Ua manaʻo paha ʻoe e pani ana kou puʻu a ua pilikia ʻoe i ka moni ʻana i ka meaʻai? Malia paha ʻo ʻoe a i ʻole kekahi āu i ʻike ai he maʻi i kapa ʻia ʻo Eosinophilic Esophagitis. He inoa lōʻihi paha ia, akā hiki iā ia ke loaʻa ka hopena nui i kou ola o kēlā me kēia lā. Akā he nūhou maikaʻi! ʻO Dupixent ka lāʻau hou loa i ʻae ʻia e mālama i kēia maʻi. E kamaʻilio kākou e pili ana i ia mea me ka maʻalahi a me ka maopopo i kēia lā.
I ka ʻōlelo maʻalahi, he aha ka Eosinophilic Esophagitis?
He maʻi mau kēia e hoʻopilikia ana i kā mākou ʻōnaehana pale. E noʻonoʻo e pili ana, aia nā ʻano ʻano like ʻole o nā cell i loko o ko mākou kino e pale iā mākou mai nā maʻi, ʻeā? ʻO kekahi ʻano o ke koko keʻokeʻo i kapa ʻia he eosinophil . ʻOiai ke kōkua pinepine nei lākou iā mākou, i loko o ke kanaka me Eosinophilic Esophagitis, hōʻiliʻili nui kēia mau cell a hoʻoulu i ka mumū i loko o ka esophagus , ka ʻōmole ma o ia mea a mākou e moni ai i ka meaʻai.
ʻO kēia mumū ke kumu o ka pehu ʻana o ka esophagus a me ka ololi. He aha ka mea e hana ai? Lilo ia i mea paʻakikī no ka meaʻai ke hele i lalo i loko o ka ʻōpū. ʻO kēia...
- Lilo i mea paʻakikī ke ale i ka meaʻai.
- Paʻa ka meaʻai i loko o ka puʻu.
- Hiki ke loaʻa ka ʻeha o ka umauma a i ʻole ke kuni ʻana.
- Hiki ke luaʻi.
I ka manawa pinepine, pili kēia maʻi i nā maʻi allergies i kekahi mau meaʻai.
Pehea e hana ai ʻo Dupixent no kēia maʻi?
ʻO ka maʻamau, kuhikuhi mua nā kauka i nā lāʻau lapaʻau e hōʻemi i ka waikawa o ka ʻōpū (Proton Pump Inhibitors). No ka laʻana, ua lohe paha ʻoe i nā lāʻau lapaʻau e like me "omeprazole" a me "lansoprazole". I kekahi manawa, kuhikuhi pū lākou i nā steroids (corticosteroids) e hōʻemi i ka mumū.
Akā hana ʻo Dupixent ma kahi ala ʻokoʻa loa.
He lāʻau pale ʻo Dupixent e hoʻopilikia pololei i kā mākou ʻōnaehana pale a kaohi i ka mumū e hoʻoulu ai i ka maʻi.
ʻO ka mea hana nui i loko o Dupixent ʻo dupilumab . I ka ʻōlelo maʻalahi, hana ia ma ke kāohi ʻana i ka hana o ʻelua mau protein i kapa ʻia ʻo interleukin-4 a me interleukin-13, ʻo ia nā hōʻailona mai kā mākou ʻōnaehana pale e hoʻoulu ai i ka mumū. Ke ālai ʻia kēia mau hōʻailona, e emi ana ka helu o nā eosinophils e hōʻiliʻili ana i loko o ka esophagus, e hōʻemi ana i ka pehu a me ka mumū. Hoʻemi pū kēia i ka paʻakikī o ka ale ʻana.
He aha ka mea i hōʻike ʻia e ka noiʻi ʻana e pili ana i kēia lāʻau lapaʻau?
Ua hana ʻia ʻelua mau noiʻi lapaʻau nui e ʻike i ka pono a me ka palekana o kēia lāʻau. ʻO nā mea a pau i komo i kēia mau noiʻi he poʻe i hoʻohana mua i kahi mea hoʻopaʻa pamu proton no kahi o ʻelua mahina akā ʻaʻole i hoʻomaikaʻi ʻia ko lākou mau hōʻailona.
- Haʻawina mua: He 12 mau makahiki a ʻoi aku ka poʻe i komo.
- ʻO ka lua o ka noiʻi: Ua komo nā keiki ʻōpio ma waena o nā makahiki 1-11.
Ma kēia mau haʻawina, ua hāʻawi ʻia kekahi hui i ka lāʻau pale ʻo Dupixent. Ua hāʻawi ʻia kekahi hui i kahi placebo. Kāhea mākou i kēia he placebo . Akā, ʻaʻohe mea i haʻi ʻia inā lākou e loaʻa ana i ka lāʻau maoli a i ʻole ka placebo.
Pehea nā hopena?
Ma hope o 4-6 mau mahina, ua hoʻomaopopo ʻia he mea hoʻoikaika maoli nā hopena.
1. Helu Eosinophil: ʻOi aku ma mua o 60% o ka poʻe e lawe ana iā Dupixent ua emi nui ka helu o nā cell eosinophil i loko o ko lākou esophagus, a hiki i ka hoʻomaha ʻana. ʻO kēia ke ʻano no kahi 5% wale nō o ka poʻe e lawe ana i ka placebo.
2. Paʻakikī i ka moni ʻana: Ma kahi noiʻi o ka poʻe ma luna o 12 mau makahiki, ʻo ka poʻe i lawe iā Dupixent ua emi iki ka paʻakikī o ka moni ʻana ma mua o ka poʻe i lawe i kahi placebo.
