Kuv paub tias nws nyuaj rau piav qhia rau hauv cov lus txog koj qhov kev xav thaum koj tus kws kho mob qhia rau koj tias koj muaj mob qog noj ntshav hauv lub mis. Nws yog ib qho ib txwm muaj ntau cov lus nug thiab kev ntshai los rau hauv koj lub siab. Tab sis ib qho tseem ceeb tshaj plaws uas tuaj yeem pab koj hla txoj kev nyuaj no yog kev nkag siab txog qhov xwm txheej tseeb ntawm koj tus mob qog noj ntshav. Kev paub txog theem ntawm tus mob qog noj ntshav, nws hom, nws qhov loj me, thiab qee cov protein hauv koj cov hlwb qog noj ntshav yog qhov tseem ceeb heev rau kev txiav txim siab txog kev kho mob.
Hais yooj yim xwb, HER2-Negative yog dab tsi?
Cia peb nkag siab qhov no li no. Cov cell hauv peb lub cev zoo li cov tsev me me. Cov tsev no muaj cov 'antennas' tshwj xeeb uas tau txais cov lus los ntawm sab nraud. Hauv kev kho mob, peb hu cov receptors no. Nws yog los ntawm cov antennas no uas ib lub cell tau txais cov lus zoo li 'kom loj hlob' thiab 'kom faib'.
HER2 (Human Epidermal Growth Factor Receptor 2) yog ib qho tshwj xeeb antenna. HER2 pab tswj kev loj hlob ntawm cov cell noj qab haus huv. Txawm li cas los xij, cov cell mob qog noj ntshav qee zaum ua ntau dhau ntawm HER2 antenna no, ntau dua li qub. Tom qab ntawd tus mob qog noj ntshav tau txais cov lus tas li qhia nws kom 'loj hlob', thiab tus mob qog noj ntshav pib kis mus sai heev. Peb hu qhov mob no ua HER2-Positive .
Yog li, yog tias koj tus kws kho mob hais tias koj tus mob qog nqaij hlav mis yog HER2-negative , qhov ntawd txhais tau tias koj cov qog nqaij hlav tsis muaj lub kav hlau txais xov HER2 ntxiv no. Hais yooj yim, koj tus mob qog nqaij hlav tsis muaj ib qho tseem ceeb uas ua rau nws loj hlob sai dua.
Qhov no yeej yog xov xwm zoo rau qee qhov, vim tias cov mob qog nqaij hlav HER2-negative feem ntau tsis hnyav npaum li cov mob qog nqaij hlav HER2-positive. Feem ntau ntawm cov mob qog nqaij hlav mis hauv ntiaj teb raug cais ua HER2-negative.
Koj paub tseeb li cas txog qhov xwm txheej HER2 ntawm koj tus mob qog noj ntshav?
Cov tsos mob ntawm ob hom mob qog nqaij hlav HER2-negative thiab HER2-positive zoo sib xws. Koj tus kws kho mob tsis tuaj yeem qhia koj tias koj muaj hom twg los ntawm kev kuaj koj tus kheej xwb. Nws yuav tsum tau coj ib qho qauv me me ntawm koj lub qog nqaij hlav (biopsy) thiab kom kuaj nws. Qhov kev kuaj no yuav txiav txim siab seb muaj pes tsawg tus protein HER2 nyob hauv cov hlwb qog nqaij hlav.
Peb yuav tsum tau saib ntau dua li HER2 xwb!
HER2 tsis yog tib yam uas cuam tshuam rau kev loj hlob ntawm mob qog noj ntshav. Muaj ob hom receptors ( hormone receptors - HR) hauv peb lub cev uas rhiab rau cov tshuaj hormones.
- Cov Tshuaj Estrogen (ER)
- Cov tshuaj Progesterone Receptors (PR)
Yog tias cov receptors no muaj nyob rau ntawm cov hlwb qog nqaij hlav, cov tshuaj hormones estrogen thiab progesterone tuaj yeem pab kom qog nqaij hlav loj hlob. Cov kws kho mob tham txog tag nrho cov receptors no ua ke. Qhov no txhais tau tias koj tus mob qog nqaij hlav HER2-negative tuaj yeem muab faib ua ob hom:
1. HR-Positive / HER2-Negative: Qhov no txhais tau hais tias tus mob qog noj ntshav tsis rhiab rau HER2, tab sis rhiab rau cov tshuaj hormones. Qhov no yog hom mob qog noj ntshav mis uas feem ntau pom .
2. HR-Negative / HER2-Negative: Qhov no txhais tau hais tias tus mob qog nqaij hlav tsis rhiab rau HER2 lossis cov tshuaj hormones. Vim tias tag nrho peb ntawm cov receptors no (HER2, ER, PR) ploj lawm, hom no kuj hu ua Triple Negative .
Kev paub txog txhua yam no yuav pab koj thiab koj tus kws kho mob kom pom tseeb dua txog tus cwj pwm ntawm koj tus mob qog noj ntshav, uas yuav pab koj xaiv txoj kev kho mob zoo tshaj plaws thiab zoo tshaj plaws rau koj.
Cov kev kho mob rau HER2-negative cancer yog dab tsi?
Vim tias koj tus mob qog noj ntshav yog HER2-negative, koj yuav tsis tau txais kev kho mob uas tsom mus rau HER2 protein. Qhov ntawd yog vim tias cov tshuaj yuav tsum muaj lub kav hlau txais xov HER2 ntawm cov hlwb qog noj ntshav kom ua haujlwm. Hloov chaw, lwm yam kev kho mob yuav raug xaiv raws li theem ntawm koj tus mob qog noj ntshav thiab seb nws puas rhiab rau cov tshuaj hormones.
- Kev Phais Mob thiab Kev Siv Hluav Taws Xob: Yog tias pom muaj mob qog noj ntshav thaum ntxov, kev phais mob tuaj yeem tshem tawm tag nrho. Kev kho mob hluav taws xob kuj tseem yuav raug pom zoo ua ntej lossis tom qab phais mob.
- Kev kho mob Endocrine/ Hormone : Kev kho mob no tseem ceeb heev yog tias koj tus mob qog noj ntshav yog HR-Positive/HER2-Negative. Nws ua haujlwm los ntawm kev txo cov tshuaj hormones xws li estrogen hauv lub cev. Thaum cov tshuaj hormones ploj mus, cov hlwb qog noj ntshav poob cov lus kom loj hlob, thiab tus mob qog noj ntshav yuav ntsws lossis tsis loj hlob lawm.
- Kev Kho Mob Siv Tshuaj Kho Mob: Qee zaum kev kho mob siv tshuaj kho mob tuaj yeem muab ua ke nrog kev kho mob hormone rau cov mob qog noj ntshav HR-positive / HER2-negative. Qhov no nyob ntawm cov yam xws li theem thiab qib ntawm mob qog noj ntshav, koj lub hnub nyoog, thiab koj txoj kev noj qab haus huv tag nrho. Qee zaum cov kev phiv ntawm kev kho mob siv tshuaj kho mob tuaj yeem ntau dua li cov txiaj ntsig, yog li nws tseem ceeb heev uas yuav tsum tham nrog koj tus kws kho mob txog qhov zoo tshaj plaws rau koj.
- Kev Kho Mob Tiv Thaiv Kab Mob: Yog tias koj tus mob qog noj ntshav tsis zoo thiab mob hnyav heev, thiab muaj lwm cov protein hu ua PD-L1, kev kho mob no yuav yog ib qho kev xaiv. Nws ua haujlwm los ntawm kev txhawb koj lub cev tiv thaiv kab mob kom tawm tsam tus mob qog noj ntshav.
Kev kwv yees thiab kev kwv yees
Qhov tseem ceeb tshaj plaws txog mob qog noj ntshav hauv lub mis yog nrhiav nws ua ntej nws kis mus rau lwm qhov ntawm lub cev. Yog tias koj tus mob qog noj ntshav HER2-negative nyob hauv lub mis, tus nqi ciaj sia nyob 5 xyoos yog siab heev. Qhov no yog qhov tseeb tshwj xeeb yog tias koj tus mob qog noj ntshav yog HR-positive.
Cov mob qog nqaij hlav triple-negative nyuaj kho dua me ntsis vim tias lawv tsis teb rau kev kho mob hormonal lossis kev kho mob HER2. Lawv kuj tseem tuaj yeem ua rau mob hnyav dua.
Hauv qab no yog cov feem pua ntawm cov neeg uas muaj sia nyob tau 5 xyoos raws li theem ntawm tus mob qog noj ntshav. Cov no tsuas yog qhov nruab nrab xwb, nco ntsoov tias koj tus kheej qhov xwm txheej yuav txawv.
| Hom mob qog noj ntshav | Nws tau kis mus li cas | Kev muaj sia nyob 5 xyoos ntawm tus txheeb ze |
|---|---|---|
| HR-Zoo / HER2-Tsis Zoo (Hom feem ntau) | Txwv rau lub mis (Localized) | 100% |
| Kis mus rau cov qog ntshav ze (cheeb tsam) | 90% | |
| Nyob deb | 31% | |
| Triple-Negative (HR-Tsis Zoo / HER2-Tsis Zoo) | Txwv rau lub mis (Localized) | 91% |
| Kis mus rau cov qog ntshav ze (cheeb tsam) | 65% | |
| Nyob deb | 12% |
Tsis txhob ntshai cov lej no. Cov no tsuas yog qhov nruab nrab ntawm ntau txhiab tus neeg xwb. Koj tus kheej txoj kev xav yuav nyob ntawm ntau yam, suav nrog koj lub cev teb li cas rau kev kho mob thiab koj txoj kev noj qab haus huv tag nrho. Yog li, qhib siab nrog koj tus kws kho mob txog koj tus mob thiab lwm yam kev kuaj mob ntxiv uas koj xav tau.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- HER2-Negative txhais tau tias koj cov qog nqaij hlav tsis muaj cov protein tseem ceeb uas ua rau lawv loj hlob sai dua. Qhov no feem ntau ua rau cov qog nqaij hlav no tsis tshua muaj zog.
- Txawm tias koj tus mob qog nqaij hlav yog HER2-negative los xij, kev paub seb nws puas rhiab rau cov tshuaj hormones (HR-positive) lossis tsis yog (HR-negative) yog qhov tseem ceeb rau kev txiav txim siab txog kev kho mob.
- Cov kev xaiv kho mob nyob ntawm hom mob qog noj ntshav thiab theem ntawm tus mob qog noj ntshav, thiab koj tus kheej txoj kev noj qab haus huv. Kev phais mob, kev siv hluav taws xob kho, kev kho tshuaj hormones, thiab kev kho mob chemotherapy yog cov kev kho mob tseem ceeb.
- Kev sib ntaus sib tua nrog mob qog noj ntshav no tsis yog ib yam dab tsi uas koj yuav tsum ua ib leeg xwb. Tham nrog koj tus kws kho mob txog tag nrho koj cov lus nug thiab kev ntshai. Kev muaj cov ntaub ntawv raug yog koj lub zog loj tshaj plaws hauv txoj kev no.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus