Ua lohe anei ʻoe i kēia maʻi kahi e polū ai ʻoe i ke anu a luhi loa? (Maʻi Anu Agglutinin)

Ke manaʻo nei ʻoe i kekahi manawa he uliuli kou mau manamana lima a me kou mau manamana wāwae ke anu loa ʻoe? A i ʻole ke manaʻo nei ʻoe he luhi a nāwaliwali loa me ke kumu ʻole? Ua mae paha kou ʻili. Inā loaʻa iā ʻoe kēia mau hōʻailona, ​​​​​​he maʻi laha ʻole paha ke kumu, akā he mea ia e pono ai kākou a pau e makaʻala. I kēia lā, e kamaʻilio mākou e pili ana i kēia maʻi i kapa ʻia ʻo 'Cold Agglutinin Disease (CAD),' ʻo ia hoʻi "ka maʻi hōʻiliʻili ʻana o nā cell koko anuanu" ma Sinhala.

He aha ka ʻōlelo ʻo 'Cold Agglutinin Disease (CAD)'? E hoʻomaopopo maʻalahi kākou.

I ka ʻōlelo maʻalahi, ʻo ka 'Cold Agglutinin Disease (CAD)' he maʻi koko kakaikahi kahi e hoʻouka hewa ai ka ʻōnaehana pale o ko mākou kino - ka ʻōnaehana e pale ai iā mākou mai nā maʻi e like me nā koa i loko o ko mākou kino - i ko mākou mau hunaola koko ʻulaʻula ponoʻī .

E noʻonoʻo, hana maʻamau kā mākou ʻōnaehana pale i kahi ʻano protein kūikawā i kapa ʻia ʻo 'antibodies' e luku i nā germs ʻino e komo i ke kino. Akā i kēia hihia o CAD, hana kā mākou ʻōnaehana pale i kahi ʻano 'antibody' kūikawā i kapa ʻia ʻo 'autoantibody', i ʻike ʻia hoʻi ʻo 'cold agglutinin'. ʻO ka mea kūikawā o kēia, ʻo ia ka hoʻouka ʻana a me ka luku ʻana i nā hunaola koko ʻulaʻula olakino i loko o ko mākou kino.

E like me kou ʻike, he ʻano nui nā hunaola koko ʻulaʻula e lawe ana i ka oxygen ma loko o ko kākou kino. Kōkua kēia oxygen i kā kākou mau hunaola e hana i ka ikehu e pono ai. No laila, ke emi ka nui o nā hunaola koko ʻulaʻula, ʻo ia hoʻi, ke loaʻa ka anemia , ʻike ko kākou kino i nā ʻano ʻoluʻolu ʻole like ʻole.

ʻO ka 'Maʻi Agglutinin Anu' no kahi hui o nā anemia i kapa ʻia ʻo 'anemia hemolytic.' ʻO ka 'anemia hemolytic' ka wā e wāwahi ai ko kākou iwi iwi i nā hunaola koko ʻulaʻula ma mua o ka hiki ke hana i nā mea hou. Ua like ia me kahi bākeke he lua i loko a hoʻomaka e hoʻokahe i ka wai.

Pehea ka maʻamau o kēia ʻano i kapa ʻia ʻo 'Cold Agglutinin Disease'?

He ʻano maʻi laha ʻole kēia. Hoʻokahi wale nō i loko o 100,000 poʻe i ʻike hou ʻia me ka maʻi i kēlā me kēia makahiki. ʻO ka mea maʻamau ia i nā wahine ma waena o 40 a me 80 mau makahiki. Eia nō naʻe, ʻo ka nui o nā maʻi i loaʻa i ka poʻe ma waena o 60 mau makahiki.

Pehea ka hopena o ka maʻi ʻAgglutinin Anu i koʻu kino?

Hiki i kēia maʻi ke hoʻoulu iā ʻoe e hoʻomohala i nā hōʻailona o ka anemia. ʻO ka anemia ka wā ʻaʻole lawa nā hunaola koko ʻulaʻula o ke kino. Ma muli o ke kumu, hiki i kēia kūlana ke mau a pōkole paha . Eia kekahi, hiki ke ʻokoʻa nā hopena ma ke kino mai ka maʻalahi a i ka koʻikoʻi .

