Ua kapa ʻia anei kēia maʻi he `(ccRCC)` hoʻoilina?

Inā he hoahānau koko kou i loaʻa i ka renal cell carcinoma, aia paha ʻoe i kahi pilikia kiʻekiʻe iki o ka loaʻa ʻana o ka maʻi ʻaʻai puʻupaʻa. Eia nō naʻe, ʻaʻole maopopo i nā kauka ke kumu.

Loaʻa i kekahi poʻe nā kūlana genetic e hoʻonui ai i ka hiki ke hoʻomohala i ka ccRCC. ʻO kahi laʻana ʻo ka maʻi Von Hippel-Landau (VHL).

I kēia mau hihia, ʻo kahi loli hoʻoilina i hoʻoili ʻia ma waena o nā hanauna e hoʻoulu ai i nā cysts a me nā tumors e hana ʻia ma nā ʻāpana like ʻole o ke kino. ʻAʻole maʻamau kēia mau tumors he maʻi kanesa. Eia nō naʻe, hiki i ka poʻe o kēia mau ʻohana ke ulu pinepine i ka ccRCC, a hiki nō hoʻi ke ulu i ka wā ʻōpio ma mua o ka maʻamau.

Inā ua ʻike ʻia ʻoe me ka ccRCC i ka wā ʻōpiopio, a inā he nui kou mau puʻupuʻu, hiki i kāu kauka ke kuhikuhi i ka hoʻāʻo genetic .

Pehea e ʻike ʻia ai kēia maʻi `(ccRCC)`?

E like me kā mākou i ʻōlelo ai ma mua, he kakaikahi wale nā ​​hōʻailona o ka maʻi ʻaʻai puʻupaʻa i kona mau pae mua. ʻO ia ke kumu e ʻike pinepine ai nā kauka i nā puʻupuʻu puʻupaʻa i ka wā e ʻimi nei lākou i nā kūlana ʻē aʻe. No ka laʻana, hiki ke ʻike ʻia kahi puʻupuʻu puʻupaʻa ma ka hanana i ka wā o ka MRI a i ʻole CT scan e ʻimi i nā pōhaku puʻupaʻa.

Hiki i nā hoʻokolohua kiʻi e like me kēia ke ʻike i ke alo o kahi puʻupuʻu. Eia nō naʻe, he paʻakikī ke ʻike maopopo mai kahi scan wale nō inā he benign a malignant paha ka puʻupuʻu.

No ka hana ʻana i kahi hōʻailona pololei , ua kuhikuhi ke kaukaHiki ke hana ʻia kahi biopsy puʻupaʻa, a i ʻole e ʻōlelo ʻia ke ʻoki ʻana e wehe i ka puʻupuʻu.

Inā wehe ʻia ka puʻupuʻu ma o ke ʻoki ʻana, lawe ʻia nā ʻiʻo mai ka puʻupuʻu a hoʻāʻo ʻia no ka maʻi kanesa. Hoʻohana ʻia nā hopena e hoʻoholo ai inā he maʻi kanesa ia a inā he ʻano i kapa ʻia ʻo "ccRCC".

ʻO ka mea kupanaha, ʻo 4 wale nō o 10 mau puʻupuʻu liʻiliʻi o nā puʻupaʻa, ʻoi aku ka liʻiliʻi ma mua o 4 kenimika ka nui, he mau puʻupuʻu maikaʻi ʻole ia, e like me nā renal oncocytomas.

He aha nā pae o ke kanesa (ccRCC)?

Ma hope o ka ʻike ʻia ʻana me ka `(ccRCC)`, hoʻoholo ke kauka i ke ``kahua o ke kanesa`` . ʻO ia hoʻi, nānā lākou i ka nui o ka puʻupuʻu a inā ua pālahalaha aku i nā ʻāpana ʻē aʻe o ke kino.

ʻEhā ʻano nui o ka Clear Cell Renal Cell Carcinoma.

• ʻO ka emi ʻana o ka manawa kūpono, ʻo ka emi ʻana o ke koʻikoʻi o ke kanesa.

E kamaʻilio ke kauka iā ʻoe e pili ana i kēia mau mea:

• I ke kahua hea kou maʻi kanesa.
• He aha ka pilikia o kona laha ʻana i nā ʻāpana ʻē aʻe o ke kino?
• He aha nā hana e hiki mai ana āu e hana ai ?

He aha nā lāʻau lapaʻau no ka `(ccRCC)`?

ʻO ka hapa nui o ka manawa, hilinaʻi nā koho lapaʻau i ka laha ʻana o ke kanesa ma ʻō aku o ka puʻupaʻa. ʻAe, e nānā kākou.

Inā ʻaʻole i pālahalaha ke kanesa ma ʻō aku o ka puʻupaʻa:

I kēia hihia, hiki ke hana ʻia ka lāʻau lapaʻau penei:

• ʻOki kino - Nephrectomy : Wehe wale ke kauka lapaʻau i ka ʻāpana o ka puʻupaʻa i loaʻa ka maʻi kanesa. Ua kapa ʻia kēia he nephrectomy hapa. A i ʻole, hiki ke wehe ʻia ka puʻupaʻa holoʻokoʻa. Ua kapa ʻia kēia he nephrectomy radical.
• Nā lāʻau lapaʻau ablative : Hoʻohana kēia mau lāʻau lapaʻau i kahi ala percutaneous e luku ai i nā hunaola kanesa ma ke komo ʻana i kahi nila ma o ka ʻili. Aia nā ʻano hana like ʻole no kēia. No ka laʻana, hiki ke luku ʻia nā hunaola kanesa ma ka hoʻohana ʻana i ke anu nui (cryoablation) a i ʻole ka wela nui (thermal ablation).

Inā ua pālahalaha ke kanesa, a i ʻole he kiʻekiʻe ka pilikia o ka laha ʻana:

I ia mau hihia, ʻo nā koho lapaʻau:

• Immunotherapy : Pili kēia i ka hoʻoulu ʻana i ka ʻōnaehana pale ponoʻī o kou kino e luku i nā hunaola kanesa. ʻO nā lāʻau lapaʻau i hoʻohana ʻia no kēia he pembrolizumab (Keytruda®) a i ʻole nivolumab (Opdivo®).
• Lapaʻau i kuhikuhi ʻia : Hana kēia lāʻau lapaʻau ma ka hoʻōki ʻana i ka ulu ʻana a me ka hoʻonui ʻana o nā hunaola kanesa. ʻO nā lāʻau lapaʻau i hoʻohana ʻia no kēia ʻo axitinib (Inlyta®) a me cabozantinib (Cabometyx®).

He maʻi ʻaʻai koʻikoʻi anei ʻo `(ccRCC)` a laha wikiwiki hoʻi?

E like me nā ʻano ʻē aʻe o ka `(carcinoma), hiki i kēia `(Clear Cell Renal Cell Carcinoma)` ke laha (metastasize) i nā ʻāpana ʻē aʻe o ke kino. ʻOi aku ka paʻakikī o ka mālama ʻana i kahi maʻi ʻaʻai i laha ma kēia ʻano (metastatic cancer).

Ke hoʻohālikelike ʻia me nā ʻano maʻi ʻaʻai puʻupaʻa ʻē aʻe, ʻoi aku ka ikaika o ka "(ccRCC)" a ʻoi aku ka wikiwiki o ka laha ʻana .

ʻO ka hapa nui o ka laha ʻana o ka Renal Cell Carcinoma i nā wahi aʻe:

• Nā kikowaena lymph
• Nā māmā
• Nā kelepa adrenal (aia ma luna o nā puʻupaʻa)
• Ake
• lolo
• Nā iwi

Pehea ka wikiwiki o ka ulu ʻana o ke kanesa (ccRCC)?

Hiki ke ʻokoʻa loa ka nui o ka ulu ʻana o ka Clear Cell Renal Cell Carcinoma. Wahi a kekahi noiʻi, hiki iā lākou ke ulu mai 0.2 a 6.5 kenimika (0.07 a 2.5 ʻīniha) i kēlā me kēia makahiki. ʻO ka awelika o ka ulu ʻana ma kahi o 2.13 kenimika (0.83 ʻīniha) i kēlā me kēia makahiki.

