E aʻo e pili ana i ka mālama ʻana iā Herceptin (Trastuzumab) no ka maʻi ʻaʻai umauma HER2-positive

Ke ʻike ʻia ʻoe a i ʻole kekahi o kou ʻohana me ka maʻi ʻaʻai umauma, he mea paʻakikī ke hōʻike i ka makaʻu a me ka hopohopo āu e manaʻo nei. He manawa naʻau loa ia. Akā, ʻo ka mea nui loa, me ka ʻepekema lapaʻau holomua i loaʻa iā mākou i kēia manawa, hiki iā mākou ke loaʻa ka manaʻolana. E noʻonoʻo kāu kauka i nā mea he nui, e like me ke ʻano o ka maʻi ʻaʻai āu, kou mau makahiki, a inā he mau maʻi ʻē aʻe kāu, e koho i nā koho lapaʻau maikaʻi loa nāu. Hoʻomaʻamaʻa pinepine ʻia ka maʻi ʻaʻai umauma me ka hui pū ʻana o ke ʻoki kino, chemotherapy, a me ka radiation.

I kēia lā, ke kamaʻilio nei mākou e pili ana i kahi lāʻau lapaʻau ʻokoʻa iki a kikoʻī. Ua kapa ʻia kēia ʻo " targeted therapy." ʻO Herceptin kekahi o ia mau lāʻau. ʻO Trastuzumab kona inoa lapaʻau. Ua lohe paha ʻoe ua kapa ʻia ʻo ia i nā inoa ʻē aʻe e like me Kanjinti, Herzuma, Ogivri. Ua kapa ʻia kēia mau mea he "biosimilars." I ka ʻōlelo maʻalahi, he mau kope olaola kēia o ka lāʻau like me Herceptin.

He aha ka Targeted Therapy a me Herceptin?

E noʻonoʻo e pili ana i ia mea, ʻaʻole wale nā ​​​​lāʻau chemotherapy maʻamau e hoʻopilikia i nā hunaola kanesa, akā i nā hunaola olakino e māhele wikiwiki ana. Akā, ʻaʻole like ia me nā lāʻau lapaʻau i kuhikuhi ʻia. Hana lākou ma ke kuhikuhi ʻana i nā pahuhopu kikoʻī. Hoʻomalu kēia mau lāʻau i nā protein kikoʻī e kōkua i nā hunaola kanesa e ulu a laha. ʻO ia ke kumu ʻaʻole lākou e hana no nā kanesa āpau. Pono e loaʻa ka protein a ka lāʻau i kuhikuhi ai i ka nui i loko o kēlā mau hunaola kanesa.

Hoʻopili ka lāʻau lapaʻau ʻo Herceptin i kahi protein i kapa ʻia ʻo HER2 . (ʻO ka inoa piha o kēia ʻo 'human epidermal growth factor receptor 2'). No laila, inā hana nui ʻia kēia protein HER2 i loko o nā hunaola kanesa, kapa mākou i kēlā ʻano maʻi ʻaʻai umauma ʻo 'HER2-positive' kanesa umauma. Hāʻawi wale ʻia ka lāʻau Herceptin i kēlā ʻano maʻi ʻaʻai umauma 'HER2-positive'.

Pehea e hana ai kēia lāʻau Herceptin i loko o ke kino?

I mea e hoʻomaopopo ai i kēia, e nānā mua kākou i ke ʻano o HER2. He mea loaʻa ka HER2 ma luna o nā cell. E noʻonoʻo iā ia he antenna liʻiliʻi ma luna o ka ʻili o kahi cell. ʻO kēia mau antenna ka mea e loaʻa ai nā hōʻailona mai waho o ke cell a hana ma luna o lākou. I loko o kahi cell olakino, aia nā mea loaʻa HER2 e kāohi i ka ulu ʻana o nā cell.

Akā, he mea ʻokoʻa ke ʻano o nā pūnaewele kanesa 'HER2-positive'. Loaʻa i kēia mau pūnaewele nā ​​kope keu o nā genes e hana ana i ka protein HER2. No laila, hana nui kēia mau pūnaewele i ka protein HER2. Me he mea lā he nui loa nā antennas ma ke kelepona. A laila, loaʻa i nā pūnaewele kanesa nā hōʻailona he nui e "ulu, māhele," a ulu koke lākou me ka ʻole o ke kaohi.

He kūpono anei ka lāʻau lapaʻau Herceptin no koʻu maʻi kanesa?

He nīnau koʻikoʻi loa kēia. Inā he 'HER2-negative' kou maʻi ʻaʻai umauma, ʻo ia hoʻi, ʻaʻohe protein HER2 keu i loko o nā hunaola kanesa, a laila ʻaʻole e holo pono ka lāʻau lapaʻau Herceptin. ʻO ka hapa nui o nā maʻi ʻaʻai umauma he 'HER2-negative'. Ma kahi o 20% he HER2-positive. E haʻi pololei kāu kauka iā ʻoe i ke ʻano o ke kanesa āu i loaʻa ai ma o nā hoʻokolohua.

Hoʻohana ʻia ka lāʻau Herceptin i nā pae mua o ka maʻi ʻaʻai umauma, a me nā pae holomua kahi i laha ai ke kanesa (metastatic).

• No ke kanesa pae mua: Inā he HER2-positive kou kanesa a he pae mua, hāʻawi ʻia ʻo Herceptin e pale i ke kanesa mai ka hoʻi hou ʻana mai ma hope o ke ʻoki ʻana. Hāʻawi pinepine ʻia kēia me ka chemotherapy a i ʻole ka lāʻau endocrine. ʻOi aku ka nui o kēia lāʻau lapaʻau inā nui ka kanesa a ua pālahalaha paha i nā lymph nodes.

• No ke kanesa holomua: Inā ua pālahalaha ke kanesa i nā ʻāpana mamao o ke kino (metastatic), hiki iā Herceptin ke kōkua i ka hoʻōki a hoʻolohi paha i kona ulu ʻana. I kekahi manawa, inā nui loa kahi puʻupuʻu e hiki ke wehe ʻia e ke ʻoki ʻana, hiki iā Herceptin a me nā lāʻau ʻē aʻe ke hoʻēmi iā ia ma mua o ke ʻoki ʻana.

He aha kāu e manaʻo ai i ka wā e loaʻa ai ka lāʻau lapaʻau?

Hāʻawi ʻia ʻo Herceptin ma ke ʻano he infusion (intravenous - IV) i loko o kahi vein. Hāʻawi ʻia ia ma ke ʻano he saline solution. Hana ʻia kēia no ka mea pono e hoʻokomo pololei ʻia ka lāʻau lapaʻau i loko o ke koko. Hiki ke hala ma waena o 30 a me 90 mau minuke e hoʻopau ai.

Aia kekahi ʻano o kēia i hāʻawi ʻia ma ke ʻano he inikini. Ua kapa ʻia ʻo 'Herceptin Hylecta'. Ua hōʻike ʻia nā noiʻi ua like ka maikaʻi o kēia me ka IV. Na kāu kauka e hoʻoholo i ke ʻano hana kūpono loa iā ʻoe.

ʻO ka lōʻihi a me ka pinepine o kou pono e lawe iā Herceptin e pili ana i ke kahua o kou maʻi ʻaʻai a me nā lāʻau lapaʻau ʻē aʻe āu e lawe nei. Inā ua holomua ke kanesa (metastatic), pono paha ʻoe e hoʻomau i ka lāʻau lapaʻau inā e hana ana ka lāʻau lapaʻau a ʻaʻohe hopena koʻikoʻi.

He mea nui loa: E nānā mau kāu kauka i ka hana o kou puʻuwai ma mua a i ka wā o ka mālama ʻana iā Herceptin, no ka mea, hiki i kēia lāʻau lapaʻau ke hoʻopilikia i ka puʻuwai i kekahi manawa.

Eia kekahi, hiki ke loaʻa nā hopena ʻaoʻao ʻē aʻe. No laila, ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau, pono ʻoe e aʻo pono i nā hōʻailona e makaʻala ai a me ka wā e hoʻomaopopo koke ai i kāu kauka. ʻAʻole hāʻawi ʻia ka lāʻau Herceptin i nā wahine hāpai a i ʻole e hoʻāʻo nei e hāpai.

Pehea ka holomua o kēia lāʻau lapaʻau?

ʻO Herceptin kahi lāʻau lapaʻau i hoʻololi i ka mālama ʻana i ka maʻi ʻaʻai umauma HER2-positive ma hope o kona ʻāpono ʻia ʻana i ka makahiki 1998.

• No ke kanesa holomua: ʻO Herceptin, ke hāʻawi wale ʻia a i ʻole me ka chemotherapy, hiki ke hoʻolohi i ka ulu ʻana o ke kanesa a kōkua i nā mea maʻi e ola lōʻihi. Eia nō naʻe, i kekahi manawa hiki i ka lāʻau ke hana no kekahi manawa a laila e pau ka hana.

• No ke kanesa mua: ʻO kēia kahi e ʻike ʻia ai ka holomua nui loa. Ua hōʻike ʻia nā haʻawina e hiki i ka hoʻohui ʻana iā Herceptin i ka chemotherapy ma hope o ke ʻoki ʻana ke hōʻemi i ka pilikia o ka hoʻi hou ʻana mai o ke kanesa ma kahi o 50% . ʻO ke ʻano kēia, ʻoi aku ka lōʻihi o ke ola o nā wahine e lawe ana iā Herceptin me ka ʻole o ke kanesa.

ʻOiai ua hāʻawi mua ʻia ka lāʻau lapaʻau no hoʻokahi a ʻelua paha makahiki, ua hōʻike nā noiʻi hou nei no nā poʻe he nui, ua lawa ka lawe ʻana iā Herceptin no 6 mau mahina wale nō. He nūhou maikaʻi kēia no ka poʻe e hopohopo nei e pili ana i nā hopena ʻaoʻao.