Yu gɛt rɛd sɛl dɛn we tan lɛk chukchuk na yu blɔd? Lɛ wi lan bɔt (Acanthocytosis)!

Yu dɔn ɛva yɛri bɔt di rɛd blɔd sɛl dɛn we de na yu blɔd? Nɔmal wan, dɛn kin rawnd, lɛk smɔl flat bɔl dɛn. Bɔt sɔntɛnde, dɛn rɛd blɔd sɛl ya kin chenj dɛn shep ɛn tek wan strenj, spayk, ɛn chukchuk shep. na dat di mεdikal tεm fכ dis kכndyushכn dεn kכl am `(Acanthocytosis)`. Jɔs tink, di Grik wɔd "acan" min chukchuk, sɔntin lɛk chukchuk. "Sayt" min wan sɛl. So, "sεl dεm we lεk tכn" na di simpul minin fכ dis.

Fɔ tru, wi ɔl gɛt sɔm pan dɛn sɛl dɛn ya we gɛt chukchuk (Acanthocytes) na wi blɔd. Bɔku tɛm, i nɔ kin bi big prɔblɛm. Bɔt, if yu gɛt tumɔs pan dɛn sɛl dɛn ya we gɛt chukchuk na yu blɔd, na da tɛm de sɔm smɔl smɔl prɔblɛm dɛn kin bigin fɔ kam. Yu no wetin kin apin? Wi gɛt wan ɔgan we dɛn kɔl di splin . I de wok lɛk filta we de klin wi blɔd. Wetin di splin de du na fɔ no di ol sɛl dɛn we dɔn pwɛl na di blɔd ɛn pwɛl dɛn. So, we dεn tכn rεd bכdi sεl dεm de pas tru di splin, di splin de tink se, "O, dεn ya de luk sכmtεm mεs, dεn nכ de lεk nכmal sεl dεm." Dɔn di splin kin bigin fɔ pwɛl dɛn sɛl dɛn ya we gɛt chukchuk kwik kwik wan. We dat apin, di nɔmba fɔ di wɛlbɔdi rɛd blɔd sɛl dɛn na yu bɔdi kin go dɔŋ. dis dεn kכl am anemia כ ``hεmolytic anemia''. Dat min se blɔd nɔ de bikɔs di rɛd blɔd sɛl dɛn de brok. nכto dat nכmכ, dis kכndyushכn we dεn kכl ``Acanthocytosis'' kin bi sayn bak fכ sεvεra כda sik dεm εn kכmplikεshכn dεm. So, we dɛn fɛn dɛn sɛl dɛn ya we gɛt chukchuk na di blɔd, i kin ɛp dɔktɔ dɛn bak fɔ no ɔda sik dɛn we de insay di blɔd.

So, us kayn simptom wi kin gεt bikoz fכ dis `(Acanthocytosis)`?

we yu splin de pwεl di rεd bכdi sεl dεm kwik kwik wan bikoz fכ sik sεl sik, wan kכndyushכn we dεn kכl ``hεmolytic anemia'' de apin. Yu kin gɛt sɔm kayn sik lɛk:

• di skin εn di yay dεm we de yכlכ: Wi kin kכl dis bak ``jaundice'', jכs lεk wetin kin apin we sכm pipul dεn gεt yכlכ fiva.
• Fɔ fil taya pasmak: Nɔto jɔs taya, bɔt fɔ fil se yu taya ilɛksɛf yu slip bɔku.
• I nɔ kin izi fɔ yu fɔ blo: I kin fil shɔt fɔ blo ivin if yu tray smɔl (dyspnea).
• Hat bit kwik kwik wan: Na filin we yu chɛst de bit tumɔs ivin we yu jɔs tinap (tachycardia).
• Blɔd we de na di urine: Sɔntɛnde di urine kin tɔn rɛd ɔ dak brawn (hematuria).
• Bɛlɛ we de at: Bɔku tɛm, dis kin apin bikɔs di splin dɔn swel.

Apat frɔm dɛn sayn ya, ɔda sayn dɛn kin apin dipen pan di sik we de ɔnda yu we mek dɛn skel sɛl ya fɔm na yu bɔdi. Tink bɔt, fɔ sɔm pipul dɛn:

• We yu de lɔs yu wet: If yu na smɔl pikin, yu kin gro sloslo.
• Prɔblɛm dɛn we de kɔdinɛt di mɔsul aktiviti: Lɛk fɔ lɔs balans (ataxia).
• di muvmεnt dεm we di bכdi pat dεm we i nכ kin kכntro: fכ egzampl, fכ blink כ tכn di nεk (tiks).
• I nɔ izi fɔ tink ɛn mɛmba: Fɔ fil lɛk se yu bren de slo (cognitive impairment).
• Prɔblɛm dɛn we gɛt fɔ du wit di we aw pɔsin de digest.
• Pale stɔl: Dis kin apin we dɛn nɔ dayjɛst di fat fayn fayn wan (steatorrhea).
• Urin we gɛt dak kɔlɔ.

If yu gɛt wan ɔ mɔ pan dɛn sik ya, i go fayn fɔ mek yu go to dɔktɔ kwik kwik wan.

Wetin mek dɛn kayn spayky sɛl ya kin fɔm na wi blɔd? Wetin na di rizin dɛn?

fכ simpul wan, di men kכz fכ `(Acanthocytosis)` na di ifekt pan di כta sεl mεmbran fכ di rεd bכdi sεl dεm, dat na di `(sεl mεmbran).` Dis sεl mεmbran na fεt `(lipids)` εn protin dεm . So, if sik ɔ kɔndishɔn de we de afɛkt dɛn impɔtant tin ya, di nɔmal rawnd shep fɔ di rɛd blɔd sɛl dɛn kin chenj ɛn dɛn kin bigin fɔ tek da shep de we tan lɛk chukchuk.

dis modifyed stεm sεl dεm, lεk aw wi bin dכn tכk, nכ kin izi fכ filta we dεn pas tru di splin. So, di splin de pwɛl dɛn. Sɔntɛnde, instead fɔ pwɛl dɛn sɛl ya, di splin kin mek sɔm pan dɛn spayna dɛn nɔ ebul fɔ waka ɛn sɛn dɛn bak na di blɔd. sכmtεm dεn kin kכl dεn modifyed stεm sεl dεm ya `(spur sεl dεm)`.

Na sɔm pan di men tin dɛn we kin mek pɔsin gɛt akantosaytɔsis:

• Sivεr liva sik: Bɔrku tɛm, spur sɛl kin bi sayn fɔ siriɔs liva sik, sɔmtɛm kin mek pɔrsin in layf de pan denja. Sɔm pipul dɛm wae gɛt liva sik kin gɛt wan sik wae dɛn kɔl spur cell anemia (SPA). Dis min se dɛn gɛt spur sɛl dɛn na dɛn blɔd, ɛn dɛn nɔ gɛt bɔku rɛd blɔd sɛl dɛn bak.
• Abetalipoproteinemia: Dis na sik we nɔ kin apin so ɔltɛm, we pɔsin kin gɛt frɔm in jɛnɛtiks. Dat min se, na frɔm mama ɛn papa dɛn kin gɛt am to pikin dɛn. dis sik de mek di bכdi nכ de ebul fכ tek di fεt dεm εn di vaytamεn dεm we de sכlv fεt fayn fayn wan (vitamin A, D, E, K).
• Nyuroakantosaytɔsis: Dis na wan sik bak we nɔ kin apin na di jɛnɛtiks. Dis kin mek i nɔ ebul fɔ kɔntrol di we aw di bɔdi de muv. εgzampl dεm na di chorea-acanthocytosis, McLeod syndrome, pantothenate-kinase asosiet nyurodijεnεreshכn (PKAN), εn di sik we tan lεk Huntington 2.

apat frכm dεn men kכz dεm ya, sכm כda kכndyushכn dεm kin mek bak ``Acanthocytosis``:

• Anorexia nervosa na wan sik wae kin kam wae pɔrsin nɔr kin want fɔ it.
• di tayroyd gland de dכn dכn (Hypothyroidism).
• Myelodysplastic syndrome na wan sik we de ambɔg di bon mɛro.
• Kidni sik.
• ɔspitul fɔ pul di splin (splenectomy).
• sכm mεdikeshכn dεm (fכ egzampl, dεn dεm we de dכn kכlestכl lεk ``statin'').

