Wan wɔndaful pawa we de insay wi bɔdi! Ɔl wetin yu nid fɔ no bɔt di ɛndoteyl!

Yu dɔn ɛva wɔnda us smɔl tin dɛn we de insay wi bɔdi, mɔ insay wi blɔd vesel dɛn, we de wok fɔ wi wɛlbɔdi? Wɛl, tide wi go tɔk bɔt sɔntin we rili impɔtant, bɔt sɔntɛm wi nɔ de tɔk bɔt bɔku tin. Dat na di ɛndoteyl . Pan ɔl we di nem tan lɛk sayɛns smɔl, fɔ tru, i rili simpul. Lɛ wi tɔk bɔt am ditayli, ɛn yu go ɔndastand aw i valyu.

Wetin na ɛndoteyl? Lɛ wi ɔndastand am simpul wan.

Fɔ tɔk am simpul wan, yu ɛndoteyl na wan smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl . I tan lɛk smɔl mɛmbran we de layn insay wata paip. Wi kin kɔl dɛn sɛl dɛn ya ɛndoteyl sɛl . Usay dɛn de?

• Insay yu at dɛn .
• Insay yu veins dɛn .
• Insay yu kapilari dɛn .
• Ɛn bak na di limf kapilari dɛn .

Imajin, di εndoteyl na di tin we de kɔnɛkt yu blɔd to di ɔda pat na yu bɔdi, we de mek infɔmeshɔn ɛn tin dɛn we de mek yu bɔdi fayn fɔ flɔ bitwin dɛn. fכ dat, di εndoteyl implεnt fכ εvri כgan εn tisu dεm na yu bכdi. di εndoteyl nכto jכs kכba. I tan lɛk pɔsin we bizi we de wok. I de du big wok fɔ mek yu blɔd kɔntinyu fɔ flɔ fayn ɛn fɔ mek yu kɔntinyu fɔ de stebul. Na dat mek sayɛnsman dɛn kin tek di ɛndoteyl as wan ɔgan we de na di ɛndokrin . Infakt, yu go sɔprayz fɔ no se dis na wan pan di big pat dɛn na yu bɔdi! if sכmtin apin to dεn sכm εndoteyl sεl dεm ya, i kin gεt big impak pan di bכdi. Na bikɔs dɛn sɛl ya de du big wok fɔ mek wi gɛt wɛlbɔdi ɛn trɛnk. fכ dat, i rili imכtant fכ no bכt dis εndoteyl εn di wok we i de du. Dɔn wi kin tray wi bɛst fɔ mek dis nɔ apin.

di kayn εndoteyl dεm de?

Yɛs, tu men kayn dɛn de we wi de tɔk bɔt. di tu dεm na di εndoteyl sεl dεm, bכt sכm difrεns de dipכnt pan usay dεn de.

• Vascular endothelium: Dis na di layn we de insay yu blɔd vesel dɛn. Fɔ tɔk am simpul wan, na di ɛndoteyl na in de ɛp fɔ mek blɔd flɔ.
• Limfatik εndoteyl: .Dis de insay yu limfatik sistɛm. di limfatik vεsεl dεm lεk wan nεtwכk fכ sכm sכm tכb dεm. Dɛn kin pul di wata we pasmak (we wi kin kɔl limf) we kin gɛda na di tisu dɛn. so, di εndoteyl fכ dεn limf vεsεl dεm de εp fכ muv di limf.

Dɛn tu tin ya rili impɔtant fɔ yu at ɛn blɔd wɛlbɔdi .

Us kayn big wok dis smɔl ɛndoteyl de du?

di εndoteyl sεl dεm de wok difrεnt wan dipכnt pan usay dεn de na di bכdi. Lɛ wi luk di men wok dɛn we di blɔd vesel ɛndoteyl de du.

di bכdi we de na di bכdi de sכmtεm (Vasoconstriction) εn di wayd (Vasodilation).

