He mea maʻamau ka manaʻo nui i ka makaʻu a me ka hopohopo ke haʻi aku kāu kauka iā ʻoe ua loaʻa i kekahi o kou ʻohana, ʻo kou makuahine a makuakāne paha, ka maʻi ʻo Parkinson. ʻOiai ʻaʻohe lāʻau lapaʻau no kēia maʻi, nui nā lāʻau lapaʻau kūpono e hiki ke kōkua i ka hoʻomalu ʻana i nā hōʻailona a mālama i kahi ola maikaʻi. No laila i kēia lā, e kamaʻilio kākou e pili ana i ke ʻano o kēia mau lāʻau lapaʻau, pehea lākou e hana ai, a me nā mea e pono ai kākou e makaʻala.
No ke aha e loaʻa ai ka maʻi Parkinson? He aha ka mea e hana ʻia me ka lāʻau lapaʻau?
I ka ʻōlelo maʻalahi, ʻo ka maʻi Parkinson kahi maʻi neurological holomua e hoʻopilikia i ka neʻe ʻana o ke kino. Hoʻokumu ʻia ia e ka nalowale mālie o nā hunaola nerve i loko o ka lolo, ʻoi aku hoʻi ma ka ʻāpana o ka lolo i kapa ʻia ʻo substantia nigra e kaohi ana i ka neʻe ʻana. Hoʻopuka kēia mau hunaola nerve i kahi neurotransmitter i kapa ʻia ʻo dopamine .
E noʻonoʻo e pili ana i ia mea, he mea nui kahi kemika i kapa ʻia ʻo dopamine no ko mākou kino e neʻe mālie, e like me ke kalaiwa ʻana ma ke alanui me ka ʻole o nā kaʻa. I ka maʻi o Parkinson, emi ka hana ʻana o kēia dopamine, e hopena ana i nā hōʻailona e like me ka neʻe lohi, ka haʻalulu, a me ka ʻoʻoleʻa.
No laila, ʻo ka pahuhopu nui o nā lāʻau lapaʻau he nui no ka maʻi o Parkinson, ʻo ia ke kaohi i nā pae haʻahaʻa o ka dopamine i loko o ka lolo.
Nā lāʻau lapaʻau i hoʻohana nui ʻia
ʻO ka maʻamau, kuhikuhi nā kauka i ka hui pū ʻana o kekahi mau lāʻau lapaʻau no nā maʻi o Parkinson, ʻaʻole hoʻokahi wale nō. E nānā kākou i nā ʻano lāʻau lapaʻau nui.
| Papa Lāʻau Lapaʻau | Pehea e hana ai | ʻIke koʻikoʻi |
|---|---|---|
| ʻO Levodopa lāua ʻo Carbidopa | He lāʻau lapaʻau ʻo Levodopa e hele i ka lolo a lilo i dopamine. Akā no ka mea ua luku ʻia i loko o ke kino ma mua o kona hiki ʻana i ka lolo, ua hui pū ʻia me kahi lāʻau i kapa ʻia ʻo carbidopa e hoʻōki iā ia. | ʻO kēia ka lāʻau lapaʻau nui a maikaʻi loa no ka maʻi o Parkinson. He mea maikaʻi loa ia i ka hōʻemi ʻana i ka lohi o ka neʻe ʻana (bradykinesia), ka paʻakikī, a me nā haʻalulu. |
| Nā Agonists Dopamine | Hoʻoulu kēia i nā mea loaʻa dopamine i loko o ka lolo a "hana" e like me ka dopamine. ʻO ia hoʻi, hana kēia mau lāʻau i ka mea like me ka hana a ka dopamine. | Hoʻohana pinepine ʻia i nā wā mua o ka maʻi a i ʻole i nā poʻe maʻi ʻōpio, kōkua nō hoʻi ia i ka mālama ʻana i ka pono o ka levodopa no kahi manawa lōʻihi. |
| Nā mea hoʻopaʻa ʻenzyme (MAO-B & COMT) | Hoʻemi kēia mau lāʻau lapaʻau i ka hana o nā enzymes i loko o ka lolo e wāwahi i ka dopamine, e ʻae ana i ka dopamine e noho i loko o ka lolo no ka manawa lōʻihi. | Hāʻawi ʻia kēia mau mea e kōkua i ka hoʻonui ʻana i ka hopena o ka levodopa a hoʻolōʻihi iā ia. |
| ʻAmantadine | Kōkua ia i ka kaohi ʻana i ka dyskinesia, ʻo ia hoʻi ka ʻūlū ʻana a i ʻole ka ʻūlū ʻana o ke kino i hiki ke hana ʻia e nā lāʻau lapaʻau e like me levodopa. | ʻOiai ua ʻike mua ʻia he antiviral, he mea pono nō hoʻi ia no nā maʻi neʻe ʻē aʻe e like me ka maʻi o Parkinson. |
| Nā lāʻau lapaʻau anticholinergic | Ke emi ka dopamine, piʻi aʻe nā hopena o kekahi kemika ʻē aʻe i kapa ʻia ʻo acetylcholine. Ke ālai nei kēia mau lāʻau i kona hopena, e hōʻemi ana i nā haʻalulu a me ka ʻoʻoleʻa o nā ʻiʻo. | He mea pono paha ia no nā maʻi me ka haʻalulu nui. |
ʻO ka mea nui loa, ʻo kāu kauka wale nō ke hoʻoholo i kahi o kēia mau lāʻau lapaʻau e hāʻawi ai a me ka nui o ka lāʻau. Aia ia i ka makahiki o ka mea maʻi, ke ʻano o nā hōʻailona, a me nā kumu ʻē aʻe he nui.
Pono anei mākou e makaʻala i nā hopena ʻaoʻao o nā lāʻau lapaʻau?
E like me nā lāʻau lapaʻau āpau, hiki i nā lāʻau lapaʻau o Parkinson ke loaʻa nā hopena ʻaoʻao. ʻOkoʻa kēia ma muli o ke ʻano o ka lāʻau lapaʻau. Mai hopohopo, ʻaʻole e loaʻa i nā kānaka a pau kēia mau hopena ʻaoʻao a pau. Akā he mea nui e makaʻala iā lākou.
- ʻO Levodopa: Hiki ke loaʻa ka nausea, ka luaʻi ʻana, ka poniuniu, ka ʻeha poʻo, ka hiamoe i ke ao, a me ka hypotension postural i ka hoʻomaka ʻana o ka lāʻau. I ka poʻe ʻelemakule, hiki ke loaʻa ka huikau, nā hallucinations, a i ʻole ka psychosis.
- ʻAgonists Dopamine: Hiki i kēia ke hana i ka nausea, ka hiamoe, ka waha maloʻo, ka huikau, a me nā hallucinations ke hoʻomaka mua ʻoe e lawe iā lākou. Eia nō naʻe, e emi pinepine kēia mau hōʻailona i loko o kekahi mau lā.
- Nā lāʻau lapaʻau ʻē aʻe: Hiki i kekahi mau lāʻau lapaʻau ke hoʻoulu i nā hopena ʻaoʻao e like me ka maʻi pākī, ka ʻeha o ka umauma, ka hiamoe ʻole, ka pehu ʻana o ka wāwae, ka paʻa ʻana o ka ʻōpū, a i ʻole ka waha maloʻo.
He ʻōlelo aʻo koʻikoʻi loa: Mai hoʻōki i ka lawe ʻana i ka levodopa a i ʻole e hōʻemi koke i ka nui me ka ʻole o ke kūkākūkā ʻana me kāu kauka. ʻO ka hana ʻana pēlā e alakaʻi ai i kahi maʻi weliweli loa a hoʻoweliweli i ke ola i kapa ʻia ʻo Parkinsonism Hyperpyrexia Syndrome. He ʻano koʻikoʻi ia e like me ka Neuroleptic Malignant Syndrome. Inā pono ʻoe e hoʻōki i ka lawe ʻana i ka lāʻau lapaʻau no kekahi kumu, e kamaʻilio me kāu kauka.
Aia kekahi mau lāʻau lapaʻau no nā hōʻailona ʻē aʻe i pili ʻole i ka neʻe ʻana?
ʻAe. ʻAʻole wale ka maʻi ʻo Parkinson e hoʻopilikia i ka neʻe ʻana. Akā he nui nā pilikia ʻē aʻe e hele pū me ia. Hiki i ke kauka ke mālama i kēlā mau mea.
| Hōʻailona | Nā Lapaʻau Hiki |
|---|---|
| Ka paʻa ʻana o ka ʻōpū | Nā lāʻau lapaʻau e kōkua i ka hoʻomaʻamaʻa ʻana i ka ʻōpala, e like me ka polyethylene glycol (e like me MiraLax). |
| Hiamoe i ke ao | Nā lāʻau lapaʻau e like me Modafinil (e like me Provigil). |
| Kaumaha a hopohopo paha | Nā lāʻau antidepressant ʻano SSRI. |
| Psychosis/Hallucinations | Nā lāʻau antipsychotic kikoʻī e like me pimavanserin. |
| Ka Hana ʻino ʻana o ka Erectile | ʻO ka lāʻau lapaʻau Sildenafil (e like me Viagra). |
He aha nā mea ʻē aʻe e hiki ke hana ma waho aʻe o ka lāʻau lapaʻau?
ʻO ka lāʻau lapaʻau hoʻokahi wale nō ʻāpana o kēia kaua. Eia kekahi, he nui nā mea ʻē aʻe e hiki ke hoʻomaikaʻi i ke ʻano o ke ola o ka mea maʻi.
He mea nui loa ka hoʻoikaika kino a me ka hoʻōla kino i ka mālama ʻana i ka maʻi Parkinson. ʻO ka ʻoiaʻiʻo, ʻo ka hoʻoikaika kino wale nō ka mea i hōʻoia ʻia e hoʻolohi i ka holomua o ka maʻi.
- Hoʻōla kino: Hiki i nā papahana hoʻōla kino i hoʻolālā kūikawā ʻia no nā maʻi o Parkinson ke hoʻomaikaʻi i ke kaulike, ka hele ʻana, a me ke kūpaʻa.
- Hoʻoikaika Kino: He mea nui loa ka hana ʻana ma ka liʻiliʻi he 150 mau minuke o ka hoʻoikaika kino cardiovascular i kēlā me kēia pule. Ua ʻike ʻia he pono nui nā hana e like me ke kaʻa paikikala a me ka mokomoko.
- Ola Kino: ʻO ka noho ʻana me kahi maʻi mau e like me Parkinson hiki ke paʻakikī i ka noʻonoʻo. No laila, inā ʻoe e kaumaha a hopohopo paha, mai kānalua e kamaʻilio me kahi loea olakino noʻonoʻo, e like me ke kauka noʻonoʻo.
Āhea wau e ʻike hou ai i ke kauka?
I ka wā e lawe ana i ka lāʻau lapaʻau Parkinson, he mea nui e ʻike pinepine i kāu kauka e nānā inā e hana ana ka lāʻau lapaʻau a inā he mau hōʻailona hou kāu. E kamaʻilio me kāu kauka, ʻoiai i nā kūlana e like me kēia.
- Inā loaʻa iā ʻoe nā hopena ʻaoʻao ʻaʻole hiki iā ʻoe ke ʻae.
- Inā ʻaʻole hoʻomaikaʻi a i ʻole e ʻino aʻe paha kāu mau hōʻailona .
- Inā manaʻo ʻoe e hoʻōki i ka lāʻau lapaʻau.
Leka Lawe-Home
- ʻOiai ʻaʻole hiki ke ho'ōla piha ʻia ka maʻi o Parkinson, hiki ke kaohi maikaʻi ʻia nā hōʻailona a hiki iā ʻoe ke ola i kahi ola maikaʻi.
- ʻO Levodopa ka lāʻau lapaʻau nui a maikaʻi loa no kēia maʻi.
- Mai ho'ōki i ka lawe ʻana i ka lāʻau lapaʻau a hoʻololi paha i ka nui no kekahi kumu me ka ʻole o ke aʻo ʻana a kāu kauka.
- He mea nui ka hoʻoikaika kino a me ka hoʻōla kino e like me ka lāʻau lapaʻau. Hiki i ka hoʻoikaika kino ke kōkua i ka kaohi ʻana i ka holomua o ka maʻi.
- Inā loaʻa iā ʻoe nā hopena ʻaoʻao a i ʻole nā pilikia ʻē aʻe, mai makaʻu e kamaʻilio me kāu kauka. Ua mākaukau mau ʻo ia e kōkua iā ʻoe.
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