Koj puas tau hnov ​​txog ib hom mob qog noj ntshav uas tsis tshua muaj neeg hu ua Chordoma? Cia peb tham txog nws!

Tej zaum koj yuav tsis tau hnov ​​​​​​txog lub npe no "chordoma" ua ntej. Qhov ntawd tsis yog qhov xav tsis thoob, vim tias qhov no yog ib hom mob qog noj ntshav uas tsis tshua muaj. Txawm li cas los xij, txawm tias nws tsis tshua muaj, nws yog ib qho tseem ceeb heev uas yuav tsum paub txog qhov no. Vim tias, hom qog no tuaj yeem tshwm sim hauv peb tus txha nraub qaum lossis ntawm lub hauv paus ntawm lub pob txha taub hau. Yog li hnub no, cia peb tham kom meej thiab yooj yim txog qhov chordoma no yog dab tsi, nws loj hlob li cas, cov tsos mob yog dab tsi, thiab kev kho mob yog dab tsi.

Chordoma yog dab tsi? Cia peb nrhiav seb yooj yim npaum li cas!

Hais yooj yim xwb, chordoma yog ib hom mob qog nqaij hlav uas tsim nyob rau hauv cov pob txha . Feem ntau nws tsim nyob rau hauv koj tus txha nraub qaum lossis hauv qab ntawm koj lub taub hau, cov pob txha saum koj lub caj dab thiab hauv qab koj lub hlwb. Cov kws kho mob faib nws ua ib hom mob qog nqaij hlav hu ua sarcoma. Sarcoma yog ib lo lus dav dav rau cov mob qog nqaij hlav uas tsim nyob rau hauv cov pob txha thiab cov nqaij mos (cov nqaij sib txuas).

Feem ntau cov chordomas loj hlob qeeb qeeb . Txawm li cas los xij, qhov teeb meem yog tias lawv tuaj yeem nyuaj me ntsis rau kev kho vim tias lawv nyob ze heev rau peb lub paj hlwb, uas yog, lub hlwb thiab tus txha caj qaum, thiab nkag mus rau hauv cov nqaij mos mos nyob ib puag ncig lawv.

Ib qho ntxiv yog tias txawm tias tom qab kho mob lawm, cov qog no muaj feem yuav rov tshwm sim dua . Feem ntau, qhov no tshwm sim rau tib qho chaw uas cov qog thawj zaug nyob. Tsis tas li ntawd, hauv 30% txog 40% ntawm cov neeg mob, cov hlwb mob chordoma tuaj yeem kis mus rau lwm qhov ntawm lub cev. Cov kws kho mob hu qhov no "metastasizing".

Chordoma kis mus rau lwm qhov ntawm lub cev qhov twg?

Yog tias chordoma metastasizes, uas yog, kis mus rau lwm qhov ntawm lub cev, qhov chaw feem ntau nws tuaj yeem kis tau yog:

• Koj lub ntsws
• Cov qog ntshav ze ntawm qhov mob qog
• Lwm cov pob txha
• Siab
• Tawv nqaij

Chordoma tuaj yeem tshwm sim qhov twg?

Chordoma tuaj yeem tshwm sim txhua qhov chaw ntawm koj tus txha nqaj qaum, tab sis muaj peb qhov chaw feem ntau:

1. Lub sacrum: Qhov no yog pob txha peb ceg ntawm koj lub pob tw. Kwv yees li 35% ntawm cov chordomas tsim ntawm no.

2. Lub hauv paus pob txha taub hau: Tshwj xeeb, ntawm lub hauv paus ntawm koj lub pob txha taub hau, hauv cov pob txha uas txhawb nqa koj lub hlwb. Cov no kuj hu ua "Clival chordomas" vim tias lawv feem ntau tsim nyob rau hauv "Clivus" pob txha, uas nyob ntawm no. Hom no kuj suav txog li 35% ntawm tag nrho cov chordomas.

3. Hauv cov pob txha caj qaum uas txav tau ('vertebrae'): Ntawd yog, cov pob txha caj qaum hauv koj lub caj dab, hauv siab, thiab nraub qaum. Chordomas tshwm sim hauv kwv yees li 30% ntawm cov no. Lawv feem ntau tshwm sim hauv cov pob txha caj qaum thib ob. Lawv kuj tseem tuaj yeem tshwm sim hauv cov pob txha caj qaum hauv qab nraub qaum (lumbar spine) thiab hauv siab (thoracic spine).

