Ua lohe anei ʻoe i ka maʻi o Parkinson? A i ʻole ka hoʻomaha ʻole i kekahi manawa ma nā wāwae, ʻo ia hoʻi, ʻo Restless Legs Syndrome? I kēia lā e kamaʻilio mākou e pili ana i kahi ʻano lāʻau lapaʻau kūikawā i hoʻohana ʻia e mālama i kekahi mau ʻano maʻi. Ua kapa ʻia kēia mau mea ʻo Dopamine Agonists. ʻOiai he paʻakikī iki ka inoa, he maʻalahi loa ke ʻano o kā lākou hana.
He aha nā agonists dopamine maoli?
I mea e hoʻomaopopo ai i kēia, e noʻonoʻo kākou i ko kākou lolo no kekahi manawa. Kamaʻilio nā ʻiole nerve i loko o ko kākou lolo kekahi me kekahi, a i ʻole e hoʻololi i nā leka, ma o nā kemika kūikawā. Kāhea mākou i kēia mau neurotransmitters . E noʻonoʻo i ko kākou mau ʻiole lolo e like me nā laka e kūpono pū ana. Ua like kēia mau neurotransmitters me nā kī kūikawā e hiki ke wehe i kēlā mau laka.
He "kī" koʻikoʻi ka Dopamine . He mea nui kēia kemika ke aʻo mākou i kekahi mea, ke manaʻo mākou i ka leʻaleʻa a me ka ʻoluʻolu, a ke kaohi mākou i nā neʻe ʻana o ko mākou kino.
I ka ʻōlelo maʻalahi, ʻo nā dopamine agonists he mau lāʻau lapaʻau e hana ana e like me ka dopamine, akā ʻaʻole maoli ka dopamine. Ua like lākou me ke kope o ke 'kī' i kapa ʻia ʻo dopamine. No ka mea, ʻaʻole hiki i ko mākou mau hunaola lolo ke ʻike i ka ʻokoʻa ma waena o nā mea ʻelua, ke loaʻa iā lākou kahi dopamine agonist, manaʻo lākou e loaʻa ana iā lākou ka dopamine. No laila, kōkua kēia mau lāʻau lapaʻau i ka lanakila ʻana i nā pilikia e kū mai ana i ka wā e haʻahaʻa ai nā pae dopamine.
He aha nā maʻi e hoʻohana ʻia ai kēia lāʻau lapaʻau?
ʻO ka emi ʻana o nā pae dopamine i loko o ke kino hiki ke alakaʻi i nā ʻano maʻi like ʻole. Aia ma lalo iho kekahi o nā ʻano maʻi e hoʻohana nui ʻia ai nā dopamine agonists.
| Kūlana olakino | He wehewehe maʻalahi |
|---|---|
| ʻO ka maʻi o Parkinson a me nā maʻi neʻe e pili ana | ʻO ke kūlana i hoʻokumu ʻia e ka nele o ka dopamine ma nā ʻāpana o ka lolo e kaohi ana i nā neʻe ʻana o ke kino. |
| ʻO ka maʻi wāwae hoʻomaha ʻole | He makemake ikaika e hoʻoneʻe i nā wāwae, ʻoi aku hoʻi i ka pō, a me ka manaʻo ʻoluʻolu ʻole. |
| Hyperprolactinemia | Hoʻonui ʻia nā pae o ka hormone prolactin i loko o ke kino. Hiki i kēia ke hana i nā pilikia e like me nā pōʻaiapuni menstrual kūpono ʻole. |
| ʻO ka maʻi ʻino Neuroleptic | He pilikia kakaikahi akā weliweli i hiki ke hana ʻia e kekahi mau lāʻau lapaʻau i hoʻohana ʻia e mālama ai i nā maʻi noʻonoʻo. |
| ʻAno 2 Diabetes | Kōkua kekahi mau agonists dopamine i ke kāohi ʻana i nā pae kō koko. |
He aha nā pono o kēia mau lāʻau lapaʻau?
Aia kekahi mau kumu he mea nui ka papa o nā lāʻau i kapa ʻia ʻo dopamine agonists no nā maʻi.