we yu gεt hεlty εndoteyl sεl dεm, dεn de εp fכ kip yu bכdi vεsεl dεm wayd (opin) so dat bכdi go fכ fכlכ tru dεm we nכ de ambɔg. Dɛn kin ansa bak to tin dɛn we de mek pɔsin want fɔ du sɔntin frɔm insay ɛn na do. Fɔ ɛgzampul, di prɛshɔn we blɔd de prɛs na di wɔl dɛn na yu blɔd vesel, di chenj we yu de chenj na yu strɛs lɛvɛl, ɛn di mɛrɛsin dɛn we yu de tek ɔl kin afɛkt dis. Dɛn kin ansa bak we di tɛmpracha chenj. Tink bɔt am, we kol wɛda , di blɔd vesel dɛn na yu an ɛn fut dɛn kin kɔnstrikt. Dis kin mek mɔ blɔd go na yu impɔtant pat dɛn, fɔ mek dɛn wam. We di wɛda wam , dɛn kin dilayt, we kin mek blɔd go fayn ɛn mek yu bɔdi kol. We yu de du ɛksɛsayz , di blɔd vesel dɛn na yu mɔsul dɛn kin big, ɛn dis kin mek dɛn gɛt di blɔd ɛn ɔksijɛn we dɛn nid. So, ilɛk wetin yu du, di ɛndoteyl de ɛp fɔ mek shɔ se ɔl ɔgan ɛn tisu na yu bɔdi gɛt di rayt blɔd.

i de kכntro di muvmεnt fכ di wata we de kכmכt na di bכdi go insay di tisu dεm

We i wɛl, di ɛndoteyl kin pas smɔl . dat min se i de alaw wata fכ pas tru in sεl dεm insay di tisu dεm. Bɔt i de wok bak lɛk gud tin we de ambɔg am . I de mek tin dɛn we yu nɔ want lɛk pɔyzin nɔ go insay di blɔd. כltu, insay sכm sik stet dεm, lεk infεkshכn /sepsis , di εndoteyl de bi sכm mכr we de pas. dis kin mek di sεl dεm we de fכt infεkshכn go insay di tisu dεm εn εp dεm fכ hεl.

I de mek blɔd nɔ klɔt we nɔ nid fɔ mek i nɔ klin (I de mek pɔsin nɔ gɛt Thrombosis ) .

Trombosis na wan sik we de mek blɔd klɔt ɛn blok di blɔd flɔ, we kin mek i gɛt siriɔs prɔblɛm dɛn. yu εndoteyl de mek kεmεkal dεm we dεn kכl naytrik oksayd εn prכstasayklin . Dɛn tin ya kin mek yu blɔd tan ɛn mek i nɔ klot. Insay sɔm sik stet dɛm, dɛn nɔ kin mek dɛn tin ya fayn fayn wan. Dis kin mek di blɔd klɔt mɔ ɛn mɔ.

usai dis εndoteyl de insay wi bכdi? Aw big i bi?

Yu ɛndoteyl de skata ɔlsay na yu bɔdi! Imajin, na yu blɔd vesel ɛndoteyl nɔmɔDi blɔd vesel dɛn lɔng lɛk 60,000 mayl . If yu aks pɔsin fɔ sho yu usay yu at de, i go pɔynt to yu chɛst. If yu aks pɔsin fɔ sho yu usay yu bren de, i go pɔynt to yu ed. Bɔt if yu aks pɔsin fɔ sho yu di ɛndoteyl, i go pɔynt to ɛni pat na yu bɔdi! Na dat mek di ɛndoteyl spɛshal. di εndoteyl sεl dεm de layn insay yu blɔd vεsul dεm. Na di sɛl dɛn we kin kam nia yu blɔd dairekt wan. Dɛn kin atak dɛn to wan basal lamina . di εndoteyl εn dis basal lamina tכgeda de mek di insay layt na di bכdi vεsul wכl, di tunica intima . Dis tunica intima na in de mek blɔd flɔ fayn fayn wan. Aw big di ɛndoteyl de? Na wan pan di big big ɔgan dɛn na yu bɔdi. We yu tink bɔt di say we di wɔl de, di avɛrej pɔsin in bɔdi kin kɔba am, ɛn i kin kɔba bitwin 3,000 ɛn 6,000 skwea mita . εn, i gεt pas 1 trilyכn εndoteyl sεl dεm ! dis dεm na di εpitel tisu dεm . Aw smɔl di ɛndoteyl sɛl dɛn? Na maykroskɔp nɔmɔ yu kin si dɛn sɛl dɛn ya . Dɛn avrej saiz na:

• I lɔng lɛk 30 to 50 maykromita (maykrɔn) .
• Na lɛk 10 to 30 maykromita wayd.
• Na lɛk 0.1 to 10 maykromita tik.

Fɔ tink bɔt di sayz we dis sɛl gɛt, tink bɔt yu yon ia. Wan ia gɛt lɛk 100 maykromita in dayamita. So, ivin we i lεng pasmak (50 maykromita), wan εndoteyl sεl na כnli af di dayamita fכ wan ia! Na dat mek wi kin gɛt pas wan trilyɔn pan dɛn spɛshal sɛl dɛn ya na wi bɔdi.

Wetin na di difrɛns bitwin Ɛndoteyl ɛn Ɛpitɛliɔm?

Dɛn tu tin ya de kɔba di tisu dɛn, bɔt smɔl difrɛns de.

• di εndoteyl de fכn insay chanεl dεm we de kכmplit insay di bכdi εn we nכ gεt nכ kכnεkshכn to di כdasay invayroment. Fɔ ɛgzampul, di blɔd vesel dɛn ɛn di lymphatic vessel dɛn.
• di εpitel de fכn insay di path dεm we de kכnεkt wit di כdasay invayroment. Fɔ ɛgzampul, yu dijestiv sistɛm ɛn yu respiratory system .

Dɛn ɔl tu spɛshal fɔ dɛn wok dɛn. di εpitεlium kin protεkt mכr , i kin akt lεk barεri fכ di כda wכld. di εndoteyl spεshal fכ gi di bכdi blכd εn כda tin dεm.

Wetin fɔ du if di ɛndoteyl dɔn pwɛl? Dat na wan kɔndishɔn we dɛn kɔl ɛndoteyl disfɔkshɔn!

εndoteyl disfכnkshכ n na we yu εndoteyl nכ ebul fכ du in nכmal wok fayn fayn wan. Dis kin apin we sɔntin pwɛl yu ɛndoteyl sɛl dɛn. Dis damej kin kam bikɔs ɔf difrɛn kayn mɛrɛsin ɛn aw pɔrsin de liv in layf.

Wetin go dɔn de mek dis apin?

• Infεkshכn dεm lεk COVID-19 .
• Di shuga na di blɔd we de go ɔp (Hyperglycemia) .
• Ay blɔd prɛshɔn (Hypertension) .
• Di kɔlɔstrel lɛvɛl we de na di blɔd de go ɔp (Hyperlipidemia) .
• Fɔ nɔ ebul fɔ du bɔku tin dɛn fɔ du.
• Smok ɛn yuz tabak .
• Sivεr infεkshכn dεm lεk sepsis .

di bad tin we kin apin we di εndoteyl dεm dכn pwεl na atεrosklεrosis.

Atεrosklεrosis na we di plek de kכmכ t s כmtεm insay yu at dεm as tεm de go. Sayɛnsman dɛn no se di fɔs tin we kin mek pɔsin gɛt at pwɛl na we di ɛndoteyl kin pwɛl. Bɔku tɛm, dis kin apin bikɔs di LDL (bad kɔlɔstrel) de na di blɔd, we i de smok, ɔ we i gɛt ay blɔd prɛshɔn fɔ lɔng tɛm. we yu εndoteyl dεm dכn pwεl, yu bכdi in imyun sistεm de kik in. I de sεnd wan kayn wayt blכd sεl we dεn k כl monosayt to di atεri wכl we dεn dכn pwεl. dis monosayt dεm kin gεt de εn mek inflameshn insay di atεri. afta dat, siriכs chenj dεm na di sεl dεm de apin, we kin mek sכmtin we dεn kכl "fεt strik" de fכm. Na de plek bigin fɔ fɔm. As tɛm de go, dis plek de gro ɛn mek yu at smɔl. Dis kin mek di blɔd nɔ flɔ. Nɔto dat nɔmɔ, bɔt dis plek de mek di blɔd klɔt mɔ ɛn mɔ. Na dat mek pipul dɛm wae gɛt pwɛl hat endothelium kin gɛt bɔrku risk fɔ gɛt dɛn sik ya.

Dɔn us ɔda sik dɛn kin apin bikɔs ɔf dis damej?

• Koronari Atɛri Sik we pɔsin kin gɛt
• At Atak we pɔsin kin gɛt
• Myocardial Ischemia (we de ridyus di blɔd we de go na di at mɔsul) .
• Pɛriferal Atɛri Disizin
• Kɔndishɔn dɛn we tan lɛk strok
• Trombosis ( we blɔd kin klɔt) .

di εndoteyl dεm we dεn dכn pwεl kin bכku bak di risk fכ:

• Kansa
• Sik dɛn we pɔsin kin gɛt
• Insulin Resistans fɔ mek yu nɔ gɛt insulin
• Kidni Sik we pɔsin kin gɛt

So aw wi go kip dis prɛshɔ ɛndoteyl wɛl?

yu kin εp fכ kip di εndoteyl sεl dεm hεlth bay we yu de ridyus di fri radikal dεm na yu bכdi. Fri radikal na atɔm dɛn we nɔ stebul. Dɛn kin pwɛl di atɔm dɛn we gɛt wɛlbɔdi na di bɔdi. Antiɔksidant dɛnAntioksidant na tin dεm we de protεkt yu bכdi (especially di εndoteyl) frכm fri radikal dεm. So, i rili impɔtant fɔ it it dɛn we gɛt bɔku antiɔksidant. Fɔd dɛn lɛk dis gɛt bɔku tin dɛn we de mek pɔsin nɔ gɛt sik:

• Brawn rays (bran rays) .
• Sitrus frut lɛk lɛmon ɛn ɔrɛnj ɛn dɛn jus
• Dak grɛn vɛjitebul dɛn (lɛk spinach, kale) .
• Oatmil we dɛn kin mek
• Rɛd ɛn yɔlɔ bɛl pepa (fish chili) .
• Swit pata we dɛn mek
• Tomato ɛn tomato jus
• Ɔl di grens dɛn

Yu kin aks yu dɔktɔ wetin yu kin du fɔ ad mɔ antiɔksidant to yu it. Yu dɔktɔ kin sɛn yu to pɔsin we sabi bɔt it. Dɛn kin ɛp yu fɔ mek smɔl chenj dɛn we izi fɔ bigin. Fɔ ɛgzampul, dɛn kin se yu fɔ it tin dɛn we de na di Mɛditarenian, we dɛn no se kin ɛp yu at ɛn yu blɔd vesel dɛn fɔ gɛt wɛlbɔdi.

Wetin na di tin dɛm we de mek fri radikal bɔku? Aw wi go protɛkt wisɛf frɔm dɛn?

Sɔm mɛrɛsin, aw yu de liv yu layf, ɛn pɔyzin kin mek yu bɔdi gɛt mɔ fri radikal. Na sɔm tin dɛn we yu fɔ wach bɔt:

• Pɔlyushɔn we di briz de pwɛl.
• Sɔm mɛrɛsin dɛn, peshɛnt sayd dɛn, ɛn tin dɛn we dɛn kin yuz fɔ klin na faktri.
• Fɔ it bɔku shuga.
• Nɔ gɛt bɛtɛ slip.
• Fat .
• Smok we de kɔmɔt frɔm tin dɛn we dɛn mek wit tabak.

Tɔk to yu dɔktɔ bɔt aw fɔ fɛt dɛn fri radikal ya ɛn protɛkt yu bɔdi frɔm di bad tin dɛn we dɛn kin du. I impɔtant bak fɔ mek dɛn chɛk yu ɛvri ia ɛn tek di mɛrɛsin dɛn we dɛn dɔn gi yu di rayt tɛm. Tɔk to yu dɔktɔ bɔt ɛksɛsayz program we fayn fɔ yu fɔ gɛt wɛlbɔdi. Dɛn tin ya kin ɛp yu at ɛn yu blɔd sistɛm fɔ wok fayn fayn wan. Ɛn dɛn kin ɛp fɔ mek yu ɛndoteyl gɛt wɛlbɔdi.

Mɛmba se ɔlman gɛt risk factor wae kin pwɛl di endothelium sɔm tɛm na in layf. Bɔt yu kin stɔp dɛn prɔblɛm ya bay we yu de liv fayn layf ɛn kɔntrol di prɔblɛm dɛn we yu gɛt.

Fɔ dɔn, di tin dɛn we impɔtant pas ɔl fɔ mɛmba (Take-Home Message) .

So, yu kin si naw se di εndoteyl we wi bin tכk bכt tide na wan pat pan wi bכdi we rili amazing εn rili imכtant. I tan lɛk pɔsin we sidɔm insay wi blɔd vesel, we de sav wi ɔl bɔdi wɛlbɔdi kwayɛt wan.

• di εndoteyl na wan layεr fכ sεl dεm we de layn insay di bכdi vεsul dεm εn di limf vεsul dεm.
• Dis kin du bɔku impɔtant wok dɛn lɛk fɔ kɔntrol di blɔd flɔ, fɔ mek blɔd nɔ klɔt, ɛn fɔ ɛp di tisu dɛn fɔ chenj tin dɛn.
• if di εndoteyl dεm dכn pwεl (endothelial dysfunction), siriכs sik dεm lεk hat sik εn strכk kin kam.
• Wi kin protɛkt dis valyu ɛndoteyl bay we wi de it gud it, ɛksesaiz, avɔyd fɔ smok, ɛn tek ɔda abit dɛn we go mek wi gɛt wɛlbɔdi.

Tɔk to yu dɔktɔ bɔt di wɛlbɔdi fɔ yu ɛndoteyl, ɛn tru am, di wɛlbɔdi fɔ yu ɔl bɔdi. I go rili ɛp yu fɔ gɛt wɛlbɔdi!