Aw dɔktɔ dɛn kin no se pɔsin gɛt akantɔsaytɔsis?

Yu dɔktɔ kin no if yu gɛt akantosaytɔsis bay we i du wan periferik blɔd smyuɛl (PBS) . Dis min se yu fɔ tek smɔl blɔd ɛn luk am ɔnda maykroskɔp. dis go sho klia wan se dεn abnכmal, spayky sεl dεm de de.

Dɔn, fɔ no di rayt tin we de mek yu gɛt dɛn sɛba sist ya, yu go nid fɔ du sɔm ɔda blɔd tɛst dɛn. Dɛn tin ya na:

• Kɔmplit blɔd kɔnt (CBC) .
• Test fɔ di wok we di liva de du
• Test dɛn we di kidni de du
• Tɛst fɔ di tayroyd ɔmon
• Blɔd fat lɛvɛl tɛst `(Lipid panɛl)`
• Jεnεtik tεst dεm: Chεk fכ jεnεtik mכtεshכn dεm we gεt fכ sכm sik dεm we dεn kin gεt fכ bכn pikin.

Apat frɔm dat, yu dɔktɔ kin tɛl yu bak fɔ du tɛst lɛk fɔ tek pikchɔ fɔ si if ɛnitin dɔn pwɛl di tisu ɔ ɔgan dɛn we de insay yu bɔdi.

Wetin na di tritmɛnt dɛm fɔ dis?

di tritmεnt fכ acanthocytosis dipכnt pan di kכz. Bɔku tɛm, we dɛn trit di sik we de ɔnda di sik fayn fayn wan, di rɛd blɔd sɛl dɛn kin kam bak to nɔmal.

Tink bɔt am, di tritmɛnt dɛm fɔ di liva sik ɛn kɔndishɔn dɛm lɛk ``Neuroacanthocytosis`` na dɛn men wan fɔ kɔntrol di simptom dɛm. Bɔku tɛm, i nɔ kin izi fɔ mɛn dɛn sik ya ɔltogɛda. Dɛn kin wɔs as tɛm de go. Bɔt pan siriɔs liva sik, sɔm tɛm dɛn de we na di liva transplant nɔmɔ go mɛn.

If yu gɛt wan sik we dɛn kɔl abetalipoproteinemia, yu go nid fɔ ridyus di fat we nɔ fayn fɔ yu ɛn gɛt inof kalori. Yu kin nid bak fɔ tek vaytamɛn sɔpɔtmɛnt fɔ mek shɔ se yu gɛt inof vaytamɛn (A, D, E, K) fɔ bil wɛlbɔdi rɛd blɔd sɛl.

If na anorexia ɔ hypothyroidism, di kɔndishɔn go ɔltɛm bɛtɛ we dɛn trit di ɔndalayn kɔndishɔn. Dɔn bak, if dɛn no se na wan mɛrɛsin de mek di akantosaytɔsis, di sik go ɔltɛm go wans dɛn dɔn stɔp di mɛrɛsin.

If a gɛt dis sik, wetin a fɔ ɛkspɛkt?

Sɔntɛnde, wan sik we dɛn kɔl akantosaytɔsis kin wɛl ɔlsay wit tritmɛnt. Dis min se di rεd bכdi sεl dεm de kam bak to nכmal.

Bɔt bɔku tɛm, di tin we go apin to yu wɛlbɔdi kin dipen pan wetin mek dɛn sɛbas gland ya gro ɛn aw yu bigin fɔ trit am kwik kwik wan.

fכ egzampl, sik dεm lεk `(Neuroacanthocytosis)` εn `(Abetalipoproteinemia)` kin mek di bכdi tisu dεm damej fכ lכng tεm. Bɔt if dɛn no di sik ɛn trit am kwik kwik wan, ., kin mek di sayn dɛm nɔr de go bifo kwik kwik wan.

Jɛnɛral wan, if yu gɛt `(Acanthocytosis)` wit liva sik, i kin siriɔs smɔl. Bɔrku pipul dɛm wae gɛt di `(spur cell anemia)` wae wi bin dɔn tɔk bɔt kin day insay sɔm mɔnt. So, di bɛst we fɔ no bɔt yu sik na frɔm di dɔktɔ we de trit yu. I go luk yu ɔl yu wɛl bɔdi ɛn wetin mek dɛn spur sɛl ya de, ɛn ɛksplen wetin de apin to yu.

we de fכ mek dis `(Acanthocytosis)` nכ apin?

Fɔ tru, if na wan sik we de na di jɛnɛtiks mek akantosaytɔsis, no we nɔ de fɔ mek i nɔ apin. Na bikɔs na sɔntin we wi gɛt frɔm wisɛf. Bɔt sɔm tin dɛn de we wi kin du fɔ ridyus di risk fɔ gɛt dis sik bikɔs ɔf sɔm ɔda tin dɛn.

• Nɔ drink ɔ stɔp fɔ drink rɔm: Dis kin ɛp fɔ mek yu nɔ gɛt liva sik we gɛt fɔ du wit rɔm.
• It tin dɛn we gɛt fayn fayn tin dɛn fɔ it: Yu bɔdi nid fɔ gɛt di rayt tin dɛn we go mek yu gɛt rɛd blɔd sɛl. If yu nid ɛp fɔ pik di rayt it fɔ yu, go to pɔsin we sabi bɔt it.
• Gɛt tritmɛnt kwik: Sɔm tin dɛn we kin mek yu gɛt sist kin siriɔs kwik kwik wan if dɛn nɔ trit yu. So, i rili impɔtant fɔ go to dɔktɔ jɔs afta yu si di sik, no se yu gɛt di sik, ɛn bigin fɔ trit yu.

Aw a go kia fɔ mi wɛlbɔdi biznɛs?

Di tin we impɔtant pas ɔl na fɔ fala di tritmɛnt we yu dɔktɔ gi yu fɔ di ɔndalayn kɔndishɔn we de mek yu gɛt akantosaytɔsis.

If yu gɛt wan sik we yu gɛt frɔm yu jɛnɛtiks we dɛn kɔl akantosaytɔsis, tink bɔt fɔ gɛt advays bɔt yu jɛnɛtiks . Wan pɔsin we de advays yu bɔt yu jɛnɛtiks kin advays yu bɔt aw di sik kin afɛkt yu ɛn yu famili, ɛn di chans we yu go pas di jɛnɛtik muteshɔn we kin mek yu gɛt am to yu pikin dɛn.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

We yu go to dɔktɔ, nɔ shem fɔ aks kwɛstyɔn dɛn lɛk dɛn wan ya:

• A fɔ wɔri fɔ gɛt dɛn sɛl dɛn ya we gɛt chukchuk (Acanthocytes) na mi blɔd?
• Us ɔda tɛst dɛn a go nid fɔ du fɔ no wetin mek dis apin?
• Us kayn tritmɛnt yu kin gi mi?
• Us kayn rizulyt a kin ɛkspɛkt frɔm dɛn tritmɛnt ya?
• A fɔ go to pɔsin we de advays mi bɔt jɛnɛtiks?

Fɔ dɔn, a fɔ se... (Tek-Home Message)

We dɔktɔ dɛn no se yu gɛt di sik, dɛn kin luk bak aw yu rɛd blɔd sɛl dɛn tan. If dεn no se yu gεt `(Acanthocytosis),` i min se yu gεt sכm abnכmal rεd bכdi sεl dεm na yu bכdi. Nɔ wɔri. Sɔntɛnde, tritmɛnt kin mek yu rɛd blɔd sɛl dɛn kam bak to nɔmal. Ɔ, e kin ɛp fɔ kɔntrol di sik we de ɔnda am. Bɔt sɔntɛnde, if yu gɛt akantosayt dɛn na yu blɔd, dat kin bi sayn fɔ wan siriɔs sik, lɛk siriɔs liva sik. So, yu dɔktɔ na di bɛst pɔrsin fɔ ɛksplen ɛksaktɔli aw fɔ gɛt `(Acanthocytosis)` kin afɛkt yu wɛl bɔdi. If yu lisin to wetin i de tɔk ɛn fala di tritmɛnt kɔrɛkt wan, bɔku tɛm yu kin kɔntrol di sik.

` Akantosaytosis, Rεd blכd sεl dεm, Skutellaria, Splin, Anemia, Liva sik