HNPCC (Kab Mob Cancer Hauv Txoj Hnyuv Uas Tsis Yog Polyposis Los Ntawm Txoj Hnyuv) yog dab tsi? Puas muaj keeb kwm mob qog noj ntshav hauv koj tsev neeg?

Qee zaum peb pom tias ntau tus tswv cuab hauv tsev neeg muaj tib hom mob qog noj ntshav. Los yog lawv hais tias cov tswv cuab hauv tib tsev neeg muaj feem yuav mob qog noj ntshav ntau dua. Qhov ntawd yog qhov peb yuav tham txog hnub no. Txawm hais tias qhov no yog ib qho teeb meem nyuaj me ntsis, cia peb sim nkag siab yooj yim.

HNPCC thiab Lynch Syndrome yog dab tsi?

Hais yooj yim xwb, HNPCC (Hereditary Nonpolyposis Colorectal Cancer) yog ib hom mob qog nqaij hlav colorectal uas tshwm sim los ntawm kev hloov pauv caj ces. Qhov no yog vim qee cov noob caj ces uas peb tau txais los ntawm peb niam peb txiv ua rau peb muaj feem yuav mob qog nqaij hlav ntau dua.

Tej zaum koj twb tau hnov ​​txog Lynch syndrome, uas tseem hu ua Lynch syndrome . HNPCC thiab Lynch syndrome yeej muaj feem cuam tshuam, tab sis lawv tsis zoo ib yam. Peb xa mus rau HNPCC ua mob qog nqaij hlav ntsig txog Lynch syndrome uas kuaj pom ua ntej hnub nyoog 50 xyoo. Qhov no tsis yog tsuas yog mob qog nqaij hlav plab hnyuv xwb, tab sis kuj yog mob qog nqaij hlav ntawm lub tsev menyuam (endometrium), txoj hnyuv me, ureter, thiab lub raum pelvis. Hauv HNPCC, mob qog nqaij hlav feem ntau tshwm sim rau sab xis ntawm txoj hnyuv.

HNPCC feem ntau npaum li cas?

HNPCC yog tus kab mob qog nqaij hlav ntawm txoj hnyuv loj (colorectal cancer). Nws tuaj yeem tshwm sim rau txhua lub hnub nyoog, tab sis feem ntau cov tsos mob tshwm sim thiab kuaj pom tus kab mob ua ntej hnub nyoog 50 xyoo.

Cov tsos mob ntawm HNPCC yog dab tsi?

Thaum pib mob, HNPCC yuav tsis ua rau muaj tsos mob dab tsi. Qhov no txhais tau tias tus mob qog noj ntshav tuaj yeem loj hlob hauv koj lub cev yam tsis muaj koj hnov ​​dab tsi li. Tab sis thaum tus mob qog noj ntshav loj hlob tuaj, koj yuav muaj cov tsos mob xws li:

• Mob plab los yog o.
• Cov zaub mov tsis qab.
• Ntshav nyob rau hauv cov quav. (Qhov no yog ib qho cim tseem ceeb heev, tsis txhob tsis quav ntsej nws!)
• Xav tias nkees txhua lub sijhawm (Qaug zog).
• Poob phaus yam tsis muaj laj thawj pom tseeb.

Dab tsi yog cov ua rau muaj HNPCC?

Raws li peb tau hais ua ntej lawm, HNPCC yog tshwm sim los ntawm kev hloov pauv ntawm cov noob caj noob ces uas tau txais los ntawm peb niam peb txiv. Thaum cov teeb meem no tau kis mus rau ib tiam dhau ib tiam, qhov kev pheej hmoo ntawm kev mob qog noj ntshav yuav nce ntxiv hauv tsev neeg ntawd. Peb hu qhov no ua 'mob qog noj ntshav hauv tsev neeg'.

Tus mob qog nqaij hlav hauv tsev neeg tseem ceeb uas ua rau muaj HNPCC yog Lynch syndrome . Nws yog tshwm sim los ntawm kev hloov pauv hauv cov noob MLH1, MSH2, MSH6, PMS2, thiab EPCAM . Lub luag haujlwm ntawm cov noob no yog kho cov qhov yuam kev uas tshwm sim thaum lub sijhawm DNA replication thaum peb cov cell faib. Xav txog, yog tias cov noob no tsis ua haujlwm zoo, cov qhov yuam kev ntawd tsis raug kho. Tom qab ntawd qhov muaj feem yuav ua rau cov cell ib txwm muaj cov cell mob qog nqaij hlav ntau dua.

