Koj puas paub txog HER2-Negative Breast Cancer? Cia peb tham!

Tej zaum koj twb tau hnov ​​​​​​ntau yam txog mob qog noj ntshav hauv lub mis lawm. Tab sis koj puas paub tiag tiag txog hom mob qog noj ntshav no hu ua 'HER2-negative'? Nws ua txawv me ntsis ntawm qee hom mob qog noj ntshav hauv lub mis, thiab kev kho mob kuj yuav txawv. Tsis txhob txhawj, hnub no peb yuav tham txog 'HER2-Negative Breast Cancer' no hauv txoj kev yooj yim uas koj tuaj yeem nkag siab, puas yog?

HER2-Negative Mis Cancer yog dab tsi?

Hais yooj yim xwb, 'HER2-negative mis mob qog noj ntshav' txhais tau hais tias cov hlwb qog noj ntshav hauv koj lub mis tsis muaj ntau dhau lossis tsawg dhau ntawm cov protein tshwj xeeb hu ua 'human epidermal growth factor 2 (HER2). Koj puas paub tias mob qog noj ntshav feem ntau tshwm sim vim yog cov tshuaj hormones (tshwj xeeb tshaj yog estrogen thiab progesterone) lossis vim yog cov protein 'HER2' no? Piv txwv li, hauv 'HER2-positive' mob qog noj ntshav hauv lub mis, cov protein 'HER2' muaj nyob rau ntawm qhov chaw ntawm cov hlwb, uas ua rau cov hlwb qog noj ntshav faib sai thiab tsim cov qog.

Tiamsis hauv cov rooj plaub 'HER2-negative', tus mob qog noj ntshav tsis loj hlob vim muaj cov protein 'HER2' ntau dhau. Qhov ntawd yog, muaj lwm yam tseem ceeb koom nrog.

Thaum koj tus kws kho mob kuaj pom tias koj muaj mob qog noj ntshav hauv lub mis, lawv yuav nrhiav koj qhov xwm txheej 'HER2' (piv txwv li, zoo lossis tsis zoo). Cov no yog cov yam ntxwv tshwj xeeb ntawm cov hlwb qog noj ntshav, uas peb hu ua 'biomarkers' , thiab thaum lawv nkag siab zoo, cov kws kho mob tuaj yeem txiav txim siab seb kev kho mob twg zoo tshaj plaws thiab zoo rau koj. Koj puas nkag siab?

Cov hom mob qog noj ntshav hauv lub mis HER2-negative tseem ceeb yog dab tsi?

Feem ntau ntawm cov mob qog noj ntshav hauv lub mis uas kuaj pom tam sim no yog hom 'HER2-negative'. Muaj ob hom tseem ceeb ntawm qhov no, cia peb saib seb lawv yog dab tsi:

1. Mob qog noj ntshav hauv lub mis uas muaj Hormone receptor-positive thiab HER2-negative (HR+/HER2-) :

Qhov no yog hom mob qog noj ntshav mis uas feem ntau pom, suav txog li 70 feem pua ​​(70%) ntawm tag nrho cov mob qog noj ntshav mis. Hauv qhov no, cov qe ntshav qog noj ntshav muaj cov receptors uas rhiab rau cov tshuaj estrogen (ER+), cov tshuaj progesterone (PR+), lossis ob qho tib si. Hais yooj yim, thaum cov tshuaj hormones no khi rau cov receptors no, cov qe ntshav qog noj ntshav pib loj hlob. Txawm li cas los xij, cov hom mob qog noj ntshav no tsis muaj cov protein HER2 ntau. Yog vim li ntawd lawv thiaj hu ua HR+/HER2-.

2. Mob qog noj ntshav hauv lub mis uas tsis muaj Hormone receptor thiab HER2-negative (HR-/HER2-) :

Hom no suav txog li 11 feem pua ​​(11%) ntawm tag nrho cov mob qog noj ntshav hauv lub mis. Cov hlwb qog noj ntshav no tsis muaj cov receptors rau estrogen lossis progesterone. Tsis tas li ntawd, raws li tau hais ua ntej, cov protein 'HER2' tsis siab. Qhov no txhais tau tias tsis yog cov tshuaj hormones lossis cov protein 'HER2' pab txhawb rau kev loj hlob ntawm cov mob qog noj ntshav no . Lwm lub npe rau qhov no yog 'Triple-Negative Breast Cancer' . Qhov no yog vim tias cov receptor estrogen, progesterone receptor, thiab 'HER2' protein yog txhua yam 'tsis zoo' hauv qhov no.

