Puas yog koj lub cev tsis teb rau Parathyroid Hormone zoo? Cia peb tham txog qhov mob txawv txawv no (Pseudohypoparathyroidism)!

Puas muaj tej lub sij hawm koj xav tias muaj ib yam dab tsi hauv koj lub cev tsis ua hauj lwm zoo? Muaj tej yam kab mob txawv txawv uas tej lub npe ua rau neeg ntshai me ntsis. Ib yam kab mob uas tsis tshua muaj neeg hnov ​​txog, tab sis tseem ceeb heev uas yuav tsum paub txog, yog Pseudohypoparathyroidism (PHP). Txawm hais tias lub npe yuav zoo li ntev me ntsis los, cia peb ua kom yooj yim xwb.

Pseudoehypoparathyroidism yog dab tsi?

Hais yooj yim xwb, qhov no yog ib qho mob caj ces tsis tshua muaj . Peb muaj cov qog me me hauv peb lub cev hu ua cov qog parathyroid. Cov no tsim cov tshuaj hormones hu ua Parathyroid Hormone (PTH). Cov tshuaj hormones PTH no tseem ceeb heev rau peb lub cev. Vim tias, cov tshuaj hormones no pab tswj cov Calcium, Phosphorus, thiab Vitamin D kom zoo hauv peb cov ntshav.

Tam sim no, koj puas paub tias muaj dab tsi tshwm sim rau ib tus neeg uas muaj pseudohypoparathyroidism (PHP)? Txawm hais tias lawv cov qog parathyroid tsim cov tshuaj PTH hormone li niaj zaus, cov hlwb hauv lawv lub cev tsis teb rau nws kom zoo, txhais tau tias lawv tsis tuaj yeem "paub" nws. Nws zoo li ib tug neeg tham nrog koj tab sis koj tsis hnov ​​​​lawv. Peb hu qhov no ua Parathyroid Hormone Resistance .

Yog li ntawd, muaj dab tsi tshwm sim? Cov calcium hauv cov ntshav txo qis, thaum cov phosphorus nce ntxiv. Qhov kev tsis sib npaug no tuaj yeem ua rau cov leeg nqaij co, loog, qaug dab peg, thiab muaj teeb meem hniav.

Qhov tseem ceeb, tus mob no hu ua PHP txawv ntawm tus mob hu ua Hypoparathyroidism. Cov neeg uas muaj hypoparathyroidism tsis tsim cov tshuaj PTH txaus thaum pib. Txawm li cas los xij, hauv PHP, cov tshuaj hormones raug tsim tawm, tab sis lub cev tsis siv nws.

Cov hom PHP tseem ceeb yog dab tsi?

Muaj ntau hom tseem ceeb ntawm PHP status no. Cia peb saib lawv yog dab tsi.

PHP-1 hom

Qhov no yog hom PHP uas feem ntau pom . Ntxiv rau qhov kev tiv thaiv PTH hormone uas tau hais ua ntej lawm, qee qhov kev hloov pauv ntawm lub cev pob txha kuj pom tau. Piv txwv li:

• Lub ntsej muag puag ncig
• Qhov siab txo qis (tsis loj)
• Mob caj dab
• Cov pob txha tawg ntawm tes thiab taw

Cov kws kho mob hu cov tsos mob no ua ke hu ua Albright Hereditary Osteodystrophy (AHO) . Cov neeg uas muaj PHP-1 muaj tus mob no vim yog ib qho gene hu ua 'GNAS' uas lawv tau txais los ntawm ib tug ntawm lawv niam lawv txiv.

PPPH (Pseudopseudohypoparathyroidism)

Qhov no yog ib daim ntawv txwv ntawm PHP-1. Cov neeg uas muaj PPHP (Pseudopseudohypoparathyroidism) tej zaum yuav muaj cov yam ntxwv ntawm lub cev uas pom hauv AHO (xws li lub ntsej muag puag ncig thiab luv luv), tab sis lawv tsis muaj kev tiv thaiv PTH hormone . Qhov no txhais tau tias lawv cov calcium thiab phosphorus theem yog ib txwm muaj.