HNPCC puas kis tau?

Tsis yog, HNPCC tsis yog ib yam kab mob sib kis tau. Qhov no txhais tau tias nws tsis kis tau ntawm ib tus neeg mus rau lwm tus los ntawm kev kov lossis txham. Txawm li cas los xij, qhov kev hloov pauv ntawm cov noob caj noob ces uas ua rau HNPCC yog kis mus los ntawm ib tiam mus rau ib tiam . Yog li ntawd, ntau tus tswv cuab ntawm tsev neeg uas muaj qhov kev hloov pauv ntawm cov noob caj noob ces no yuav muaj mob qog nqaij hlav plab lossis lwm yam mob qog nqaij hlav uas cuam tshuam nrog Lynch syndrome.

Qhov tseem ceeb yog tias cov noob caj noob ces tsis zoo no thiab qhov kev pheej hmoo ntawm kev tsim HNPCC tuaj yeem tau txais los ntawm niam txiv mus rau menyuam yaus.

Cov kws kho mob kuaj mob qog nqaij hlav li cas?

Feem ntau cov kws kho mob yuav kuaj lub cev kom paub seb puas muaj mob qog nqaij hlav hauv plab hnyuv. Tom qab ntawd lawv pom zoo kom ua qhov kev kuaj mob plab hnyuv , uas yog kev ntxig ib lub raj me me, ci ntsa iab los ntawm koj lub qhov quav los kuaj sab hauv ntawm koj lub plab hnyuv.

Yog tias leej twg hauv koj tsev neeg muaj HNPCC, koj yuav tsum qhia rau koj tus kws kho mob paub . Nws tseem ceeb heev.

Yuav ua li cas thiaj kuaj tau kom paub tseeb tias HNPCC yog dab tsi?

Koj tus kws kho mob yuav pom zoo kom kuaj cov noob caj noob ces kom paub seb koj puas muaj kev hloov pauv ntawm cov noob caj noob ces uas cuam tshuam nrog Lynch syndrome. Koj tus kws kho mob kuj tseem yuav nug txog:

• Puas muaj leej twg hauv koj tsev neeg (niam, txiv, kwv tij neej tsa) puas tau muaj mob qog nqaij hlav plab hnyuv? Tshwj xeeb tshaj yog tias kuaj pom tias muaj mob ua ntej hnub nyoog 50 xyoo.
• Nws kuj tseem ua kom koj tsis muaj lwm yam mob qog nqaij hlav hnyuv loj uas yog los ntawm noob caj noob ces hu ua Familial Adenomatous Polyposis (FAP) , uas yog los ntawm kev hloov pauv caj ces txawv ntawm HNPCC.

Puas yog phais mob rau HNPCC?

Yog, HNPCC feem ntau kho nrog kev phais. Kev phais no hu ua colectomy . Nws cuam tshuam nrog kev tshem tawm ib feem lossis tag nrho ntawm txoj hnyuv loj. Muaj ntau hom kev phais:

• Kev phais ib feem ntawm txoj hnyuv lossis kev phais ib feem ntawm txoj hnyuv: Hauv qhov no, tsuas yog ib feem ntawm txoj hnyuv uas muaj mob qog noj ntshav raug tshem tawm xwb.
• Proctectomy: Qhov no suav nrog kev tshem tawm cov hnyuv loj thiab qhov quav.
• Tag Nrho Cov Hnyuv Loj: Hauv qhov no, tag nrho cov hnyuv loj raug tshem tawm.

Muaj lwm yam kev kho mob dab tsi rau HNPCC?

Yog tias mob qog nqaij hlav hauv plab tau kis mus rau lwm qhov ntawm lub cev (metastasized), koj tus kws kho mob yuav pom zoo kom siv cov kev kho mob xws li:

• Kev kho mob qog noj ntshav: Qhov no suav nrog kev muab tshuaj los rhuav tshem cov hlwb qog noj ntshav.
• Kev kho mob tiv thaiv kab mob: Qhov no cuam tshuam txog kev txhawb nqa peb lub cev lub cev tiv thaiv kab mob kom tawm tsam cov hlwb qog noj ntshav.

Cov kws kho mob feem ntau nyiam kev kho mob tiv thaiv kab mob vim tias nws feem ntau ua haujlwm tau zoo dua thiab muaj tsawg dua cov kev mob tshwm sim.

Puas tuaj yeem tiv thaiv HNPCC tau?

Cov mob qog noj ntshav hauv tsev neeg no yog tshwm sim los ntawm kev hloov pauv caj ces uas tau txais los ntawm noob caj ces. Yog li ntawd, tsis muaj txoj hauv kev los tiv thaiv cov kev hloov pauv caj ces no kom tsis txhob tshwm sim . Txawm li cas los xij, yog tias ib tug neeg hauv koj tsev neeg muaj Lynch syndrome lossis HNPCC, nws yog ib qho tseem ceeb heev uas yuav tsum tham nrog koj tus kws kho mob txog seb koj puas yuav tsum tau kuaj caj ces.

Kev kuaj mob tsis tu ncua thiab, yog tias tsim nyog, kev phais tiv thaiv tuaj yeem txo qhov kev pheej hmoo ntawm kev tuag rau cov neeg uas muaj HNPCC.

Kuv yuav paub li cas yog tias kuv muaj feem yuav mob HNPCC?

Yog tias kev kuaj noob caj noob ces lees paub tias koj muaj kev hloov pauv ntawm noob caj noob ces uas cuam tshuam nrog Lynch syndrome, koj tus kws kho mob yuav pom zoo kom kuaj mob qog nqaij hlav colorectal pib thaum koj muaj hnub nyoog 20 xyoo . Yog tias kuaj pom mob qog nqaij hlav thaum ntxov, txoj kev kho mob yuav zoo dua.

Yog tias kuv muaj HNPCC, kuv yuav tsum tau tos dab tsi ntxiv?

Yog koj muaj HNPCC, tej zaum koj yuav muaj feem yuav mob qog noj ntshav lwm yam uas cuam tshuam nrog HNPCC ntau dua. Yog li ntawd, koj tus kws kho mob kuj tseem yuav kuaj xyuas koj cov qog noj ntshav no tas li:

• Mob qog nqaij hlav hauv hlwb
• Mob qog nqaij hlav
• Mob qog nqaij hlav
• Mob qog nqaij hlav zes qe menyuam
• Mob qog noj ntshav hauv plab
• Mob qog nqaij hlav
• Mob qog nqaij hlav hauv tsev menyuam/Endometrial

Puas kho tau HNPCC?

Kab mob Lynch syndrome no kho tsis tau tag nrho vim nws yog ib yam mob uas los ntawm noob caj noob ces. Txawm li cas los xij, kev phais kom tshem tag nrho cov hnyuv loj (total colectomy) tuaj yeem kho HNPCC thiab tiv thaiv kev loj hlob ntawm mob qog nqaij hlav hnyuv loj .

Cov neeg uas muaj HNPCC yuav muaj mob li cas?

Kwv yees li ntawm 60% ntawm cov neeg uas kuaj pom tias muaj tus kab mob HNPCC tseem muaj sia nyob tom qab tsib xyoos . Qhov ntawd txhais tau tias 60 ntawm 100 tus neeg mob tseem muaj sia nyob tsib xyoos tom qab lawv kuaj pom tias muaj tus kab mob HNPCC. Feem pua ​​​​​​ntawm cov neeg uas muaj tus kab mob Lynch syndrome muaj sia nyob hauv 10 xyoo yog nruab nrab ntawm 70% thiab 88%. Cov ntaub ntawv no yuav zoo li txaus ntshai, tab sis nco ntsoov tias nrog kev kuaj pom thaum ntxov thiab kev kho mob kom zoo, qhov mob no tuaj yeem tswj tau feem ntau .

Kuv yuav saib xyuas kuv tus kheej li cas yog tias kuv muaj HNPCC?

