Lo lus "mob qog noj ntshav" ua rau peb txhua tus ntshai me ntsis, puas yog? Tab sis nrog kev nce qib ntawm kev tshawb fawb kho mob, ntau txoj hauv kev tshiab thiab ua tiav los tawm tsam mob qog noj ntshav tau tshwm sim. Hnub no, peb yuav tham txog txoj kev kho mob zoo uas tau tham txog ntau heev, tshwj xeeb tshaj yog rau mob qog noj ntshav mis. Qhov no hu ua Targeted Therapy . Cia peb saib seb nws yog dab tsi, nws ua haujlwm li cas, thiab koj yuav tsum paub dab tsi txog nws.
Hais yooj yim xwb, kev kho mob Targeted Therapy yog dab tsi?
Xav txog nws, chemotherapy, raws li peb feem ntau paub, rhuav tshem cov cell uas faib sai. Qhov no tuaj yeem ua rau puas tsuaj tsis yog cov cell mob qog noj ntshav xwb tab sis kuj tseem ua rau cov cell noj qab haus huv hauv peb lub cev. Yog vim li cas chemotherapy feem ntau ua rau muaj kev phiv xws li plaub hau poob thiab xeev siab.
Tiam sis txoj kev kho mob no hu ua Targeted Therapy txawv ntawm qhov ntawd heev. Yog hais kom meej, qhov no yog kev kho mob 'ntse' heev. Nws tsom thiab tawm tsam tsuas yog cov hlwb qog noj ntshav xwb . Txoj kev kho mob no siv peb lub cev lub cev tiv thaiv kab mob los rhuav tshem cov hlwb qog noj ntshav, lossis thaiv cov cim qhia tias cov hlwb qog noj ntshav xav tau kom loj hlob. Qhov no ua rau muaj kev puas tsuaj tsawg dua rau cov hlwb noj qab haus huv. Qhov zoo ntawm qhov no yog tias cov kev mob tshwm sim feem ntau tsawg dua li kev kho mob chemotherapy.
Kev kho mob no ua haujlwm ua ob txoj hauv kev tseem ceeb:
1. Kev Siv Cov Tshuaj Tiv Thaiv Kab Mob: Cov tshuaj tiv thaiv kab mob no yog tsim los ntawm cov hlwb tshwj xeeb hauv peb lub cev lub cev tiv thaiv kab mob. Cov tshuaj tiv thaiv kab mob no yog tsim los ntawm kev dag ntxias hauv chav kuaj mob thiab muab rau lub cev ua tshuaj. Cov no txuas rau cov hlwb mob qog noj ntshav thiab tiv thaiv lawv kom tsis txhob loj hlob lossis rhuav tshem lawv.
2. Cov tshuaj me me: Cov no yog cov tshuaj uas noj tau ua tshuaj ntsiav. Lawv ua haujlwm los ntawm kev thaiv cov kev taw qhia hauv cov hlwb qog noj ntshav uas pab lawv faib thiab loj hlob.
Koj tus kws kho mob yuav txiav txim siab seb hom kev kho mob twg yog qhov zoo rau koj raws li hom mob qog noj ntshav hauv lub mis uas koj muaj.
HER2-Positive Mis Cancer thiab Nws Txoj Kev Kho Mob
Kwv yees li ntawm 20% ntawm cov neeg uas muaj mob qog noj ntshav hauv lub mis, lossis kwv yees li ib ntawm tsib tus neeg, muaj qhov tsis zoo hauv ib lub noob hu ua 'HER2'. Qhov tsis zoo no ua rau lub noob ua ntau daim qauv. Yog tias muaj cov protein 'HER2' ntau dhau ntawm cov hlwb qog noj ntshav, peb hu qhov mob qog noj ntshav ntawd ua "mob qog noj ntshav hauv lub mis HER2-positive."
Yog tias koj tus mob qog noj ntshav yog 'HER2-positive', muaj cov kev kho mob tshwj xeeb thiab muaj txiaj ntsig zoo rau nws.
- Trastuzumab :Qhov no yog txoj kev kho mob tseem ceeb rau mob qog noj ntshav 'HER2-positive'. Cov tshuaj no muaj nyob rau hauv ntau lub npe lag luam xws li 'Herceptin', 'Kanjinti', 'Ogivri'. Nws yog ib qho kev txhaj tshuaj uas muab rau hauv cov leeg ntshav. Nws ntseeg tau tias yuav tswj tau mob qog noj ntshav hauv peb txoj hauv kev tseem ceeb:
- Cov qe mob qog noj ntshav lo rau ntawm qhov chaw thiab tiv thaiv lawv kom tsis txhob loj hlob.
- Nws pab rhuav tshem cov hlwb qog noj ntshav los ntawm kev ua cim qhia peb lub cev tiv thaiv kab mob.
- Thaum muab nrog rau kev kho mob chemotherapy, nws ua rau kev kho mob ntawd ua tiav ntau dua.
- Pertuzumab: Cov tshuaj no, uas muaj lub npe lag luam 'Perjeta', yog lwm yam tshuaj tiv thaiv kab mob uas muab rau mob qog noj ntshav 'HER2-positive'. Nws feem ntau muab ua ke nrog 'Trastuzumab' thiab cov tshuaj kho mob qog noj ntshav 'docetaxel'. Txawm li cas los xij, nws tsis haum rau cov poj niam cev xeeb tub, vim nws yuav ua rau tus menyuam hauv plab raug mob.
- Lwm cov tshuaj: `Ado-trastuzumab emtansine (Kadcyla), `Margetuximab (Margenza), thiab `Fam-trastuzumab deruxtecan-nxki (Enhertu)` kuj yog cov tshuaj niaj hnub no uas tau muab rau hom mob qog noj ntshav no, tshwj xeeb tshaj yog thaum mob qog noj ntshav tau kis mus rau lwm qhov (ua ntej lawm) lossis thaum lwm yam kev kho mob tsis ua haujlwm.
- Cov Tshuaj: Lapatinib (Tykerb) thiab Neratinib (Nerlynx) yog cov tshuaj uas tsom rau cov mob qog nqaij hlav HER2-positive uas tuaj yeem noj ua cov tshuaj. Cov no feem ntau kuj muab tom qab lwm yam kev kho mob.
Kev Kho Mob Cancer Mis HER2-Negative
Yog tias koj cov qog nqaij hlav tsis muaj qhov tsis zoo ntawm cov noob caj ces 'HER2' uas tau hais los saum toj no, txhais tau tias tsis muaj protein 'HER2' ntau dhau, ces qhov qog nqaij hlav ntawd hu ua "HER2-negative mis mob qog nqaij hlav." Tom qab ntawd koj yuav tau txais lwm hom kev kho mob.
Kuj muaj cov tshuaj kho mob tshwj xeeb rau hom mob qog noj ntshav no thiab.
- Cov tshuaj xws li Everolimus (Afinitor), Palbociclib (Ibrance), thiab Ribociclib (Kisqali) yog muab ua ke nrog kev kho mob hormone. Cov no yog kev kho mob uas muab rau cov poj niam, tshwj xeeb tshaj yog tom qab lub sijhawm tas lawm, uas lawv cov mob qog noj ntshav tau kis mus rau lwm qhov.
- Cov Tshuaj PARP Inhibitors: Yog tias koj tus mob qog noj ntshav yog HER2-negative thiab koj muaj kev hloov pauv ntawm BRCA gene, koj yuav tau txais ib pawg tshuaj tshwj xeeb hu ua PARP inhibitors, xws li Olaparib (Lynparza) thiab Talazoparib (Talzenna). Cov no kuj yog cov kev kho mob uas tsom mus rau cov hlwb qog noj ntshav.
Qhov tseem ceeb yog tias tag nrho cov kev kho mob no yog txiav txim siab los ntawm cov noob caj noob ces thiab qib cellular ntawm koj tus mob qog noj ntshav. Yog li nws yog ib qho tseem ceeb uas yuav tsum tham txog qhov no nrog koj tus kws kho mob thiab xaiv txoj kev kho mob uas zoo tshaj plaws rau koj.
Cov kev mob tshwm sim feem ntau yog dab tsi?
Raws li tau hais ua ntej lawm, txawm hais tias muaj tsawg dua cov kev mob tshwm sim dua li kev kho mob chemotherapy, kev kho mob targeted therapy tseem tuaj yeem ua rau muaj qee qhov kev mob tshwm sim. Cov no sib txawv ntawm ib hom tshuaj mus rau lwm hom tshuaj. Yog tias koj muaj kev mob tshwm sim , qhia rau koj tus kws kho mob tam sim ntawd . Feem ntau, lawv tuaj yeem tswj tau.
| Cov Kev Mob Tshwm Sim Feem Ntau |
|---|
| Kev ua xua - tawv nqaij tawm pob, khaus. |
| Xeev siab thiab raws plab. |
| Kub taub hau thiab mob khaub thuas. |
| Mob lub cev, qaug zog, thiab tsis muaj zog. |
| Ua pa nyuaj thiab o. |
| Kiv taub hau . |
Yuav ua li cas thiaj paub txog qhov xwm txheej ceev?
Yog koj muaj ib lossis ntau yam ntawm cov tsos mob hauv qab no, nws yuav yog xwm txheej ceev. Tsis txhob tsis quav ntsej lawv. Hu rau koj tus kws kho mob tam sim ntawd. Yog tias koj tsis tuaj yeem tiv tauj nws, mus rau Chav Kho Mob Ceev (ETU) ntawm lub tsev kho mob ze tshaj plaws.
| Ua tib zoo mloog cov cim no! | |
|---|---|
| Kub taub hau: Kub taub hau ntau tshaj 100.4 Fahrenheit (38 Celsius). Yog tias koj kub taub hau tom qab txias, qhia rau koj tus kws kho mob tam sim ntawd. | Teeb meem qhov ncauj: Cov qhov txhab tshiab hauv qhov ncauj, cov pob dawb, tus nplaig o, lossis cov pos hniav los ntshav. |
| Mob caj pas: Qaug, mob, khaus, lossis "o" hauv caj pas. | Hnoos: Hnoos tshiab los yog hnoos tas li. |
| Teeb meem tso zis: Tso zis ntau zaus, muaj kab mob hauv txoj hnyuv tso zis, lossis muaj ntshav hauv cov zis. | Teeb meem plab: Mob plab heev, xeev siab, ntuav, cem quav, lossis raws plab uas kav ntev tshaj 2-3 hnub. |
| Ua pa nyuaj: Ua pa luv txawm tias siv zog me ntsis los xij. | Kev los ntshav txawv txawv: Ntshav hauv cov quav. |
| Kev o: Kev o ntawm ob txhais ceg lossis pob luj taws. | Qaug zog heev: Xav tias qaug zog heev uas koj ua tsis tau dab tsi. |
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Kev Kho Mob Targeted yog ib txoj kev kho mob niaj hnub uas tsom mus rau thiab tawm tsam cov hlwb mob cancer ntawm lub mis, txawv ntawm kev siv tshuaj kho mob chemotherapy ib txwm muaj.
- Hom kev kho mob uas koj tau txais yuav nyob ntawm hom mob qog noj ntshav uas koj muaj (piv txwv li, seb nws yog 'HER2-positive' lossis 'HER2-negative'). Yuav muaj kev kuaj tshwj xeeb los txiav txim qhov no.
- Cov kev kho mob no kuj tseem muaj cov kev mob tshwm sim, yog li qhia rau koj tus kws kho mob paub txog txhua yam kev hloov pauv lossis kev tsis xis nyob uas koj xav.
- Nco ntsoov nrhiav cov tsos mob thaum muaj xwm txheej ceev xws li kub taub hau heev, ua pa nyuaj, thiab o tuaj txawv txawv. Yog tias koj pom ib qho ntawm cov no, nrhiav kev pab kho mob tam sim ntawd.
- Kev kho mob qog noj ntshav yog ib txoj kev taug kev. Koj tus kws kho mob thiab pab pawg neeg saib xyuas kev noj qab haus huv yog koj cov phooj ywg zoo tshaj plaws hauv txoj kev taug kev no. Yog li ntawd, ntseeg lawv thiab ua haujlwm nrog lawv.
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