ʻO nā mea e pono ai ʻoe e ʻike e pili ana i ka lāʻau pale hou loa no ka kaohi ʻana i ka cholesterol (PCSK9 Inhibitors)

Ke hakakā nei hoʻi ʻoe me ka cholesterol ? Malia paha ke lawe nei ʻoe i ka lāʻau lapaʻau i kuhikuhi ʻia e kāu kauka, ke kāohi nei i kāu ʻai , a me ka hoʻoikaika kino. Akā he mea paʻakikī nō naʻe ke hoʻohaʻahaʻa i kāu mau pae cholesterol, ʻeā? I kekahi manawa, ʻaʻohe mea pehea ʻoe e hoʻāʻo ai, hiki i nā pae cholesterol maikaʻi ʻole i loko o kou kino ke noho kiʻekiʻe. Ma kēia ʻatikala, e kamaʻilio mākou e pili ana i kahi papa lāʻau hou e hiki ke kōkua i kēlā poʻe.

I ka ʻōlelo maʻalahi, he aha kēia mau mea pale PCSK9?

He inoa paʻakikī paha kēia, akā hana maʻalahi loa ia. ʻO nā mea hoʻopaʻa PCSK9 kahi papa o nā lāʻau lapaʻau e hoʻohaʻahaʻa i ka cholesterol. ʻO ke kikoʻī, kuhikuhi lākou i ka LDL (Low-Density Lipoprotein) cholesterol , ʻo ia ka "cholesterol maikaʻi ʻole" e hōʻino i ko mākou kino. Loaʻa i kekahi poʻe nā pae cholesterol kiʻekiʻe i ko lākou ola a pau. No kēlā poʻe, hiki i kēia ʻano lāʻau ke kōkua nui.

ʻAe, e nānā kākou i ke ʻano o ka inoa ʻo `PCSK9`. ʻO `PCSK9` kahi ʻano protein kūikawā i hana ʻia e ko kākou ake. ʻO ka inoa o kēia protein ʻo `proprotein convertase subtilisin/kexin type 9`. ʻO kāna hana, ʻo ia ke kāohi i nā mea i kapa ʻia ʻo `LDL receptors` i loko o ko kākou kino. Ua ʻike ʻia nā noiʻi lapaʻau inā hana maoli ke kino o ke kanaka i ka protein `PCSK9` hou aʻe, ʻoi aku ka nui o ka cholesterol o kēlā kanaka.

ʻO wai ka mea e pono ai kēia lāʻau lapaʻau?

He nīnau koʻikoʻi loa kēia. No ka mea, ʻaʻole hāʻawi ʻia kēia lāʻau i nā mea āpau me ka cholesterol kiʻekiʻe. ʻElua mau kūlana nui e kuhikuhi ai kāu kauka i kēia lāʻau `PCSK9 inhibitor`:

1. Ke ʻole e kāohi ʻia ka cholesterol e nā lāʻau lapaʻau ʻē aʻe: Inā ʻoe e hoʻohana nei i nā lāʻau lapaʻau hoʻohaʻahaʻa cholesterol ʻē aʻe, e like me `(statins),` akā kiʻekiʻe nō kou pae cholesterol, hiki iā ʻoe ke noʻonoʻo i kēia lāʻau lapaʻau ma ke ʻano he hana aʻe.

2. Ma kekahi mau kūlana hoʻoilina: Loaʻa i kekahi poʻe kahi kūlana hoʻoilina o ka cholesterol kiʻekiʻe. Ua kapa ʻia kēia he "familial hypercholesterolemia" i ka ʻepekema lapaʻau.He kōkua nui nō hoʻi kēia lāʻau lapaʻau no ka poʻe me kēia maʻi.

Pehea e hana ai kēia lāʻau lapaʻau i loko o ke kino?

I mea e maopopo ai i kēia, e lawe kākou i kahi laʻana liʻiliʻi.

E noʻonoʻo ʻoe he mau "lima hopu kolesterol" ko kou kino. Kāhea mākou i kēia mau mea he "nā mea loaʻa LDL." Loaʻa kēia mau "mea loaʻa" ma ka ʻili o ko kākou mau hunaola ake. Hopu kēia mau "lima" i ka cholesterol maikaʻi ʻole e lana ana i loko o ke koko (LDL cholesterol) a lawe iā ia i loko o ke ake. A laila wāwahi ke ake i kēlā cholesterol a lawe aku mai ke kino. He hana maʻamau kēia.

Akā, aia kekahi mea ʻino iki ma ʻaneʻi. ʻO ia ka protein `(PCSK9)` a mākou i kamaʻilio ai ma mua. Hana kēia protein `PCSK9` e like me ka `ʻokiʻoki`. ʻO kāna hana, ʻo ia ka luku ʻana i kēlā mau lima hopu cholesterol, ʻo ia hoʻi, nā `mea loaʻa LDL`, a hoʻēmi i kā lākou hana. Ke piʻi aʻe ka protein `PCSK9` i loko o ke kino, emi iho ka helu o nā `lima` e hopu ana i ka cholesterol. A laila, ʻaʻole hiki ke wehe ʻia ka cholesterol maikaʻi ʻole i loko o ke koko e ke akepaʻa a hōʻiliʻili i loko o ke koko.

I kēia manawa, ua maopopo paha iā ʻoe ka hana a ka lāʻau `PCSK9 inhibitor`. I mea e pololei ai, ke kāohi nei kēia lāʻau i ka protein `PCSK9` e hana ana e like me ka ʻokiʻoki. ʻO ia hoʻi, ke lawe ʻia kēia lāʻau, ʻaʻole hiki i ka protein `PCSK9` ke luku i kēlā mau lima hopu cholesterol (nā mea loaʻa LDL).

He aha ka mea e hana ʻia i kēlā manawa?

• Aia nā mea loaʻa LDL hana hou aʻe.
• Hopu kēia mau 'lima' ikaika i ka nui o ka cholesterol ʻino i loko o ke koko a lawe aku i ke akepaʻa.
• Hoʻopau ke akepaʻa i kēlā cholesterol mai ke kino.

ʻO ka hopena hope loa , he emi nui ka nui o ka cholesterol maikaʻi ʻole i loko o kou koko.

Pehea ka maikaʻi o kēia lāʻau lapaʻau? A he aha nā ʻano?

ʻO nā mea hoʻopaʻa PCSK9 kahi papa o nā lāʻau i hōʻike ʻia he pono loa no kekahi poʻe. Ua ʻike kekahi mau noiʻi hiki i kēia mau lāʻau ke hōʻemi i nā pae cholesterol maikaʻi ʻole (LDL cholesterol) a hiki i ka 70% a hiki nō hoʻi ke hōʻemi i ka pilikia o ka hōʻeha puʻuwai ma kahi o ka hapakolu.

ʻElua ʻano o nā 'mea hoʻopale PCSK9' i hoʻohana nui ʻia ma Sri Lanka a me ke ao nei:

• ʻAlirocumab (inoa hōʻailona: Praluent®)
• ʻEvolocumab (inoa hōʻailona: Repatha®)

Pehea ʻoe e lawe ai i ka lāʻau lapaʻau?

ʻAʻole kēia he pila e lawe i kēlā me kēia lā. Hāʻawi ʻia nā 'mea hoʻopale PCSK9' ma ke ʻano he inikini.ʻO ka maʻamau, pono ʻoe e loaʻa i kēia lāʻau pale i kēlā me kēia mau pule a i ʻole i kēlā me kēia mau mahina, e like me ka mea i hoʻoholo ai kāu kauka.

ʻOiai e lawe ana i kēia lāʻau lapaʻau, e hana kāu kauka i nā hoʻokolohua koko maʻamau e nānā i ka maikaʻi o ka hana a ka lāʻau. I kekahi manawa hiki ke hāʻawi wale ʻia kēia lāʻau lapaʻau, a i kekahi manawa hiki ke hāʻawi ʻia me ka hui pū ʻana me kahi lāʻau lapaʻau āu e lawe nei, e like me ka statin.

He aha nā pōmaikaʻi a me nā hopena ʻaoʻao hiki ke loaʻa?

E like me nā lāʻau lapaʻau āpau, hiki i kēia lāʻau lapaʻau ke loaʻa nā pono a me nā hopena ʻaoʻao liʻiliʻi. Eia nō naʻe, ʻaʻole ʻike ka hapa nui o ka poʻe i nā hopena ʻaoʻao koʻikoʻi.

Ua lawa anei ka lāʻau lapaʻau wale nō? ʻAʻole, he ʻāpana kēia o kahi hoʻolālā nui aʻe.

He mea nui loa kēia. Inā ʻoe e lawe i kahi mea hoʻopaʻa PCSK9 a i ʻole kekahi lāʻau hoʻohaʻahaʻa cholesterol ʻē aʻe, hoʻokahi wale nō ʻāpana o kāu hoʻolālā lapaʻau holoʻokoʻa. Nui nā mea ʻē aʻe hiki iā ʻoe ke hana e pale i ke olakino o kou puʻuwai, me ka hilinaʻi ʻole i ka lāʻau lapaʻau.

• ʻAi maikaʻi: E ʻai liʻiliʻi i ka ʻaila, ke kō, a me ka paʻakai, a e ʻai hou aku i nā mea kanu, nā huaʻai, nā greens, a me nā meaʻai i kiʻekiʻe i ka fiber.
• Hoʻoikaika Kino: E hana i nā hoʻoikaika kino olakino no ka puʻuwai, e like me ka hele wikiwiki, ka holo ʻana, a i ʻole ke kaʻa paikikala, ma ka liʻiliʻi he mau lā o ka pule.
• Hoʻokele koʻikoʻi: Hoʻomaha i kou noʻonoʻo ma o nā mea e like me ka noʻonoʻo ʻana a me ka yoga.
• Hiamoe maikaʻi: E hiamoe ma ka liʻiliʻi he 7-8 mau hola i kēlā me kēia pō.
• E pale i ka puhipaka: Inā ʻoe e puhipaka, e hoʻōki loa.

E loaʻa iā ʻoe nā hopena maikaʻi loa ke hoʻohui ʻoe i kēia mau hoʻololi nohona me ka lāʻau lapaʻau.

Nā mea hoʻopaʻa PCSK9, cholesterol, cholesterol, cholesterol LDL, hōʻeha puʻuwai, hahau, hypercholesterolemia ʻohana, statin, Alirocumab, Evolocumab