Cov hom chordoma tseem ceeb yog dab tsi?

Lub Koom Haum Kev Noj Qab Haus Huv Ntiaj Teb (WHO) tau faib chordoma ua peb hom tseem ceeb. Cov kev faib tawm no yog raws li seb cov hlwb qog noj ntshav zoo li cas hauv qab lub tshuab microscope ('histology').

1. Classic/conventional chordoma: Qhov no yog hom uas pom ntau tshaj plaws (80% txog 90% ntawm tag nrho cov chordomas). Cov cell hauv hom no yog ib hom cell tshwj xeeb uas muaj qhov zoo li "npuas". Chondroid chordoma yog lwm hom ntawm hom no. Nws suav txog li ntawm 5% thiab 15% ntawm tag nrho cov chordomas. Chondroid chordoma feem ntau tshwm sim ntawm lub hauv paus ntawm lub pob txha taub hau.

2. Dedifferentiated chordoma: Qhov no yog ib hom mob tsis tshua muaj (tsawg dua 5%). Nws yog tus cwj pwm los ntawm kev sib xyaw ua ke ntawm cov hlwb tsis zoo. Hom no loj hlob sai dua, ua rau mob hnyav dua, thiab muaj feem yuav kis mus rau lwm qhov ntawm lub cev ntau dua li lwm hom.

3. Chordoma tsis zoo sib txawv: Qhov no kuj tsis tshua muaj . Muaj tsawg dua 60 tus neeg mob tau raug sau tseg rau hauv cov ntaub ntawv kho mob txog tam sim no. Ib qho tshwj xeeb ntawm hom no yog tias ib lub noob hu ua `(SMARCB1)` lossis `(INI1)` raug kaw (rho tawm). Hom chordoma no feem ntau pom muaj nyob rau hauv cov menyuam yaus thiab cov tub ntxhais hluas.

Leej twg yuav muaj feem mob chordoma tshaj?

Kab mob Chordoma tuaj yeem tshwm sim rau txhua lub hnub nyoog, rau txhua tus neeg. Txawm li cas los xij, nws feem ntau tshwm sim rau cov neeg laus hnub nyoog ntawm 50 thiab 80. Cov menyuam yaus tsuas yog raug cuam tshuam los ntawm qee qhov teeb meem me me, kwv yees li 5% ntawm tag nrho cov rooj plaub.

Kuj tau pom tias cov txiv neej muaj feem yuav mob chordoma li ntawm 1.5 npaug ntau dua li cov poj niam.

Qhov no feem ntau tshwm sim li cas?

Chordoma yog ib hom mob qog noj ntshav uas tsis tshua muaj . Nws cuam tshuam rau kwv yees li ib ntawm ib lab tus tib neeg txhua xyoo. Qhov ntawd txhais tau tias, piv txwv li, hauv Tebchaws Meskas, tsuas yog kwv yees li 300 tus neeg mob tshiab raug kuaj pom txhua xyoo.

Chordomas suav txog li ntawm 1% thiab 4% ntawm tag nrho cov pob txha qog nqaij hlav thawj zaug.

Cov tsos mob ntawm chordoma yog dab tsi?

Thaum lub chordoma loj hlob tuaj, nws tuaj yeem muab kev nyuaj siab rau cov hlab ntsha lossis lub hlwb nyob ib puag ncig. Qhov kev nyuaj siab no ua rau muaj cov tsos mob . Cov tsos mob kuj tseem tuaj yeem sib txawv nyob ntawm qhov chaw uas lub qog nyob hauv tus txha nqaj qaum.

Cov tsos mob ntawm chordoma suav nrog mob, tsis muaj zog, thiab/lossis loog ntawm nraub qaum, caj npab, lossis ceg .

