We yu yon bɔdi atak yu bren? (Autoimmune Encephalitis) Lɛ wi lan bɔt am.

Yu dɔn ɛva tink bɔt wetin go apin if yu yon bɔdi in difɛns sistɛm, we na di imyun sistɛm , bigin fɔ wok agens yu yon bren? I de mek pɔsin fred smɔl, nɔto so? Na di kayn sik wae wi go tɔk bɔt tide, wae dɛn kɔl Autoimmune Encephalitis (AE). Fɔ tɔk am simpul wan, wetin kin apin we wi imyun sistɛm we de wok lɛk sɛntinɛl na wi bɔdi, mistek atak di wɛlbɔdi sɛl dɛn na wi yon bren ɛn di tin dɛn we de kɛr mɛsej bitwin dɛn. I tan lɛk se wi os sikyɔriti gad tink se wi na tifman ɛn atak wi.

So wetin na dis ɔtoimyun ɛnsɛfalaytis?

Okay, mek wi ɛksplen smɔl mɔ. Autoimmune Encephalitis (AE) nɔto wan sik, na wan grup fɔ sik. Insay ɛni wan pan dɛn tin ya, inflamɛns , ɔ swɛlin de insay yu bren. Dis na bikɔs, lɛk aw wi bin dɔn tɔk, yu imyun sistɛm kin mistek atak sɔm prɔtin ɛn nyurotransmitta dɛn na yu bren in wɛlbɔdi nɛv sɛl dɛn . Tink bɔt am, wi bren tan lɛk kɔmpleks kɔmpyuta sistɛm. dis nεv sεl dεm εn nyurotransmitta dεm lεk waya εn signal dεm we de insay. So, we di imyun sistεm atak am, di wan ol sistεm de go haywire. Dis na wae mek sɔm kayn sik lɛk wae yu nɔr de mɛmba, wae yu de fil lɛk yu de fil, ɛn yu kin gɛt saykosis .

Wetin na di sayn dɛm fɔ dis? Aw wi kin no am?

Bikɔs difrɛn kayn ɔtoimyun ɛnsɛfalaytis de, di sayn dɛm kin difrɛn bad bad wan. Dɔn bak, dɛn sayn ya nɔ kin apin wantɛm wantɛm. Dɛn kin bigin smɔl smɔl fɔ sɔm wik to mɔnt. If yu ɔ pɔsin we yu sabi gɛt dɛn sik ya, i impɔtant fɔ go to dɔktɔ wantɛm wantɛm.

Na sɔm tin dɛn we yu go gɛt:

• Fɔ fil lɛk se yu kɔgnitiv abiliti de go dɔŋ smɔl smɔl. I tan lɛk se yu bren de slo smɔl.
• Prɔblɛm fɔ mɛmba tin dɛn. I kin at fɔ mɛmba nyu tin dɛn, ɛn yu kin ivin fɔgɛt ol tin dɛn.
• Kɔnfyus. Yu nɔ go ebul fɔ no usay yu de ɔ wetin yu de du.
• Di sik dɛn we kin mek pɔsin sik. Sɔntɛnde, i nɔ kin izi fɔ kɔntrol dɛn tin ya wit standad ɛpilepshi mɛrɛsin.
• Muvmɛnt dɛn we nɔmal. fכ egzampl, di mכt εn fes muvmεnt dεm we dεn de ripit כva εn כva, di mכsul dεm de twit, εn di sכt rεspכns to ivin di sכm sכm tin (`exaggerated startle response`).
• I nɔ izi fɔ tɔk (aphasia). I nɔ izi fɔ mek wɔd ɛn tɔk wetin yu tink bɔt.
• Lɔs fɔ balans (ataxia) ɔr kɔdineshɔn prɔblɛm we yu de waka. Yu kin waka lɛk pɔsin we dɔn chak.
• Mental dizayd (`Saykosis`).Dis kin inklud fɔ si, yɛri, ɛn fil tin dɛn we nɔto rial tin (hallucinations). I kin mek bak yu gɛt lay lay tin dɛn ɛn yu kin gɛt paranoia, we na lay lay biliv se ɔda pipul dɛn de tray fɔ du yu bad.

Impɔtant: If yu gɛt wan ɔ mɔ pan dɛn sik ya, i nɔ min se yu gɛt Autoimmune Encephalitis. Bɔt if yu gɛt ɛni wan pan dɛn sik ya, i go fayn fɔ mek yu go to dɔktɔ we sabi du di wok wantɛm wantɛm ɛn mek dɛn chɛk yu.

Us ɔda prɔblɛm dɛn dis kin mek pɔsin gɛt?

Awtoimyun ɛnsɛfalaytis kin mek yu gɛt prɔblɛm if dɛn nɔ trit am fayn, na dat mek i impɔtant fɔ no di sik ɛn bigin fɔ trit am kwik kwik wan.

