He nui loa anei kou gastrin i loko o kou ʻōpū? E kamaʻilio kākou e pili ana i ka (Hypergastrinemia)!

Ke manaʻo pinepine nei ʻoe i ka ʻeha o ka ʻōpū, ka piha, a i ʻole nā ​​pilikia ʻē aʻe o ka ʻōpū? I kekahi manawa ʻo ke kumu o kēia, ʻo ia ka nui o ka hormone i kapa ʻia ʻo (Gastrin) i hana ʻia i loko o kou kino ma mua o ka maʻamau. I kēia lā, e kamaʻilio mākou e pili ana i kēia maʻi i kapa ʻia ʻo (Hypergastrinemia) me nā kikoʻī a me ka maʻalahi loa.

He aha ka (Hypergastrinemia)? E hoʻomaopopo pono kākou!

I ka ʻōlelo maʻalahi, ʻo (Hypergastrinemia) ʻo ia hoʻi ke kiʻekiʻe o (Gastrin), kahi hormone e kōkua i ko mākou kino e ʻeli i ka meaʻai, ʻoi aku ka kiʻekiʻe ma mua o ka mea e pono ai. Hoʻopuka ʻia kēia hormone (Gastrin) e kahi ʻano cell kūikawā ma ka paia o ka ʻōpū ma ka ʻaoʻao haʻahaʻa o ko mākou ʻōpū, ʻo ia hoʻi, kokoke i ka ʻōpū liʻiliʻi. Kāhea mākou i kēia (G cells).

E nānā, ʻo kēia hormone (Gastrin) ka mea e haʻi aku i ko kākou ʻōpū, "ʻAe, e hoʻokuʻu i ka waikawa." He mea nui loa kēia waikawa ʻōpū, ʻo ia hoʻi (gastric acid), no kākou. No ka mea, kōkua kēia waikawa ʻōpū iā kākou e hoʻoheheʻe i ka meaʻai a kākou e ʻai ai a omo i nā meaolaola i loko o ia meaʻai, no ka laʻana (amino acids) a me nā protein.

Eia nō naʻe, ʻoi aku ka paʻakikī o ka mea hiki ke hana me ka (Hypergastrinemia). I kekahi manawa hiki iā ia ke hoʻonui i ka nui o ka waikawa o ka ʻōpū (hyperchlorhydria), a i kekahi manawa hiki iā ia ke hoʻemi i ka waikawa o ka ʻōpū (hypochlorhydria). No laila, pehea ka hopena o (Hypergastrinemia) iā ʻoe ma muli o nā kūlana olakino ʻē aʻe āu i loaʻa ai, nā ʻoki kino āu i loaʻa ai, a me nā lāʻau lapaʻau āu e lawe nei.

ʻO wai ka mea i ʻoi aku ka paʻakikī o ka loaʻa ʻana o kēia maʻi?

ʻO kaʻoiaʻiʻo, hiki i kēia kūlana i kapa ʻia ʻo "Hypergastrinemia" ke loaʻa i kekahi, me ka nānā ʻole i ka makahiki a i ʻole ke kāne. No laila, he mea maikaʻi no kākou a pau e makaʻala i kēia.

He aha nā kumu o ka (Hypergastrinemia)?

Hiki ke nui nā kumu no kēia ʻano, me ka "Hypergastrinemia." Hoʻemi kekahi mau kumu i ka hana ʻakika o ka ʻōpū, aʻo kekahi e hoʻonui i ka hana ʻakika o ka ʻōpū. E nānā kākou i nā mea ʻelua ma ke kaʻawale.

Nā kumu o ka emi ʻana o ka waikawa o ka ʻōpū

Ke hiki mai ka "Hypergastrinemia", e emi paha ka hana maʻamau o ka waikawa o ka ʻōpū ma muli o kēia mau kumu:

• Nā antacids no ka ʻāʻī ʻana o ka puʻuwai a i ʻole GERD (Gastroesophageal Reflux Disease): Inā ʻoe e hoʻohana mau ana i kēia ʻano lāʻau lapaʻau, hiki nō hoʻi ke lilo i kumu.
• ʻO ka gastritis atrophic mau loa: ʻO kēia ka wā e nāwaliwali mālie ai ka paia o ka ʻōpū a lilo i mumū i ka hala ʻana o ka manawa.
• Ka maʻi ʻaʻai colorectal: Hiki ke hoʻopilikia ʻia kēia.
• ʻO ka maʻi ʻo (H. pylori): ʻO (Helicobacter pylori) he bacteria e hiki ke noho i loko o ka ʻōpū. ʻO kēia maʻi kekahi kumu o (Hypergastrinemia).
• Ka hāʻule ʻana o ka puʻupaʻa: Hiki ke hana ʻia kēia ʻano ke hana pono ʻole nā ​​puʻupaʻa.
• Ka hoʻohana ʻana i nā mea pale o ka pamu proton (PPI):ʻO ka hoʻohana lōʻihi ʻana i nā lāʻau PPI (e like me omeprazole) no ka gastritis, acid reflux, indigestion, a i ʻole ka maʻi ʻōpū peptic kekahi kumu nui.
• Vagotomy: Pili kēia i ka wehe ʻana i kahi ʻāpana o ke aʻalolo vagus. Holo kēia aʻalolo mai ka lolo a i ka ʻōpū a lawe i nā hōʻailona i ka puʻuwai a me ka ʻōnaehana hoʻoheheʻe. Hiki ke loaʻa ka Hypergastrinemia ma hope o kēia ʻoki kino.

Nā kumu o ka hoʻonui ʻia o ka waikawa o ka ʻōpū

I kēia manawa, e nānā kākou i nā kumu o ka hoʻonui ʻia ʻana o ka hana ʻakika o ka ʻōpū (Hypergastrinemia):

• ʻO ka hyperplasia Antral G-cell (pseudo-Zollinger-Ellison syndrome / Ps-ZES): He ʻano laha ʻole kēia. Ua like ia me ka Zollinger-Ellison syndrome, akā ʻaʻohe puʻupuʻu e hana ana i ka gastrin i loko o ka pancreas a i ʻole ka hapa mua o ka ʻōpū liʻiliʻi (duodenum).
• Ka ālai ʻana o ka puka ʻōpū: Hiki ke hana ʻia kēia ʻano ke ālai ʻia ke alahele mai ka ʻōpū a i ka ʻōpū liʻiliʻi. E noʻonoʻo e like me ka paipu wai i pani ʻia.
• ʻO ka neoplasia endocrine lehulehu ʻano-1 (MEN-1): ʻO kēia kūlana ke kumu o ka ulu ʻana o nā ʻōpū neuroendocrine i loko o nā kelepa adrenal, nā kelepa thyroid, a i ʻole nā ​​kelepa parathyroid.
• ʻO ka maʻi antrum i mālama ʻia: Hiki ke hana kēia ʻano inā waiho ʻia kahi ʻāpana liʻiliʻi o ka ʻōpū haʻahaʻa (ka antrum) ma hope o ke ʻoki ʻana e wehe i nā ʻōpū a mālama paha i nā ʻōpū.
• ʻO ka maʻi Zollinger-Ellison (ZES): He kūlana kēia e hana nui ai nā puʻupuʻu i ka hormone gastrin. Hiki i kēia kūlana (ZES) ke hana i nā ʻōpū ʻeha.

He aha nā hōʻailona o ke ʻano (Hypergastrinemia)?

Inā loaʻa iā ʻoe ka (Hypergastrinemia), hiki iā ʻoe ke ʻike i nā hōʻailona e like me:

• ʻEha ʻōpū: Hiki iā ʻoe ke ʻeha pinepine i ka ʻōpū.
• Ka maʻi kahe mau: Ka maʻi kahe e mau ana no kekahi mau lā.
• Nā maʻi ʻōpū pancreatic: Hiki i kēia ke lilo i mau maʻi ʻaʻai a i ʻole nā ​​​​maʻi ʻōpū maikaʻi ʻole.
• ʻŌpū ʻōpū: Nā ʻeha e kū mai me ka mumū o ka ʻōpū.
• ʻEsophagitis koʻikoʻi: ʻO ka mumū nui a me ka ʻeha ma ka esophagus.

Pehea e ʻike ai nā kauka i kēia maʻi?