He aha ka helu ola no ka `(ccRCC)`?

Ma keʻano laulā, ʻo ka helu ola ʻelima makahiki no (ccRCC) ma waena o 50% a me 69% .

Eia nō naʻe, pili ka manawa kūpono o kēia ho'ōla ʻana i ka nui o kou puʻupuʻu. Ma keʻano laulā, ʻaʻole i kūleʻa ka lāʻau lapaʻau no nā puʻupuʻu nui a i ʻole inā ua pālahalaha ka `(ccRCC)` i nā ʻāpana ʻē aʻe o ke kino. I ia mau hihia, inā he puʻupuʻu nui a inā paha ua pālahalaha ke kanesa, ʻo ka nui o ke ola ʻana o ʻelima makahiki ma kahi o 10%. No laila he mea nui e ʻike koke a hoʻomaka koke i ka lāʻau lapaʻau.

Pehea lā wau e mālama ai iaʻu iho?

He mea maʻamau ke manaʻo i nā ʻano manaʻo like ʻole ke ʻike ʻoe he Clear Cell Renal Cell Carcinoma kou. Hiki iā ʻoe ke manaʻo i nā ʻano mea like ʻole, me ka makaʻu, ka huhū, ke kaumaha, ka hopohopo, a me ke kaumaha.

Loaʻa i ka poʻe he nui ka hōʻoluʻolu ma ke aʻo ʻana i ka nui o ka hiki e pili ana i (ccRCC) a me ke noi ʻana i ke kōkua mai kā lākou poʻe aloha. He manaʻo maikaʻi nō hoʻi e hui pū me nā hui kākoʻo (ccRCC) hiki ke hoʻomaopopo pono i kāu mea e hele nei.

He mea nui hoʻi e hilinaʻi i kāu hui lapaʻau. E nīnau iā lākou i kāu mau nīnau e pili ana i nā koho lapaʻau a me ke kaʻina hana ho'ōla.

Eia kekahi mau ala ʻē aʻe e hiki ai iā ʻoe ke mālama iā ʻoe iho:

• E lawe i nā lāʻau lapaʻau a pau i kauoha ʻia e nā kauka e like me ke kuhikuhi ʻana .
• E pale i ka wīwī ma ka ʻai ʻana i nā meaʻai kiʻekiʻe i ka protein a me nā calorie.
• E hiamoe maikaʻi e like me ka hiki.
• Ke hoʻāʻo nei e hoʻokele i ke kaumaha ma o nā mea e like me ka hanu hohonu, ka noʻonoʻo ʻana, ka yoga, ka art therapy, a i ʻole nā ​​​​hana hōʻoluʻolu e like me nā puʻupuʻu.
• ʻOiai ka ikaika o kou kino.Ke komo ʻana i ka hana kino.

Āhea wau e ʻike ai i ke kauka?

Inā ʻike ʻoe i kekahi o kēia mau hōʻailona, ​​e ʻike koke i ke kauka:

• Inā he koko i loko o ka mimi.
• Inā he puʻupuʻu a ʻeha paha kou ma kou lima, ʻaʻole ia e nalo .
• Inā loaʻa iā ʻoe ke kuni i wehewehe ʻole ʻia a i ʻole ka pohō kaumaha .

Inā ʻoe e mālama ʻia nei no (ccRCC), e kamaʻilio koke me kāu kauka inā loaʻa iā ʻoe nā hōʻailona hou a i ʻole inā e ʻoi aku ka ʻino o kāu mau hōʻailona . Hiki iā lākou ke haʻi iā ʻoe pehea e hoʻokele ai i kāu mau hōʻailona, ​​​​hoʻololi i kāu nui o ka lāʻau lapaʻau, a i ʻole e ʻōlelo i kahi lāʻau hou. ʻO kahi ʻāpana koʻikoʻi o kāu lāʻau lapaʻau, ʻo ia ke noho olakino e like me ka hiki.

