Mek wi lan bɔt di supa klin savis insay yu bɔdi! (Ɔtofaji)?

Tide wi go tɔk bɔt wan rili wɔndaful ɛn rili impɔtant prɔses we kin apin na wi yon bɔdi. I tan lɛk wan supa klin savis we de wok insay wi bɔdi ɔltɛm. Sɔntɛm yu nɔ bin dɔn yɛri bɔt am bifo, bɔt na sɔntin we kin rili afɛkt wi wɛlbɔdi, mɔ we wi de ol. Wi de kol am ``Auto PH agy``. Di wɔd de sawnd smɔl strenj, nɔto so? Bɔt lɛ wi ɛksplen am simpul wan.

Wetin na ``Otophagy''? Fɔ tɔk am simpul wan...

Imajin se as yu de yuz yu os, ɛni wan pan di tin dɛn we yu de yuz de ol, sɔm de brok, ɛn sɔm nɔ gɛt yus. Wetin wi kin du da tɛm de? Wi kin pul tin dɛn we nɔ gɛt yus, sɔntɛnde wi kin tek di gud pat dɛn pan ol tin dɛn ɛn mek nyu tin, ɔ wi kin klin di os ɛn kip am fayn, nɔto so? di sem tin kin apin insay di sεl dεm, we na di sכmכl yunit dεm na wi bכdi.

Fɔ tɔk am simpul wan, `(Autophagy)` na wan prɔses we di sɛl dɛn na wi bɔdi kin pul ol, damej, ɔ yuslɛs pat dɛn na dɛn bɔdi ɛn risaykul dɛn, we min se dɛn kin yuz dɛn bak. I tan lɛk se wi sɛl dɛn de klin dɛnsɛf. dis kin bi bak se na "kwaliti kכntrol" sistεm na wi sεl dεm. Bikɔs if dɔti we nɔ nid fɔ gɛda insay wan sɛl, da sɛl de nɔ go ebul fɔ wok fayn. `(Autophagy)` de pul da west de εn if nid de, i de mek yusful tin dεm kכmכt pan am, we de εp di sεl fכ wok fayn fayn wan.

Wetin mek dis ``Autophagy'' impɔtant so?

Naw yu kin de tink se, "Okay, i fayn fɔ mek sɛl dɛn de klin dɛnsɛf, bɔt wetin na di big tin?" כtofagi rili implεnt fכ wi sεl dεm fכ liv εn fכ wok fayn fayn wan. Lɛ wi luk sɔm pan di men pɔynt dɛn:

• Dɛn kin mek di sɛl pat dɛn we dɔn pwɛl ɛn mek dɛn wok bak: Jɔs lɛk aw dɛn kin mek nyu tebul bay we dɛn tek di gud wud dɛn frɔm chia we dɔn brok, na so di sɛl dɛn kin mek nyu pat dɛn bak we go ɛp dɛn frɔm dɛn ol pat dɛn.
• I de pul di pat dɛn we nɔ gɛt yus ɛn we de tek ples: We di sɛl ful-ɔp wit tin dɛn we nɔ nid, i nɔ kin ebul fɔ wok fayn fayn wan. כtofagi de pul dis lod we nכ nid, we de mek wan envayroment fכ di sεl fכ wok fri wan.
• I de pwɛl tin dɛn lɛk jem, baktri, ɛn vayrɔs we de pwɛl di sɛl dɛn: Dis prɔses kin ivin no ɛn pwɛl sɔm bad bad tin dɛn we de go insay wi sɛl dɛn. Dat min se dis kin ɛp wi imyun sistɛm bak.

apat frכm dis, ``Autophagy'' gεt big kכnεkshכn to aw wi de ol εn aw lכng wi de liv hεlth.כltu, as wi de ol, dis prכsεs fכ ``Autophagy'' de slo dכn sכmtεm. Wetin kin apin na dat di dɔti kin bigin fɔ gɛda insay di sɛl dɛn, ɛn di wok we di sɛl dɛn de du kin go dɔŋ. So, fɔ mek yu kɔntinyu fɔ du dis prɔses fayn fayn wan kin impɔtant fɔ mek yu gɛt wɛlbɔdi ɛn lɔng layf.

Aw dis prɔses `(Autophagy)` kin rili apin?

