Hiki ke ho'ōla loa ʻia ka maʻi diabetes Type 2? E ʻike kākou i ka ʻike hou loa!

Ua lilo ka maʻi diabetes i maʻi maʻamau i waena o nā kānaka he nui ma ko kākou ʻāina. Malia paha ua hoʻopilikia ʻia kekahi o kou ʻohana, he hoaaloha, a ʻo ʻoe iho paha e kēia maʻi. ʻO ka maʻi diabetes Type 2 ma ke ʻano kūikawā he pilikia olakino koʻikoʻi e hoʻopilikia ana ma mua o 400 miliona mau kānaka ma ka honua holoʻokoʻa. Inā ʻaʻole i kāohi pono ʻia, hiki iā ia ke alakaʻi i nā pilikia weliweli e like me ka hōʻino ʻana o nā puʻupaʻa, ka nalowale o ka ʻike, ka maʻi puʻuwai, a me ka maʻi lolo. ʻOiai aia ma mua o 30 mau ʻano lāʻau lapaʻau e kāohi i kēia maʻi, ʻaʻohe o lākou e hiki ke "ho'ōla" loa. Akā... hōʻike ka noiʻi hou e loli paha kēia kūlana. E nānā kākou pehea.

ʻO ka mea a mākou i noʻonoʻo ai e pili ana i ka maʻi diabetes no ka manawa lōʻihi

Ma kahi o iwakālua mau makahiki i hala aku nei, inā ʻoe e nīnau i kahi loea e pili ana i ka maʻi diabetes, e ʻōlelo ʻo ia ʻo ke kumu nui o kēia ʻo ke 'kū'ē ʻana o ka insulin'. I ka ʻōlelo maʻalahi, ʻo ka insulin kahi hormone i hana ʻia e kā mākou pancreas. ʻO kāna hana nui ka lawe ʻana i ka glucose (kō) i loaʻa mai ka meaʻai a mākou e ʻai ai a hoʻokomo i loko o nā pūnaewele o ko mākou kino. ʻO ia ka manawa e loaʻa ai ka ikehu i nā pūnaewele.

E noʻonoʻo i ka insulin ma ke ʻano he kī, a me nā pūnaewele ma ke ʻano he puka. ʻO ka insulin ke kī e wehe ai i ka puka i hiki ai i ka glucose ke komo i loko o nā pūnaewele.

Akā, ʻaʻole pane pono nā pūnaewele o ke kanaka me ke kū'ē ʻana o ka insulin i kēia insulin. Me he mea lā ua popo ka puka kī ma ka puka. A laila, no ka mea, ʻaʻole hiki ke wehe ʻia ka puka, pono ka pancreas e hana i nā kī insulin hou aʻe. I ka hala ʻana o ka manawa, lilo ka pancreas i nāwaliwali mai ka hana nui ʻana. ʻO ia ka manawa e kū mai ai ka maʻi diabetes type 2. ʻO kēia ka moʻolelo a mākou i ʻike ai no ka manawa lōʻihi.

ʻO ka ʻike hou koʻikoʻi loa: Ka moʻolelo o nā cell beta

I kēia manawa, ua ʻike nā kānaka ʻepekema ʻaʻole wale ke kūʻē ʻana o ka insulin i ka pilikia. ʻO ka hapalua ʻē aʻe o ka pilikia aia i loko o kā mākou mau pūnaewele beta . ʻO kēia nā pūnaewele e noho ana i loko o ka pancreas a ua like me nā hale hana liʻiliʻi e hana ana i ka insulin.

ʻO ka hapa nui o nā pūnaewele beta e pono ai ko kākou kino e hana ʻia i nā makahiki mua o ko kākou ola. Akā, ua hānau ʻia kekahi poʻe me nā pūnaewele beta he nui aʻe ma mua o nā poʻe ʻē aʻe. No laila, inā paha e loaʻa iā lākou ke kū'ē ʻana i ka insulin ma hope o ke ola, hiki i kā lākou mau hale hana pūnaewele beta ke hana i ka insulin hou aʻe e hoʻoponopono ai.

Eia nō naʻe, i ka wā e loaʻa ai i kekahi me ka hemahema hānau ʻana o nā cell beta ke kū'ē i ka insulin, pono nā cell i koe e hana ikaika ma mua o ka hiki iā lākou ke lawelawe. I ka hopena, luhi kēlā mau cell a make. ʻO ia ka poʻe e loaʻa i ka maʻi diabetes type 2.