PHP-2 hom

Cov neeg uas muaj PHP-2 muaj kev tiv thaiv PTH hormone, uas txhais tau tias lawv muaj calcium tsawg thiab phosphorus ntau. Tab sis lawv tsis muaj cov yam ntxwv ntawm lub cev (xws li lub ntsej muag puag ncig thiab luv luv) zoo li pom hauv AHO. Cov kws tshawb fawb tseem tsis tau paub meej tias qhov teeb meem caj ces twg ua rau hom PHP-2 no.

Cov tsos mob ntawm PHP yog dab tsi?

Cov tsos mob ntawm PHP yuav txawv ntawm ib tus neeg mus rau ib tus neeg . Qhov no txhais tau tias tsis yog txhua tus yuav muaj cov tsos mob zoo ib yam. Qee cov tsos mob uas pom ntau suav nrog:

• Cov leeg nqaij ntswj
• Cov leeg nqaij mob ntau zaus : Zoo li ib ceg raug rub.
• Kev tsis muaj zog lossis tingling hauv cov ceg
• Qaug dab peg
• Cov hniav tawm qeeb
• Kev ua kom cov hniav enamel tsis muaj zog
• Ntshav siab qis
• Cov plaub hau thiab cov rau tes tawg yooj yim
• Kev ntxhov siab
• Kev Nyuaj Siab

Cov neeg uas muaj PHP-1 yuav muaj cov tsos mob ntxiv uas nrog rau tus mob Albright hereditary osteodystrophy (AHO) uas tau hais ua ntej lawm. Ib txhia neeg uas muaj PHP kuj tseem yuav muaj cov tsos mob no:

• Lub ntsej muag puag ncig
• Short stature (low stature) (sawv luv luv)
• Mob caj dab
• Cov pob txha hauv tes thiab taw : Cov pob qij txha, tshwj xeeb tshaj yog cov ntiv tes plaub thiab tsib, yuav zoo li tig mus rau sab hauv.
• Kev Rog Phem : Nws txhais tau tias rog dhau.
• Kev tsis pom kev zoo : tej yam xws li cataracts, pom kev tsis meej, thiab rhiab rau lub teeb.
• Cov pob txha tawg hauv qab koj daim tawv nqaij
• Kev loj hlob qeeb : Qee tus menyuam yuav muaj qee qhov kev loj hlob qeeb.

Dab tsi yog cov ua rau PHP?

Qhov ua rau muaj tus kab mob no yog qhov sib txawv ntawm peb cov noob caj noob ces, tshwj xeeb tshaj yog cov noob caj noob ces hu ua 'GNAS' . Ib txhia neeg tau txais nws los ntawm lawv niam lawv txiv . Qhov ntawd txhais tau tias nws yog los ntawm noob caj noob ces. Tab sis qee zaum qhov mob no tuaj yeem tshwm sim yam tsis muaj keeb kwm tsev neeg thiab tsis muaj qhov ua rau pom.

Feem ntau tus kab mob PHP raug kuaj pom thaum tseem yog menyuam yaus lossis thaum yau , tab sis qee zaum nws tuaj yeem tshwm sim thaum laus.

Cov teeb meem uas yuav tshwm sim ntawm PHP yog dab tsi?

Yog koj muaj tus kab mob PHP, koj yuav muaj lwm yam teeb meem ntawm lub cev endocrine . Cov teeb meem cuam tshuam nrog cov tshuaj hormones no tuaj yeem ua rau muaj cov tsos mob xws li tsis muaj zog thiab tsis muaj kev xav sib deev.

Qee cov neeg uas muaj tus kab mob PHP muaj feem yuav mob ntau dua xws li:

• Kab mob ParkinsonismQhia cov tsos mob zoo ib yam li tus kab mob Parkinson.
• Muaj teeb meem nrog kev txawj txav mus los me me : Qhov no txhais tau tias muaj teeb meem nrog cov haujlwm me me xws li khawm lossis sau ntawv.
• Kab Mob Carpal Tunnel Syndrome : Tshwj xeeb tshaj yog rau cov neeg uas muaj PHP-1. Qhov no yog ib qho mob uas cov hlab ntsha hauv lub dab teg raug nias, ua rau loog thiab mob hauv tes.
• Kev mob pob txha caj qaum
• Kev pw tsaug zog apnea : Tshwj xeeb tshaj yog rau cov menyuam yaus.