Yog koj muaj tej yam tsos mob tshiab ntawm mob qog noj ntshav hauv plab hnyuv, qhia rau koj tus kws kho mob tam sim ntawd . Yuav kom pab tiv thaiv tau mob qog noj ntshav hauv plab hnyuv, koj ua tau cov no:

• Tsis txhob haus luam yeeb.
• Noj zaub mov kom noj qab nyob zoo.
• Ua si nawv tsis tu ncua.
• Tau txais txhua yam kev kuaj mob qog noj ntshav uas koj tus kws kho mob pom zoo.
• Txwv kev haus cawv.
• Tswj koj qhov hnyav kom noj qab nyob zoo.

Puas yog kuv tus menyuam muaj feem yuav mob HNPCC?

Yog koj muaj Lynch syndrome, koj tus menyuam muaj 50% feem pua ​​uas yuav tau txais cov noob caj noob ces uas ua rau nws hloov pauv. Qhov no txhais tau tias yog koj muaj ob tug menyuam, ib tug yuav tau txais cov noob caj noob ces thiab lwm tus yuav tsis tau. Yog tias cov noob caj noob ces hloov pauv no yog los ntawm kev yug los, tus menyuam ntawd muaj feem yuav mob HNPCC ntau dua.

Cov mob qog nqaij hlav FAP thiab HNPCC puas zoo ib yam?

HNPCC thiab FAP (Familial Adenomatous Polyposis) yog ob hom mob qog nqaij hlav hauv plab hnyuv uas muaj keeb kwm los ntawm noob caj ces, tab sis lawv yog tshwm sim los ntawm kev hloov pauv hauv cov noob caj ces sib txawv .

Cov neeg uas muaj FAP muaj ntau cov polyps hauv lawv txoj hnyuv loj. Qee zaum muaj ntau txhiab tus me me no hu ua polyps. Txawm li cas los xij, cov neeg uas muaj HNPCC tsis muaj ntau cov polyps, thiab qee zaum mob qog noj ntshav tuaj yeem tshwm sim yam tsis muaj polyps. Cov polyps uas tshwm sim hauv HNPCC feem ntau yog tiaj tus.

Cov polyps uas tshwm sim hauv ob qho mob no suav tias yog precancerous , txhais tau tias lawv tuaj yeem hloov mus ua mob qog noj ntshav hauv lub sijhawm luv luv.

Cov yam tseem ceeb tshaj plaws uas peb yuav tsum nco ntsoov los ntawm zaj dab neeg no yog

HNPCC (Kab Mob Cancer Colorectal Uas Tsis Yog Kab Mob Los Ntawm Keeb Kwm) yog ib hom kab mob cancer colorectal uas tshwm sim los ntawm qhov tsis zoo ntawm noob caj ces uas tau kis mus rau ntau tiam neeg. Nws kuj tseem cuam tshuam nrog Lynch syndrome.

• Yog tias muaj keeb kwm tsev neeg muaj mob qog noj ntshav, nws yog ib qho tseem ceeb heev uas yuav tsum tham nrog koj tus kws kho mob txog qhov ntawd.
• Txawm tias koj tsis muaj tsos mob los xij, yog tias koj muaj kev pheej hmoo , mus kuaj mob tsis tu ncua.
• Yog tias kuaj pom thaum ntxov, kev kho mob yuav zoo dua.
• Kab mob HNPCC tsis yog ib yam kab mob sib kis tau, tab sis nws tuaj yeem tau txais los ntawm noob caj noob ces.
• Nws yog ib qho tseem ceeb heev uas yuav tsum ua neej noj qab haus huv thiab ua raws li cov lus qhia kho mob.

Yog koj muaj lus nug ntxiv txog qhov no, tsis txhob ntshai nug koj tus kws kho mob. Lawv yuav pab koj.

` HNPCC, Lynch syndrome, mob qog nqaij hlav colorectal, mob qog nqaij hlav colon, mob qog nqaij hlav rectal, kev hloov pauv caj ces, mob qog nqaij hlav uas los ntawm noob caj ces, kev kuaj mob qog nqaij hlav, kev soj ntsuam colonoscopy, kev phais, kev siv tshuaj kho mob chemotherapy, kev kho mob immunotherapy