Eia kekahi laʻana, inā ʻaʻole koʻikoʻi ka CAD, hiki ke ʻike lohi loa ʻia nā hōʻailona. Hiki ke hala nā makahiki no ka ʻike ʻia ʻana o ke ʻano. Eia nō naʻe, i nā hihia koʻikoʻi, hiki i ka CAD ke alakaʻi i nā maʻi puʻuwai koʻikoʻi, a hiki ke hoʻoweliweli i ke ola.He hiki nō paha ia ke hana ʻia.

Aia ka huaʻōlelo "anuanu" ma ka inoa o kēia maʻi. No laila, ʻike nui ʻia kēia mau hōʻailona ma nā wahi me nā aniau anuanu a i nā lā anuanu paha.

He aha nā hōʻailona o ka 'Maʻi Anu Agglutinin'?

ʻO nā hōʻailona o CAD e pili pinepine ana i ka anemia a me ke kahe koko maikaʻi ʻole ma ke kino. ʻO kēia mau hōʻailona:

• Manaʻo luhi loa (Fatigue) : ʻAʻole wale ka luhi, akā, he manaʻo ola ʻole.
• Nāwaliwali : Lilo ke kino i nāwaliwali loa a ʻaʻole hiki iā ia ke hana i kekahi mea.
• Pōniuniu : He manaʻo o ka wili ʻana.
• Ka hou ʻana : Ka hou ʻana me ka makehewa.
• Paʻakikī ka hanu ʻana (dyspnea) : Paʻakikī ka hanu ʻana ʻoiai me ka hoʻoikaika iki.
• Piʻi ka helu o ka puʻuwai (tachycardia) : Piʻi ka helu o ka puʻuwai.
• Pallor : Ua nalowale ke koko o ka ʻili a lilo i keʻokeʻo.
• Lilo nā manamana lima, nā manamana wāwae, a me nā pepeiao i polū ke kau ʻia i ke anu (ʻo Raynaud's phenomenon) : Ke hele ʻoe i kahi anu e like me Nuwara Eliya, a i ʻole ke pā ʻoe i ka wai anuanu, lilo kou mau manamana lima, nā manamana wāwae, a me nā pepeiao i polū, i kekahi manawa keʻokeʻo. Hiki ke hele pū ʻia kēia me ka mae ʻana o ka ʻōpū.

Hiki paha iā ʻoe ke loaʻa nā hōʻailona o ka jaundice . Ke luku ʻia nā hunaola koko ʻulaʻula, hoʻokuʻu lākou i kahi mea melemele i kapa ʻia ʻo bilirubin. Ke hōʻiliʻili kēia bilirubin i loko o ke kino, loaʻa ka jaundice. ʻO nā hōʻailona o ka jaundice:

• Mimi ʻeleʻele ʻeleʻele.
• ʻEā, he melemele ke keʻokeʻo o nā maka a me nā iris.

He aha nā kumu o ka 'Maʻi Anu Agglutinin'?

ʻO ka maʻi Agglutinin Anu kahi ʻano anemia hemolytic autoimmune. ʻO ke ʻano kēia e hoʻouka ana kā mākou ʻōnaehana pale ponoʻī i kā mākou mau cell ponoʻī. I ka CAD, hoʻāla ʻia kā mākou ʻōnaehana pale e nā kūlana anu a hana i kahi autoantibody e "tag" i nā cell koko ʻulaʻula e luku iā lākou. Hoʻopili pū nā cell koko ʻulaʻula i hōʻailona ʻia a hui pū (agglutinate). Hiki ke hopu maʻalahi ʻia a luku ʻia nā cell i hui pū ʻia e kekahi ʻāpana ʻē aʻe o kā mākou ʻōnaehana pale, i kapa ʻia ʻo macrophages.

Hoʻomaka kēia kaʻina hana ke hāʻule ka mahana ma lalo o 3-4 degere Celsius (37-39 degere Fahrenheit). E noʻonoʻo he 37 degere Celsius ka mahana maʻamau o ko kākou kino. Hoʻomaka kēia pilikia ke hōʻike ʻia kākou i nā mahana haʻahaʻa loa ma mua o kēlā.

Hoʻopilikia ka CAD i ka papa hana maʻamau no ko mākou kino e hana i nā hunaola koko ʻulaʻula olakino. ʻO ka maʻamau, ola kahi hunaola koko ʻulaʻula no kahi o 120 mau lā. I loko o kēia manawa, hiki i ko mākou iwi iwi ke hana i nā hunaola koko ʻulaʻula hou e pani i nā mea i make. Akā i ka CAD, ua hoʻopilikia ʻia kēia pōʻaiapuni.

ʻAʻole maopopo i nā kānaka noiʻi ke kumu e hoʻouka ai kā mākou ʻōnaehana pale i nā hunaola olakino.I kekahi manawa hiki ke hoʻokumu ʻia ka CAD e kekahi maʻi lapaʻau ʻē aʻe. Ua kapa ʻia kēia ʻo 'CAD lua'. Inā ʻaʻole hiki ke loaʻa kēlā loulou, ʻo ia hoʻi, ulu ka CAD me ke kumu ʻole, ua kapa ʻia ʻo 'CAD mua' a i ʻole 'CAD idiopathic'.

He aha nā kūlana ʻē aʻe e pili pū ana me ka `Maʻi Anu Agglutinin`?

ʻO ka maʻamau, pili ka CAD lua me nā maʻi, nā maʻi autoimmune, a me nā maʻi lymphoproliferative. Eia kekahi laʻana:

• ʻO ka mononucleosis maʻi (ke kuni glandular)
• ʻO ka maʻi pneumonia mycoplasma
• ʻO ka maʻi Cytomegalovirus
• Lupus
• ʻO ka ʻāʻī rheumatoid
• ʻO ka lymphoma ʻaʻole-Hodgkin
• Leukemia lymphocytic mau loa
• ʻO ka maʻi macroglobulinemia o Waldenstrom

Me he mea lā he mea huikau iki kēia mau inoa iā ʻoe, akā he mau inoa kikoʻī kēia i hoʻohana ʻia e nā kauka, no laila he mea maikaʻi iā ʻoe ke ʻike iā lākou.

Pehea e ʻike ai i ka maʻi anu agglutinin? (Diagnosis)

E nīnau kāu kauka e pili ana i kāu mau hōʻailona a nānā i kāu mōʻaukala olakino. A laila, e kauoha lākou i kekahi mau hoʻāʻo koko kūikawā e nānā inā loaʻa iā ʻoe ka anemia hemolytic a inā he mau autoantibodies e pili ana i ka CAD.

ʻO nā hoʻāʻo koko i hoʻohana ʻia no ka ʻike ʻana i ka anemia hemolytic:

• Helu koko piha (CBC) : Hāʻawi kēia i ka ʻike kikoʻī e pili ana i kou mau hunaola koko ʻulaʻula. Hiki iā ia ke nānā i ka nui o nā hunaola koko ʻulaʻula āu, pehea ko lākou nui, a me kou pae hemoglobin. He protein koʻikoʻi ka Hemoglobin e kōkua i nā hunaola koko ʻulaʻula e lawe i ka oxygen.
• ʻO ka helu ʻana o nā reticulocyte : Ke ana kēia i ka nui o nā hunaola koko ʻulaʻula makua ʻole (reticulocytes) i loko o kou kino. Ke hoʻopau ka ʻōnaehana pale i nā hunaola koko ʻulaʻula makua, hoʻāʻo ke kino e hana hou aku i kēia mau hunaola makua ʻole ma ke ʻano he ala e uku ai.
• Nā hoʻāʻo pae serum : ʻO ke kiʻekiʻe o nā pae o ka lactate dehydrogenase (LDH) a me ka bilirubin i loko o ke koko, a me ka emi ʻana o nā pae o ka haptoglobin he mau hōʻailona ia o ka anemia hemolytic.

A laila, no ka hoʻoholo ʻana inā ʻo CAD ke kumu o kou anemia hemolytic, e nānā kāu kauka no ke alo o nā autoantibodies e hoʻouka i nā hunaola koko ʻulaʻula. ʻO nā hoʻokolohua i hana ʻia no kēia:

• Hoʻāʻo Coombs pololei (DAT) : Nānā kēia hoʻāʻo no ke alo o nā autoantibodies e pili ana me CAD. I ka hoʻāʻo ʻana, hoʻokaʻawale ʻia kāu mau hunaola koko ʻulaʻula mai ke koena o kou koko a waiho ʻia i loko o kahi ʻano i kāohi ʻia. A laila hoʻohui ʻia kahi hopena kūikawā. Inā pili nā hunaola koko ʻulaʻula me ka hopena a hui pū (agglutinate), ua maikaʻi ka hoʻāʻo, ʻo ia hoʻi, aia ka autoantibody.
• `Hoʻāʻo titer agglutinin anu`ʻO ke ana ʻana o kēia hoʻāʻo i ka nui o kēia mau 'autoantibodies' i loko o kou koko. ʻO ke kiʻekiʻe o kēia mau 'autoantibodies' he hōʻailona ia o CAD.

Ke hōʻoia ʻia kāu hōʻailona, ​​​​e nānā pū kāu kauka e ʻike inā pili kāu CAD i kahi maʻi kumu ('secondary CAD`).

Pehea e mālama ʻia ai ka maʻi ʻanuʻu Agglutinin?

Ma muli o ke koʻikoʻi o kāu mau hōʻailona, ​​​​hiki i ka lāʻau lapaʻau ke komo pū me nā loli o ke ʻano o ka nohona, nā lāʻau lapaʻau, a i kekahi manawa nā hoʻoili koko i nā kūlana pilikia .

• ʻAno nohona : Inā loaʻa iā ʻoe ka CAD, e aʻo aku paha kāu kauka iā ʻoe e pale i nā mahana anu . ʻO kēia ka mea nui loa. Pono ʻoe e hana i nā mea e like me ke komo ʻana i nā lole mahana, pale i nā ʻauʻau anu, a kaupalena i kāu huakaʻi i nā aniau anuanu.
• Nā Lāʻau Lapaʻau : ʻO ka lāʻau lapaʻau maʻamau i hoʻohana ʻia no ka mālama ʻana i ka CAD ʻo ia ka 'Rituximab' . Hana kēia ma ka hoʻōki ʻana i kāu ʻōnaehana pale mai ka hana ʻana i nā 'autoantibodies' e hoʻouka i kāu mau hunaola koko ʻulaʻula. Ua ʻāpono ʻia nei kekahi lāʻau lapaʻau hou i kapa ʻia ʻo 'Sutimlimab' . Hana kēia ma ka hoʻōki pololei ʻana i ka ʻōnaehana pale mai ka hoʻouka ʻana i kāu mau hunaola koko ʻulaʻula.
• Nā hoʻoili koko a me ka hoʻololi plasma : Inā lilo kāu CAD i mea koʻikoʻi, pono paha kāu kauka e hāʻawi iā ʻoe i kahi hoʻoili koko a i ʻole ka hoʻololi plasma e hoʻopaʻa i kou kūlana. Hana ka hoʻololi plasma ma ka hoʻemi ʻana i ka nui o nā autoantibodies i loko o kou koko.

Inā loaʻa iā ʻoe ka 'CAD lua', e mālama pū kāu kauka i ke kūlana kumu.

Hiki ke pale ʻia ke CAD?

ʻO ka mea pōʻino, ʻaʻole hiki ke pale ʻia ka maʻi Anu Agglutinin. Eia nō naʻe, hiki iā ʻoe ke hoʻokele i nā hōʻailona a ola i kahi ola maikaʻi.

Pehea ka lōʻihi e hiki ai iā ʻoe ke ola me ka maʻi ʻo Cold Agglutinin?

