Koj puas tau xav tias peb lub cev muaj peev xwm tawm tsam mob qog noj ntshav ntawm nws tus kheej? Qhov tseeb, peb lub cev muaj ib pab tub rog tiv thaiv zoo kawg nkaus hu ua lub cev tiv thaiv kab mob. Tab sis qee zaum, vim tias tus yeeb ncuab hu ua mob qog noj ntshav hnyav dhau me ntsis, nws nyuaj rau peb cov tub rog yeej kev sib ntaus sib tua ib leeg. Thaum lub sijhawm zoo li no, peb yuav tham txog kev kho mob uas muab kev cob qhia tshwj xeeb rau peb cov tub rog, ua rau nws muaj zog dua, thiab xa nws rov qab mus rau hauv kev sib ntaus sib tua.
Kev kho mob TIL no yog dab tsi?
Hais yooj yim xwb, kev kho mob TIL yog ib hom kev kho mob tshiab rau mob qog noj ntshav. Nws ua haujlwm los ntawm kev pab koj lub cev lub cev tiv thaiv kab mob paub thiab rhuav tshem cov hlwb qog noj ntshav.
Tus phab ej ntawm kev kho mob no yog ib hom cell tshwj xeeb hu ua Tumor-Infiltrating Lymphocytes , uas peb hu ua TILs luv.
Xav txog nws zoo li cov tub rog (cov hlwb tiv thaiv kab mob) uas saib xyuas peb lub cev. Tab sis cov tub rog no, hu ua TILs, tseem tshwj xeeb dua. Lawv nkag mus rau hauv lub qog nws tus kheej, kawm nws qhov tsis muaj zog, thiab kawm paub yuav ua li cas kom rhuav tshem nws zoo tshaj plaws. Hauv lwm lo lus, lawv zoo li cov tub rog tshwj xeeb uas mus tob rau hauv lub yeej yeeb ncuab thiab soj ntsuam nws.
Tab sis qhov teeb meem yog, peb lub cev tsis tuaj yeem tsim cov hlwb TIL txaus los tawm tsam cov qog nqaij hlav no.
Qhov ntawd yog qhov uas kev kho mob TIL los txog. Nws cuam tshuam nrog kev nce koj cov cell TIL los ntawm ntau txhiab lab. Tus kws phais mob tshem ib daim me me ntawm koj lub qog. Tom qab ntawd lawv xa nws mus rau chav kuaj mob, cais cov tub rog TIL, thiab loj hlob lawv kom txog thaum lawv muaj ntau txhiab lab. Thaum kawg, cov tub rog super no, ua los ntawm koj cov cell, rov qab qhia rau hauv koj lub cev.
Cov kev kho mob no kho tau hom mob qog noj ntshav twg?
Los ntawm xyoo 2024, Lub Chaw Saib Xyuas Khoom Noj thiab Tshuaj ntawm Teb Chaws Asmeskas (FDA) tau pom zoo rau kev kho mob TIL hu ua lifileucel (Amtagvi®) . Nws yog tshwj xeeb rau melanoma, ib hom mob qog nqaij hlav ntawm daim tawv nqaij. Uas yog, melanoma uas tsis tuaj yeem kho tau los ntawm kev phais ib leeg, lossis uas tau kis mus rau lwm qhov ntawm lub cev (mob qog nqaij hlav metastatic). Kev kho mob no yuav haum rau ib tus neeg uas tsis teb rau kev kho mob uas feem ntau muab los ntawm cov kws kho mob qog nqaij hlav.
Ntxiv rau, cov kws kho mob tab tom tshawb nrhiav qhov ua tau zoo ntawm kev kho mob TIL no rau ntau hom mob qog noj ntshav, suav nrog:
- Mob qog noj ntshav hauv lub mis
- Mob qog nqaij hlav ntawm lub tsev menyuam
- Mob qog nqaij hlav plab
- Mob qog noj ntshav hauv taub hau thiab caj dab
- Mob qog nqaij hlav ntsws uas tsis yog mob me
Cov txheej txheem kho mob ua haujlwm li cas?
Qhov no tsis yog ib yam dab tsi uas yuav ua tiav ib zaug. Txawm hais tias qhov tseem ceeb tshaj plaws yog txhaj tshuaj TIL cell, muaj ntau kauj ruam uas yuav tsum tau ua ua ntej ntawd. Cia peb saib tag nrho cov txheej txheem no ib kauj ruam zuj zus.
| Cov kauj ruam | Kev piav qhia txog yam uas tab tom tshwm sim |
|---|---|
| 1. Tshem tawm ib feem ntawm cov qog nqaij hlav | Ib tug kws phais yuav phais ib daim me me ntawm koj lub qog, uas loj li txiv kab ntxwv qaub, thiab xa mus rau chav kuaj mob. Koj yuav raug muab tshuaj loog, yog li koj yuav tsis hnov mob thaum lub sijhawm no. |
| 2. Kev rho tawm thiab kev loj hlob ntawm cov hlwb TIL | Hauv chav kuaj, cov hlwb TIL raug rho tawm ntawm lub qog thiab loj hlob mus txog ntau txhiab lab. Cov txheej txheem no feem ntau siv sijhawm li tsib lub lis piam. Tom qab ntawd, cov hlwb no raug xa mus rau tsev kho mob qhov chaw uas koj yuav tau txais kev kho mob. |
| 3. Muab tshuaj kho mob qog nqaij hlav | Koj yuav raug xa mus rau tsev kho mob thiab muab tshuaj chemotherapy rau tsib txog xya hnub. Qhov no yog los npaj koj lub cev rau cov hlwb TIL tshiab tuaj txog. |
| 4. Rov qhia txog cov hlwb TIL | Tam sim no los txog qhov tseem ceeb. Cov qe ntshav TIL uas loj hlob lawm raug txhaj rau hauv koj lub cev ib zaug, ib yam li cov kua ntsev. Qhov no siv sijhawm li ob teev. |
| 5. Muab Interleukin-2 | Thaum kawg, rau peb txog tsib hnub, koj yuav tau txais tshuaj hu ua interleukin-2 (IL-2). Qhov no yog lwm hom kev kho mob tiv thaiv kab mob. Nws "ua kom" cov hlwb TIL tshiab uas tau txhaj tshuaj thiab txhawb kom lawv tawm tsam mob qog noj ntshav. |
Koj yuav tsum tau nyob hauv tsev kho mob ob peb hnub tom qab kho mob. Thaum lub sijhawm no, pab pawg kho mob yuav saib xyuas koj lub cev txoj kev teb rau kev kho mob. Rau ob peb lub lis piam tom ntej no, nws yog ib qho tseem ceeb kom nyob ze rau tsev kho mob kom koj tuaj yeem tau txais kev kho mob sai yog tias muaj kev phiv tshwm sim.
Cov txiaj ntsig thiab kev pheej hmoo ntawm kev kho mob no yog dab tsi?
Cov txiaj ntsig yog dab tsi?
Kev kho mob TIL yog kev kho mob uas haum rau koj tus kheej heev , muaj zog heev. Vim tias nws siv koj cov hlwb, muaj kev puas tsuaj tsawg kawg nkaus rau cov hlwb noj qab haus huv. Yog li ntawd, qhov kev pheej hmoo ntawm cov kev mob tshwm sim kuj tsawg.
Qhov tseem ceeb tshaj, cov txiaj ntsig ntawm kev kho mob no kav ntev . Cov qe ntshav TIL uas tau txhaj tshuaj yuav nyob hauv koj lub cev tau ntau xyoo, tawm tsam cov qe ntshav qog noj ntshav.
Txoj kev kho mob no tau muab kev cia siab tshiab rau ntau tus neeg mob melanoma uas yav dhau los xav tias tsis muaj kev kho. Raws li kev tshawb fawb xyoo 2023, plaub xyoos tom qab tau txais kev kho mob TIL, xya ntawm kaum tus neeg tau tswj hwm lawv tus kab mob lossis kho tau zoo.
Kev pheej hmoo thiab cov kev mob tshwm sim
Ib yam li kev kho mob twg los xij, muaj kev pheej hmoo ntawm txhua kauj ruam ntawm cov txheej txheem. Cov kev mob tshwm sim feem ntau yog tshwm sim los ntawm kev siv tshuaj kho mob qog noj ntshav thiab kev kho mob IL-2. Cov kev mob tshwm sim los ntawm kev siv TIL cell tsis tshua muaj.
| Cov kev mob tshwm sim feem ntau | |
|---|---|
| Mob raws plab | Kev qaug zog |
| Kub taub hau thiab mob khaub thuas | Lub plawv dhia tsis xwm yeem (arrhythmia) |
| Ntshav siab qis | Xeev siab thiab ntuav |
| Mob pob khaus ntawm daim tawv nqaij | |
Tsis tshua muaj, vim yog kev kho mob IL-2Tej zaum yuav muaj teeb meem loj xws li cov hlab ntsha uas xau dej, tab sis tsis txhob txhawj, koj tus kws kho mob yuav tham txog txhua yam kev pheej hmoo no nrog koj ua ntej pib kho mob.
Yuav siv sijhawm ntev npaum li cas rau kuv kom rov qab zoo li qub?
Koj yuav pib zoo dua li ob lub lis piam tom qab koj qhov koob tshuaj IL-2 kawg. Vim tias cov txheej txheem kho mob no muaj ntau yam, xws li phais thiab chemotherapy, nws yuav siv sijhawm me ntsis rau lub cev kom rov zoo.
Thaum twg koj yuav tsum mus ntsib kws kho mob?
Tom qab kho mob lawm, yog tias koj muaj cov cim qhia tias muaj kev kis kab mob (kub taub hau, mob lub cev), lossis yog tias koj muaj tej yam tshwm sim tsis tau xav txog thiab hnyav, hu rau koj tus kws kho mob tam sim ntawd.
Yog koj xav tias muaj kev hloov pauv lossis tsis xis nyob, tsis txhob yig qhia rau koj tus kws kho mob. Tsis txhob sim txiav txim siab seb nws puas yog qhov ib txwm muaj lossis tsis yog. Nws yog qhov zoo tshaj plaws los qhia nws tam sim ntawd.
Yog tias koj muaj mob melanoma uas tsis tau teb rau lwm yam kev kho mob, TIL tej zaum yuav yog qhov kev xaiv zoo rau koj. Yog tias koj tus kws kho mob pom zoo kom siv txoj kev kho mob no, nug txhua yam lus nug uas koj muaj txog nws. Tham nrog koj tus kws kho mob txog cov txiaj ntsig thiab kev pheej hmoo. Koj tus kws kho mob yog koj qhov chaw zoo tshaj plaws los qhia koj cov ntaub ntawv.
Cov Lus Qhia Txog Kev Coj Mus Tsev
- Kev kho mob TIL yog ib txoj kev kho mob tshiab thiab muaj zog uas siv koj cov hlwb tiv thaiv kab mob los tawm tsam mob qog noj ntshav.
- Qhov no suav nrog kev loj hlob ntawm ntau txhiab lab lub hlwb uas tau los ntawm ib qho mob qog noj ntshav hauv chav kuaj thiab tom qab ntawd rov txhaj tshuaj rau hauv lub cev.
- Tam sim no, nws feem ntau tau pom zoo rau mob qog noj ntshav melanoma uas tsis tau teb rau lwm yam kev kho mob, tab sis nws kuj tseem nyob rau theem tshawb fawb rau lwm yam mob qog noj ntshav.
- Qhov no yog ib qho txheej txheem nyuaj uas muaj ntau kauj ruam, suav nrog kev phais, kev kho mob qog noj ntshav, thiab tshuaj.
- Txhua lub sijhawm, tham txog cov txiaj ntsig, qhov tsis zoo, thiab kev pheej hmoo ntawm kev kho mob no nrog koj tus kws kho mob thiab txiav txim siab raws li kev paub.
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Tsis muaj lus teb tau muab tso tawm. Ntxiv koj cov lus tawm ntawm no thawj zaug.
Ntxiv koj cov lus