I mea e ʻike pololei ai i ka hypergastrinemia, pono nā kauka e hoʻoholo i ka nui o ka waikawa e hana nei kou ʻōpū. Ana pū lākou i ka pae o ka gastrin i loko o kou koko.

• Ma mua o kēia hoʻokolohua, e haʻi aku kāu kauka iā ʻoe e hoʻokē ʻai (ʻaʻole e ʻai) no kekahi manawa .
• Eia kekahi, inā he mea hoʻohana ʻoe i ka (PPI),Pono ʻoe e hoʻōki i ka lawe ʻana i kēlā lāʻau lapaʻau ma kahi o hoʻokahi pule ma mua o ka hoʻāʻo.
• A laila, lawe lākou i kahi hāpana o kou koko a nānā i kāu mau pae Gastrin. I kekahi manawa, lawe paha lākou i kēia mau hāpana koko i nā manawa he nui i ka lā, ma luna o kekahi mau lā, e ʻike inā loli kāu mau pae Gastrin.

Inā kānalua kāu kauka i ka hypergastrinemia, hiki iā lākou ke kauoha i nā hoʻokolohua hou aʻe e kāpae i nā kūlana ʻē aʻe. ʻO kēia mau mea:

• Hoʻāʻo hoʻoulu ʻana o Secretin: Pili kēia i ka hāʻawi ʻana iā ʻoe i kahi hoʻokomo ʻana o kahi hormone i kapa ʻia ʻo secretin, i hana ʻia e ka ʻāpana mua o kou ʻōpū liʻiliʻi (duodenum). Inā piʻi koke kou pae gastrin i ka nui, he hōʻailona paha ia o ka maʻi Zollinger-Ellison.
• Hoʻāʻo pH ʻōpū: Nānā kēia i nā pae waikawa i loko o kou ʻōpū. Inā emi ka pH ma mua o 2, he hōʻailona paha ia o ka maʻi Zollinger-Ellison.

Pehea e mālama ʻia ai ka Hypergastrinemia?

ʻO ke ʻano o ka mālama ʻana i ka hypergastrinemia e pili ana i ke kumu.

• ʻO ke kanesa o ka kolona, ​​ka pale ʻana o ka esophagus, ka maʻi puʻupaʻa, a me nā kūlana e like me (MEN-1) a me (ZES): Ke mālama ʻia kēia mau kūlana (pinepine ma o ke ʻoki ʻana), e hoʻopau pū ʻia nā hōʻailona o (Hypergastrinemia).
• ʻO ka gastritis atrophic (ACG) a me ka maʻi H. pylori: Hiki ke mālama ʻia kēia mau kūlana me nā antibiotics.
• Nā mea hoʻopaʻa pale o ka pamu proton (PPI): Inā ʻoe e lawe ana i ka PPI, e hoʻoholo pinepine ʻia ka hypergastrinemia i loko o ʻelima a ʻehiku mau lā ma hope o ka hoʻōki ʻana i ka lāʻau.
• ʻO ka maʻi antrum i mālama ʻia: ʻO ka wehe ʻana i ke koena o ka ʻiʻo antral ma ka ʻaoʻao haʻahaʻa o ka ʻōpū hiki ke hoʻemi i ka nui o ka waikawa ʻōpū keu i hana ʻia.

ʻO ka mea nui loa, ʻo ia ke kamaʻilio me kāu kauka e pili ana i ka lāʻau lapaʻau maikaʻi loa no kou kūlana.

Hiki iaʻu ke hōʻemi i ka pilikia o ka (Hypergastrinemia)?

Inā he mea hoʻohana lōʻihi ʻoe i nā antacids a i ʻole PPIs, aia kahi pilikia o ka loaʻa ʻana o ka hypergastrinemia. No laila, he mea nui e kamaʻilio me kāu kauka e pili ana i ke ʻano o ka mālama ʻana i kēia pilikia.

Inā loaʻa iaʻu ka (Hypergastrinemia), he aha kaʻu e manaʻo ai? He aha ka mea e hiki mai ana inā ʻaʻole i mālama ʻia?

Inā ʻaʻole mālama pono ʻia ka hypergastrinemia, e mau ana ke kiʻekiʻe o nā pae gastrin o ke kino. Manaʻo nā kānaka noiʻi e hiki i kēia ke kōkua i ka ulu ʻana o nā hunaola kanesa. Eia kekahi laʻana:

• Nā maʻi ʻaʻai koko: e like me ka leukemia, lymphoma, a me ka myeloma maha.
• Ka maʻi ʻaʻai ʻōpū
• Ka maʻi ʻaʻai pancreatic

Eia kekahi, ʻo ka (Hypergastrinemia) lōʻihi hiki ke alakaʻi i nā ʻōpū ʻōpū (gastric carcinoids) a i ʻole gastric adenocarcinoma. ʻElua ʻano o (gastric carcinoids):

• ʻAno I gastric carcinoids: Hoʻopili ʻia kēia me ke ʻano o ka gastritis atrophic mau loa.
• ʻIke pinepine ʻia ia i nā wahine.
• Hiki ke ʻike ʻia ma nā wahi he nui o ka ʻōpū.
• Haʻahaʻa ka manawa kūpono e loaʻa ai ka maʻi ʻaʻai.
• ʻO nā carcinoids gastric ʻano II: Pili kēia mau mea me nā kūlana ZES a me MEN-1.
• Hiki ke hana ia i nā kāne a me nā wahine.
• Hiki ke ʻike ʻia ma nā wahi he nui o ka ʻōpū.
• I kekahi manawa hiki ke lilo i ka maʻi ʻaʻai (ma waena o 7% a me 12%).

He aha ka manaʻo no kekahi me ka (Hypergastrinemia)?

ʻO ke kūlana olakino o ka wā e hiki mai ana o kahi kanaka me ka "Hypergastrinemia" e pili ana i kekahi mau kumu:

• Ke kumu o ka maʻi.
• ʻIke hoʻoilina.
• Moʻolelo olakino.
• Ka nohona.

Eia nō naʻe, me ka mālama kūpono, hiki i nā poʻe me ka "Hypergastrinemia" ke alakaʻi i nā ola hana a maʻamau.

Loaʻa iaʻu ka (Hypergastrinemia), pehea e hiki ai iaʻu ke mālama iaʻu iho?

Inā ʻoe e lawe ana i nā antacids a i ʻole nā ​​​​PPI no ka manawa lōʻihi, he mea nui e hana i nā hoʻokolohua lapaʻau maʻamau. E kūkākūkā me kāu kauka no ka ʻōlelo aʻo.

Āhea wau e ʻike ai i ke kauka?

Inā ʻike ʻoe i kekahi o kēia mau hōʻailona hou, a i ʻole inā manaʻo ʻoe e ʻoi aku ka ʻino o kāu mau hōʻailona i kēia manawa, e ʻike pono i ke kauka a loaʻa i kahi nānā piha.

Nā mea e hoʻomanaʻo ai i ka hōʻuluʻulu manaʻo

ʻAe, e hoʻomanaʻo wale kākou i ka mea a kākou i kamaʻilio ai:

• ʻO ka Hypergastrinemia ka hoʻonui ʻia ʻana o ka hormone gastrin i loko o ke kino.
• Hoʻopilikia kēia hormone (Gastrin) i nā pae waikawa i loko o ka ʻōpū (hiki i ka waikawa ke hoʻonui a emi paha).
• Nui nā kumu - nā mea e like me ka (PPI)/ka hoʻohana mau ʻana i nā antacids, ka maʻi (H. pylori), ka gastritis, (Zollinger-Ellison syndrome).
• Hoʻomaopopo nā kauka i kēia ma ka hoʻāʻo ʻana i ka pae o ka "Gastrin".
• Hoʻokumu ʻia ka lāʻau lapaʻau ma ke kumu kumu.
• Mai hoʻowahāwahā i nā hōʻailona, ​​​​​​no ka mea, hiki iā lākou ke ulu i nā puʻupuʻu a me ke kanesa inā ʻaʻole mālama ʻia! E ʻimi koke i ke kōkua lapaʻau.

Manaʻolana wau he mea pono kēia ʻike nou. E ola kino!

ʻO Hypergastrinemia, Gastrin, ʻAkika ʻōpū, Hoʻoheheʻe ʻana, Zollinger-Ellison syndrome, H. pylori, PPI, Gastritis, Mumū ʻōpū