- Ka nui o ka holomua: Ua hōʻoia ʻia e ka noiʻi he pono loa kēia ʻano lāʻau lapaʻau i ka mālama ʻana i nā ʻano maʻi he nui.
- Hiki ke hoʻohana ʻia no nā ʻano maʻi like ʻole: E like me kā mākou i kūkākūkā ai ma luna, hoʻohana ʻia kēia mau mea no nā ʻano maʻi like ʻole, mai nā maʻi neʻe o ka lolo a hiki i nā pilikia hormonal.
- Hoʻohui pū ʻia me nā lāʻau lapaʻau ʻē aʻe: ʻO kahi laʻana maikaʻi ʻo ka maʻi Parkinson. ʻO ka hoʻohui ʻana i kahi agonist dopamine me ka lāʻau lapaʻau 'Levodopa' i hoʻohana ʻia no kēia maʻi hiki ke hāʻawi i kahi hopena kiʻekiʻe aʻe me kahi mahele haʻahaʻa o ka levodopa. Kōkua pū lākou i ka hoʻopaneʻe ʻana i ka hoʻomaka ʻana o ka levodopa.
- Hoʻōla ola: I kekahi manawa hiki i kēia mau lāʻau lapaʻau ke kōkua i ka hoʻopakele ʻana i nā ola. No ka laʻana, hiki iā lākou ke kaohi i kahi maʻi weliweli i kapa ʻia ʻo 'Neuroleptic Malignant Syndrome'.
ʻAʻohe pilikia a me nā hopena ʻaoʻao?
E like me nā lāʻau lapaʻau āpau, aia nā hopena ʻaoʻao. Akā, mai makaʻu. ʻO ka mea nui loa, ʻo ia ka makaʻala i kēia mau mea. Ma ke ʻano laulā, ʻo ke kiʻekiʻe o ka nui, ʻo ka nui o ka manawa kūpono o kēia mau hopena ʻaoʻao.
| Nā hopena ʻaoʻao maʻamau | |
|---|---|
| - Ka paʻa ʻana o ka ʻōpū | - Ka luaʻi a me ka luaʻi |
| - Pōʻino | - ʻEha poʻo |
| - Nā pilikia ʻōpū | - Ka hiolo ʻana i ke kū ʻana (Orthostatic hypotension) |
Nā pilikia o ka hoʻokele impulse
He mea kēia e pono e kūkākūkā hou ʻia me nā kikoʻī. He kemika ka Dopamine e kōkua iā mākou e ʻike i nā mea e like me ka leʻaleʻa a me ka ʻoluʻolu. No laila, ʻoiai kēia mau lāʻau lapaʻau e hoʻoulu ai i kēlā kaʻina hana, hiki iā lākou ke hoʻopilikia i ka hiki o kekahi poʻe ke kāohi i ko lākou mau impulses . ʻO ia hoʻi, ʻaʻole hiki iā lākou ke kāohi i ko lākou makemake e hana i kekahi mea. Eia kekahi laʻana:
- Ka nui o ka hoʻopilikia ʻana i ka piliwaiwai.
- Ke kūʻai ʻana i nā mea me ke kaohi ʻole, ʻoiai inā ʻaʻole pono ʻoe iā lākou.
- Ka moekolohe nui.
- ʻAi nui ʻole i kāohi ʻia.
He mea nui loa kēia. Inā ʻike ʻoe a i ʻole kou ʻohana i kekahi mau loli ʻē i kāu ʻano, mai hilahila a kamaʻilio me kāu kauka i ka wā hikiwawe loa. He mea nui e hoʻomaopopo i kāu kauka e pili ana i kēia, no ka mea, he hopena ʻaoʻao paha ia o ka lāʻau lapaʻau.
He aha ka mea e hana ai inā e hoʻōki koke ʻoe i ka lawe ʻana i ka lāʻau lapaʻau?
