Lɛ wi lan bɔt Anaplastic Large Cell Lymphoma (ALCL) insay simpul wɔd dɛn.

Yu dɔn ɛva yɛri bɔt Anaplastic Large Cell Lymphoma (ALCL)? Sɔntɛm dis nem tan lɛk se i kɔmplikt smɔl. Bɔt nɔ wɔri, dis na wan kayn kansa we nɔ kin bɔku. Tide wi go tɔk bɔt wetin na ALCL, aw i de divɛlɔp, wetin na di sayn dɛm, wetin na di tritmɛnt dɛm, ɛn bɔku ɔda tin dɛm na wan rili simpul we we yu go ɔndastand. Jɔs lɛk we yu de tɔk to yu padi.

Wetin na ALCL (Anaplastik Big Sɛl Limfoma)?

Fɔ tɔk am simpul wan, ALCL na wan kayn kansa we nɔ kin bɔku, we nɔ kin bɔku, we de pan wan big grup we gɛt kansa we dɛn kɔl Nɔn-Hɔdgkin Limfoma . Yu no se lɛk ɔl di Nɔn-Hɔdgkin Limfoma, ALCL na wan kayn kansa bak? I kin apin we wan kayn wayt blɔd sɛl we dɛn kɔl limfosayt na wi bɔdi de gro we wi nɔ ebul fɔ kɔntrol am ɛn i de gro kwik kwik wan pas aw i fɔ gro.

Tink bɔt dɛn limfosayt ya lɛk smɔl sojaman dɛn na wi bɔdi. Dɛn na pat pan wi imyun sistɛm, we de protɛkt wi frɔm jem ɛn sik dɛn. tu men kayn limfosayt dεm de: B sεl dεm εn T sεl dεm . insay ALCL, yu T limfosayt dεm, כ T sεl dεm, de gro abnכmal wan.

Naw lɛ wi si wetin dis nem "anaplastic large cell lymphoma" min.

• Anaplastic : Dis wɔd min se we yu si am ɔnda maykroskɔp, dɛn kansa sɛl ya kin luk rili strenj ɛn difrɛn we yu kɔmpia am wit wɛlbɔdi T limfosayt sɛl dɛn. I tan lɛk se dɛn dɔn chenj di we aw dɛn shep ɛn aw dɛn de luk.
• Big Sεl : dis min se di T limfosayt dεm we de bihayv abnכmal de sho se dεn big pas nכmal T sεl dεm. Dis difrɛns de klia wan ɔnda maykroskɔp.
• Limfoma : Limfoma na kansa we kin apin bikɔs di wayt blɔd sɛl dɛn we dɛn kɔl limfosayt de gro we dɛn nɔ kin kɔntrol. ALCL de divεlכp spεshal frכm T limfosayt dεm.

Dɔn gɛt am? Fɔ tɔk am simpul wan, ALCL na kansa we di T sɛl dɛn kin big pasmak, chenj chenj, ɛn gro we dɛn nɔ kin ebul fɔ kɔntrol.

Difrɛn kayn ALCL de?

Yes, difrɛn kayn ALCL dɛn de. Dɛn kin sheb dɛn tin ya bay usay di kansa de na yu bɔdi ɛn di kayn we aw di kansa sɛl dɛn de.

ALCL we gɛt sistɛm

Dis na di men kayn. "Sistemik" min se i kin afɛkt di wan ol bɔdi. I kin afɛkt yu limf no dɛm , ɔ "gland dɛm" lɛk aw wi kin kɔl dɛm, ɛn insay ɔgan dɛm lɛk yu liva ɛn lɔng, ɛn sɔmtɛm yu skin.

Sεstεmik ALCL dεn sheb am to tu tכp dεm. wan de bays pan if mכtεshכn de insay wan jin we dεn kכl ``Anaplastic Lymphoma Kinase (ALK)'' jin . di jin dεm lεk sכm sכm instrכkshכn buk dεm fכ wi sεl dεm, εn dεn jin dεm ya de tεl ivin wan T limfosayt aw fכ wok.

• ALK-positiv ALCL: Dis na wan kayn kεnsar we gεt mכtεshכn na di ALK jin. Bɔku tɛm, dis na kansa we kin mek pɔsin vɛks. Bɔt i kin apin mɔ pan pikin dɛn ɛn yɔŋ pipul dɛn . Bɔt gud tin na dat, dis kayn tin kin ansa fayn we dɛn tek kimotɛrapi .
• ALK-negative ALCL : Dis kayn nכ gεt di ALK jin mכtεshכn. Dis na kansa bak we de gro fast fast (agresiv). Bɔt i kin afɛkt pipul dɛn we dɔn ol , bɔku tɛm di wan dɛn we dɔn pas 60 ia. Dis kayn kin go insay rɛmishɔn afta kemotɛrapi ɛn afta dat i kin kam bak. So, ALK-nεgεtiv ALCL at fכ trit, εn di prכgnosis wכs pas ALK-positiv ALCL.

Ɔda kayn ALCL dɛn

di kayn ALCL dεm de bak we de gro sloslo pas di sistεmik tכp dεm.

• Primary cutaneous ALCL : Dis na wan kayn we kin afɛkt di skin mɔ. Sɔm kayn sik lɛk blista, bɔmp, ɛn ɛkzema kin apin. Bɔku tɛm (lɛk 90%) i nɔ kin skata pas di skin.
• Breast implant-associated ALCL (BIA-ALCL) : dis na wan kayn ALCL we de divεlכp arawnd di brεst implant dεm. Dɛn kin no am lɛk 10 ia afta dɛn dɔn mek di bɔdi big ɔ we dɛn dɔn mek di bɔdi bak.

Udat kin gɛt ALCL?

Pan ɔl we ALCL kin divɛlɔp pan pipul dɛn we gɛt ɛni ej, sɔm kayn dɛn kin afɛkt sɔm grup dɛn mɔ.

• ALK-positiv ALCL : Dis kin afɛkt pikin dɛn we dɔn rich let fɔ go skul, yɔŋ pipul dɛn, ɛn yɔŋ pipul dɛn we dɔn pas 20 ɛn 30 ia . I kin apin mɔ pan man dɛn .
• ALK-negative ALCL : Dis kin mɔs afɛkt pipul dɛn we dɔn pas 60. I kin apin smɔl bak pan man dɛn.
• Praymari cutaneous ALCL : Dis kin apin mɔ pan big pipul dɛm we dɔn pas 40. I kin apin mɔ pan man ɛn wayt pipul dɛm.
• BIA-ALCL : Dɛn kin no dis sik pan pipul dɛm wae dɔn pas 50 ia . I kin divεlכp pan pipul dεm we dεn bin gεt כl tu di silikon εn salin brεst implant. Dɛn dɔn si se i rili gɛt fɔ du wit di tin dɛn we dɛn kin put na di bɔdi we gɛt tɛkstɔr .

Aw ALCL kɔmɔn?

ALCL na rili wan kansa we nɔ kin bɔku . na כnli lεk 2% pan di nכn-Hכdgkin limfoma dεm na big pipul dεm dεn kin no se na ALCL. Dat na wan rili smɔl pasɛnt.

Wetin na di sayn dɛm fɔ ALCL?

Di simptom dɛm fɔ ALCL kin difrɛn difrɛn wan bay di kayn.

Simptom dɛm fɔ sistɛm ALCL

insay כl tu di ALK-positiv εn ALK-negativ ALCL, di limf no dεm we swεla de kכmכn usay di kεnsar de gro. Dɛn kin fil lɛk se yu gɛt smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl . Ɔda sayn dɛn we de sho se yu gɛt dis sik na:

• Fiva we kin kam ɔltɛm.
• Fɔ fil se yu taya bad bad wan (`Fatigue`).
• Swet na nɛt (`Nayt swet`).
• We yu de lɔs yu wet we yu nɔ ɛksplen.

We dɛn no se bɔku pipul dɛn gɛt di kansa, i kin dɔn spre smɔl, we min se i de na `advanced stej` . If na so i bi, di kansa kin dɔn pas to ɔgan dɛn lɛk yu lɔng, liva, ɔ bon. Dɔn, di sayn dɛm kin apin dipen pan di ɔgan we di sik afɛkt. Fɔ ɛgzampul, if yu chɛst tayt ɔ yu de kɔf ɔltɛm, di ALCL kin dɔn afɛkt di chɛst.

Karakta dεm fכ praymari kכtan ALCL

yu kin si di chenj na di skin pan dis kayn.

• Rɛd ɔ rɛd-brawn bɔmp dɛn we nɔ kɔmɔn kin apia na wan ɔ mɔ say dɛn na di skin, we kin gro big wan as tɛm de go.
• Raised lumps , we big pas kɔyn. Sɔntɛnde, dɛn tin ya kin mek pɔsin it.
• Di bɔmp dɛn kin wund ɛn afta dat i kin tɔn to skab .

Karakta dεm fכ BIA-ALCL (Brεst Implant-Asכsiet ALCL) .

insay dis, yu kin si klia chenj dεm na di brεst.

• Brest de pen.
• Brest we de swel.
• Wan skin rash ɔ ɛkzema.
• Swel ɔ wata we de gɛda nia yu brɔst implant.
• Wan sɔlid mas nia di brɔst implant.

dεn kin si dεn chenj dεm ya na wan brεst, bכt sכmtεm dεn kin si chenj dεm na di tu bכdi.

Wetin kin mek pɔsin gɛt ALCL?

ALCL de apin we di limfosayt sεl dεm we wi bin tכk bכt fכs de mכltiply we dεn nכ kכntro εn bigin fכ gro pas di hεlty tisu we de rawnd dεm. Risach pipul dεm stil nכ no εksεkεkt wetin mek dεn limfosayt sεl dεm ya kin bi kεnsar (malignant sεl dεm).

כltu, dεn dכn no sεvεra jεnεtik mכtεshכn dεm we dεn kin si wit ALCL. Dɛn kin tink se dɛn jɛnɛtik chenj ya kin mek di sɛl dɛn we gɛt wɛlbɔdi kin chenj to kansa sɛl dɛn.

fכ egzampl, di men kכntribyushכn fכ ALK-positiv ALCL na mכtεshכn dεm na di ALK jin . semweso, כda jin mכtεshכn dεm de kכmכn bak pan כda tכp dεm fכ ALCL.

Aw dɛn kin no ALCL? (Diagnosis) .

Yu dɔktɔ go fɔs du yu bɔdi ɛgzam fɔ chɛk fɔ si if yu gɛt sayn dɛn we de sho se yu gɛt ALCL, lɛk di limf no dɛn we dɔn swel. If dɛn saspek dis, dɛn go du sɔm difrɛn tɛst ɛn prosidur dɛn.

• Di we aw dɛn kin tek pikchɔ: Dɛn tin ya kin ɛp fɔ no usay di kansa de. Di kayn imej tɛst we yu nid go difrɛn dipen pan di kayn ALCL. Yu dɔktɔ kin du ɛkstrem rayt na yu chɛst , CT skan , ɔ MRI fɔ luk fɔ tumbu dɛn. PET/CT skan ɔ PET skan kin ɛp fɔ no if di kansa dɔn skata ɔlsay na di bɔdi. If dɛn sɔprayz se BIA-ALCL de, dɛn kin du ɔltrasɔund na di bɔdi .
• Blɔd wok : Di dɔktɔ go du difrɛn blɔd tɛst dɛn, lɛk kɔmplit blɔd kɔnt (CBC), fɔ chɛk fɔ si if i gɛt sayn dɛn fɔ ALCL. If di nɔmba fɔ di blɔd sɛl dɛn (rɛd blɔd sɛl dɛn, wayt blɔd sɛl dɛn, ɔ pletlɛt dɛn) nɔ fayn, dat kin bi sayn fɔ ALCL. dεn go luk bak fכ sכ m εnzym dεm εn כda mak dεm na di bכdi, biכs dεn kin bi sayn dεm bak fכ ALCL.
• Bayopsi : Di onli we fɔ kɔnfɔm se yu gɛt ALCL na fɔ gɛt bayɔpsi. We dɛn de du bayɔpsi, di dɔktɔ kin tek wan smɔl smɔl tisu we dɛn kin tink bɔt ɛn chɛk am ɔnda maykroskɔp. We di dɔktɔ stɔdi dɛn sɛl ya, i go ebul fɔ no uskayn ALCL yu gɛt. Dis kin ɛp bak fɔ plan di tritmɛnt we go wok fayn pas ɔl.

Aw dɛn kin trit ALCL?

Di ɔspitul tritmɛnt fɔ sistɛm ALCL na kemotɛrapi . כpεrayshכ n na di tritmεnt we dεn kin fכs fכ praymari kכtan ALCL εn BIA-ALCL.

Tritmɛnt fɔ sistɛm ALCL

ALK-positiv εn ALK-nεgεtiv anaplastik big sεl limfoma dεm kin rεspכnd fayn to sistεmik kεmothεrapi. Sistem kimotɛrapi involv fɔ gi mɛrɛsin dɛn we de kil kansa tru wan vein, we de travul ɔlsay na di bɔdi tru di blɔd fɔ kil di kansa sɛl dɛn.

Bɔku tɛm, di kimotɛrapi fɔ di sistɛm ALCL kin yuz wan kɔmbayn drɔgs we de wok togɛda fɔ kil di kansa sɛl dɛn. Sɔm ɛgzampul dɛn na:

• BV-CHP : Dis inklud di drɔgs dɛn we dɛn kɔl `Brentuximab Vedotin`, `Cyclophosphamide`, `Doxorubicin (Hydroxydaunorubicin)`, ɛn `Prednisone`.
• CHOP : Dis involv fɔ yuz drɔgs we dɛn kɔl `Cyclophosphamide`, `Doxorubicin (Hydroxydaunorubicin)`, `Vincristine (Oncovin®)`, ɛn `Prednisone`.
• CHEOP : Dis involv fɔ yuz drɔgs we dɛn kɔl `Cyclophosphamide`, `Doxorubicin (Hydroxydaunorubicin)`, `Etoposide`, `Vincristine (Oncovin®)`, ɛn `Prednisone`.

Dɛn tritmɛnt ya kin mek ɔl di sayn dɛm fɔ kansa dɔn insay shɔt tɛm (wi kin kɔl dis `rɛmishɔn`).(Dεn kכl am "rεlaps") כltu, di kεnsar kin kam bak. If yu dɔktɔ tink se di kansa go kam bak, dɛn kin se yu fɔ transplant stem sɛl we yu de na remishɔn. Wan stem sɛl transplant de tek di sɛl dɛn we dɛn dɔn pwɛl bay kemotɛrapi wit wɛlbɔdi sɛl dɛn. afta dat dεn hεlty sεl dεm ya de mek hεlty (we nכ de kεnsar) bכdi sεl dεm.

If di kansa kam bak, yu dɔktɔ kin tɛl yu fɔ yuz difrɛn ɔda kemotɛrapi tritmɛnt dɛn we dɛn mek fɔ mɛn limfoma.

Tritmɛnt fɔ praymari kutan ALCL

Di tritmɛnt we dɛn kin yuz mɔ fɔ dis na ɔpreshɔn . If di kansa dɔn skata to di limf no dɛm, yu kin nid bak fɔ gɛt raytin tɛrapi . Redyushɔn tɛrapi de wok bay we i de dayrɛkt ɛnaji to di kansa sɛl dɛn ɛn pwɛl dɛn.

Bɔku tɛm, praymari kutan ALCL kin kam bak insay fayv ia afta dɛn dɔn trit am. If dis apin, dɛn go nid fɔ du ɔpreshɔn ɛn redyushɔn tɛrapi bak.

If yu gɛt lokaliz tumor dɛm we yu nɔ go ebul fɔ pul wit ɔpreshɔn, ɔ if di kansa de kɔntinyu fɔ kam bak, yu kin nid ɔda tritmɛnt. Dɛn tin ya kin bi:

• Oral Methotrexate : Na drɔg we dɛn kin yuz fɔ trit non-Hodgkin lymphoma.
• Bexarotene : Na drɔg we dɛn kin yuz fɔ trit T-sɛl limfoma we de afɛkt di skin.
• Brentuximab Vedotin : Na drɔg we dɛn kin yuz fɔ trit sistɛm ALCL ɛn ɔda kayn ALCL we kin kam bak.
• Interferon : Na drɔg we de ɛp yu imyun sistɛm fɔ no ɛn fɛt di kansa sɛl dɛm, inklud limfoma.

Tritmɛnt fɔ BIA-ALCL

BIA-ALCL kin wɛl wit ɔpreshɔn fɔ pul yu brɔst implant ɛn ɛni kansa sɛl we de rawnd am. If dɛn nɔ ebul fɔ du ɔpreshɔn, dɛn kin gi dɛn raytin tɛrapi fɔ kil di kansa sɛl dɛn.

If di kansa kam bak ɔ i skata pas di bɔdi, yu dɔktɔ kin tɛl yu fɔ tek kimotɛrapi tritmɛnt dɛn we dɛn kin yuz fɔ trit ALK-negative ALCL. Dɛn tin ya kin inklud CHOP kemotɛrapi ɛn tritmɛnt dɛn lɛk Brentuximab Vedotin.

Aw siriɔs ALCL de?

I nɔ mata di kayn kansa, ALCL na siriɔs kansa we nid fɔ tek tɛm wach am ɛn gɛt di rayt tritmɛnt. Bɔt yu prɔgnosis ɛn tritmɛnt plan dipen pan tin dɛm lɛk di kayn ALCL we yu gɛt, aw yu de ansa to tritmɛnt, ɛn yu Intanɛshɔnal Prɔgnostik Indeks (IPI) skɔ.

Di IPI na ɔnkɔlɔjis dɛn bin divɛlɔp am fɔ ɛp fɔ prɛdikt di autkam fɔ fast-grɔw nɔ-Hɔdgkin limfoma, inklud sistɛm ALCL. Di mak de bays pan dɛn tin ya:

• yu ej.
• Yu ebul fɔ du wok dɛn we yu de du ɛvride.
• Aw fa yu kansa dɔn skata (kansa stej).
• di nכmba fכ di sεbas gland dεm we dεn afekt.

If yu gɛt sistɛm ALCL, aks yu dɔktɔ aw yu IPI skɔ de afɛkt yu chans fɔ wɛl.

Wetin na di sɔvayv rɛt fɔ ALCL?

di rεt fכ sכvayv fכ sεstεmik ALCL de difrεnt bכku. ALK-positiv ALCL de sho se i de liv lכng tεm pas ALK-nεgεtiv ALCL. dipכnt pan tin dεm lεk yu kεnsar tכp εn IPI skכ, di fayv ia sכvayv rεt fכ ALK-positiv ALCL kin kכmכt frכm 33% to 90%. semweso, di fayv ia sכvayv rεt fכ ALK-nεgεtiv ALCL kin kכmכt frכm 13% to 74%.

Praymari kutan ALCL ɛn BIA-ALCL gɛt rili gud sɔvayv rɛt. Pan ɔl we praymari cutaneous ALCL kin go insay rɛmishɔn ɛn kam bak insay fayv ia, di tritmɛnt dɛn we dɛn kin fala kin mek yu layf lɔng. di rεt we de liv na bכt 80% fayv ia afta dεn no di sik. Insay BIA-ALCL, if dɛn pul di kansa kpatakpata wit ɔpreshɔn, bɔku tɛm di kansa kin dɔn kpatakpata.

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

Na sɔm impɔtant kwɛstyɔn dɛn we yu fɔ aks yu dɔktɔ:

• Us kayn ALCL a gɛt?
• Na wan ples nɔmɔ mi kansa de, ɔ i dɔn skata?
• Udat na di spɛshal pipul dɛn we de na di tim we de kia fɔ mi?
• Us tritmɛnt yu kin kɔmɛnt fɔ mi?
• Aw a go ebul fɔ kɔntrol di sayd ɛfɛkt dɛn we di tritmɛnt kin gɛt?
• Wetin na mi IPI skɔ?
• Wetin na di chans fɔ mek mi kansa go insay `rɛmishɔn`?
• Wetin na di chans fɔ mek mi kansa kam bak?
• Aw ɔltɛm a nid fɔ kam fɔ fala-ap visit fɔ wach mi kɔndishɔn?

Na nɔmal tin fɔ fil fɔ fred we yu kam fɔ no se yu gɛt kansa. Bɔt di tin we impɔtant pas ɔl fɔ mɛmba na dat ALCL nɔto wan kayn kansa we gɛt di sem tin we kin apin . Di kayn ALCL we yu gɛt de sho if i de skata kwik ɔ sloslo. Dat go shep yu tritmɛnt opshɔn dɛm ɛn aw yu de si tin. Sɔm pipul dɛn ALCL kin skata kwik kwik wan. Fɔ ɔda pipul dɛn, i kin gro sloslo, ɛn i kin gi yu inof tɛm fɔ gɛt tritmɛnt dɛn we go ɛp fɔ kɔntrol di kansa. Tɔk to yu dɔktɔ bɔt di tin dɛn we go apin to yu bay aw yu dɔn no se yu gɛt di sik.

Di impɔtant tin dɛn we yu nid fɔ mɛmba (Take-Home Message) .

Okay, so lɛ wi sɔma sɔm pan di impɔtant tin dɛn we yu nid fɔ mɛmba frɔm wetin wi dɔn tɔk bɔt.

• ALCL na wan kayn kansa we nɔ kin bɔku, ɛn difrɛn kayn kansa de.
• Nɔto ɔl kayn ALCL na di sem. Sɔm kin skata kwik kwik wan, sɔm kin skata.
• Di tritmɛnt ɛn chans fɔ wɛl kin difrɛn difrɛn wan fɔ di kayn ALCL wae yu gɛt, yu ej, ɛn yu ɔl wɛl bɔdi.
• Pan ɔl we ALK-positiv ALCL kin apin mɔ pan yɔŋ pipul dɛn, i kin ansa fayn to tritmɛnt.
• ALK-negativ ALCL kin afɛkt mɔ big pipul dɛn ɛn i kin kɔmplikt smɔl fɔ trit.
• di prכgnosis fכ di kכtan ALCL εn brεst implant-asכsiet ALCL (BIA-ALCL) jεnarali gud.
• Nɔ panik. If yu gɛt ɛni dawt ɔ ɛni sayn, go to dɔktɔ wantɛm wantɛm.
• Tɔk to yu dɔktɔ opin wan bɔt yu sik, yu tritmɛnt, ɛn ɛni kwɛstyɔn we yu go gɛt. Na dɛn go ebul fɔ ɛp yu di bɛst we.

Mɛmba se nɔto ɔl di wan dɛn we dɛn kin gɛt kansa kin rili siriɔs. Ivin wit ALCL, wit kɔrɛkt diagnosis, tritmɛnt kwik, ɛn gud monitarin, bɔku pipul dɛn kin gɛt saksesful autkam.

` Anaplastik Big Sεl Limfoma, ALCL, Limfoma, Kεnsar, T Sεl dεm, ALK Jin, Kεmothεrapi