Loaʻa iā ʻoe kahi puʻupuʻu e like me kēia i loko o kou puʻupaʻa? (Renal Angiomyolipoma) - Mai hopohopo, e kamaʻilio kākou e pili ana i kēia me nā kikoʻī!

Ua manaʻo paha ʻoe e hiki i nā ʻano puʻupuʻu like ʻole ke ulu i loko o ko kākou mau puʻupaʻa? I kekahi manawa ua ʻike ʻia kēia mau puʻupuʻu me ka ulia pōpilikia i ka wā o kahi hoʻāʻo i hana ʻia no kekahi mea ʻē aʻe me ka ʻole o nā hōʻailona. No ka laʻana, ʻo kahi ʻano puʻupuʻu e ulu ana i loko o ka puʻupaʻa, akā pinepine ʻaʻole ia he maʻi kanesa (ʻo ia hoʻi he benign), ua kapa ʻia ʻo `(Renal Angiomyolipoma)` a i ʻole `(AML)`. ʻOiai paha he paʻakikī iki ka inoa, e kamaʻilio maʻalahi kākou e pili ana iā ia, ma ke ʻano hiki iā ʻoe ke hoʻomaopopo.

He aha kēia `(Renal Angiomyolipoma)` a i ʻole `(AML)`?

I ka ʻōlelo maʻalahi, ʻo ka Renal Angiomyolipoma kahi puʻupuʻu e ulu ana i loko o kou puʻupaʻa. ʻO ka mea maikaʻi loa, ʻo ka hapa nui o kēia mau puʻupuʻu ʻaʻole ia he maʻi kanesa (benign) . ʻO ia hoʻi, ʻaʻole paha lākou e hoʻoulu i nā pilikia nui. Eia nō naʻe, i nā hihia kakaikahi, hiki i kēia mau puʻupuʻu ke haki a hoʻoulu i ke kahe koko , hiki ke koʻikoʻi loa, a i kekahi manawa hiki ke hoʻoweliweli i ke ola.

I kēia manawa, ke noʻonoʻo nei paha ʻoe, "He aha ke ʻano o ka hoʻomohala ʻana i kahi puʻupuʻu?" Loaʻa i ko mākou kino nā ʻāpana e māhelehele a ulu maʻamau e mālama i ko mākou kino. Eia nō naʻe, i kekahi manawa hoʻomaka kēia mau ʻāpana e ulu me ka ʻole o ka hoʻomalu ʻia a nui loa . ʻO ia ka manawa e hoʻokumu ʻia ai kahi puʻupuʻu. ʻO kēia puʻupuʻu i kapa ʻia ʻo `(Renal Angiomyolipoma)` ua hana ʻia me ʻekolu mau ʻāpana nui:

• Nā kīʻaha koko
• Nā pūnaewele ʻiʻo
• a me nā hunaola momona (momona)

Hoʻohui pū ʻia kēia mau mea ʻekolu e hana i kēia hua kūikawā.

Pehea ka maʻamau o kēia kūlana i kapa ʻia ʻo `(AML)`?

ʻO ka ʻoiaʻiʻo, ʻo kēia ke ʻano maʻamau o ka puʻupaʻa benign (ʻaʻole cancerous). Ma ke ʻano helu, pili kēia maʻi ma waena o 2 a me 6 o kēlā me kēia 1,000 poʻe . He mea maʻamau ia i nā wahine ma luna o 50 mau makahiki. No laila, inā he wahine ʻoe i kēia hui makahiki, he mea maikaʻi ke makaʻala i kēia.

Ua pili anei kēia `(Renal Angiomyolipoma)` i nā maʻi ʻē aʻe?

ʻAe, i kekahi manawa hiki ke ʻike ʻia kēia kūlana `(Renal AML)` me kekahi mau pilikia olakino ʻē aʻe. ʻO ia hoʻi, aia kekahi ʻano no kēia mau puʻupuʻu `(AML)` e ulu i waena o ka poʻe me kēlā mau maʻi. ʻO kekahi o ia mau maʻi:

• ʻO Lymphangioleiomyomatosis (LAM) - He maʻi laha ʻole kēia e hoʻopilikia nui ana i nā māmā.
• ʻO Neurofibromatosis ʻano 1 - He ʻano genetic kēia e hoʻoulu ai i nā ʻōpū i loko o ka ʻōnaehana nerve.
• ʻO ka Tuberous Sclerosis Complex (TSC) - He kūlana hoʻoilina nō hoʻi kēia. Hoʻomohala nā ʻōpū maikaʻi i nā ʻāpana like ʻole o ke kino, e like me ka lolo, nā puʻupaʻa, ka puʻuwai, nā māmā, a me ka ʻili. ʻIke pinepine ʻia nā ʻōpū AML me kēia kūlana.
• `(maʻi von Hippel-Lindau)` - He maʻi hoʻoilina nō hoʻi kēia, hiki ke hoʻoulu i nā puʻupuʻu a me nā cysts piha i ka wai e hana i loko o nā ʻōkana like ʻole.

No laila, inā loaʻa iā ʻoe kēia maʻi, e ʻimi pū nā kauka no ka `(AML)`.

No ke aha e ulu ai kēia `(Renal Angiomyolipoma)`? He aha ke kumu?

ʻO ke kumu nui o kēia, ʻo ia kā mākouʻO ka loli i loko o kahi gene ua kapa ʻia he mutation genetic. I ka pololei, hana ʻia kēia loli i loko o ʻelua mau genes i kapa ʻia ʻo `(TSC1)` a i ʻole `(TSC2)`. Ua kapa ʻia kēia mau genes ʻo "nā genes suppressor tumor" . ʻO ia hoʻi, ʻo ka hana a kēia mau genes ka kaohi ʻana i ka ulu ʻole o kā mākou mau cell.

Hoʻopuka kēia gene `(TSC)` i kahi protein i kapa ʻia ʻo tuberin . Kōkua kēia protein i ka hoʻomalu ʻana i ka ulu ʻana a me ka nui o nā cell. No laila, e noʻonoʻo, he aha ka mea e hana ʻia inā he mutation a loli paha i kēia gene `(TSC)`? A laila ua hoʻopilikia ʻia ka hana ʻana o ka protein tuberin. A laila ʻaʻole holo pono ka hōʻailona e "hoʻōki" i nā cell. ʻO ka hopena, hoʻomaka nā cell e ulu me ke kāohi ʻole ʻia , a i ka hopena e hana ʻia kahi puʻupuʻu e like me `(AML)`. Maopopo iā ʻoe?

He aha nā hōʻailona o ka `(Renal Angiomyolipoma)`?

ʻAʻole ʻike ka nui o ka poʻe he Renal AML ko lākou! ʻO kēia no ka mea ʻaʻohe hōʻailona o ka hapa nui o ka manawa . ʻIke wale ʻia ia i ka wā e hana ʻia ai kahi hoʻāʻo puʻupaʻa (e like me ka ultrasound scan) no kekahi kumu ʻē aʻe.

Eia naʻe, i kekahi manawa, hiki i kēia puʻupuʻu `(AML)` ke hana i nā hōʻailona. I kekahi manawa ua ʻike ʻia ka puʻupuʻu ma muli o kahi kūlana i kapa ʻia ʻo `(retroperitoneal hemorrhage)` . He ʻoi aku ka koʻikoʻi o kēia. I ka ʻōlelo maʻalahi, haki kahi hapa o ka puʻupuʻu a hoʻomaka ke kahe ʻana i loko o ka hakahaka ma hope o ka lua ʻōpū. He pilikia kēia a hiki ke hoʻoweliweli i ke ola.

Eia kekahi, aia kekahi mau hōʻailona ʻē aʻe i ʻike pinepine ʻole ʻia:

• Anemia - ʻO ke ʻano kēia, ʻaʻole lawa nā hunaola koko ʻulaʻula olakino o ke kino.
• Ke ʻeha a ʻoluʻolu ʻole paha ma ka ʻōpū, ke kua, a me ke pelvis .
• Ke kū ʻana o ke koko a i ʻole nā ​​hunaola koko i loko o ka mimi (Hematuria) .
• Ke koko kiʻekiʻe (hypertension) .
• Ka hāʻule ʻana o nā puʻupaʻa - He mea kākaʻikahi loa kēia.
• Ke manaʻo nei i kahi puʻupuʻu e like me ka paʻa ʻia ʻana i ka lima .
• Ka maʻi ʻōpū mimi .

Inā loaʻa iā ʻoe kekahi a ʻoi aku paha o kēia mau hōʻailona, ​​​​ʻoi aku ka maikaʻi o ka ʻimi ʻana i ke kōkua lapaʻau.

Pehea e ʻike ʻia ai kēia maʻi `(Renal Angiomyolipoma)`?

E like me kā mākou i ʻōlelo ai ma mua, ʻo ka hapa nui o ka manawa, ʻike ʻia kēia mau puʻupuʻu "AML" ma ke ʻano ulia. Loaʻa lākou i ka wā o ka nānā ʻana i ka ʻōpū no kekahi kumu ʻē aʻe, a i ʻole i ka wā o ka nānā maʻamau ʻana i ka poʻe me nā maʻi pili, e like me ka "Tuberous Sclerosis" a mākou i kamaʻilio ai ma mua.

Hiki i ke kauka ke haʻi maopopo inā loaʻa iā ʻoe ka renal AML ma ka hana ʻana i kekahi mau hoʻokolohua kiʻi e lawe i nā kiʻi o loko o kou ʻōpū :

• (CT scan) (Computered Tomography scan)
• (MRI) (Kiʻi Hoʻohālikelike Magnetic)
• `(ʻIke ultrasound)` (ʻIke ultrasound)

I ka hapanui o nā hihia, ua lawa kekahi o kēia mau hoʻokolohua kiʻi e hana i ka hōʻailona. No ka mea, aia ka momona i loko o kēia Renal Angiomyolipomas, ʻike pinepine ʻia lākou he melemele gula ma nā scan. Hiki i kēia mau puʻupuʻu ke ʻokoʻa ka nui mai 1 cm a i kahi 20 cm . ʻO ka nui maʻamau i ʻike ʻia ma kahi o 9 cm.

Akā, pehea inā i kekahi manawa ʻaʻole hiki i ka hui lapaʻau ke ʻike maopopo inā he ʻano maikaʻi ʻole a he maʻi kanesa paha kahi puʻupuʻu? I kēlā hihia, hiki iā lākou ke ʻōlelo aku i kahi biopsy puʻupaʻa . Pili kēia i ka wehe ʻana i kahi ʻāpana liʻiliʻi o ka puʻupuʻu a me ka nānā ʻana iā ia ma lalo o kahi microscope. E kōkua kēia i ka hoʻoholo ʻana inā he maʻi kanesa nā cell a ʻaʻole paha.

He aha nā lāʻau lapaʻau no ka `(Renal Angiomyolipoma)`?

Hiki ke ʻokoʻa loa ka lāʻau no ka `(Renal Angiomyolipoma)`. Aia ia i nā kumu he nui, e like me ka nui o ka puʻupuʻu, inā he mau hōʻailona, ​​a me kou olakino holoʻokoʻa. Aia kekahi mau koho lapaʻau nui:

1. Nānā ikaika:

Ua kapa ʻia hoʻi kēia ʻo "e nānā a kali." Inā he liʻiliʻi ka Renal Angiomyolipoma (ʻoi aku ka liʻiliʻi ma mua o 4 kenimika) a ʻaʻohe ona hōʻailona , ​​​​hiki i kāu kauka ke kuhikuhi i kēia ala. ʻAʻole ʻoe e hāʻawi ʻia i kekahi lāʻau lapaʻau. Eia nō naʻe, e nānā ʻia ʻoe no kekahi mau loli i ka puʻupuʻu me nā scans i nā manawa maʻamau .