Cov yam ntxwv ntawm lub pob txha taub hau chordoma:

Yog tias koj muaj chordoma ntawm lub hauv paus ntawm koj lub pob txha taub hau, uas nyob hauv qab koj lub hlwb, koj yuav muaj cov tsos mob zoo li:

• Pom kev ob sab (Diplopia)
• Pom kev tsis meej
• Mob taub hau
• Lub ntsej muag tsis muaj zog lossis mob

Cov yam ntxwv ntawm chordoma hauv lub pob txha tailbone / sacrum:

Yog tias koj muaj chordoma ntawm qhov qis tshaj plaws ntawm koj tus txha nraub qaum, ze ntawm sacrum, koj yuav muaj cov tsos mob zoo li:

• Ib lub pob los yog ib lub pob uas tawm los ntawm daim tawv nqaij
• Nyuaj siab tso zis los yog quav (ua haujlwm tsis zoo ntawm lub zais zis los yog plab hnyuv)
• Mob hauv qab nraub qaum lossis thaj tsam pob tw

Nco ntsoov tias, qee zaum cov tsos mob no yuav tsis meej pem nrog lwm yam mob uas tshwm sim. Yog vim li ntawd nws thiaj li tseem ceeb uas yuav tsum nrhiav kev pab kho mob yog tias koj muaj cov tsos mob uas tsis tu ncua thiab tsis tshua muaj.

Vim li cas Chordoma thiaj loj hlob tuaj? Dab tsi yog cov ua rau?

Cov kws tshawb nrhiav tseem tsis tau paub meej tias dab tsi ua rau chordoma, tab sis lawv ntseeg tias muaj kev hloov pauv hauv cov noob hu ua TBXT koom nrog.

Muaj cov lus ceeb toom txog ntau tsev neeg uas muaj chordoma. Thaum lawv raug kuaj, lawv pom tias tau txais ib qho kev theej ntawm cov noob '(TBXT)'. Tsis tas li ntawd, kev hloov pauv ntawm cov noob '(TBXT)' tau pom nyob rau hauv cov neeg uas muaj chordoma tab sis tsis muaj leej twg hauv tsev neeg muaj tus kab mob no.

Chordoma tsim los ntawm cov hlwb hauv ib lub qauv hu ua "notochord." Qhov "notochord" no yog ib lub qauv ib ntus uas tseem ceeb heev rau kev loj hlob ntawm cov hlab ntsha ntawm tus menyuam thaum nws tab tom loj hlob. Feem ntau, qhov "notochord" no ploj mus li yim lub lis piam ntawm kev xeeb tub. Txawm li cas los xij, rau cov neeg tsawg heev, qee cov hlwb "notochord" no yuav nyob hauv cov pob txha ntawm tus txha nqaj qaum lossis lub hauv paus ntawm lub pob txha taub hau.

Yog li, qhov kev xav tam sim no yog tias yog muaj kev hloov pauv hauv cov noob caj noob ces `(TBXT)` uas tau hais ua ntej lawm, cov hlwb `(notochord)` uas tseem tshuav no yuav pib loj hlob tsis zoo thiab tsim ua chordoma.

Tsis tas li ntawd xwb, cov neeg uas muaj mob caj ces hu ua "Tuberous sclerosis" muaj feem yuav mob chordoma ntau dua. Mob "Tuberous sclerosis" no ua rau qaug dab peg, kev loj hlob qeeb, thiab mob qog nqaij hlav hauv ntau qhov ntawm lub cev. Qhov no yog tshwm sim los ntawm kev hloov pauv hauv ob lub noob hu ua "TSC1" thiab "TSC2"

Yuav ua li cas thiaj paub txog chordoma?

Yog koj muaj cov tsos mob ntawm chordoma, tus kws kho mob yuav nug txog koj cov tsos mob thiab keeb kwm kev kho mob ua ntej. Tom qab ntawd lawv yuav kuaj lub cev thiab kuaj lub paj hlwb.

Yog tias tus kws kho mob xav tias muaj qog, nws yuav xaj kom kuaj duab xws li X-ray, CT scan, lossis MRI scan. Qhov MRI scan no feem ntau pab tau rau kev kuaj mob chordoma.

Tom qab ntawd, koj tus kws kho mob yuav xa koj mus rau tus kws kho mob tshwj xeeb txog mob qog nqaij hlav kom paub meej tias koj tau kuaj mob thiab tau txais kev pom zoo thib ob. Lawv kuj tseem yuav ua cov kev kuaj duab ntxiv kom paub qhov chaw tseeb ntawm chordoma, saib seb nws puas tau kis mus rau lwm qhov ntawm lub cev, thiab ua lwm yam kev kuaj mob.

Txawm li cas los xij, tib txoj kev los kuaj mob chordoma yog kev kuaj nqaij . Qhov no suav nrog kev coj ib qho me me ntawm lub qog, feem ntau yog siv koob kuaj nqaij, thiab kuaj nws hauv qab lub tshuab microscope. Tsuas yog tom qab ntawd tus kws tshwj xeeb thiaj li paub tseeb tias nws puas yog chordoma.

Cov kev kho mob rau Chordoma yog dab tsi?

Txoj kev kho mob tseem ceeb thiab zoo tshaj plaws rau chordoma yog tshem tawm tag nrho cov qog nqaij hlav los ntawm kev phais . Cov kws kho mob hu qhov no tias "En bloc resection." Yog tias cov qog nqaij hlav raug tshem tawm tag nrho li no, tus neeg mob muaj lub sijhawm zoo tshaj plaws los nyob ntev.

Txawm li cas los xij, nyob ntawm seb cov qog nyob qhov twg, qhov no tuaj yeem ua tau nyuaj heev. Tshwj xeeb, nws feem ntau tsis yooj yim sua kom tshem tawm cov chordomas uas nyob ntawm lub hauv paus ntawm lub pob txha taub hau.

Vim tias chordoma hauv tus txha nqaj qaum tuaj yeem ua rau koj tus txha nqaj qaum thiab cov hlab ntsha tseem ceeb thiab cov hlab ntsha nyob ib puag ncig nws puas tsuaj. Yog tias qhov no raug puas tsuaj thaum lub sijhawm phais, nws tuaj yeem ua rau muaj kev tsis taus mus sij hawm ntev lossis txawm tias tuag. Tsis tas li ntawd, chordoma ntawm lub hauv paus ntawm lub pob txha taub hau nyuaj rau tshem tawm tag nrho vim nws nyob ze rau lub hlwb, cov hlab ntsha cranial, thiab tus txha nqaj qaum. Cov kws phais hlwb sim tshem tawm ntau npaum li ntau tau ntawm cov qog nqaij hlav, thaum ua kom muaj kev nyab xeeb li ntau tau.

Feem ntau cov pob txha chordoma tsis teb zoo rau kev kho mob hluav taws xob lossis tshuaj kho mob qog nqaij hlav ua kev kho mob tseem ceeb. Txawm li cas los xij, tom qab phais mob, koj pab neeg kho mob yuav pom zoo kom siv kev kho mob hluav taws xob los tiv thaiv cov qog kom tsis txhob rov qab los.

Cov kws tshawb nrhiav tam sim no tab tom tshawb nrhiav cov kev kho mob tshiab rau chordoma, xws li kev kho mob targeted thiab immunotherapy. Tej zaum yuav muaj kev sim tshuaj uas koj tuaj yeem koom nrog.

Puas tiv thaiv tau chordoma?

Qhov tseeb, tsis muaj dab tsi koj ua tau los tiv thaiv cov chordomas kom tsis txhob loj hlob. Feem ntau, lawv loj hlob yam tsis muaj kev npaj ua ntej.

Txawm li cas los xij, yog tias ib tug neeg hauv koj tsev neeg tau muaj Chordoma, lossis yog tias koj muaj mob hu ua "Tuberous sclerosis," nws yog ib qho tseem ceeb uas koj mus ntsib kws kho mob tsis tu ncua rau kev kuaj mob. Tom qab ntawd lawv tuaj yeem saib xyuas koj rau cov cim ntawm Chordoma. Qhov sai dua qhov no tau txheeb xyuas, qhov ntau dua nws yuav yog tias kev kho mob yuav ua tiav.

Muaj feem yuav rov zoo los ntawm chordoma li cas? (Kev kwv yees)

Qhov kev kwv yees, lossis kev pom, rau chordoma nyob ntawm ntau yam:

• Qhov chaw ntawm lub qog thiab ntau npaum li cas thiaj li phais tau: Yog tias lub qog tuaj yeem raug tshem tawm tag nrho, qhov muaj feem yuav rov zoo yog siab. Yog tias tsuas yog siv lwm yam kev kho mob yam tsis tau phais, qhov muaj feem yuav tsawg.
• Seb tus mob qog noj ntshav puas tau kis mus rau lwm qhov ntawm lub cev (metastasized): Yog tias nws tau kis mus rau qhov chaw deb, cov feem pua ​​​​​​ntawm kev ciaj sia yuav raug txo qis.
• Koj lub hnub nyoog thaum kuaj pom tias muaj tus kab mob no: Feem ntau, cov neeg uas muaj hnub nyoog tshaj 60 xyoo yuav muaj sia nyob tsawg dua me ntsis.
• Seb qhov mob qog nqaij hlav puas txawv txav los tsis yog: Cov hom mob zoo li "Poorly differentiated chordoma" muaj qhov kev kwv yees phem dua li "conventional chordoma".

Koj pab neeg kho mob tuaj yeem muab cov ntaub ntawv tseeb tshaj plaws rau koj txog yam koj yuav tsum tau xav txog raws li koj tus mob, yog li tsis txhob ntshai nug lawv cov lus nug.

Qhov no puas yuav ua rau tuag taus?

Yog, chordoma tuaj yeem ua rau tuag taus. Feem ntau, kev tuag tshwm sim tom qab lub qog rov tshwm sim, rhuav tshem cov ntaub so ntswg hauv koj lub hlwb qaum, lub hlwb, lossis lub hlwb.

Ib txoj kev tshawb fawb ntawm 357 tus neeg mob chordoma tau qhia tias cov nqi ciaj sia yog raws li nram no:

• Tom qab peb xyoos: 80.5%
• Tom qab tsib xyoos: 68.4%
• Kaum xyoo tom qab: 39.2%

Tiam sis nco ntsoov, cov no tsuas yog qhov nruab nrab xwb. Koj pab neeg kho mob tuaj yeem muab cov ntaub ntawv qhia ntxiv txog cov feem pua ​​​​​​ntawm kev ciaj sia nyob raws li koj qhov xwm txheej tshwj xeeb.

Puas yog Chordoma Cancer lossis ib qho mob qog nqaij hlav ib txwm muaj?

Chordoma yeej yog mob qog nqaij hlav (mob qog nqaij hlav). Tsis muaj ib hom qog nqaij hlav twg uas suav tias tsis yog mob qog nqaij hlav.

Kuv yuav tsum mus ntsib kws kho mob thaum twg?

Kab mob Chordoma tuaj yeem rov tshwm sim dua txawm tias tom qab kho mob lawm los xij, txawm tias ntau xyoo tom qab los xij. Yog li ntawd, kev saib xyuas koj pab neeg kho mob mus sij hawm ntev yog qhov tseem ceeb heev.

Yog koj muaj cov tsos mob tshiab, lossis yog koj cov tsos mob uas twb muaj lawm zuj zus tuaj , nco ntsoov nrog koj tus kws kho mob tham.

Thaum kawg, ob peb yam yuav tsum nco ntsoov (Cov Lus Coj Mus Tsev)

Nws yog ib qho ib txwm muaj uas yuav ntshai thiab ntxhov siab thaum koj paub tias koj muaj mob qog nqaij hlav pob txha tsis tshua muaj. Chordoma yog ib yam mob qog nqaij hlav uas nyuaj kho vim nws qhov chaw nyob.

Txawm li cas los xij, ntseeg siab tias koj pab neeg kho mob yuav tsim ib txoj kev npaj kho mob kom ntxaws uas haum rau koj thiab yuav pab koj kho koj tus chordoma thiab txhim kho koj lub neej zoo .

• Nws yog ib qho tseem ceeb kom paub txog cov tsos mob thaum ntxov: nrhiav kev pab kho mob yog tias koj mob tas li, tsis muaj zog, lossis pom kev hloov pauv.
• Nrhiav kev pab tswv yim los ntawm kws kho mob: Vim tias chordoma yog ib yam kab mob tsis tshua muaj, nws yog ib qho tseem ceeb heev uas yuav tsum nrhiav kev kho mob los ntawm pab pawg kws kho mob uas muaj kev paub dhau los.
• Yuav tsum tau mus kuaj mob tsis tu ncua txawm tias tom qab kho mob lawm los xij: Vim tias muaj kev pheej hmoo ntawm kev rov qab mob dua, mus koom kev kuaj mob raws li cov kws kho mob qhia.

Vam tias cov ntaub ntawv no yuav pab tau koj. Yog koj muaj lus nug dab tsi, tsis txhob yig nug koj tus kws kho mob.

" Chordoma, mob qog noj ntshav, mob qog noj ntshav, pob txha, txha nraub qaum, pob txha taub hau, sacrum, clivus