He mea nui loa nō hoʻi kēia. Inā ʻoe e hoʻōki koke i ka hoʻohana ʻana i ka lāʻau lapaʻau dopamine agonist a i ʻole e hōʻemi i ka nui me ka ʻole o ke aʻo ʻana a ke kauka , hiki i kekahi poʻe ke loaʻa i kekahi mau ʻano ʻeha. Kāhea mākou i kēia Dopamine Agonist Withdrawal Syndrome (DAWS) . ʻO nā hōʻailona e hiki mai ana:
- Hopohopo a me ka hoʻomaha ʻole
- Ka hou nui ʻana
- Luhi
- ʻEha kino
- Ka luaʻi
No laila, ʻo ka mea nui e hoʻomanaʻo ai, ʻo ia ka hoʻōki ʻole i ka lawe ʻana i kēia lāʻau lapaʻau a hoʻololi paha i ka nui me ka ʻole o ke aʻo ʻana a kāu kauka.
Aia kekahi mau kūlana kahi i maikaʻi ʻole ai ke lawe ʻana i kēia lāʻau lapaʻau?
ʻAe, ʻaʻole kūpono kekahi poʻe no kēia ʻano lāʻau lapaʻau. Kāhea mākou i kēia mau "contraindications".
- Nā makuahine hāpai a me nā makuahine hānai:ʻAʻole ʻōlelo ʻia kēia lāʻau lapaʻau i kēia mau wā no ka mea hiki ke hoʻopilikia i ka hānai waiū.
- ʻO nā kānaka me ke koko kiʻekiʻe: Hiki i kekahi mau agonists dopamine ke hoʻonui hou i ke koko.
- Nā kānaka me nā maʻi puʻupaʻa a i ʻole ke akepaʻa: No ka mea, hoʻopilikia kēia mau maʻi i ke kaʻina hana o ka hoʻopau ʻana i nā lāʻau lapaʻau mai ke kino.
- ʻO ka poʻe e lawe ana i kekahi mau lāʻau lapaʻau ʻē aʻe: ʻOiai inā ʻoe e lawe ana i nā lāʻau MAOI, pono ʻoe e hoʻōki i ka lawe ʻana iā lākou no ʻelua pule ma mua o ka hoʻomaka ʻana i kēia lāʻau lapaʻau.
- ʻO ka poʻe me ka mōʻaukala o ka psychosis: Hiki i kēia mau lāʻau lapaʻau ke hoʻonui i ka pilikia o nā hōʻailona psychotic.
Inā loaʻa iā ʻoe kekahi o kēia mau kūlana, e haʻi i kāu kauka e pili ana i ia mea ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau.
He aha ka ʻokoʻa ma waena o ka dopamine a me nā agonists dopamine?
He nīnau kēia a ka poʻe he nui. Inā haʻahaʻa ka dopamine, no ke aha e hāʻawi ai i nā agonists dopamine ma kahi o ka hāʻawi pololei ʻana i ka dopamine? Nui nā kumu.
ʻO ke kumu nui, ʻo ia ka pale koko-lolo . E noʻonoʻo i ko kākou lolo he kānana pale. ʻAʻole hiki i ka dopamine i lawelawe ʻia ma waho ke hele ma o kēia kānana a komo i loko o ka lolo. Eia nō naʻe, hiki i nā lāʻau lapaʻau dopamine agonist ke hele ma o kēia pale a komo pololei i loko o ka lolo. ʻO ia ke kumu i ʻoi aku ai ka maikaʻi o lākou.
Leka Lawe-Home
- ʻO ka dopamine agonist kahi ʻano lāʻau lapaʻau e hoʻoulu ai i nā hunaola lolo ma ke ʻano e like me ka dopamine kemika, akā ʻaʻole ia ka dopamine ponoʻī.
- Hoʻohana ʻia kēia mau mea e mālama i nā kūlana he nui, e like me ka maʻi o Parkinson a me Restless Legs Syndrome.
- E like me nā lāʻau lapaʻau a pau, hiki i kēia mau mea ke loaʻa nā hopena ʻaoʻao, ʻoiai nā pilikia kaohi.
- Inā ʻike ʻoe a i ʻole kou ʻohana i kekahi mau loli ʻē, e kamaʻilio koke me kāu kauka.
- Mai ho'ōki koke i ka lawe ʻana i kēia lāʻau lapaʻau a hoʻololi paha i ka lāʻau me ka ʻole o ke aʻo ʻana a ke kauka.
- ʻO ke kamaʻilio ākea a me ka ʻoiaʻiʻo me kāu kauka ke ala maikaʻi loa e hoʻokō ai i nā hopena holomua loa.
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