2. Lāʻau lapaʻau:

Hoʻolohe kekahi mau puʻupuʻu AML i kahi papa o nā lāʻau i kapa ʻia ʻo mTOR inhibitors . He mau lāʻau lapaʻau i kuhikuhi ʻia kēia e kuhikuhi ana i ka hoʻololi ʻana o ka gene. Hiki i kēia mau lāʻau ke hoʻōki i ka ulu ʻana o ka puʻupuʻu a hoʻemi paha iā ia.

3. ʻOki kino:

Hiki i ke kauka ke ʻōlelo i ke ʻoki kino i nā hihia aʻe:

• Inā loaʻa i ka `(AML)` nā hōʻailona (e.g. ʻeha, kahe koko).
• Inā he 4 kenimika a ʻoi aku paha ka nui o ka puʻupuʻu (no ka mea, ʻoi aku ka nui o ka pahū ʻana a me ke kahe ʻana o ke koko i nā puʻupuʻu nui).
• Inā he kānalua he maʻi kanesa paha ka puʻupuʻu .
• Inā he wahine ʻoe o ka makahiki hānau keiki (hiki i nā loli hormonal i ka wā hāpai ke hōʻemi i ka pilikia o ka ulu ʻana o ka puʻupuʻu a me ka pahū ʻana).
• Noho ʻoe ma kahi e paʻakikī ai ke kiʻi i ka mālama ulia pōpilikia a i ʻole nā ​​​​lawelawe hahai (no ka mea, i ka wā pilikia, e like me ke kahe ʻana o ke koko, pono ka mālama wikiwiki).

Aia kekahi mau ʻano hana lapaʻau:

• Embolization: Pili kēia i ke ālai ʻana i nā kīʻaha koko e hoʻolako koko i ka puʻupuʻu. He hana pono loa kēia i nā hihia o ke kahe koko ma muli o Renal AML.
• `(Nephrectomy)` (Nephrectomy):I kēia, ua wehe ʻia kekahi hapa a i ʻole nā ​​​​​​mea āpau o ka puʻupaʻa i hoʻopilikia ʻia.
• ʻO ke ʻoki ʻana i ka puʻupaʻa hapa a i ʻole ke ʻoki ʻana me ka nephron: ʻO kēia ka wehe ʻana i ka puʻupuʻu wale nō, e waiho ana i ka ʻāpana olakino o ka puʻupaʻa. Hoʻāʻo nā kauka e hoʻohana i kēia ʻano hana i nā manawa āpau e hiki ai.
• ʻO ka hoʻopau ʻana o ke alapine radio: Hoʻohana kēia i ka wela kiʻekiʻe e luku i nā ʻiʻo maʻamau (tumor).

Hiki iaʻu ke hōʻemi i koʻu pilikia o ka hoʻomohala ʻana i ka Renal AML?

ʻO kaʻoiaʻiʻo, ʻaʻohe mea hiki iā mākou ke hana e pale aku i nā hoʻololi genetic e alakaʻi ai i ka ulu ʻana o `(Renal Angiomyolipoma)`. He mau mea ia e hana ʻia ma waho o ko mākou mana.

Eia nō naʻe, inā loaʻa iā ʻoe kekahi o nā kūlana pili i kūkākūkā ʻia ma mua (e.g. Tuberous Sclerosis Complex, Lymphangioleiomyomatosis, Neurofibromatosis type 1, von Hippel-Lindau disease) , he mea nui loa ia e loaʻa nā hoʻokolohua kiʻi maʻamau . A laila, inā ua ulu aʻe ʻo AML, hiki ke ʻike ʻia i ka wā mua . Ma kēlā ʻano, hiki ke hoʻomaka mua ʻia ka lāʻau e pono ai a hiki ke hoʻemi ʻia ka pilikia o nā pilikia.

Inā loaʻa iaʻu kēia maʻi, he aha kaʻu e manaʻo ai?

ʻO ka nūhou maikaʻi, ʻo ka hapa nui o Renal Angiomyolipomas he liʻiliʻi a kākaʻikahi ke kumu i nā pilikia koʻikoʻi . Eia nō naʻe, hiki i kahi hapa liʻiliʻi ke lilo i mea ʻino a kahe koko nui paha. No laila, he mea nui e nānā pono iā lākou inā loaʻa iā ʻoe ʻo Renal AML. E haʻi aku kāu kauka iā ʻoe i ka pinepine o kou pono e hana i nā hoʻokolohua kiʻi.

E hoʻomanaʻo, hiki i ka AML ke hoʻi hou ma hope o ka mālama ʻana. No laila, he mea nui loa ia e hoʻomau i ka launa pū me kāu hui lapaʻau a loaʻa nā nānā maʻamau e like me kā lākou e ʻōlelo ai.

Āhea wau e ʻimi ai i ke aʻo lapaʻau?

Inā ua ʻike ʻia ʻoe me ka renal AML, a inā he maʻi kou e pili ana i ka AML, he mea nui e makaʻala i nā hōʻailona o ke kahe koko retroperitoneal . Inā ʻike ʻoe i kekahi o kēia mau hōʻailona, ​​e ʻimi koke i ke kōkua lapaʻau :

• Inā he koko i loko o kou mimi.
• Inā loaʻa iā ʻoe ka ʻeha mau loa a mau loa ma kou ʻōpū luna a i ʻole ka ʻūhā.
• Inā ʻike ʻoe i nā hōʻailona o ka haʻalulu:
• Ka huikau
• Ka wikiwiki o ka puʻuwai
• Pōʻino
• Ka hanu pāpaʻu
• ʻIli keʻokeʻo

Inā ʻike ʻoe i kekahi mea e like me kēia, mai hoʻokaʻulua.

ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai (Leka Lawe-Home)

ʻAe, ʻo ka `(Renal Angiomyolipoma)` a i ʻole `(AML)` a mākou e kamaʻilio nei he puʻupuʻu ia e hana ʻia ana i loko o ka puʻupaʻa, a ʻo ka maʻamau ʻaʻole ia he maʻi kanesa (benign).ʻO ka hapa pinepine, ʻike ʻia kēia ma kahi hanana, i ka wā o kahi hoʻokolohua ʻē aʻe. Inā ua ʻike ʻia ʻoe me kēia ʻano `(Renal AML)`, mai hopohopo . E kamaʻilio me kāu kauka e hoʻoholo i ke ʻano lapaʻau a i ʻole ke ʻano nānā ʻana i kūpono loa iā ʻoe.

ʻO ka mea nui loa, ʻo ia ke nānā mau ʻana i kēia mau puʻupuʻu . Ma ka hana ʻana pēlā, hiki iā ʻoe ke pale i kahi maʻi koʻikoʻi e like me ke kahe koko mai ka ulu ʻana. No ka mea, inā hana ʻia kekahi mea e like me ia, hiki ke hoʻoweliweli i ke ola. No laila, e hahai i nā ʻōlelo a kāu kauka a e hoʻāʻo ʻia i ka manawa kūpono. Aia kou olakino ma kou mau lima!

ʻO Renal Angiomyolipoma, AML, Nā ʻōpū puʻupaʻa, Maʻi puʻupaʻa, Tuberous Sclerosis, Ke kahe koko ʻana o ke koko o ka puʻupaʻa, Nā hoʻololi ʻana o ke ʻano