Cov kws kho mob kuaj mob PHP li cas?

Yog koj xav tias koj muaj tus kab mob PHP, koj tus kws kho mob yuav kuaj koj lub cev ua ntej. Lawv kuj yuav nug txog koj keeb kwm tsev neeg . Tom qab ntawd lawv yuav ua ntau yam kev kuaj ntxiv kom paub tseeb tias koj tau kuaj mob. Cov no suav nrog:

• Kev kuaj ntshav : Ntsuas cov tshuaj hormones, tshwj xeeb yog calcium, phosphorus, thiab PTH.
• Kev kuaj zis : Xyuas seb cov calcium thiab phosphorus nyob hauv cov zis muaj pes tsawg.
• Kev kuaj noob caj noob ces : Tshawb xyuas seb puas muaj kev hloov pauv hauv cov noob 'GNAS'.
• Electrocardiogram (EKG) : Tshawb xyuas seb puas muaj qhov tsis zoo ntawm lub plawv dhia.
• Cov Duab X-ray Tes : Xyuas seb puas muaj pob txha tawg thiab lwm yam kev hloov pauv.
• Kev Ntsuas CT (CT - Computed Tomography scan) : Txhawm rau saib seb puas muaj kev hloov pauv hauv lub hlwb.

Nws yog raws li cov ntaub ntawv tau los ntawm cov kev kuaj no uas tus kws kho mob tuaj yeem lees paub qhov xwm txheej PHP kom raug.

PHP kho li cas?

Tseem tsis tau muaj tshuaj kho tau tus mob no . Tiamsis tsis txhob txhawj. Yog koj kho thiab tswj tau zoo, koj yuav tswj tau koj cov tsos mob thiab ua neej nyob li qub.

Lub hom phiaj tseem ceeb ntawm kev kho mob yog kom tswj tau cov calcium thiab phosphorus kom raug hauv koj cov ntshav . Kev tswj cov qib no tuaj yeem txo cov tsos mob tau zoo heev. Qhov no yog kev kho mob mus tas li .

Cov kev xaiv kho mob yuav muaj xws li:

• Cov tshuaj calcium thiab vitamin D : ua ntsiav tshuaj los yog kua.
• Calcitriol capsules : Qhov no yog ib yam tshuaj uas ua rau kom muaj calcium ntau ntxiv hauv lub cev.
• Kev txhaj tshuaj Calcitriol
• Kev kho mob hormone loj hlob lossis kev hloov kho thyroid hormone : yog tias tsim nyog.
• Kev noj zaub mov uas muaj calcium ntau, thiab muaj phosphorus tsawg : Raws li tus kws noj haus qhia.

Qhov tseem ceeb tshaj plaws yog ua raws li cov lus qhia kho mob kom zoo thiab mus kuaj mob raws sijhawm.

Kuv yuav tsum mus ntsib kws kho mob thaum twg?

Yog koj muaj PHP, nws yog ib qho tseem ceeb uas koj yuav tsum mus ntsib koj tus kws kho mob tsis tu ncua kom kuaj xyuas koj cov calcium thiab phosphorus . Qhov kev saib xyuas tsis tu ncua no yuav pab tswj txhua yam.

Yog tias koj muaj cov tsos mob hnyav xws li ua pa nyuaj tam sim ntawd, cov leeg nqaij ntswj heev, lossis qaug dab peg , mus rau chav kho mob ceev hauv tsev kho mob ze tshaj plaws tam sim ntawd lossis hu rau 1990.

Koj tuaj yeem cia siab li cas thaum nyob nrog qhov xwm txheej PHP?

Yog koj muaj tus kab mob PHP, koj yuav tsum txuas ntxiv ua haujlwm nrog koj tus kws kho mob thawj zaug . Vim tias tus kab mob PHP tuaj yeem cuam tshuam rau ntau qhov ntawm lub cev, koj yuav tsum tau mus ntsib ntau tus kws tshwj xeeb los tswj koj cov tsos mob tshwj xeeb. Koj pab neeg kho mob yuav suav nrog:

• Cov kws kho mob endocrinologist : Cov kws tshwj xeeb hauv cov tshuaj hormones.
• Cov kws phais mob orthopedic : Rau cov teeb meem ntsig txog pob txha.
• Cov Kws Kho Mob Me Nyuam : Yog tias nws yog menyuam yaus.
• Cov kws kho mob hlwb : Rau cov teeb meem ntsig txog lub paj hlwb.
• Cov kws kho lub cev
• Cov kws kho mob ua haujlwm
• Cov kws noj haus
• Cov kws kho hniav
• Cov kws tshawb fawb txog noob caj noob ces
• Cov kws tshwj xeeb tswj kev mob

Koj yuav tsum tau noj cov tshuaj no rau tas koj lub neej .

Kev loj hlob thiab kev txawj ntse muaj peev xwm sib txawv ntau nyob ntawm hom thiab qhov hnyav ntawm tus kab mob. Txawm li cas los xij , feem ntau, cov neeg uas muaj PHP muaj lub neej ntev li qub piv rau cov neeg uas tsis muaj PHP . Koj tus kws kho mob tuaj yeem qhia koj tias yuav tsum xav li cas raws li koj tus mob.

Vim tias PHP yog ib yam mob tsis tshua muaj, nws yuav nyuaj rau nrhiav lwm tus uas muaj tib yam mob li koj . Nws kuj tseem yuav ua rau koj kho siab qee zaum. Yog tias koj lossis koj tus menyuam raug kuaj pom tias muaj PHP, tham nrog koj tus kws kho mob txog cov pab pawg txhawb nqa thiab cov peev txheej kev kawm . Cov no tuaj yeem pab koj nrhiav txoj hauv kev los txhim kho koj cov tsos mob thiab lub neej zoo.

Cov Lus Qhia Txog Kev Coj Mus Tsev

Zoo, yog li cia peb los saib qee yam uas yuav tsum nco ntsoov txog pseudohypoparathyroidism (PHP) uas peb tau tham txog.

• PHP yog ib qho mob caj ces tsis tshua muaj uas lub cev tsis teb rau cov tshuaj parathyroid hormone (PTH) kom zoo.
• Qhov no ua rau cov calcium hauv cov ntshav txo qis thiab phosphorus nce ntxiv.
• Muaj ntau hom tseem ceeb : PHP-1, PHP-2, thiab PHP-3.Yog. PHP-1 tuaj yeem ua rau muaj kev hloov pauv hauv cov pob txha hu ua AHO.
• Muaj ntau yam tsos mob tshwm sim, xws li cov leeg nqaij co, loog, qaug dab peg, teeb meem hniav, siab luv, thiab lub ntsej muag puag ncig .
• Qhov ua rau muaj qhov no yog kev hloov pauv hauv cov noob 'GNAS' .
• Txawm hais tias tsis muaj kev kho kom zoo tag nrho los xij, cov tsos mob tuaj yeem tswj tau los ntawm kev kho mob mus tas li (calcium, vitamin D, kev noj zaub mov tshwj xeeb).
• Kev kuaj mob tsis tu ncua thiab kev txhawb nqa ntawm cov kws kho mob tshwj xeeb yog qhov tseem ceeb.
• Cov neeg feem coob tuaj yeem ua neej nyob tau ib lub neej li qub .
• Kev pab los ntawm cov pab pawg txhawb nqa yog qhov tseem ceeb heev rau kev ua kom lub hlwb muaj zog.

Tsis txhob hnov ​​qab, koj tsis nyob ib leeg. Txawm hais tias qhov no yog ib qho mob tsis tshua muaj, nws tuaj yeem tswj tau zoo nrog cov lus qhia kho mob thiab kev txhawb nqa zoo. Nco ntsoov tias cov kws kho mob, tsev neeg, thiab cov phooj ywg nyob ntawd rau koj thaum koj xav tau lub zog.

Pseudohypoparathyroidism , PHP, parathyroid hormone, calcium, phosphorus, cov kab mob caj ces, AHO