Cov tsos mob ntawm tus mob qog noj ntshav hauv lub mis HER2-negative yog dab tsi?

Qhov tseeb, cov tsos mob ntawm HER2-negative mis mob qog noj ntshav zoo ib yam li lwm yam mob qog noj ntshav mis. Koj yuav tsum paub txog cov hauv qab no:

• Yog koj pom muaj kev hloov pauv txawv txawv ntawm qhov loj lossis cov duab ntawm ib lossis ob lub mis.
• Yog tias koj pom ib lub qog tshiab, ib lub qog me me, lossis ib lub pob khov kho hauv koj lub mis lossis qhov chaw mos, tshwj xeeb tshaj yog tias lub qog tsis hloov pauv nrog koj lub voj voog txhua hli.
• Kev hloov pauv ntawm daim tawv nqaij ntawm lub mis lossis lub txiv mis. Piv txwv li:
• Kev ua kom daim tawv nqaij du, zoo li daim tawv txiv kab ntxwv
• Tawv nqaij ntsws, ntsws
• Tawv nqaij tawv tawv
• Kev khaus tas li
• Kev hloov xim ntawm daim tawv nqaij (liab, ntshav, xim av, lossis tsaus ntuj nti).
• Cov kua tawm ntawm lub txiv mis . Qhov no yuav yog xim liab zoo li ntshav, kua ntshiab, lossis xim dawb zoo li mis nyuj (yog tias koj tsis cev xeeb tub lossis pub niam mis).
• Kev tig lub txiv mis (yog tias nws tsis tau muaj ua ntej).

Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias mob qog noj ntshav hauv lub mis tsis yog ib txwm ua rau muaj kev hloov pauv pom tseeb hauv koj txoj kev zoo li cas . Tsis tas li ntawd, ntau yam kev hloov pauv no kuj tuaj yeem pom hauv cov mob tsis muaj teeb meem, ib txwm muaj (piv txwv li cysts, fibroadenoma). Yog vim li cas nws thiaj li tseem ceeb heev uas yuav tsum saib xyuas koj lub mis tas li thiab tau txais kev kuaj mob qog noj ntshav hauv lub mis raws li hnub nyoog . Yog tias koj muaj kev txhawj xeeb txog kev hloov pauv, nco ntsoov mus ntsib kws kho mob kom paub seb nws puas yog ib qho cim ntawm mob qog noj ntshav lossis lwm yam mob.

Dab tsi ua rau muaj mob qog nqaij hlav mis HER2-negative?

Hais yooj yim xwb, mob qog noj ntshav hauv lub mis HER2-negative yog tshwm sim los ntawm kev hloov pauv hauv cov noob caj noob ces, lossis DNA, hauv cov hlwb mis, hu ua kev hloov pauv , uas ua rau cov hlwb ntawd dhau los ua cov hlwb qog noj ntshav. Cov hlwb qog noj ntshav no ces faib thiab loj hlob sai yam tsis muaj kev tswj hwm, tsim cov qog nqaij hlav.

Cov Yam Uas Ua Rau Muaj Kev Pheej Hmoo

Cov kws tshaj lij tseem tsis tau paub tseeb tias qhov ua rau muaj cov kev hloov pauv caj ces no yog dab tsi hauv cov mob qog noj ntshav hauv lub mis HER2-negative. Txawm li cas los xij, lawv tau txheeb xyuas ntau yam uas tuaj yeem ua rau muaj kev pheej hmoo ntawm kev mob qog noj ntshav hauv lub mis feem ntau. Cov no suav nrog:

• Kev hloov pauv caj ces los ntawm noob caj ces : Tsis muaj kev hloov pauv caj ces tshwj xeeb uas cuam tshuam nrog mob qog noj ntshav hauv lub mis uas cuam tshuam nrog HER2. Txawm li cas los xij, yog tias ib tus neeg tau txais kev hloov pauv hauv cov noob caj ces xws li BRCA1 lossis BRCA2, lawv muaj feem yuav mob qog noj ntshav hauv lub mis (thiab qee yam mob qog noj ntshav) ntau dua.
• Koj lossis ib tug neeg hauv koj tsev neeg tau muaj mob qog noj ntshav hauv lub mis ua ntej lawm.Yog tias koj tau muaj mob qog noj ntshav hauv lub mis ua ntej lawm, koj muaj qee qhov kev pheej hmoo uas nws yuav rov qab los. Tsis tas li ntawd, yog tias koj cov txheeb ze ntshav (tshwj xeeb tshaj yog koj niam, txiv, cov kwv tij neej tsa, cov menyuam) tau muaj mob qog noj ntshav hauv lub mis, koj kuj muaj qee qhov kev pheej hmoo siab dua me ntsis.
• Kev raug tshuaj hormones estrogen lossis progesterone ntev : Yog tias koj pib koj thawj zaug muaj hli thaum koj tseem hluas (piv txwv li, ua ntej hnub nyoog 12 xyoos), lossis yog tias koj lub cev tsis muaj hli lig (piv txwv li, tom qab hnub nyoog 55 xyoos), koj lub cev tau raug cov tshuaj hormones no ntev heev. Qhov no kuj tuaj yeem yog ib qho kev pheej hmoo. Qee cov kev kho mob hloov tshuaj hormones kuj tseem tuaj yeem ua rau koj muaj kev pheej hmoo ntau ntxiv thaum siv sijhawm ntev.
• Kev haus dej cawv : Kev tshawb fawb pom tias haus ntau tshaj ib khob dej ib hnub kuj ua rau muaj kev pheej hmoo ntawm mob qog noj ntshav hauv lub mis.

Ntxiv rau qhov no, tej yam xws li hnub nyoog nce ntxiv, kev rog dhau, thiab tsis tawm dag zog kuj tseem tuaj yeem ua rau muaj kev pheej hmoo ntawm mob qog noj ntshav hauv lub mis feem ntau.

Yuav kuaj mob qog noj ntshav hauv lub mis HER2-negative li cas?

Feem ntau cov kws kho mob kuaj pom tias muaj mob qog noj ntshav hauv lub mis HER2-negative los ntawm kev kuaj lub mis . Qhov no suav nrog kev coj ib daim qauv me me (ib daim) ntawm cov nqaij los ntawm ib lub pob lossis thaj chaw uas muaj kev txhawj xeeb thiab xa mus rau chav kuaj mob. Nyob ntawd, tus kws kho mob kuaj xyuas cov qauv hauv qab lub tshuab microscope kom pom tias puas muaj cov hlwb qog noj ntshav.

Yog tias cov hlwb qog nqaij hlav raug kuaj pom tseeb lawm, ces yuav muaj kev kuaj tshwj xeeb los saib seb muaj pes tsawg tus protein 'HER2' nyob rau saum npoo ntawm cov hlwb qog nqaij hlav ntawd, lossis muaj pes tsawg daim qauv ntawm cov noob 'HER2' uas muaj nyob.

• Yog tias koj muaj cov protein lossis gene 'HER2' ib txwm (tsawg), koj muaj mob qog noj ntshav hauv lub mis 'HER2-negative'.

Ob qhov kev kuaj mob tseem ceeb uas tau ua rau lub hom phiaj no yog:

1. Kev Tshuaj Xyuas Kab Mob (IHC) : Qhov kev kuaj no siv cov tshuaj tiv thaiv kab mob thiab cov xim tshwj xeeb los ntes cov protein HER2 ntawm qhov chaw ntawm cov hlwb qog nqaij hlav. Yog tias qhov tshwm sim IHC yog 0 lossis 1+, tus mob qog nqaij hlav raug suav hais tias yog HER2-negative. Yog tias qhov tshwm sim yog 2+ (qee zaum hu ua "equivocal" lossis "borderline"), kev kuaj hu ua FISH kuj tseem ua los xyuas kom meej qhov xwm txheej HER2.

2. Kev kuaj mob Fluorescence in situ hybridization (FISH) : Qhov kev kuaj no saib seb muaj pes tsawg daim qauv ntawm HER2 gene, uas ua rau HER2 protein, muaj nyob rau hauv cov hlwb qog nqaij hlav. Qhov no siv lub tshuab microscope tshwj xeeb thiab cov cim fluorescent (lub teeb ci). Hauv cov xwm txheej uas qhov tshwm sim ntawm kev kuaj IHC tsis meej, xws li 2+, qhov kev kuaj FISH tuaj yeem lees paub qhov xwm txheej HER2 (tsis zoo lossis zoo).