Okay, naw lɛ wi si aw dis wɔndaful klin we de wok insay wan sɛl. Dis kin tan lɛk sayɛns smɔl, bɔt lɛ a ɛksplen am simpul wan.

dis `(Autophagy)` prכsεs de fεsilit bay wan spεshal tכ p protin . dεn kכl dεn tin ya `(Autophagy-related proteins)` כ `(ATGs)`. dis `(ATG)` protin dεm de kכlekt di west insay di sεl, dat na di ol εn dεm we dεn dכn pwεl pat dεm, εn fכm wan strכkchכ we lεk mεmbran rawnd dεm. dis dεn kכl am `(Autophagosome)`. Tink bɔt am lɛk dɔti bag.

afta dat, dis ``Autophagosome'', dat garbage bag, de go to כda spεshal pat pan di sεl. dεn kכl am ``Lysosome.'' Dis ``Lysosome'' lεk "garbage disposal system" insay di sεl. Wetin i de du na fɔ dayjɛst di tin dɛn we de insay da dɔti bag de, dat na fɔ brok dɛn to smɔl smɔl.

Di wɔd "Autophagy" rili kɔmɔt frɔm tu Grik wɔd dɛn. "Autos" min "sɛf" ɛn "Phagomai" min "fɔ it." I min "fɔ it insɛf." I tan lεk se di sεl de "it" in yon pat dεm we i nכ want, nכto?

So afta di `(Lysosome)` dכn daygεst di west, i de rilis di gud pat dεm (lεk raw mεtirial) we dεn kin yuz bak. Dɔn di sɛl kin yuz dɛn raw matirial dɛn de fɔ mek nyu pat dɛn we i nid. Yu nɔ tink se dat na wɔndaful tin?

na us tεm dis prכsεs fכ ``Autophagy'' de stimulate insay wi bכdi?

dis prכsεs fכ ``Autophagy'' kin aksεlayt we wi sεl dεm nכ gεt di nyutriεnt כ כ ksijεn we dεn nid, כ we di sεl dεm gεt sכm damej.

tink bɔt am dis we: `(Autophagy)` na risaykul prɔses we de ɛp wan sɛl fɔ mek i yuz in risɔs dɛn fayn fayn wan. So, we di tin dεm we di sεl gεt frכm כdasay (lεk it, כksijεn) dכn sכm, di sεl gεt fכ yuz di risכs dεm we i gεt bכku bכku wan. na da tεm dis `(Autophagy)` prכsεs de bi mכr aktif.

Fɔ tɔk am simpul wan, i tan lɛk se sɛl de "it" insɛf ɛn tray fɔ liv. Bɔt di gud tin bɔt dis na dat di sɛl dɛn kin bigin fɔ wok fayn fayn wan bikɔs ɔf dis tray fɔ liv.

wi kin intenshכnal indyuz dis prכsεs fכ ``Autophagy''?

Naw yu kin de tink se, "Ah, so wi kin stat dis di we aw wi want am? Dat go fayn!" wεl, sכm we dεm de fכ gi wi sεl dεm sכm " strεs " εn εp dεm fכ stat dis prכsεs fכ ``Autophagy''. Dɛn na:

• Fastin: Dis min se yu nɔ fɔ it fɔ sɔm tɛm. dis min se di bכdi de stכp fכ gεt nyutriεnt frכm di כda wכl εn di sεl dεm de fכs fכ risaykul dεn כwn pat dεm fכ prodyuz enεji.
• Fɔ stɔp di kalori: Dis min se yu fɔ ridyus di kalori we yu de it fɔ wan de we yu nɔ stɔp fɔ it ɔl, lɛk fɔ fast. dis kin mek bak ``Autophagy`` biכs di sεl dεm kin fil se dεn nכ gεt nyutriεnt dεm.
• Swich to it we gɛt bɔku fat, we nɔ gɛt bɔku kab: Dis na wetin bɔku pipul dɛn kin kɔl ``Keto it.`` Wetin kin apin pan dis na di we aw di bɔdi de yuz ɛnaji kin chenj. Bifo i gɛt kabɔhaydrɛt (stach, shuga), i kin bigin fɔ bɔn fat fɔ gɛt ɛnaji. dis swich kin stat di prכsεs fכ ``Autophagy.``
• εksεsayz: we wi de du εksεsayz, spεshal wan we wi mכsul dεm de כnda sכm strεs, di aktiviti fכ di ``ATGs'' protin dεm we wi bin dכn tכk bכt kin inkrεs εn ``Autophagy'' kin stimulate. Dis kin difrɛn difrɛn wan bay di kayn ɛksesaiz we dɛn de du ɛn aw i tranga.

Bɔt, sɔntin de we rili impɔtant fɔ mɛmba na ya. pan tap we we dεn de fכ stimulate `(Autophagy)`, dεn nכ fit fכ כlman. fכ egzampl, if yu bεlε, yu de gi bεlε, כ yu gεt mεdikal kכndyushכn lεk `(Diabetes Mellitus)`, fast, rεstrikt kalori, כ wan wan tεm chenj to `(Keto diet)` kin bi denja. Semweso, i nɔ fayn fɔ mek yu bigin fɔ du ɛksɛsayz we yu de tray tranga wan wantɛm wantɛm we yu nɔ tɔk to dɔktɔ.

