Cia peb kawm txog cov kab mob txawv txawv uas nrog mob qog noj ntshav (Paraneoplastic Syndromes)!

Koj puas tau hnov ​​​​​​dua ib tug neeg uas muaj mob qog noj ntshav uas muaj cov tsos mob uas tsis yog vim mob qog noj ntshav nws tus kheej, tab sis yog los ntawm lwm yam kab mob? Zoo li mob qog noj ntshav nyob hauv ib feem ntawm lub cev, tab sis nws cov teebmeem kis mus rau lwm qhov. Qhov ntawd yog qhov peb hu ua (Paraneoplastic Syndromes) . Qhov no yuav zoo li nyuaj me ntsis, tab sis cia peb tham txog qhov xwm txheej. Tsis txhob ntshai, nws yog ib qho tseem ceeb heev uas yuav tsum paub txog qhov no.

Kab mob paraneoplastic yog dab tsi?

Hais yooj yim xwb, thaum koj muaj mob qog noj ntshav, peb hu nws ua Paraneoplastic Syndrome , uas yog thaum lwm cov tsos mob tshwm sim hauv lub cev yam tsis yog los ntawm cov hlwb qog noj ntshav. Xav txog, muaj mob qog noj ntshav hauv lub cev, tab sis qee cov tshuaj hormones lossis cov protein uas nws tso tawm ua rau ib lub cev hauv lub cev pib ua haujlwm txawv. Lossis, qee zaum peb lub cev tiv thaiv kab mob , thaum sim rhuav tshem cov hlwb qog noj ntshav, ua yuam kev tawm tsam cov hlwb zoo thiab. Peb hu qhov no ua kev teb autoimmune . Cov tsos mob no kuj tuaj yeem tshwm sim hauv cov xwm txheej zoo li no.

Cov kab mob Paraneoplastic syndromes tuaj yeem cuam tshuam rau ntau yam kab mob hauv lub cev. Piv txwv li, koj lub paj hlwb , endocrine system (lub cev uas tsim cov tshuaj hormones), raum , pob txha , pob qij txha , daim tawv nqaij, thiab ntshav tuaj yeem raug cuam tshuam.

Feem ntau, cov tsos mob ntawm ib qho ntawm cov no (Paraneoplastic Syndromes) yog thawj cov cim qhia ntawm mob qog noj ntshav. Yog li ntawd, nws yog ib qho tseem ceeb heev uas yuav tsum paub txog qhov no.

Leej twg yuav raug kev cuam tshuam los ntawm tus mob no? (Leej twg raug kev cuam tshuam los ntawm paraneoplastic syndromes?)

Cov kab mob Paraneoplastic feem ntau tshwm sim rau cov neeg hnub nyoog nruab nrab thiab cov neeg laus dua, tshwj xeeb tshaj yog cov neeg uas muaj mob xws li mob qog nqaij hlav ntsws , mob qog nqaij hlav lymphatic , mob qog nqaij hlav zes qe menyuam , lossis mob qog nqaij hlav mis . Tib yam uas ua rau mob qog nqaij hlav kuj tuaj yeem ua rau cov kab mob no.

Cov no muaj pes tsawg zaus? (Cov kab mob paraneoplastic syndromes muaj pes tsawg zaus?)

Cov Kab Mob Paraneoplastic tshwm sim ntawm 8% thiab 20% ntawm cov neeg uas muaj mob qog noj ntshav. Qhov no txhais tau tias tsis yog txhua tus neeg mob qog noj ntshav muaj cov tsos mob no, tab sis lawv tuaj yeem cuam tshuam rau ntau tus neeg.

Cov mob qog noj ntshav twg muaj feem cuam tshuam nrog cov kab mob paraneoplastic?

Txhua tus neeg uas muaj mob qog nqaij hlav (Paraneoplastic Syndrome)Txawm hais tias muaj ib qho twg los xij, muaj ntau hom mob qog noj ntshav uas feem ntau cuam tshuam nrog cov mob no:

• Mob qog noj ntshav hauv lub mis
• Mob qog noj ntshav hauv plab
• Kab mob ntshav dawb (leukemia)
• Lymphoma
• Mob qog nqaij hlav ntsws (tshwj xeeb tshaj yog mob qog nqaij hlav ntsws me me)
• Mob qog nqaij hlav zes qe menyuam
• Mob qog nqaij hlav pancreatic
• Mob qog nqaij hlav prostate
• Mob qog nqaij hlav
• Mob qog nqaij hlav

Dab tsi ua rau muaj cov kab mob paraneoplastic?