Ntxiv rau cov kev kuaj 'HER2' no, tus kws kho mob kuj tseem yuav kuaj xyuas cov qauv biopsy thiab nrhiav seb puas muaj estrogen receptors (ETU) thiab progesterone receptors (PR) nyob rau hauv qog nqaij hlav.

Tej zaum koj yuav tsum tau ua cov txheej txheem thaij duab xws li mammogram, ultrasound, CT scan, lossis MRI scan kom paub txog theem ntawm koj tus mob qog noj ntshav (uas yog, kom pom tias tus mob qog noj ntshav loj npaum li cas thiab seb nws puas tau kis mus rau cov qog ntshav lossis lwm qhov chaw deb ntawm lub cev).

Koj tus kws kho mob yuav muab tag nrho cov ntaub ntawv no (HER2 status, HR status, mob qog noj ntshav theem, thiab cov yam ntxwv mob qog noj ntshav) los tsim cov phiaj xwm kho mob zoo tshaj plaws rau koj.

Cov kev kho mob rau mob qog noj ntshav hauv lub mis HER2-negative yog dab tsi?

Kev kho mob zoo tshaj plaws rau mob qog noj ntshav hauv lub mis HER2-negative yuav txawv ntawm ib tus neeg mus rau ib tus neeg. Nws nyob ntawm ntau yam, suav nrog theem ntawm koj tus mob qog noj ntshav, seb nws yog hormone receptor-positive lossis negative (HR+/HER2- lossis HR-/HER2-), thiab koj txoj kev noj qab haus huv tag nrho.

Feem ntau, kev kho mob yuav muaj xws li:

• Kev phais mob qog noj ntshav hauv lub mis : Kev tshem tawm cov qog noj ntshav thiab tej zaum qee cov nqaij noj qab nyob zoo nyob ib puag ncig nws. Qhov no tuaj yeem yog kev phais lumpectomy, uas tshem ib feem ntawm lub mis, lossis kev phais mastectomy, uas tshem tag nrho lub mis.
• Kev Kho Mob Hluav Taws Xob : Cov hluav taws xob muaj zog heev yog siv los rhuav tshem cov hlwb qog nqaij hlav uas tseem tshuav tom qab phais, lossis kom lub qog nqaij hlav me ua ntej phais.

Ntxiv rau cov kev kho mob yooj yim no, muaj lwm cov kev kho mob tshwj xeeb nyob ntawm hom mob qog noj ntshav:

Kev kho mob rau HR+/HER2- (hormone receptor-positive, HER2-negative) mob qog noj ntshav hauv lub mis

Vim tias hom mob qog noj ntshav no nyob ntawm cov tshuaj hormones, cov kev kho mob no kuj tseem ceeb ntxiv rau kev phais thiab / lossis kev kho mob hluav taws xob:

• Kev Kho Mob Hormone : Cov kev kho mob no ua haujlwm los ntawm kev txo cov tshuaj hormones estrogen lossis progesterone uas pab kom mob qog noj ntshav loj hlob, lossis los ntawm kev tiv thaiv cov tshuaj hormones ntawd kom tsis txhob khi rau cov hlwb qog noj ntshav. Piv txwv li:
• Cov tshuaj uas ua rau cov aromatase inhibitors (piv txwv li Anastrozole, Letrozole, Exemestane)
• Cov tshuaj agonists uas ua rau cov tshuaj hormones tso tawm los ntawm cov zes qe menyuam (GnRH) tsis ua haujlwm (tso tseg cov tshuaj hormones los ntawm cov zes qe menyuam)
• Cov tshuaj xaiv estrogen receptor modulators (SERMs) `(piv txwv li Tamoxifen, Raloxifene)

Muaj tej lub sij hawm, koj yuav tau phais (oophorectomy) kom tshem koj cov zes qe menyuam, uas tsim cov estrogen. Kev kho mob Hormone tuaj yeem muab ib leeg lossis ua ke nrog kev kho mob tsom mus rau ntau xyoo.

• Kev kho mob tsom mus rau : Cov kev kho mob no tsom mus rau qhov tsis muaj zog tshwj xeeb hauv cov hlwb qog noj ntshav thiab tawm tsam lawv kom tiv thaiv kev loj hlob thiab kev kis mus rau lwm qhov ntawm cov hlwb qog noj ntshav. Rau cov hlwb qog noj ntshav HR+/HER2-, cov tshuaj hu ua CDK4/6 inhibitors (piv txwv li Palbociclib, Ribociclib, Abemaciclib) yog siv ua ke nrog kev kho mob hormone. Cov no thaiv ib qho enzyme uas tswj kev faib ntawm cov hlwb qog noj ntshav.
• Kev Kho Mob Siv Tshuaj: Rau qee qhov mob qog noj ntshav hauv lub mis HR+/HER2, tshwj xeeb tshaj yog tias mob qog noj ntshav tau kis mus rau lwm qhov lossis hnyav heev, cov kws kho mob yuav pom zoo kom siv tshuaj kho mob nrog rau kev kho mob hormone thiab/lossis kev kho mob uas tsom mus rau qhov mob.

Kev kho mob qog noj ntshav mis HR-/HER2- (triple-negative)

Vim tias mob qog noj ntshav mis triple-negative tsis yog nyob ntawm cov tshuaj hormones, kev kho mob hormone tsis zoo. Ntxiv nrog rau kev phais thiab/lossis kev kho mob hluav taws xob, cov kev kho mob hauv qab no feem ntau yog siv:

• Kev Kho Mob Siv Tshuaj Kho Mob : Kev kho mob siv tshuaj kho mob yog ib txoj kev kho mob tseem ceeb heev rau mob qog noj ntshav peb zaug uas tsis muaj zog. Cov kws kho mob siv ntau hom tshuaj kho mob siv tshuaj kho mob sib txawv. Lawv yuav muab ib hom tshuaj lossis ntau hom tshuaj sib xyaw ua ke.
• Kev Kho Mob Tiv Thaiv Kab Mob : Qhov no yog ib txoj kev kho mob tshiab. Nws ua haujlwm los ntawm kev txhawb nqa koj lub cev lub cev tiv thaiv kab mob kom paub thiab rhuav tshem cov hlwb qog noj ntshav. Pembrolizumab (Keytruda®) yog ib hom tshuaj kho mob tiv thaiv kab mob uas tau pom zoo los ntawm Lub Chaw Haujlwm Saib Xyuas Khoom Noj thiab Tshuaj (FDA) thiab muab nrog rau kev kho mob chemotherapy rau qee hom mob qog noj ntshav mis triple-negative.
• Kev kho mob tsom rau cov qog nqaij hlav : Rau cov qog nqaij hlav peb zaug uas tsis zoo nrog kev hloov pauv ntawm BRCA gene, cov tshuaj tsom rau cov qog nqaij hlav hu ua PARP inhibitors (piv txwv li, Olaparib, Talazoparib) raug siv. Tsis tas li ntawd, rau cov kab mob kis mus rau lwm qhov, cov tshuaj kho mob tsom rau cov qog nqaij hlav tshiab (piv txwv li, cov tshuaj antibody-drug conjugates) tam sim no muaj.

Cov kev mob tshwm sim ntawm cov kev kho mob yog dab tsi?

Txawm hais tias kev kho mob qog noj ntshav tuaj yeem tawm tsam qog noj ntshav tau zoo, txhua yam kev kho mob, suav nrog kev siv tshuaj chemotherapy, kev kho mob hluav taws xob, kev kho mob hormone, kev kho mob targeted, thiab kev kho mob immunotherapy, tuaj yeem ua rau muaj qee qhov kev phiv. Cov no tuaj yeem yog ib ntus lossis ntev. Piv txwv li, qaug zog, xeev siab, ntuav, plaub hau poob, tsis xav noj mov, mob qhov ncauj, hloov pauv ntawm daim tawv nqaij, raws plab lossis cem quav, thiab cov qe ntshav qis.

Nco ntsoov nrog koj tus kws kho mob tham txog cov kev mob tshwm sim no, lawv yuav kav ntev npaum li cas, thiab yuav tswj lawv li cas. Lawv kuj tseem yuav xa koj mus rau cov kws kho mob tshwj xeeb . Kev kho mob palliative tsis yog rau theem kawg ntawm mob qog noj ntshav xwb, tab sis kuj pab koj tswj koj lub neej zoo los ntawm kev tswj cov tsos mob thiab cov kev mob tshwm sim thoob plaws kev kho mob.

Tus nqi kho mob rau mob qog noj ntshav hauv lub mis HER2-negative yog dab tsi?

Hauv txhua tus mob qog nqaij hlav mis HER2-negative, tus nqi ciaj sia nyob siab dua thaum tus mob qog nqaij hlav tsuas yog nyob rau hauv lub mis thiab tsis tau kis mus (theem hauv zos) dua li thaum tus mob qog nqaij hlav tau kis mus rau cov kabmob deb hauv lub cev (piv txwv li, siab, ntsws, hlwb, pob txha) (mob qog nqaij hlav kis mus rau lwm qhov lossis theem deb).Tus nqi ciaj sia rau cov mob qog nqaij hlav uas tsuas yog kis mus rau cov qog ntshav ze xwb tab sis tsis tau kis mus rau cov kabmob nyob deb (theem cheeb tsam) yog qhov chaw nyob nruab nrab.

Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias koj txoj kev pheej hmoo ntawm kev rov zoo, lossis kev kwv yees, nyob ntawm cov yam ntxwv tshwj xeeb rau koj qhov kev kuaj mob. Cov no suav nrog seb tus mob qog noj ntshav tau kis mus deb npaum li cas (theem), seb tus mob qog noj ntshav puas muaj cov tshuaj hormones receptor status (HR+/HER2- lossis HR-/HER2-), cov qog noj ntshav ua phem npaum li cas (qib), koj lub hnub nyoog, kev noj qab haus huv tag nrho, thiab koj teb li cas rau kev kho mob. Cov no yog cov khoom uas koj tus kws kho mob tuaj yeem tham nrog koj txog thiab piav qhia rau koj txog yam yuav tsum tau cia siab. Cov ntaub ntawv tsuas yog qhov nruab nrab xwb, thiab lawv yuav tsis zoo ib yam rau txhua tus.

Kuv yuav saib xyuas kuv tus kheej li cas? (Kev saib xyuas tus kheej)

Txawm koj yog ib tus neeg uas muaj mob qog noj ntshav hauv lub mis HER2-negative theem pib lossis ib tus neeg uas muaj mob qog noj ntshav theem siab, nws yog ib qho tseem ceeb uas yuav tsum siv sijhawm los saib xyuas koj tus kheej. Qhov no yuav pab tau koj ob qho tib si lub cev thiab lub hlwb. Nov yog qee yam uas koj tuaj yeem ua tau:

• So thaum koj xav tau : Nws yog ib qho ib txwm muaj uas koj yuav xav tias nkees thiab qaug zog, ob qho tib si los ntawm mob qog noj ntshav thiab kev kho mob qog noj ntshav. Thaum koj xav tias nkees, so thiab so. Mloog koj lub cev.
• Noj zaub mov kom noj qab nyob zoo thiab muaj txiaj ntsig zoo : Qee cov kev kho mob qog noj ntshav tuaj yeem cuam tshuam rau koj txoj kev ntshaw thiab kev saj. Tab sis sim noj zaub mov kom sib npaug kom tau txais cov as-ham uas koj lub cev xav tau. Muaj txiv hmab txiv ntoo, zaub, fiber, thiab cov khoom noj uas muaj protein ntau. Yog tias koj tsis paub meej tias yuav noj cov khoom noj dab tsi thiab cov khoom noj dab tsi tsis yog, nrog tus kws noj zaub mov tham kom tau lus qhia.
• Kev Ua Si (tab sis tsis txhob ua ntau dhau) : Nws yog ib qho tseem ceeb uas yuav tsum ua kev tawm dag zog tsis tu ncua rau qib uas haum rau koj, raws li koj tus kws kho mob pom zoo. Txawm tias taug kev me me lossis yoga kuj tuaj yeem zoo. Nws tuaj yeem ua rau koj lub zog muaj zog, txhim kho koj lub siab, thiab pab txo cov kev phiv. Txawm li cas los xij, nug koj tus kws kho mob seb hom kev tawm dag zog twg haum rau koj thiab koj yuav tsum ua ntau npaum li cas, raws li koj qhov kev kuaj mob thiab kev kho mob.
• Tswj kev ntxhov siab : Nws yog ib qho ib txwm muaj uas yuav muaj kev ntxhov siab, ntxhov siab, thiab ntshai nrog tus kab mob zoo li no. Nrhiav txoj hauv kev los tswj nws uas ua haujlwm rau koj. Txawm hais tias kev xav thiab kev ua pa ua haujlwm rau qee tus, lwm tus yuav nyiam koom nrog cov haujlwm muaj tswv yim xws li nyeem phau ntawv, mloog nkauj, kos duab, lossis ua teb. Teem sijhawm txhua hnub rau txhua yam kev ua ub no uas pab koj xav tias so thiab so.
• Tau txais kev txhawb nqa kev puas siab puas ntswsNws yog ib qho tseem ceeb uas yuav tsum tham txog koj txoj kev xav nrog tsev neeg thiab cov phooj ywg zoo. Nws kuj tseem yuav pab tau koj kom koj sib txuas lus nrog lwm tus neeg uas kuaj pom tias muaj mob qog noj ntshav thiab qhia lawv tej kev paub dhau los. Nug koj tus kws kho mob txog cov pab pawg txhawb nqa lossis cov kev pab cuam kom dim ntawm mob qog noj ntshav.

Kuv yuav tsum mus ntsib kws kho mob thaum twg?

Nws yog ib qho tseem ceeb heev uas yuav tsum sib txuas lus nrog koj tus kws kho mob tas li, thaum lub sijhawm kho mob thiab tom qab kho mob.

• Yog tias koj muaj cov tsos mob tshiab (piv txwv li, mob tas li, muaj pob tshiab, ua pa nyuaj, poob phaus yam tsis paub meej), lossis yog tias koj cov tsos mob tam sim no zoo li hnyav zuj zus , mus ntsib lossis qhia rau koj tus kws kho mob tam sim ntawd .
• Tom qab kho mob tas, koj tus kws kho mob yuav teem sijhawm mus ntsib kws kho mob tas li . Xyuas kom koj ua raws li cov sijhawm teem tseg no. Cov no yog los xyuas seb puas rov qab muaj mob dua, tswj cov kev phiv los ntawm kev kho mob mus sij hawm ntev, thiab xyuas koj txoj kev noj qab haus huv tag nrho. Cov sijhawm teem tseg no tseem ceeb heev thaum tsib xyoos tom qab kho mob . Qhov no yog thaum mob qog noj ntshav feem ntau rov qab tshwm sim.

Kuv yuav tsum nug kuv tus kws kho mob li cas?

Thaum koj nrog koj tus kws kho mob tham, tsis txhob ntshai nug tej lus nug uas koj muaj, txawm tias me me los xij. Nov yog qee cov lus nug uas koj tuaj yeem nug los pab koj:

• Kuv tus mob qog noj ntshav hormone receptor puas zoo los yog tsis zoo?
• Hom mob qog noj ntshav thiab theem twg ntawm kuv tus mob qog noj ntshav?
• Koj xav kom kuv kho li cas? Vim li cas?
• Cov kev kho mob no yuav muaj tej yam tshwm sim luv luv thiab ntev li cas? Yuav ua li cas thiaj li txo tau tej yam tshwm sim no?
• Kev kho mob yuav siv sijhawm ntev npaum li cas?
• Koj tuaj yeem qhia kuv dab tsi txog kuv qhov kev kwv yees?
• Kuv puas tuaj yeem ua kuv tej haujlwm niaj hnub (ua haujlwm, ua haujlwm hauv tsev) thaum lub sijhawm kho mob?
• Puas muaj tej yam tshwj xeeb uas kuv yuav tsum tau ua tib zoo saib xyuas txog kuv txoj kev noj haus thiab kev tawm dag zog?
• Kuv ua tau dab tsi los txo qhov kev pheej hmoo ntawm kev mob qog noj ntshav rov qab los?
• Yog tias kuv xav tau kev pab txhawb nqa lossis kev qhia tswv yim, kuv puas tuaj yeem tau txais kev xa mus rau nws?

Nws yog ib lub tswv yim zoo kom sau cov lus nug no cia thiab nug lawv, yog li koj yuav tsis hnov ​​qab dab tsi.

Puas zoo dua yog HER2-positive los yog negative?