No laila, ʻo ka pahuhopu nui loa i kēia manawa, ʻo ia ka loaʻa ʻana o kahi lāʻau lapaʻau e hiki ke hoʻoulu hou i kēia mau cell beta e make ana a i ʻole e hoʻonui i ka nui o nā cell e loaʻa ana. Inā hiki ke hana ʻia kēlā, hiki ke ho'ōla ʻia ka maʻi diabetes type 2, ʻaʻole wale ke kāohi ʻia.

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ʻO nā lāʻau lapaʻau hou loa i lawe mai i ka manaʻolana

I ka noiʻi ʻana a nā kānaka ʻepekema i kēia, ua loaʻa iā lākou kahi lāʻau lapaʻau e hiki ke kōkua i ka ulu ʻana o kēia mau cell beta. Ua kapa ʻia ʻo harmine . He hui ia i loaʻa maoli i nā mea kanu like ʻole a puni ka honua.

Hana kēia lāʻau lapaʻau, i kapa ʻia ʻo harmine, ma ke ālai ʻana i kahi enzyme i kapa ʻia ʻo DYRK1A i loko o nā cell beta. Ke ālai ʻia kēia, hoʻomaka nā cell beta e māhele, hoʻonui, a hoʻonui i ka nui. I nā hoʻokolohua ma nā ʻiole, ua loaʻa i nā ʻiole maʻi diabetes i hāʻawi ʻia i kēia lāʻau lapaʻau ka piʻi ʻekolu manawa o ka nui o nā cell beta! I ka manawa like, ua hoʻi hou ko lākou pae kō koko i ka maʻamau.

Akā, i mea e holomua ai kēia i loko o kānaka, ua ʻike nā kānaka ʻepekema he mea ʻē aʻe ka mea e pono ai. No laila, ua hoʻāʻo lākou i ka lāʻau harmine me kekahi papa lāʻau ʻē aʻe i hoʻohana mua ʻia no ka maʻi diabetes. Ua kapa ʻia kēlā papa lāʻau he GLP1R agonists . Inā he kanaka ʻoe e lawe ana i ka lāʻau maʻi diabetes, ua lohe paha ʻoe i kēia mau inoa: (exenatide), (liraglutide), (lixisenatide) kekahi o nā lāʻau lapaʻau o kēia papa. Hana lākou ma ka hoʻoulu ʻana i nā cell beta a me ka hoʻoikaika ʻana i ka hana ʻana o ka insulin.

No laila, he aha ka mea i hana ʻia i ka wā i hui pū ʻia ai kēia mau lāʻau ʻelua? He mea kupaianaha nā hopena!

Ua hāʻawi kēia mau hopena i ka hilinaʻi nui e holomua ana kēia ʻano lapaʻau i nā kānaka pū kekahi.

He aha ka pilikia e hiki mai ana a no ke aha he mea nui kēia?

ʻO ka pilikia nui loa i kēia manawa, pehea e hāʻawi pololei ai i kēia hui lāʻau i nā cell beta. Ke ʻōlelo nei nā kānaka ʻepekema, "Loaʻa iā mākou kahi pūʻolo e hoʻōla i nā cell beta, akā ʻaʻole mākou i ʻike i ka helu wahi e hoʻouna aku ai." Ma ke ʻano he hopena, ke noʻonoʻo nei lākou e hoʻohana i kahi mea i kapa ʻia ʻo monoclonal antibodies . Ua like kēia me kahi lawelawe leka akamai e hiki ke hāʻawi pololei i kā mākou pūʻolo lāʻau i nā cell beta.

No ke aha he mea nui kēia?

E noʻonoʻo wale, ʻo nā lāʻau lapaʻau maʻi diabetes o kēia manawa ke kaohi wale i nā pae kō koko. Inā ʻoe e hoʻōki i ka lawe ʻana i ka lāʻau, e hoʻi hou mai ka maʻi.

ʻO ka mea wale nō i kokoke i kahi hopena mau loa a hiki i kēia manawa, ʻo ia ke ʻoki kino bariatric . ʻO ia hoʻi, ke ʻoki kino e hōʻemi i ke kaumaha. Hoʻopau pinepine kēia i ka maʻi diabetes i ka hoʻomaha ʻana. Akā no ka 400 miliona mau kānaka o ka honua, ʻaʻole pono ke ʻoki kino. He pipiʻi, he pilikia, a he lōʻihi ka manawa e ho'ōla ai.

Akā inā holomua kēia hui lāʻau hou, hiki iā ia ke hoʻololi i ke ola o nā miliona o ka poʻe a puni ka honua. ʻAʻole ia e kāohi wale i nā hōʻailona, ​​​​hoʻihoʻi ia i ke kumu o ka maʻi, ʻo ia ka nalowale ʻana o nā cell beta.