Pehea e hoʻohana ai au i kēia lāʻau lapaʻau?
He wai ʻo Dupixent. Hāʻawi ʻia ia ma ke ʻano he inikini subcutaneous . Na kāu kauka e hoʻoholo inā e hāʻawi iā ia i hoʻokahi manawa i ka pule a i ʻole i kēlā me kēia ʻelua pule, ma muli o kou makahiki a me kou kaumaha. Hāʻawi pinepine ʻia ia ma ka ʻūhā, ka ʻōpū, a i ʻole ka lima o luna.
Loaʻa kēia lāʻau lapaʻau i ʻelua ʻano:
- Peni i hoʻopiha mua ʻia: He maʻalahi loa kēia e hoʻohana. ʻAʻole pono ʻoe e hopohopo e pili ana i kahi syringe.
- Syringe i hoʻopiha mua ʻia: Hoʻohana pinepine ʻia kēia no nā keiki ʻōpio.
ʻO ka mea nui loa, ma mua o kou hoʻohana ʻana no ka manawa mua, e hōʻike pololei kāu kauka a i ʻole kahi kahu maʻi i aʻo ʻia iā ʻoe pehea e hoʻokomo ai. He mea nui hoʻi e heluhelu a hoʻomaopopo i ka pepa kuhikuhi e hele mai me ka lāʻau lapaʻau.
Nā hopena ʻaoʻao a pehea e mālama ai iā lākou?
E like me nā lāʻau lapaʻau āpau, hiki iā Dupixent ke hana i nā hopena ʻaoʻao liʻiliʻi. Akā, mai hopohopo, hiki ke hoʻokele ʻia ka hapa nui o lākou.
| Nā hopena ʻaoʻao maʻamau | Pehea e hoʻokele ai |
|---|---|
| Nā hopena ʻili ma kahi i hoʻokomo ʻia(ʻUlaʻula, ʻeha, pehu, ʻeha) | ʻO ke ala maikaʻi loa e hana ai i kēia, ʻo ia ke hoʻololi i nā wahi i hoʻokomo ʻia ai . No ka laʻana, inā ʻoe e hoʻokomo i loko o kou ʻūhā ʻākau i hoʻokahi manawa, e hoʻokomo i loko o kou ʻūhā hema i ka manawa aʻe. E pale i ka hoʻokomo ʻana i nā wahi i ʻeha, palapū, a ʻeha paha. |
| Nā maʻi ʻōpū hanu (anu, ʻeha puʻu) | E hahai i nā hana maikaʻi loa e pale aku iā ʻoe iho mai nā maʻi. E holoi pinepine i kou mau lima. E noho mamao aku mai ka poʻe maʻi. E kiʻi i kāu panakō maʻi flu i ka hikiwawe loa. |
ʻO kēia nā hopena ʻaoʻao nui e ʻike ʻia. Akā inā manaʻo ʻoe i kekahi mea ʻokoʻa a i ʻole he ʻoluʻolu ʻole, e ʻoluʻolu e haʻi i kāu kauka .
Hiki paha nā pilikia me nā lāʻau lapaʻau ʻē aʻe?
ʻAe, no laila he mea nui loa kēia mea.
- E haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau āpau āu e lawe ai: Ma mua o kou hoʻomaka ʻana iā Dupixent, pono ʻoe e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau āpau āu e lawe ai (me nā huaora, nā lāʻau lapaʻau lāʻau, a me nā mea hoʻohui). He mea nui loa kēia inā ʻoe e lawe ana i ka lāʻau lapaʻau no ka hānō.
- E makaʻala me nā lāʻau pale: ʻAʻole ʻōlelo ʻia kekahi mau lāʻau pale ola i ka wā e lawe ana i kēia lāʻau. No laila, inā e loaʻa iā ʻoe kahi lāʻau pale, e kamaʻilio me kāu kauka e pili ana i ia mea ma mua o ka hoʻomaka ʻana i ka lāʻau.
Mai ho'ōki i ka lawe ʻana i ka lāʻau lapaʻau me ke kūkākūkā ʻole me kāu kauka, ʻoiai inā ua hoʻomaka ka lāʻau lapaʻau e hana a ua hoʻomaikaʻi kou mau hōʻailona. ʻO ka hana ʻana pēlā e hoʻonui hou ai i kou mau hōʻailona.
Leka Lawe-Home
- ʻO ka Eosinophilic Esophagitis kahi maʻi lōʻihi e pili ana i ka ʻōnaehana pale e hoʻoulu ai i ka paʻakikī i ke ale ʻana.
- He injection subcutaneous hou ʻo Dupixent i ʻae ʻia e mālama i kēia maʻi.
- Hoʻopili kēia i nā hōʻailona pale e hoʻoulu ai i ka mumū, ʻo ia ke kumu o ka maʻi, a kaohi i nā hōʻailona.
- Hiki ke loaʻa nā hopena ʻaoʻao liʻiliʻi e like me ka ʻulaʻula a me ka pehu ma kahi i inikini ʻia, akā hiki ke mālama ʻia.
- He mea nui e hoʻomaopopo i kāu kauka e pili ana i nā lāʻau lapaʻau ʻē aʻe āu e lawe nei a me nā lāʻau pale āu i hoʻonohonoho ʻia e loaʻa.
- Mai ho'ōki i ka lāʻau lapaʻau a hoʻololi paha i ka lāʻau me ka ʻole o ke aʻo ʻana a ke kauka.
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