Qhov no yog ib lo lus nug uas ntau tus neeg nug. Tab sis nws nyuaj rau muab cov lus teb yooj yim rau qhov no, vim qhov tseeb yog tias nws 'nyob ntawm' .

Piv txwv li, cov mob qog noj ntshav hauv lub mis HER2-positive feem ntau loj hlob sai dua thiab hnyav dua li cov mob qog noj ntshav HER2-negative. Txawm li cas los xij, muaj qhov zoo rau qhov no. Muaj cov kev kho mob tshwj xeeb uas tuaj yeem tsom mus rau cov protein HER2, piv txwv li, Herceptin, Perjeta, thiab lawv zoo heev rau cov mob qog noj ntshav HER2-positive. Cov kev kho mob no tsis ua haujlwm rau cov mob qog noj ntshav HER2-negative, vim tias cov mob qog noj ntshav ntawd tsis muaj protein HER2 ntau npaum li cas los tsom mus rau.

Ntawm qhov tod tes, yog tias mob qog noj ntshav 'HER2-negative' yog 'HR+' (hormone receptor-positive), uas yog, hom 'HR+/HER2-', ces muaj cov kev kho mob hormone zoo heev thiab cov kev kho mob tsom mus rau lub hom phiaj xws li 'CDK4/6 inhibitors'. Qhov tseeb, mob qog noj ntshav mis 'HR+/HER2-' raug suav hais tias muaj qhov kev kwv yees zoo tshaj plaws ntawm cov hom mob qog noj ntshav mis uas twb muaj lawm.

Tiam sis yog tias tus mob qog noj ntshav yog 'HER2-negative' (HR-) (hormone receptor-negative), uas yog, triple-negative, feem ntau nws tuaj yeem ua rau mob hnyav dua li lwm hom, thiab kev kho mob tuaj yeem nyuaj me ntsis. Tab sis tam sim no muaj chemotherapy, immunotherapy, thiab cov kev kho mob tshiab rau qhov ntawd thiab.

Yog li ntawd, nws tsis tuaj yeem hais tias ib qho "zoo dua" lossis "phem dua" dua li lwm qhov. Qhov tseem ceeb tshaj plaws yog txheeb xyuas qhov subtype ntawm koj tus mob qog noj ntshav thiab tau txais kev kho mob zoo tshaj plaws uas tsim nyog rau nws.

Thaum kawg, kuv yuav tsum qhia rau koj ... (Cov Lus Coj Mus Tsev)

Thaum koj raug kuaj pom tias muaj mob qog noj ntshav hauv lub mis 'HER2-negative', nws yog ib qho ib txwm muaj uas koj yuav ntshai thiab ntxhov siab. Tab sis nco ntsoov, qhov no tsis yog qhov kawg ntawm lub ntiaj teb. Kev tshawb fawb thiab kev kho mob thev naus laus zis tau nce qib heev niaj hnub no, thiab muaj ntau txoj kev kho mob zoo rau hom mob qog noj ntshav no.

Qhov tseem ceeb tshaj plaws yog:

• Paub txog qhov xwm txheej no kom zoo.
• Nco ntsoov paub txog kev hloov pauv hauv koj lub cev, tshwj xeeb yog koj lub mis.
• Yog koj muaj lus nug dab tsi, mus ntsib kws kho mob raws sijhawm thiab mus kuaj mob.
• Tham nrog koj tus kws kho mob yam qhib siab thiab ncaj ncees, nug tag nrho koj cov lus nug, thiab nkag siab zoo txog cov kev kho mob.

Nco ntsoov tias, koj tsis yog tib tug neeg uas nyob hauv txoj kev no. Muaj cov kws kho mob, cov kws tu mob, koj tsev neeg, thiab koj cov phooj ywg zoo tshaj plaws uas nyob ntawd los pab thiab txhawb nqa koj. Ua kom koj muaj lub siab zoo, ua raws li koj cov kws kho mob cov lus qhia, thiab tau txais kev txhawb nqa uas koj xav tau, thiab koj yuav muaj peev xwm daws qhov teeb meem no tau zoo thiab rov zoo. Thov kom koj muaj zog!

` Mob qog noj ntshav hauv lub mis, HER2-negative, cov tsos mob ntawm mob qog noj ntshav, kev kho mob qog noj ntshav, kev noj qab haus huv ntawm cov poj niam, kev kho mob hormone, triple-negative