Peb twb tau tham txog lawm tias muaj ob qho laj thawj tseem ceeb rau qhov no.

1. Cov tshuaj uas cov hlwb qog nqaij hlav tso tawm: Qee cov qog nqaij hlav tso cov tshuaj hormones thiab cov protein . Cov tshuaj no ua rau qee cov kabmob hauv lub cev ua haujlwm tsis zoo. Yog tias tsis kho, qhov no tuaj yeem ua rau puas tsuaj mus tas li.

2. Kev ua haujlwm tsis zoo ntawm lub cev tiv thaiv kab mob: Peb lub cev tiv thaiv kab mob muaj los tiv thaiv peb ntawm cov kab mob. Lub cev no tsim cov tshuaj hu ua cov tshuaj tiv thaiv kab mob . Cov tshuaj tiv thaiv kab mob no paub thiab rhuav tshem cov hlwb tsis zoo, xws li cov hlwb mob qog noj ntshav. Tab sis qee zaum, cov cim no sib xyaw ua ke thiab cov tshuaj tiv thaiv kab mob pib tawm tsam cov hlwb noj qab haus huv thiab. Thaum ntawd cov tsos mob ntawm (Paraneoplastic Syndrome) tshwm sim.

Cov tsos mob ntawm cov kab mob paraneoplastic yog dab tsi?

Cov tsos mob uas tshwm sim hauv qhov no tuaj yeem sib txawv ntawm ib tus neeg mus rau ib tus neeg. Nws nyob ntawm seb lub cev twg raug cuam tshuam. Qhov xav tsis thoob, ntau dua 60% ntawm cov neeg mob, cov tsos mob ntawm tus kab mob no tshwm sim ua ntej kuaj pom tias muaj mob qog noj ntshav. Yog li ntawd, yog tias cov tsos mob no raug lees paub thaum ntxov, mob qog noj ntshav tuaj yeem kuaj pom thiab kho tau thaum ntxov. Tom qab ntawd qhov muaj feem yuav ua tiav ntawm kev kho mob siab dua.

Cov tsos mob feem ntau

Nov yog qee cov tsos mob uas tshwm sim ntau tshaj plaws:

• Ua npaws
• Tsis qab los noj mov thiab poob phaus
• Kev hws hmo ntuj

Thaum lub paj hlwb raug cuam tshuam

Yog tias koj lub paj hlwb hauv nruab nrab (uas yog, koj lub hlwb thiab tus txha caj qaum) thiab lub paj hlwb peripheral (cov hlab ntsha uas tawm ntawm lub hlwb thiab tus txha caj qaum) raug cuam tshuam, koj yuav muaj cov tsos mob zoo li:

• kiv taub hau
• pom ob sab
• Kev hais lus nyuaj
• Kev tsis nco qab
• Cov mob qaug dab peg ( qaug dab peg )
• Cov leeg tsis muaj zog
• Txo cov reflexes, kev xav lossis kev sib koom tes
• Tsis muaj kev xav hauv koj txhais tes thiab ob txhais ceg

Xav txog seb, ib tug neeg muaj mob qog nqaij hlav ntsws, tab sis lawv cia li pib tsis nco qab, hais lus tsis meej thaum lawv hais lus, thiab nyuaj rau lawv tuav tau qhov sib npaug thaum lawv taug kev. Thaum ntawd cov kws kho mob xav tias qhov no yog (Paraneoplastic Syndrome) .

Thaum lub endocrine system raug cuam tshuam

Yog tias koj lub cev hormonal cuam tshuam, koj yuav muaj cov tsos mob zoo li no:

• Qaug zog heev
• Ntshav siab
• Cov leeg tsis muaj zog
• Xeev siab thiab ntuav
• Qhov hnyav nce sai sai yam tsis muaj laj thawj

Thaum cov pob qij txha, pob txha thiab cov leeg raug cuam tshuam (Cov pob qij txha, pob txha thiab cov leeg - mob pob qij txha)

Yog tias cov kab ke no raug cuam tshuam:

• Cov mob xws li mob pob qij txha
• Mob pob qij txha, o lossis mob nqaij tawv

Thaum nws cuam tshuam rau daim tawv nqaij (Tawv nqaij)

Qee zaum daim tawv nqaij kuj tuaj yeem raug cuam tshuam:

• Khaus
• Flushing
• Tawv nqaij tuab
• Cov tawv nqaij loj hlob zoo (tsis yog mob qog noj ntshav)

Cov hom mob paraneoplastic syndromes yog dab tsi?

Muaj ntau hom Paraneoplastic Syndromes . Lawv raug faib ua pawg raws li lawv cuam tshuam rau txhua lub cev.

Cov kab mob paraneoplastic ntawm lub paj hlwb

Piv txwv li:

• `(Cerebellar degeneration)`: Qhov no yog kev puas tsuaj rau lub cerebellum, cuam tshuam rau tej yam xws li kev sib npaug thiab kev taug kev.
• Dysautonomia: Cuam tshuam rau kev ua haujlwm ntawm lub paj hlwb autonomic.
• Kab mob hlwb (Encephalitis): Kab mob o ntawm lub hlwb.
• Encephalomyelitis: o ntawm lub hlwb thiab tus txha caj qaum.
• Lambert-Eaton myasthenic syndrome (LEMS): Ua rau cov leeg tsis muaj zog.
• Myasthenia gravis (MG): Qhov no yog lwm yam mob uas ua rau cov leeg tsis muaj zog.
• Myelopathy: Cov kab mob cuam tshuam rau cov hlab ntsha hauv lub paj hlwb.
• Neuromyotonia: Cov leeg nqaij ua haujlwm tas li.
• `(Opsoclonus-myoclonus syndrome)`: Kev txav mus los tsis zoo ntawm lub qhov muag thiab cov leeg nqaij.
• `(Neuropathy (peripheral neuropathy))`: Kev puas tsuaj rau cov hlab ntsha peripheral.
• `(Tus mob tawv nqaij tawv)`: Cov leeg nqaij tawv thiab mob heev.

Cov kab mob endocrine paraneoplastic

Piv txwv li:

• `(Cushing's syndrome): Ib qho mob uas tshwm sim los ntawm kev nce ntxiv ntawm cov tshuaj hormone cortisol.
• Hypercalcemia: Cov calcium ntau ntxiv hauv cov ntshav.
• `(Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH))`: Ib yam mob uas ua rau lub cev khaws dej ntau ntxiv.

Cov kab mob paraneoplastic rheumatic

(cuam tshuam rau cov pob qij txha, pob txha, cov leeg thiab cov ntaub so ntswg sib txuas)

Piv txwv li:

• `(Eosinophilic fasciitis)`
• `(Ntshav muag liab)`
• `(Kab mob pob txha caj qaum hypertrophic)`
• `(Palmar fasciitis)`
• `(Paraneoplastic polyarthritis)`

Cov kab mob paraneoplastic ntawm cov ntshav

Piv txwv li:

• `(Paraneoplastic erythrocytosis)`: Cov qe ntshav liab ntau ntxiv.
• `(Paraneoplastic thrombocytosis)`: Cov ntshav platelets nce ntxiv.

Cov tsos mob ntawm daim tawv nqaij paraneoplastic

Piv txwv li:

• Acanthosis nigricans: Cov tawv nqaij dub thiab tuab ua tej daim me me.
• Dermatomyositis: o ntawm daim tawv nqaij thiab cov leeg.
• Leukocytoclastic vasculitis: o ntawm cov hlab ntsha me me.
• `(Paraneoplastic pemphigus)`: Ib yam mob uas ua rau daim tawv nqaij ua pob liab.
• `(Sweet syndrome)`: Kub taub hau thiab mob tawv nqaij.

Cov kab mob paraneoplastic raum

Kab mob Paraneoplastic glomerulonephritis yog ib qho mob uas cuam tshuam rau lub raum.

Yuav kuaj mob paraneoplastic syndromes li cas?

Koj tus kws kho mob yuav kuaj mob no los ntawm kev nug koj txog koj keeb kwm kev kho mob, kuaj lub cev, thiab ua ntau yam kev kuaj ntxiv.

• Kev kuaj mob hlwb: Vim tias tus mob no feem ntau cuam tshuam rau lub paj hlwb, koj tus kws kho mob yuav hais kom koj ua qee yam los xyuas seb koj lub hlwb thiab cov leeg ua haujlwm li cas. Lawv yuav kuaj xyuas seb puas muaj kev hloov pauv hauv koj lub zog, kev nco, thiab kev sib koom tes.
• Kev kuaj duab: Cov kev kuaj xws li CT scans , MRIs , thiab ultrasounds yuav siv tau los saib seb puas muaj qog ua rau muaj cov tsos mob.
• Kev kuaj ntshav: Kev kuaj ntshav tuaj yeem qhia tau tej yam uas yuav ua rau muaj kev xav tias muaj mob qog noj ntshav. Lawv kuj tseem tuaj yeem kuaj xyuas cov tshuaj tiv thaiv kab mob uas cuam tshuam nrog cov kab mob paraneoplastic . Cov kev kuaj no kuj tseem tuaj yeem txiav txim siab seb cov tsos mob puas yog los ntawm lwm yam ua rau, xws li kev kis kab mob lossis kev tsis sib npaug ntawm cov tshuaj hormones.
• Kev tho qhov txha nraub qaum / kev tho qhov lumbar: Qee zaum, koj cov kua cerebrospinal (CSF) raug kuaj seb puas muaj cov tshuaj tua kab mob uas tawm tsam cov hlwb noj qab haus huv. Qhov no suav nrog kev ntxig ib rab koob me me rau hauv koj lub nraub qaum qis thiab coj cov qauv ntawm cov kua. Tom qab ntawd nws raug kuaj xyuas.

Yuav tswj lossis kho cov mob no li cas? (Yuav tswj lossis kho cov kab mob paraneoplastic li cas?)

Qhov tseem ceeb tshaj plaws yog kho tus mob qog noj ntshav uas ua rau koj cov tsos mob. Tib lub sijhawm, koj kuj tswj koj cov tsos mob kom txo qhov kev puas tsuaj rau koj lub cev cov kab ke lossis cov txheej txheem.

Qee cov kev kho mob siv los tswj cov Paraneoplastic Syndromes :

• Cov tshuaj Corticosteroids:Cov tshuaj xws li '(Cortisone)' lossis '(prednisone). Cov no ua haujlwm los ntawm kev txo qhov o (o) hauv lub cev.
• Kev Tiv Thaiv Kab Mob: Cov tshuaj uas txo qhov kev teb ntawm koj lub cev tiv thaiv kab mob. Koj tus kws kho mob yuav sau ntawv rau cov tshuaj raws li hom paraneoplastic syndrome uas koj muaj.
• Tshuaj immunoglobulin txhaj rau hauv cov hlab ntsha (IVIG): Kev kho mob no ua haujlwm los ntawm kev rhuav tshem cov tshuaj tua kab mob uas tsis zoo. Hauv qhov no, cov tshuaj tua kab mob zoo raug muab ua koob tshuaj, uas rhuav tshem cov tshuaj tua kab mob uas tsis zoo.
• Plasmapheresis: Qhov no suav nrog kev tshem tawm cov plasma (cov kua ntawm cov ntshav) ntawm cov ntshav kom txo cov tshuaj tua kab mob, uas muaj nyob hauv cov plasma no thiab tuaj yeem ua rau cov nqaij noj qab haus huv puas tsuaj.
• Kev Kho Mob Lub Cev thiab Kev Hais Lus: Qhov no suav nrog kev tawm dag zog cov leeg nqaij los txhim kho cov dej num xws li kev hais lus thiab kev txav mus los. Tej zaum koj yuav xav tau kev kho mob no yog tias koj muaj tus kab mob paraneoplastic syndrome ntsig txog lub paj hlwb.

Yog tias kuv muaj tus kab mob paraneoplastic syndrome, kuv yuav tsum tau tos li cas?

Koj qhov kev kwv yees feem ntau nyob ntawm seb koj tus mob qog noj ntshav theem twg. Qee zaum, cov tsos mob uas tshwm sim los ntawm tus kab mob no yuav tsis hnyav heev thiab ib ntus xwb. Lwm cov xwm txheej, cov tsos mob yuav hnyav heev thiab xav tau kev tswj hwm mus sij hawm ntev.

Tham nrog koj tus kws kho mob txog seb theem ntawm koj tus mob qog noj ntshav thiab koj txoj kev teb rau kev kho mob yuav cuam tshuam li cas rau koj txoj kev zoo rov qab.

Muaj teeb meem dab tsi cuam tshuam nrog cov kab mob paraneoplastic?

Qhov no tuaj yeem ua rau muaj ntau yam teeb meem. Qee qhov yuav me me, thaum lwm qhov tuaj yeem loj heev thiab txawm tias muaj kev phom sij rau lub neej yog tias tsis kho. Koj tus kws kho mob yuav piav qhia txog cov teeb meem uas yuav tshwm sim thiab cov kev xaiv kho rau koj.

Thaum twg kuv yuav tsum hu rau kws kho mob txog cov kab mob paraneoplastic?

Yog tias koj muaj cov tsos mob ntawm tus kab mob paraneoplastic syndrome yam tsis muaj laj thawj pom tseeb, mus ntsib kws kho mob. Tshwj xeeb tshaj yog tias koj tau kho mob qog noj ntshav hauv tsib xyoos dhau los thiab muaj cov tsos mob no, nws yog ib lub tswv yim zoo kom rov kuaj dua. Qhov no kuj tseem yuav pab koj tus kws kho mob txiav txim siab seb tus kab mob qog noj ntshav puas tau rov qab los.

Kuv yuav tsum nug kuv tus kws kho mob li cas?

Qee cov lus nug uas koj tuaj yeem nug koj tus kws kho mob:

• Ua rau kuv cov tsos mob yog dab tsi?
• Kuv tus mob (Paraneoplastic Syndrome) cuam tshuam li cas rau kuv txoj kev npaj kho mob qog noj ntshav?
• Kuv muaj cov kev kho mob twg?
• Kuv liParaneoplastic Syndrome cuam tshuam li cas rau kuv txoj kev zoo rov qab?
• Puas yog kuv cov tsos mob yuav zoo dua tom qab kev kho mob qog noj ntshav?
• Yuav ua li cas tswj cov tsos mob rau lub sijhawm luv luv? Yuav ua li cas tswj cov tsos mob rau lub sijhawm ntev?

Thaum kawg, cov lus coj mus tsev

Cov qog nqaij hlav qog nqaij hlav tuaj yeem ua rau muaj kev hloov pauv tsis tau xav txog hauv lub cev. Qee zaum, lawv kuj tuaj yeem suav nrog cov tsos mob ntawm tus kab mob paraneoplastic . Vim tias muaj ntau hom kab mob no thiab cov tsos mob sib txawv, nws yuav siv sijhawm ntev rau koj tus kws kho mob kom paub tias koj cov tsos mob muaj feem cuam tshuam nrog mob qog nqaij hlav. Txawm li cas los xij, thaum kuaj pom tseeb, nws tuaj yeem kho cov tsos mob thiab, qhov tseem ceeb tshaj plaws, kho tus mob qog nqaij hlav hauv qab .

Txoj kev zoo tshaj plaws los tswj tus kab mob Paraneoplastic Syndrome yog nrhiav kev kho mob zoo tshaj plaws rau tus mob qog noj ntshav. Yog li ntawd, tsis txhob tso tseg cov tsos mob. Yog tias koj muaj kev tsis ntseeg, mus ntsib kws kho mob sai li sai tau. Tsuas yog thaum ntawd peb txhua tus thiaj li noj qab nyob zoo.

Cov kab mob Paraneoplastic, mob qog noj ntshav, cov tsos mob, lub paj hlwb, lub endocrine system, lub cev tiv thaiv kab mob, kev kho mob qog noj ntshav