Aw lɔŋ yu fɔ fast fɔ bigin `(Autophagy)`?

stכdi dεm pan animal dεm sho se כtofagi kin trigεr bay we yu fast fכ 24 to 48 awa. כltu, dεn nכ rich inof risεch yet fכ εksεkt aw lכng i tek fכ כtofagi fכ kik in insay mכtalman.

So, if yu de tink fɔ mek big chenj to yu it lɛk fɔ fast, mek shɔ se yu tɔk to dɔktɔ. Pan ɔl we fɔ fast kin fayn fɔ sɔm pipul dɛn, i kin ambɔg ɔda pipul dɛn wɛlbɔdi. So nɔ tek risk we yu nɔ nid.

Wetin na di rilayshɔn bitwin `(Autophagy)` ɛn sik?

trade, sayɛnsman dεm bin de tink se ``Autophagy`` na jכs nכmal prכsεs fכ klin sεl dεm, wan kayn "haus kipin." כltu, risεch we dεn du fכ di pas 20 ia dεn sho se ``Autophagy`` kin ple imכtant rol fכ prεvεnt εn rεspכnd to sik .

fכ egzampl, stכdi dεn sho se prכblεm wit di prכsεs fכ ``Autophagy'' kin kכmכt wit dεn sik kכndishכn dεm ya:

• `(Krohn in sik)` (Krohn in sik)
• `(Dayabetes)` (Dayabetis) .
• At sik
• `(Huntington in sik)` (Huntington in sik)
• Kidni sik
• Liva sik
• `(Parkinson in sik)` (Parkinson in sik)

כlso, dεn fכnshכn se prכblεm wit di prכsεs fכ `(Autophagy)` de lεk fכ kεnsar . we ``garbage`` de kכmכt insay wan sεl, i kin inkrεs di risk fכ mistek insay di jεnεtik mεtirial, dat na, `(DNA)`. dis chenj dεm na `(DNA)` kin mek `(Jεnεtik mכtεshכn)`, we kin mek di kεnsar sεl dεm fכm.

Bɔt i at fɔ tɔk if `(Autophagy)` gud ɔ bad fɔ mek pɔsin nɔ gɛt sik. fכ egzampl, sכm stכdi dεn sho se `(Autophagy)` de εp fכ mek tכmכro nכ fכm insay di fכs stej dεm fכ kεnsar. כltu, כda risεch dεn sho se `(Autophagy)` kin mek di kεnsar sεl dεm wok mכr efyushכn εn ivin εp di kεnsar tכmכro dεm fכ gro.

כlso, bכku stכdi dεm we dεn dכn du pan di link bitwin כtofagi εn sik dεn nכ dכn du pan mכtalman. Bɔku tɛm dɛn dɔn du dɛn pan animal dɛn lɛk mays. So, as sayɛnsman dɛn de lan mɔ bɔt dis prɔses, wi kin ebul fɔ gɛt klia pikchɔ bɔt aw i kin afɛkt sɔm sik dɛn ɛn wi wɛlbɔdi fɔ lɔng tɛm.

Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .

dis biεn tεm, we dεn bin de tכk bכku bכt `(Autophagy)`, sכm pipul dεn bin de kכl am jכs "hεlth tren" - wan we fכ de yכng εn gεt hεlty sεl dεm. Bɔt, `(Autophagy)` na rili nɔto so simpul.

na tru se כtofagi implεnt fכ hεlty sεl dεm. Na tru bak se prɔblɛm wit di ɔtofagi prɔses gɛt fɔ du wit sɔm sik dɛn. Bɔt nɔto inɔf risach de fɔ se fɔ mek pɔsin gɛt ɔtofaji fayn fɔ mek pɔsin liv fayn layf.

Dipen pan yu wɛlbɔdi, fɔ fast, fɔ kɔt di kalori, fɔ chenj bad bad wan pan yu it, ɔ fɔ bigin ɛksɛsayz we yu de tray tranga wan wantɛm wantɛm , kin denja. So, i impɔtant fɔ tɔk to yu dɔktɔ bifo yu mek ɛni chenj na yu layf we go afɛkt di we aw yu bɔdi de du tin. I nɔ fayn fɔ jɔs tek dis as ‘trend’ ɛn wantɛm wantɛm stɔp fɔ it, kɔt kalori, ɔ bigin fɔ du ɛksɛsayz we yu de du tranga wan. Na yu dɔktɔ nɔmɔ no wetin bɛtɛ fɔ yu bɔdi.

` כtofagi, sεl klin, fast, sεl hεlth, ol, bכdi fכnshכn, hεlty liv