Ua ʻike pono anei ʻoe i ke ʻano o ka endothelin i loko o kou kino? Pehea kona hopena i ko mākou koko koko!

Ua lohe paha ʻoe i ka huaʻōlelo 'Endothelin'? Ua lohe paha ʻoe i ke kauka e ʻōlelo ana i kēia inoa iā ʻoe a i ʻole kekahi o kou ʻohana i ke kamaʻilio ʻana e pili ana i ka lāʻau lapaʻau, a ua ʻike paha ʻoe iā ia ma kekahi wahi i ka heluhelu ʻana e pili ana i kahi maʻi. ʻOiai he mea liʻiliʻi kēia i hana ʻia i loko o ko mākou kino, hana maikaʻi ia i ka mālama ʻana i ko mākou koko, a i ʻole 'kaomi' e like me kā mākou e ʻike nei, ma ka pae kūpono. Eia naʻe, inā e hoʻonui ʻia kēia endothelin i loko o ke kino ma mua o ka mea e pono ai, hiki ke loaʻa nā pilikia olakino like ʻole. No laila, i kēia lā e kamaʻilio mākou e pili ana i ke ʻano o kēia endothelin a me kāna hana i ko mākou kino ma ke ʻano maʻalahi hiki iā ʻoe ke hoʻomaopopo.

No laila he aha kēia endothelin?

I ka ʻōlelo maʻalahi, he protein liʻiliʻi ka endothelin e kōkua ana i ka hoʻopaʻa ʻana i nā kīʻaha koko i loko o ko mākou kino. I ka pololei, he peptide ia. He mau kaulahao protein pōkole nā ​​peptides i hana ʻia me nā mea liʻiliʻi i kapa ʻia ʻo amino acids. Kōkua pū kēia i ke kūkulu ʻana i nā protein nui i loko o ko mākou kino.

Ua ʻike anei ʻoe i ka mea nāna i hana i kēia endothelin? Aia kahi papa o nā ʻāpana i loko o ko kākou mau kīʻaha koko. Ua kapa ʻia ʻo ia ʻo ka endothelium. ʻO kēia kahi nui i loko o ko kākou kino e hana ai i ka endothelin.

He aha ka endothelium? Hiki iā ʻoe ke wehewehe iki?

E noʻonoʻo i nā kīʻaha koko ma loko o ko kākou kino e like me kahi pūnaewele o nā paipu e lawe ana i ka wai. ʻO loko o kēlā mau paipu, ma ka ʻaoʻao kahi e kahe ai ke koko, ua uhi ʻia e kahi papa lahilahi o nā cell. Ua kapa ʻia kēlā papa o nā cell ʻo ka endothelium . ʻOiai ke ʻano kupanaha, ua manaʻo ʻia hoʻi ʻo ia kekahi o nā ʻōkana nui loa i loko o ko kākou kino!

Hoʻopuka kēia mau pūnaewele endothelial i nā mea like ʻole. Hoʻomalu kēia mau mea i ka hoʻonui ʻana a me ka paʻa ʻana o ko mākou mau kīʻaha koko, i kapa ʻia ʻo ke kani vascular . Hoʻoholo kēia kani vascular i ka paʻakikī o ko mākou puʻuwai e pamu i ke koko a me ka paʻakikī o ka hana e hoʻopuni i ke koko ma ke kino holoʻokoʻa.

Hana pū ka endothelium a me ka endothelin e hana i kekahi mau hana koʻikoʻi ʻē aʻe:

• Kōkua ia i ke kāpili ʻana o ke koko. He mea nui loa kēia e hoʻōki i ke kahe ʻana o ke koko ke loaʻa iā ʻoe kahi ʻeha.
• Hoʻokele ia i nā pae o nā wai a me nā paʻakai (electrolytes) i loko o ko kākou koko.
• Kōkua nō hoʻi ia i ka kaohi ʻana i ka mumū ma ka pale ʻana i nā mea ʻawahia mai ke komo ʻana i loko o ko kākou mau ʻiʻo.

No laila he aha ka hana a ka endothelin i ke kino?

Ua ʻōlelo mua mākou he mea kōkua ka endothelin i ka hoʻopaʻa ʻana i nā kīʻaha koko. ʻO ka ʻoiaʻiʻo, ʻo ka endothelin ka mea hoʻoulu vasoconstrictor ikaika loa i loko o ko mākou kino. E wehewehe iki kākou i kēia huaʻōlelo:

• ʻO ka ʻāpana "Vaso" e pili ana i nā kīʻaha koko i loko o kā mākou ʻōnaehana cardiovascular.
• "Mea hoʻopaʻa" a i ʻole "mea hoʻopaʻa"ʻO ke kūpaʻa ʻana, ʻo ia hoʻi ka hoʻohaiki ʻia ʻana o nā kīʻaha koko. Hoʻolohi kēia i ke kahe ʻana o ke koko, a i kekahi manawa hoʻōki iā ia.

No laila, ʻo ka hana a ka endothelin, ʻo ia ka hoʻonui ʻana i ko mākou koko. Ke paʻa nā kīʻaha koko, pono ka puʻuwai e hana ikaika e pamu i ke koko. ʻO ia ke kumu e piʻi ai ke kaomi.

He aha ka mea e hana ai inā piʻi aʻe ka pae o ka endothelin?

ʻO ka maʻamau, hana ka endothelin ma ke ʻano maikaʻi no ko mākou kino. Eia nō naʻe, inā no kekahi kumu e piʻi aʻe ai kēia pae endothelin i loko o ke kino, hiki iā ia ke hana i kekahi mau maʻi e hōʻino ai i ko mākou puʻuwai a me nā māmā . E noʻonoʻo i ka mea e hana ʻia inā paʻa loa kahi paipu wai. Pēlā nō ia.

ʻO kekahi o nā kūlana i hiki ke hana ʻia e ka piʻi ʻana o nā pae endothelin:

• Atherosclerosis (maʻi arterial): Ma kēia, hōʻiliʻili nā waihona momona i loko o nā kīʻaha koko , e hoʻohaiki ana i nā kīʻaha koko.
• ʻO ka maʻi puʻuwai haki: Ka nāwaliwali o ka puʻuwai ma muli o ke kaumaha koke.
• Aia kekahi mau ʻano maʻi kanesa .
• Cardiomyopathy : Ka nāwaliwali o ka ʻiʻo o ka puʻuwai.
• ʻO ka maʻi cardiovascular (puʻuwai) a me ka hāʻule ʻana o ka puʻuwai.
• ʻO ka maʻi ʻaʻa coronary , a me kahi kūlana i kapa ʻia ʻo endothelial dysfunction .
• Ke koko kiʻekiʻe a me ka preeclampsia .
• Maʻi puʻupaʻa a me ka hāʻule ʻana o ka puʻupaʻa .
• ʻO ka fibrosis pulmonary a me ke koko kiʻekiʻe pulmonary .
• Scleroderma : Mānoanoa o ka ʻili a me nā ʻiʻo pili.

E noʻonoʻo, ua loaʻa iā Nimal ke koko kiʻekiʻe no kekahi manawa. Ua ʻōlelo ke kauka ua haiki iki kona mau kīʻaha koko, a ʻo kona mau pae endothelin paha ke hoʻopilikia nei iā ia. Ua ʻōlelo aʻo pū ʻo ia inā ʻaʻole ʻo ia e lawe pono i kāna lāʻau lapaʻau, hiki ke alakaʻi i ka hāʻule puʻuwai. No laila, ʻaʻole ia he manaʻo maikaʻi e lawe māmā i kēia mea endothelin.

Aia kekahi mau ʻano endothelin?

ʻAe, aia nā ʻano endothelins. Ua ʻike mua nā kānaka noiʻi lapaʻau iā lākou i ka makahiki 1987. ʻEkolu mau ʻano nui o nā endothelins, i hana ʻia me ʻehā mau peptides amino acid. He mau vasoconstrictors nā mea ʻekolu.

ʻO ke ʻano endothelin maʻamau a ikaika loa i loko o ko kākou kino, ʻo ia ka endothelin-1 (ET-1). Ke aʻo nei nā kānaka noiʻi pehea e hoʻopilikia ai nā ʻano ʻelua ʻē aʻe, ʻo ka endothelin-2 (ET-2) a me ka endothelin-3 (ET-3), i ko kākou kino. I kēia manawa, ua kau ka hapa nui o ka manaʻo ma ka ET-1.

He aha nā mea loaʻa endothelin?

Loaʻa i kēlā me kēia ʻiʻo i loko o ko kākou kino nā mea loaʻa endothelin. Ua like kēia mau mea loaʻa me nā ʻūpā puka. Ke hele mai nā molekala endothelin a nakinaki i kēia mau mea loaʻa, hoʻouna lākou i kahi leka i kēlā mau cell e hana i kekahi mea. Penei ke kamaʻilio ʻana o ka endothelin me nā cell ma loko o ko kākou kino.

Pehea e ana ʻia ai nā pae endothelin?

Inā makemake nā kauka e ʻike i kou pae endothelin, e hana lākou i kahi hoʻāʻo koko . Ana kēia i ka pae o ka endothelin-1 (ET-1). Loaʻa ia i loko o kahi ʻāpana o ke koko i kapa ʻia ʻo plasma. ʻO ka plasma ka ʻāpana wai o ke koko i koe ma hope o ka wehe ʻia ʻana o nā hunaola koko ʻulaʻula, nā hunaola koko keʻokeʻo, a me nā platelets.

Hiki ke hana ʻia kēia hoʻāʻo koko ma ke keʻena o kāu kauka, kahi haukapila, a i ʻole kahi lab. He paʻakikī ke ana ʻia nā ʻano endothelin ʻē aʻe i ke koko ma kēia ʻano.

ʻO ke anakahi ana no ka endothelin he picograms no ka milliliter (pg/mL).

• ʻO ka pae maʻamau o ka ET-1 plasma i loko o kahi kanaka makua ma kahi o 1 pg/mL a i 2 pg/mL.
• ʻOi aku ke kiʻekiʻe o nā pae ET-1 i nā keiki ʻōpio.
• Eia kekahi, aia paha he ʻokoʻa iki ma kēia mau pae ma waena o nā lāhui like ʻole.

ʻO ka maʻamau, ʻo ka poʻe me kekahi mau maʻi puʻuwai a māmā paha, e like me ke koko kiʻekiʻe o ka pulmonary arterial, ua kiʻekiʻe ko lākou pae ET-1. Eia kekahi, hiki i kekahi mau lāʻau lapaʻau puʻuwai, e like me ka balloon angioplasty, ke hoʻonui i nā pae endothelin no kekahi manawa.

He aha nā Endothelin Receptor Antagonists (ERA)?

He ʻano lāʻau lapaʻau kēia i hāʻawi ʻia i ka wā e piʻi ai ka pae o ka endothelin. Hana nā Endothelin Receptor Antagonists (ERA) ma ka hoʻemi ʻana i ka nui o ka endothelin i loko o ko mākou kino.

No kēia mau mea kekahi ʻano lapaʻau i kapa ʻia ʻo "targeted therapy." ʻO ia hoʻi, hele pololei kēia mau lāʻau lapaʻau a hoʻouka wale i nā cell pilikia, me ka ʻole o ka hōʻino nui ʻana i nā cell olakino. E like me ka sniper, paʻi pololei lākou i ka pahuhopu. Hoʻohana nui ʻia nā lāʻau lapaʻau ERA e mālama i kekahi mau ʻano koko kiʻekiʻe i loko o nā māmā (pulmonary arterial hypertension).

Aia kekahi mau hopena ʻaoʻao i kēia mau lāʻau ERA?

E like me nā lāʻau lapaʻau a pau, hiki i nā lāʻau ERA ke hana i kekahi mau hopena ʻaoʻao.

• ʻAʻole pono nā wahine hāpai a i ʻole nā ​​​​wahine e hoʻāʻo nei e hāpai e lawe i kēia mau lāʻau lapaʻau ERA. ʻO kēia no ka mea hiki i kēia mau lāʻau lapaʻau ke hana i nā kīnā hānau i loko o ke keiki i hānau ʻole ʻia. He mea nui loa kēia.
• I ka liʻiliʻi loa, hiki i kēia lāʻau lapaʻau ke hōʻino i ke akepaʻa. No laila, hiki i kāu kauka ke kauoha i nā hoʻāʻo koko e nānā mau i ke olakino o kou akepaʻa.
• ʻO nā hopena ʻaoʻao ʻē aʻe:
• Ka paʻa ʻana o ka ʻōpū.
• Pehu ʻana o ka maka (edema) a i ʻole ka ʻulaʻula.
• ʻEha poʻo .
• Ka luaʻi a me ka luaʻi.
• Ka pulse wikiwiki a me ka helu o ka puʻuwai.

Inā manaʻo ʻoe i kekahi mea e like me kēia, pono ʻoe e haʻi koke aku i kāu kauka i hiki iā ia ke hana i nā hana e pono ai.

No laila, he aha nā mea e pono ai kākou e hoʻomanaʻo mai kēia moʻolelo? (Leka Lawe-Home)

ʻAe, ua kamaʻilio nui mākou e pili ana i ka endothelin. I ka pōkole:

• ʻO ka Endothelin kahi protein koʻikoʻi i hana ʻia i loko o ke kino e kōkua ai i ka hoʻopaʻa ʻana i ko mākou mau kīʻaha koko a kaohi i ke kahe koko.
• Hana ʻia kēia mai kahi papa o nā pūnaewele i kapa ʻia ʻo endothelium e uhi ana i loko o ko mākou mau kīʻaha koko.
• Inā kiʻekiʻe loa nā pae endothelin, hiki i nā kīʻaha koko ke lilo i mea paʻa loa, e alakaʻi ana i nā pilikia e like me ke koko kiʻekiʻe, nā maʻi puʻuwai, a me nā maʻi māmā .
• Hiki ke ana ʻia nā pae Endothelin-1 (ET-1) i loko o ke koko me kahi hoʻāʻo koko .
• ʻO nā Endothelin receptor antagonists (ERAs) kahi ʻano lāʻau lapaʻau e hoʻohaʻahaʻa i nā pae endothelin. Hoʻohana kūikawā ʻia lākou no ke koko kiʻekiʻe i loko o nā māmā.
• Inā ʻoe e lawe ana i ka lāʻau ERA, pono ʻoe e makaʻala loa i ka wā hāpai a me ke olakino o kou ake.

No laila, inā he pilikia kou a i ʻole kekahi āu i ʻike ai me Endothelin, ʻoi aku ka maikaʻi o ka ʻimi ʻana i ke aʻo lapaʻau. Manaʻolana wau ua hāʻawi kēia ʻatikala iā ʻoe i kahi ʻike. E noho olakino!

ʻEndothelin , ke koko, maʻi puʻuwai, maʻi māmā, endothelium, peptides