ʻO ka poʻe i loaʻa i ka maʻi CAD e ola mau ana e like me ka poʻe o ko lākou mau makahiki i loaʻa ʻole iā lākou ka maʻi CAD. Wahi a kahi noiʻi hou, hiki i ka poʻe i loaʻa i ka maʻi 68 makahiki ke manaʻo e ola a hiki i ko lākou mau makahiki 80, ma ka awelika. ʻO ia hoʻi, me ka mālama pono ʻana a me ka hoʻokele ʻana, hiki iā ʻoe ke manaʻo e ola i kahi ola maikaʻi.

He aha nā nīnau e pono iaʻu e nīnau aku i kaʻu kauka?

Inā ua ʻike ʻia ʻoe me CAD, he mea maikaʻi ke nīnau i kāu kauka i nā nīnau e like me kēia:

• Ua pili anei koʻu CAD i kahi maʻi kumu?
• He aha nā hōʻailona e kōkua iaʻu e ʻike inā e maikaʻi aʻe ana paha koʻu kūlana?
• Pono anei au e hoʻomau i ka lawe ʻana i ka lāʻau lapaʻau no kēia maʻi?
• He aha ke aniau maikaʻi loa no ka poʻe me CAD e noho ai?
• He aha nā pae mahana e pono iaʻu e pale aku ai e mālama i koʻu mau hōʻailona?

ʻO kou ʻike me ka maʻi Anu Agglutinin (CAD) e pili ana i ka mea mua ('mua') a i ʻole ka lua ('lua'). ʻO ke koʻikoʻi o kāu mau hōʻailona e hoʻopilikia pū i ke ʻano o kou pono ʻana i ka lāʻau lapaʻau. Ma ka mālama ʻana i ke kūlana kumu, hiki paha i kāu kauka ke ho'ōla i kāu CAD. ʻOiai inā he CAD lōʻihi kou, hiki iā ʻoe ke kaohi i kāu mau hōʻailona anemia a noho maikaʻi ma ka pale ʻana i ke anu a me ka lawe ʻana i kāu mau lāʻau lapaʻau e like me ke kauoha.

Nā mea nui e hoʻomanaʻo mai nā mea a mākou i kūkākūkā ai (Leka Lawe-Home)

• ʻO ka Maʻi Anu Agglutinin (CAD) kahi maʻi laha ʻole kahi e hoʻouka ai ko mākou ʻōnaehana pale ponoʻī i ko mākou mau hunaola koko ʻulaʻula a hoʻonui ʻia e ke anu.
• Hiki i nā hōʻailona ke komo pū me ka ʻeha o nā hono, ka luhi nui, ka ʻili keʻokeʻo, nā manamana lima e polū ana i ke anu, a i kekahi manawa ka jaundice .
• Hiki i kēia ke lilo i 'kumu mua' (kumu ʻole) a i ʻole 'lua' (i hoʻokumu ʻia e kekahi maʻi ʻē aʻe).
• Aia nā hoʻāʻo koko e ʻike ai.
• ʻO ka mālama ʻana paha e komo pū me ka pale ʻana i ke anu, ka lāʻau lapaʻau, a i kekahi manawa ke hoʻoili koko.
• ʻOiai ʻaʻole hiki ke pale ʻia kēia, me ka mālama pono ʻana, hiki iā ʻoe ke ola i kahi ola maikaʻi.
• Inā loaʻa iā ʻoe kēia mau hōʻailona, ​​mai kānalua e ʻimi i ke kōkua lapaʻau. ʻO ka wikiwiki o kou ʻike ʻana, ʻo ka maʻalahi hoʻi ka mālama ʻana.

E hoʻomanaʻo, no ka ʻike wale nō kēia ʻatikala. Inā loaʻa iā ʻoe kekahi mau hōʻailona, ​​e ʻike pono i ke kauka no ka ʻōlelo aʻo.

ʻO ka maʻi Agglutinin anu, CAD, anemia, nā hunaola koko ʻulaʻula, ʻōnaehana pale, anu, autoimmune, anemia hemolytic, maʻi koko