He aha nā nīnau e pono iaʻu e nīnau aku i ke kauka?

He mea maikaʻi ke nīnau i kāu kauka i nā nīnau e like me kēia:

• "He aha ka lāʻau lapaʻau maikaʻi loa noʻu?"
• "He aha nā hopena ʻaoʻao o ka lāʻau āu e ʻōlelo nei?"
• "Aia wau i ka pilikia o ka maʻi kanesa metastatic?"
• "Pehea e hiki ai iaʻu ke hōʻemi i ka pilikia o ka hoʻolaha ʻana i kēia `(ccRCC)`?"
• "Aia kekahi o koʻu ʻohana koko i ka pilikia o ka loaʻa ʻana o ka `(ccRCC)`?"
• "Aia kekahi mau hōʻailona o nā pilikia e pono iaʻu e makaʻala loa?"

He kōkua wale nō kēia mau nīnau iā ʻoe. Mai kānalua e nīnau i kāu kauka i kekahi mea āu e noʻonoʻo nei, ʻaʻohe mea liʻiliʻi. He mea nui loa e hoʻomaopopo pono ʻoe i nā mea āpau.

He aha ka ʻokoʻa ma waena o ke kanesa puʻupaʻa 'clear cell' a me ke kanesa 'papillary'?

ʻO kēia ka `(Clear Cell Renal Carcinoma)` a me ka `(Papillary Renal Cell Carcinoma)`. Ua like loa nā hōʻailona o nā mea ʻelua. Ua like loa nō hoʻi nā lāʻau lapaʻau.

ʻO ka ʻokoʻa nui ke ʻano o kēia mau hunaola kanesa ke nānā ʻia ma lalo o ka microscope.

• ʻIke ʻia nā hunaola kanesa papillary he mau ulu lōʻihi, lahilahi, e like me ka manamana lima.
• `(ccRCC)` Ua like nā hunaola kanesa me nā pehu moakaka.

Ma kahi o hoʻokahi i loko o 10 mau kānaka me ka renal cell carcinoma he ʻano papillary.

ʻO ka mea hope loa, kekahi mau mea e hoʻomanaʻo ai (Leka Lawe-Home)

Maopopo iaʻu ke paʻakikī o ka ʻike ʻana he maʻi kanesa kou. Hiki i nā manaʻo e like me ka makaʻu, ke kaumaha, ka huhū, ka huikau, a me ka mehameha ke hiki mai iā ʻoe i ka manawa hoʻokahi. Malia paha ke manaʻo nei ʻoe i kēia mau mea a pau i ka manawa hoʻokahi. A i ʻole, e manaʻo paha ʻoe ua kaʻawale ʻoe mai kou mau manaʻo i kou hoʻāʻo ʻana e kū i kēia maʻi. E hoʻomaopopo he mea maʻamau nā mea āu e manaʻo nei.

ʻO Clear Cell Renal Cell Carcinoma (ccRCC) ke ʻano maʻamau o ka maʻi puʻupaʻa. Hiki iā ia ke ulu wikiwiki a ʻoi aku ka ikaika ma mua o nā ʻano maʻi puʻupaʻa ʻē aʻe.

He nui kou mau pilikia, a pono ʻoe e kamaʻilio me kekahi e pili ana i kou mau manaʻo a me kou mau manaʻo.Mai kānalua e noi i ke kōkua mai kāu mau kauka a hilinaʻi i kāu ʻōnaehana kākoʻo (ʻohana, nā hoaaloha).

Hiki i kēia ke lilo i huakaʻi paʻakikī, akā e lawe i hoʻokahi ʻanuʻu i ka manawa, a e lokomaikaʻi iā ʻoe iho. E hoʻomanaʻo he hiki i ka ʻike mua ʻana a me ka mālama mua ʻana ke hana i kahi ʻokoʻa nui. ʻAʻole ʻoe hoʻokahi.

ʻO ke kanesa puʻupaʻa, ccRCC, Clear Cell Renal Cell Carcinoma, maʻi puʻupaʻa, nā hōʻailona kanesa, ka mālama ʻana i ke kanesa, ke olakino puʻupaʻa