Koj puas pib koj hnub nrog koj nraub qaum mob thiab mob thaum koj sawv thaum sawv ntxov? Koj puas nkees ntawm qhov mob uas los ntawm koj cov pob qij txha thaum koj taug kev lossis txav mus los? Cov no yuav yog cov tsos mob ntawm ankylosing spondylitis , lossis luv luv AS. Qhov no yog ib qho mob o ntev uas tshwm sim hauv tus txha nraub qaum thiab lwm cov pob qij txha. Yog li ntawd, yog tias koj muaj qhov mob no, koj tus kws kho mob yuav tau tham txog ib hom tshuaj tshwj xeeb hu ua TNF Inhibitors. Cia peb tham txog qhov no yooj yim thiab meej hnub no.
Vim li cas cov pob qij txha thiaj mob hauv AS? TNF yog dab tsi?
Zoo, cia peb hais yooj yim xwb. Peb txhua tus muaj lub cev tiv thaiv kab mob hauv peb lub cev. Nws yog yam uas tiv thaiv peb los ntawm kev tawm tsam cov kab mob uas ua rau muaj kab mob. Tab sis nyob rau hauv cov xwm txheej zoo li AS, lub cev tiv thaiv kab mob no dhau los ua haujlwm ntau dhau. Nws zoo li tus neeg zov uas ib txwm ceev faj.
Thaum qhov no tshwm sim, peb lub cev pib tsim ntau cov protein tshwj xeeb hu ua Tumor Necrosis Factor, lossis TNF . Cov protein TNF no yog qhov ua rau mob o hauv peb cov pob qij txha, uas txhais tau tias o, o, liab, thiab mob. Qhov no yog vim li cas cov pob qij txha xws li koj nraub qaum thiab lub duav thiaj li tawv, o, thiab mob.
Yog li cov TNF Inhibitors no yog dab tsi?
Hais yooj yim xwb, cov tshuaj TNF inhibitors yog ib hom tshuaj uas 'thaiv' cov protein TNF uas peb tau tham txog ua ntej, uas yog lub luag haujlwm ua rau mob. Cov no tsis zoo li cov tshuaj tua kab mob ib txwm muaj. Cov tshuaj tua kab mob tsuas yog txo qhov mob ib ntus xwb. Tab sis cov tshuaj TNF inhibitors ua haujlwm tob dua li ntawd.
Cov tshuaj no mus ncaj qha rau cov protein TNF uas ua rau mob thiab tiv thaiv nws kom tsis txhob ua haujlwm. Qhov no txo qhov mob hauv cov pob qij txha, tswj qhov mob, o, thiab mob nqaij. Lawv kuj pab tiv thaiv kev puas tsuaj rau cov pob qij txha raws sijhawm.
Cov kws kho mob kuj hu cov tshuaj no ua 'TNF blockers', 'biologics', lossis 'anti-TNF drugs'. Muaj ntau hom TNF inhibitors uas tau pom zoo rau AS:
- Adalimumab
- Certolizumab pegol
- Etanercept
- Golimumab
- Infliximab
Feem ntau koj tus kws kho mob yuav xav txog kev kho mob no thaum koj cov tsos mob tsis raug tswj los ntawm cov tshuaj tua kab mob (NSAIDs). Tsis yog txhua yam tshuaj TNF inhibitors ua haujlwm rau txhua tus. Ib yam tshuaj yuav ua haujlwm zoo rau qee tus neeg, tab sis tsis yog rau lwm tus. Yog li koj tus kws kho mob yuav sim ntau yam tshuaj kom txog thaum lawv pom qhov uas ua haujlwm zoo tshaj plaws rau koj.
Cov tshuaj no siv li cas?
Muaj ob txoj kev tseem ceeb los muab cov tshuaj no, uas yuav sib txawv nyob ntawm hom tshuaj uas koj tau txais.
1. Ua ib qho kev txhaj tshuaj hauv qab daim tawv nqaij (Tshuaj Txhaj)
Muaj tej tshuaj uas yog txhaj rau hauv lub cev. Qhov zoo tshaj plaws yog koj muab tau rau hauv tsev. Koj tus kws kho mob lossis tus kws tu mob uas tau kawm tiav yuav qhia koj yuav ua li cas muab rau hauv lub cev kom raug. Feem ntau muab rau hauv daim tawv nqaij ntawm koj lub plab lossis koj lub duav. Qhov tseem ceeb yog tig qhov chaw txhaj tshuaj, tsis yog tib qho txhua zaus.
2. Ib yam li cov kua ntsev uas muab rau hauv cov leeg ntshav (Intravenous Infusion)
Cov tshuaj xws li Golimumab thiab Infliximab yog muab ua cov kua ntsev rau hauv cov leeg ntshav. Qhov no yuav tsum tau koj mus rau tsev kho mob lossis chaw txhaj tshuaj. Kev kho mob no yuav siv sijhawm ntau teev. Feem ntau tus kws kho mob yuav muab cov tshuaj rau koj li ob teev thiab tom qab ntawd yuav saib xyuas koj li ob teev ntxiv kom pom tias koj puas muaj kev tsis haum tshuaj loj. Tej zaum koj yuav tsum tau noj cov tshuaj no txhua ob lub lis piam thaum xub thawj, tab sis lub sijhawm no yuav raug txo qis dua.
Cov txiaj ntsig ntawm TNF Inhibitors yog dab tsi?
Cov kev tshawb fawb tau qhia tias cov neeg uas muaj AS tau txais txiaj ntsig zoo los ntawm kev kho mob no.
- Qhov mob raug txo qis heev.
- Kev ua haujlwm ntawm cov pob qij txha thiab kev ywj pheej zoo dua.
- Cov tsos mob xws li pob qij txha nruj thiab o thaum sawv ntxov yuav txo qis.
- Txo qhov o ntawm cov pob qij txha thiab lwm yam pob qij txha.
- Ua rau qeeb qeeb qhov kev puas tsuaj mus tas li rau cov pob qij txha raws sijhawm.
Muaj coob tus neeg pib pom qhov txawv tom qab noj tshuaj ob lossis peb zaug xwb. Txawm li cas los xij, qee zaum nws yuav siv sijhawm txog peb lub hlis kom pom tag nrho cov txiaj ntsig ntawm cov tshuaj no. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum ua siab ntev rau kev kho mob.
Peb kuj paub txog cov kev mob tshwm sim.
Ib yam li lwm yam tshuaj, cov tshuaj no muaj tej yam tshwm sim tsis zoo. Txawm li cas los xij, feem ntau cov neeg tsuas muaj tej yam tshwm sim me me xwb. Qhov tseem ceeb tshaj plaws yog kom paub txog qhov no thiab qhia rau koj tus kws kho mob tam sim ntawd yog tias koj muaj teeb meem dab tsi.
Vim tias cov tshuaj no ua rau peb lub cev tiv thaiv kab mob tsis ua haujlwm, peb lub peev xwm los tawm tsam cov kab mob yuav raug txo qis me ntsis. Qhov no ua rau muaj kev pheej hmoo ntawm kev kis kab mob ntau ntxiv me ntsis.
Muaj kev pheej hmoo tias tus kab mob ntsws (TB) yuav rov qab los. Tsis txhob txhawj, koj tus kws kho mob yuav kuaj koj rau tus kab mob ntsws thiab lwm yam kab mob ua ntej koj pib noj tshuaj no.
Hauv qab no yog qee cov kev mob tshwm sim uas feem ntau yuav tshwm sim.
| Cov teebmeem sab nraud | Kev piav qhia thiab yam yuav tsum paub |
|---|---|
| Cov tshuaj tiv thaiv ntawm qhov chaw txhaj tshuaj | Tej zaum yuav muaj qhov liab, khaus, thiab o ntawm qhov chaw txhaj tshuaj. Feem ntau qhov no yuav ploj mus hauv ib lub lim tiam. |
| Kev pheej hmoo ntawm kev kis kab mob | Tej zaum yuav muaj feem yuav mob xws li kub taub hau, mob khaub thuas, mob ntsws, thiab mob tawv nqaij. Qhia rau koj tus kws kho mob yog tias koj kub taub hau lossis hnoos. |
| Lwm yam kab mob uas tshwm sim ntau | Mob taub hau, tawv nqaij ua pob, xeev siab, mob plab, raws plab, sinusitis, thiab lwm yam. |
| Cov kev tsis haum loj heev (tsis tshua muaj) | Tej yam xws li o ntawm daim di ncauj, ua pa nyuaj, ntshav qis, thiab lwm yam. Yog tias muaj dab tsi zoo li no tshwm sim, nrhiav kev pab kho mob tam sim ntawd lossis mus rau Chav Kho Mob Thaum Muaj Xwm Ceev (ETU) ze tshaj plaws. |
Qee zaum, cov tshuaj no yuav ua rau muaj kev pheej hmoo ntawm kev mob qog nqaij hlav ntawm daim tawv nqaij (mob qog nqaij hlav uas tsis yog melanoma), yog li koj tus kws kho mob yuav paub txog qhov ntawd thiab.
Leej twg yuav tsum tsis txhob siv cov tshuaj no?
Cov tshuaj TNF inhibitors tsis haum rau txhua tus. Koj tus kws kho mob yuav tsis sau ntawv kom koj noj yog tias koj muaj ib qho ntawm cov mob hauv qab no:
- Yog koj yog ib leej niam pub niam mis .
- Tam sim no koj muaj tus kab mob uas tseem tab tom kis.Yog tias muaj tus kab mob sib kis.
- Yog tias koj muaj keeb kwm ntawm cov kab mob xws li lupus lossis ntau yam sclerosis .
- Yog koj muaj mob qog noj ntshav lossis cov hlwb ua ntej mob qog noj ntshav (qhov no yuav txawv nyob ntawm tus kws kho mob qhov kev txiav txim siab hauv cov mob qog noj ntshav uas muaj hnub nyoog ntau dua 10 xyoo thiab tau kho thiab kho kom zoo).
- Yog koj muaj keeb kwm ntawm kab mob plawv hnyav .
Cov no puas siv tau thaum cev xeeb tub?
Qhov no yog ib lo lus nug tseem ceeb rau ntau tus neeg. Cov kev tshawb fawb tau qhia tias feem ntau ntawm cov tshuaj no muaj kev nyab xeeb siv thaum cev xeeb tub. Txawm li cas los xij, qee cov tshuaj, tshwj xeeb tshaj yog nyob rau hauv peb lub hlis thib ob lossis thib peb ntawm cev xeeb tub, tuaj yeem hla lub placenta mus rau tus menyuam.
Yog li ntawd, yog tias koj tab tom yuav muaj menyuam, nrog koj tus kws kho mob rheumatologist tham txog qhov no. Nws yuav pom zoo kom siv tshuaj uas zoo tshaj plaws rau koj, xws li Certolizumab, uas tsis hla lub placenta.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- TNF Inhibitors yog ib hom tshuaj tshwj xeeb, muaj zog uas tswj kev o, uas yog qhov ua rau mob ankylosing spondylitis (AS).
- Cov no tsis zoo li cov tshuaj tua kab mob ib txwm muaj; lawv cuam tshuam rau cov txheej txheem ntawm lub cev tiv thaiv kab mob uas yog lub hauv paus ntawm tus kab mob.
- Vim muaj kev pheej hmoo siab ntawm kev kis kab mob, koj tus kws kho mob yuav saib xyuas koj kom zoo ua ntej thiab thaum lub sijhawm kho mob.
- Qhia rau koj tus kws kho mob tam sim ntawd txog tej yam tsos mob tshiab uas koj muaj, tshwj xeeb tshaj yog kub taub hau lossis cov cim qhia tias muaj kab mob.
- Yog tias koj tab tom npaj yuav cev xeeb tub lossis cev xeeb tub, nws yog ib qho tseem ceeb uas yuav tsum nrog koj tus kws kho mob tham txog cov tshuaj no.
- Tsis txhob hloov qhov ntau npaum li cas lossis tsum tsis txhob noj tshuaj yam tsis tau kev qhia los ntawm kws kho mob.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus