Yu smɔl pikin kin fil taya ɔltɛm, i kin gɛt blu bɔdi, ɔ i kin gɛt fiva ɔltɛm? Sɔntɛnde, dɛn tin ya kin bi jɔs nɔmal sayn dɛm. Bɔt sɔmtɛm, dɛn smɔl smɔl tin ya kin bi sayn fɔ wan siriɔs kɔndishɔn insay di bɔdi. Tide wi go tɔk bɔt wan kayn blɔd kansa we kin apin mɔ pan yɔŋ pikin dɛn, bɔt i kin afɛkt big pipul dɛn bak. I nem na Acute Lymphoblastic Leukemia, ɔ (ALL) fɔ shɔt tɛm. Nɔ wɔri, wi go tɔk bɔt ɔltin insay simpul wɔd dɛn.
Fɔ tɔk am simpul wan, wetin ƆLTIN min?
Acute Lymphoblastic Leukemia (ALL) na wan kayn kansa we kin kam na wi blɔd. Wi blɔd gɛt rɛd blɔd sɛl, wayt blɔd sɛl, ɛn pletlɛt. Wan kayn wayt blɔd sɛl dɛn kɔl am limfosayt. Jɔs lɛk wi kɔntri in ami, dɛn sɛl ya de protɛkt wi bay we dɛn de fɛt sik dɛn ɛn jem dɛn we de kam insay wi bɔdi.
dis limfosayt sεl dεm de kכmכt na di bon mכro insay wi bon dεm. sכmtεm, bikoz fכ wan jεnεtik mכtεshכn na dεn limfosayt sεl dεm ya, dεn kin bigin fכ bi kεnsar sεl dεm insted fכ bi hεlty sεl dεm. Dɛn kansa sɛl ya kin sheb ɛn bɔku kwik kwik wan we dɛn nɔ kin kɔntrol, ɛn dis kin mek di sɛl dɛn we gɛt wɛlbɔdi kɔmɔt. Dɛn jɔs kɔl dis ƆL.
Dɛn kansa sɛl ya nɔ kin jɔs de na di bon mɛro. Dɛn kin travul tru di blɔd ɛn spre (mɛtastas) ɔlsay na di bɔdi.
Bɔt di tin we impɔtant pas ɔl na dat ƆL, pan ɔl we na siriɔs sik, na sik we pɔsin kin mɛn ɔltogɛda wit di rayt tritmɛnt. Di rit we dɛn kin mɛn kin rili bɔku, mɔ pan yɔŋ pikin dɛn.
Wetin na di men kayn ALL?
we wi de tכk bכt limfosayt dεm, tu men tכp dεm de: B sεl dεm εn T sεl dεm. ƆL kansa de kɔmɔt frɔm dɛn tu kayn sɛl ya.
| Di kayn kansa we yu gɛt | Simpul ɛksplen |
|---|---|
| B-sεl כL (B-sεl כL) . | Dis na di kayn we we pipul dɛn kin gɛt mɔ. i de mek lεk 85% pan כL pan pikin dεm εn 75%-80% pan כL pan big pipul dεm. B sεl dεm na di kayn sεl dεm we de mek antibodi dεm agens di jεm dεm na wi bכdi. |
| T-sεl כL (T-sεl כL) . | Dis na tin we nɔ kin apin smɔl. na lεk 25% pan di big pipul dεm εn 12%-15% pan di pikin dεm de gεt dis kayn. T sel dεm na di kayn sεl dεm we de kil jεm dεm dεn wan dεm εn εp כda sεl dεm na di imyun sistεm. |
Apat frɔm dɛn tu kayn ya, wan kayn de bak we nɔ kin bɔku we dɛn kɔl Natural Killer ALL. Yu dɔktɔ go du di tɛst dɛn we yu nid fɔ no ustɛm yu ɔ yu pikin gɛt.
Us sayn dɛn wi kin si?
We ƆL de divɛlɔp, di bɔdi in wɛlbɔdi blɔd sɛl dɛn kin dɔn, ɛn dis kin mek pɔsin gɛt difrɛn sayn dɛn. Dɛn sayn ya kin kam wantɛm wantɛm ɔr kin kam smɔl smɔl.
Impɔtant: Fɔ gɛt dɛn sik ya nɔ min se yu gɛt ƆL. Bɔt if yu gɛt dɛn sik ya fɔ pas tu wiks, i impɔtant fɔ go to dɔktɔ fɔ advays.
| Di sayn we de sho se di sik de | Wetin dat min? |
|---|---|
| I kin taya ɔltɛm ɛn i kin gɛt pale | Bikɔs di rɛd blɔd sɛl dɛn na di bɔdi de go dɔŋ (anemia), ivin fɔ du smɔl smɔl wok dɛn kin mek yu taya, ɛn di bɔdi kin tan lɛk se i nɔ gɛt bɛtɛ blɔd. |
| Fɔ sik ɔltɛm | As di wayt bכdi sεl dεm we gεt hεlty de dכn, di bכdi in ebul fכ fכt sik (immunity) de dכn. Dis kin mek sik dɛn lɛk fiva ɛn kol kin kam bɔku tɛm. |
| Blɔd ɛn brus | As di pletlɛt dɛn we de ɛp fɔ mek di blɔd klɔt de go dɔŋ, di blɔd we de kɔmɔt na di nos, di gam we de blɔd, ɛn ivin smɔl smɔl wund dɛn kin mek big blu spat dɛn na di bɔdi. Uman dɛn kin blɔd bɔku we dɛn de gɛt mɔnt. |
| Rɛd spat dɛn na di skin (petechiae) . | We blɔd de kɔmɔt na di fayn fayn blɔd vesel dɛn we de ɔnda di skin, dat kin mek smɔl smɔl rɛd spat dɛn de na di skin lɛk se na pin de chuk dɛn. |
| Bon ɛn jɔyn pen | As di kansa sel dεm de fulכp di bon mכro, bad bad pen kin apin na di bon dεm εn di joyn dεm. |
| Di limf no dɛm we dɔn swel | di lכmp dεm (nodules) na ples dεm lεk di nεk, di armpit dεm, εn di groin kin swel we yu nכ de fil pen. |
| Ɔda tin dɛn we de apin | Yu kin si sɔm sayn dɛm bak lɛk wae yu nɔr kin want fɔ it, yu nɔr kin gɛt bɔku bɔku bɔdi, yu kin swet na nɛt, ɛn yu nɔr kin ebul fɔ blo fayn. |
Wetin mek dis sik kin apin? Wetin na di tin dɛn we kin mek pɔsin gɛt dis sik?
Nɔr wan patikyula kɔz nɔr de fɔ ƆL kansa. Di men tin we kin mek i apin, lɛk aw wi bin dɔn tɔk bɔt, na di chenj dɛn we kin apin na di jɛnɛtiks we kin apin we di blɔd sɛl dɛn de mek. pan yכŋ pikin dεm, dεn mכtεshכn ya kin apin bifo dεn ivin bכn dεm.
Bɔt dɛn dɔn no bɔku tin dɛn we kin mek pɔsin gɛt dis sik mɔ ɛn mɔ.
- Ej: Di risk kin pasmak pan pikin dɛm we nɔ rich 15 ia yet, mɔ di wan dɛm we ol bitwin 2-5 ia, ɛn big pipul dɛm we dɔn pas 50 ia.
- Sɔm kayn sik wae de kam pan pɔrsin wae gɛt dis sik: Pipul wae gɛt sɔm kayn sik wae de kam pan pɔrsin wae gɛt dis sik, lɛk Down syndrome, kin gɛt smɔl risk fɔ gɛt ALL.
- We yu gɛt raytin: If yu gɛt bɔku raytin, fɔ ɛgzampul, if yu bin dɔn gɛt raytin tritmɛnt fɔ ɔda kansa bifo tɛm, dat kin mek yu gɛt mɔ prɔblɛm.
- Sɔm vayrɔs dɛm: Dɛn biliv bak se sɔm vayrɔs infɛkshɔn dɛm lɛk di Epstein-Barr vayrɔs kin mek di risk bɔku.
- Yuz tabak: Pan big pipul dɛn, we pɔsin gɛt tin dɛn we kin mek pɔsin gɛt kansa lɛk fɔ yuz tabak, dat kin mek bak.
Aw dɔktɔ kin no kɔrɛkt wan bɔt dis sik?
We yu go to dɔktɔ wit di sayn dɛm we yu bin dɔn tɔk bɔt, i go aks yu fɔs wan ditayl kwɛstyɔn bɔt yu simptom dɛm. Dɔn i go du wan ɛgzam pan in bɔdi ɛn ɔda fɔ du bɔku tɛst fɔ no if i gɛt di sik.
- Blɔd tɛst dɛn:Wan rutin Ful Blɔd Kɔnt (FBC) tɛst kin no if di nɔmba fɔ di sɛl dɛn we de na di blɔd nɔ fayn.
- Bon mכro bayopsi: Dis na di men tεst we dεn kin yus fכ kכnfכm di diagnosis. dεn tek sכm sכm bon mכro frכm wan sayt lεk di hip bon כnda anεsthεsia εn dεn de egzamin am כnda maykroskכp. Dis kin sho klia wan if di kansa sɛl dɛn de ɛn if na so, us kayn.
- Imej tɛst: Dɛn kin du CT skan ɛn PET skan fɔ si if di kansa dɔn skata to ɔda pat dɛn na di bɔdi, fɔ ɛgzampul, to di chɛst.
- Spinal tap/Lumbar pancture: If eni dawt de se di kansa sel dεm dכn spre to di bren כ di spεnal kכd, dεn kin tek sכm spεnal fluid frכm di spayna εn tεst am.
Wetin na di tritmɛnt fɔ ƆL?
Bɔku tritmɛnt dɛn de fɔ ƆL. Yu dɔktɔ go disayd di bɛst tritmɛnt plan fɔ yu bay bɔku tin dɛn, lɛk yu ej, di kayn sik we yu gɛt, ɛn di jenɛtik mak dɛn we de na yu kansa sɛl dɛn.
Di men tritmɛnt: Kemotɛrapi
Kimotɛrapi na pawaful mɛrɛsin we de kil kansa sɛl dɛn. Na di men tritmɛnt fɔ ƆL. Dɛn kin gi dis tritmɛnt difrɛn difrɛn stej dɛm, i kin tek frɔm sɔm mɔnt to tu to tri ia.
| Di stej dɛn we dɛn kin gɛt fɔ trit am | Wetin de apin? |
|---|---|
| 1. Di fɔs pat (Rɛmishɔn Indukshɔn) . | Dis kin tek lɛk 4-6 wiks. Di men gol na fɔ pwɛl bɔku kansa sɛl dɛn kwik kwik wan. Insay dis tɛm, bɔku tɛm yu go gɛt fɔ de na ɔspitul. |
| 2. Tritmεnt fכ di nεv sεstem (CNS-directed therapy) . | Dɛn kin gi dis tritmɛnt fɔ mek di kansa sɛl dɛn nɔ go skata to di bren ɛn spɛshal kɔd, ɔ fɔ pwɛl dɛn if dɛn dɔn skata. Bɔku tɛm, dɛn kin du dis na di fɔs stej. |
| 3. Kɔnsolidɛshɔn faz | Afta di sik dɔn dɔn, dis pat kin bigin fɔ pwɛl ɛni kansa sɛl we lɛf. Yu go de na ɔspitul fɔ sɔm dez ɛvri sɔm wik fɔ sɔm mɔnt ɛn dɛn go gɛt mɛrɛsin dɛn we dɛn kin put insay yu bɛlɛ (IV). |
| 4. Di faz fɔ mentenɛns | Dis na di las ɛn lɔng stej. I kin tek lɛk 2-3 ia so. Di gol ya na fɔ mek di sik nɔ kam bak. Bɔku tɛm, dɛn kin gi mɛrɛsin we dɛn kin tek bay mɔt ɛn we dɛn kin put insay dɛn bɛlɛ na di klinik. Nɔ nid fɔ go na ɔspitul bɔku tɛm. |
Ɔda tritmɛnt dɛn
- Targeted therapy: Dis kin min fɔ gi drɔgs we de atak sɔm patikyula chenj dɛn we de na di jɛnɛtiks we dɛn kin si na di kansa sɛl dɛn nɔmɔ. Fɔ ɛgzampul, dis tritmɛnt kin rili wok fɔ pipul dɛn we gɛt wan chenj na dɛn jɛnɛtiks we dɛn kɔl Filadɛlfia kromozom.
- Immunotherapy: Dis min fɔ mek wi yon imyun sistɛm wok fɔ pwɛl di kansa sɛl dɛn. CAR-T sɛl tɛrapi na wan mɔdan tritmɛnt we de ɔnda dis kategori.
- Radieshɔn tɛrapi: Dɛn kin yuz redyushɔn tɛrapi pan kes dɛm we di kansa nɔr de ansa to kemotɛrapi ɔ we di sik kam bak.
- Bɔn mɛrɔ transplant: If ɔda tritmɛnt dɛn nɔ wok ɔ di risk fɔ mek di sik kam bak rili bɔku, dɛn kin sɛn yu fɔ gɛt bon mɛrɔ transplant frɔm pɔsin we gɛt wɛlbɔdi.
Wetin na di chans fɔ mɛn dis sik?
Dis na di big kwɛstyɔn we de na ɔlman in maynd. ƆL na kansa we de ansa fayn fayn wan we dɛn gi am tritmɛnt.
Insay pikin dɛn, di tin dɛn we kin apin kin rili prɔmis. 98% pan di pikin dεm we de gεt di rayt tritmεnt kin rich komplit rεmishכn fכ di sik. di rεt we de liv afta 5 ia afta di sik dεn kכl de hכy lεk 90%.
Dis pasɛnt kin smɔl smɔl pan big pipul dɛn. di 5 ia sכvayv rεt fכ big pipul dεm de bitwin 30% - 40%.
Bɔt i impɔtant fɔ ɔndastand se dɛn tin ya na jɔs statystik. Di we aw pɔsin kin biev we i gɛt tritmɛnt kin rili difrɛn frɔm ɔda pɔsin. So nɔ mek yu fred wit dɛn nɔmba dɛn ya. Na di dɔktɔ we de trit yu nɔmɔ go ebul fɔ gi yu di bɛst infɔmeshɔn bɔt yu ɔ yu pikin in sik.
Na nɔmal tin fɔ fil lɛk se yu layf de fɔdɔm we dɛn no se yu gɛt kansa. Ɛspɛshali if na yu pikin. Bɔt mɛmba se ƆL na sik we pɔsin kin mɛn pas bɔku ɔda kayn kansa dɛn. Trust yu medikal tim. Dɛn go de wit yu pan dis joyn, gi yu ɔl di sɔpɔt ɛn ɛksplen we yu nid.
Mɛsej we dɛn kin kɛr go na os
- Acute Lymphoblastic Leukemia (ALL) na kansa we de kam na di limfosayt, we na wan kayn wayt blɔd sɛl.
- Pan ɔl we dis sik kin bɔku pan yɔŋ pikin dɛn, i kin kam pan ɛnibɔdi we ol ɛni ej.
- If yu gɛt sɔm sayn dɛn lɛk fɔ taya ɔltɛm, fɔ de shayn, fɔ sik ɔltɛm, yu bɔdi de blu, ɛn yu bon dɛn de pen fɔ pas tu wiks, go to dɔktɔ wantɛm wantɛm.
- Pan ɔl we ALL na siriɔs sik, dɛn kin mɛn am kpatakpata wit tritmɛnt dɛn lɛk kemotɛrapi. Di rit we dɛn kin mɛn kin rili bɔku, mɔ pan pikin dɛn.
- De tritmɛnt kin tek lɔng tɛm ɛn taya, bɔt nɔr frayd am, trɔst yu dɔktɔ dɛm, ɛn fala dɛn instrɔkshɔn dɛm ɛksaktɔli.
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