• Pεrmanεnt impεryans fכ tink abiliti (`Kכgnitiv impεryans`).
• Di stet dεm we de fכ εpileptik fכ lכng tεm (`status epilepticus`).
• Kɔma.
• Ivin day kin apin. Bɔt dis kin apin mɔ if dɛn nɔ de fɛn tritmɛnt ɔ if dɛn delay fɔ di tritmɛnt.

Wetin mek wi gɛt dis? Wetin na di rizin dɛn?

Risach pipul dεm biliv se כtoimyun εnεsεfalaytis kin apin we wi imyun sistεm de mek antibodi dεm agens spεshal protin dεm na di sεf fכ wi כwn nεv sεl dεm כ insay dεm. Dɛn antibodi dɛn ya kin tay pan dɛn prɔtin dɛn de ɛn stɔp dɛn fɔ wok. Dis kin mek di bren inflamɛns.

Lεk bכku כtoimyun kכndyushכn dεm, dεn nכ כndastand gud gud wan yet wetin mek wi imyun sistεm de atak hεlty sεl dεm dis we. Sɔntɛnde, ɔtoimyun ɛnsɛfalaytis (AE) kin apin wit kansa. Dɔktɔ dɛn kin kɔl dis paraneoplastic AE. Ɔda tɛm, infɛkshɔn lɛk di hεpi simpul vayrɔs kin mek am bak. Bɔt fɔ bɔku pipul dɛn, notin nɔ de we dɛn no se kin mek pɔsin gɛt AE.

Udat de pan denja fɔ gɛt dis sik?

If yu gɛt dɛn tin ya, yu go gɛt ɔtoimyun ɛnsɛfalaytis smɔl:

• If yu gɛt kansa ɔ if yu gɛt nyu wan, mɔ di smɔl smɔl kansa we de na di lɔng sɛl, taymoma, ɛn ovarian kansa .
• If yu dɔn tek sɔm imyun tritmɛnt dɛn (immune checkpoint inhibitors) fɔ kansa .
• If yu bin dɔn gɛt infɛkshɔn na yu bren (infectious encephalitis) .

Bɔt i impɔtant fɔ mɛmba se ɔtoimyun ɛnsɛfalaytis (AE) kin kam ivin if yu nɔ gɛt ɛni wan pan dɛn tin ya we kin mek yu gɛt prɔblɛm.

Aw dɛn kin no dis sik? Us tɛst dɛn nid fɔ du?

Dɔktɔ dɛn kin no aw pɔsin kin gɛt ɔtoimyun ɛnsɛfalaytis bay di sayn dɛn we kin apin fɔ sɔm tɛm ɛn di tɛst we kin sho se yu gɛt inflamɛns insay yu bren.

Bikɔs bɔku ɔda tin dɛn de we kin mek yu gɛt di sem kayn sayn to dis `AE` kɔndishɔn, yu kin nid fɔ du sɔm tɛst. Sɔntɛnde, i kin tek sɔm wiks fɔ gɛt diagnosis. Nɔ wɔri, di dɔktɔ dɛn go du wetin bɛtɛ fɔ yu.

Dis na sɔm pan di tɛst ɛn we dɛn we dɛn kin yuz fɔ no if pɔsin gɛt AE:

• Fɔ chɛk yu bɔdi ɛn fɔ tek yu kɔmplit mɛdikal istri.
• wan spεshal egzamεn we riliyt to di nεv sεstem (`Nyurolכjik εgzam`).
• Test dɛn we pɔsin kin gɛt we i de ɔndastand.
• Blɔd tɛst dɛn.
• Tɛst dɛn we dɛn kin du fɔ tek pikchɔ dɛn na di bren. fכ egzampl, wan bren MRI skan (`Brain MRI`).
• wan tεst we involv fכ tek sεribrospεnal fכluid (`Spinal tap`).
• EEG (Ilektroɛnsɛfalogram) tɛst. Dis de mekɔp di ilɛktrik wok we di bren de du.

Yu dɔktɔ kin tɛl yu bak fɔ du ɔda tɛst fɔ no ɔda tin dɛn we de apin to yu.

Wetin na di tritmɛnt dɛm fɔ dis?

Tu men gol dεm de fכ trit כtoimyun εnεfalaytis: fכ sכpres di imyun sistεm (immunosuppression) εn fכ pul wan tכmכro, if i de.

Fɔs layn tɛrapi

Dɛn tritmɛnt ya kin wok bay we dɛn kin ridyus di inflamɛns na di bren.

• Kɔtikosterɔyd - Dis na pawaful mɛrɛsin dɛm we de ridyus inflamɛns.
• IV immunoglobulins (IVIG) - dis na sכlushכn we gεt hεlty antibodi dεm. Dɛn kin gi dɛn insay di bɛlɛ.
• Plasmapheresis - Dis na di we aw dɛn kin pul di bad bad antibodi dɛm na yu blɔd ɛn di blɔd we dɛn dɔn klin kin kam bak na yu bɔdi.

Wetin fɔ du if dis tritmɛnt nɔ wok fayn?

If di fɔs layn tritmɛnt dɛn nɔ de gi di tin dɛn we dɛn want, dɔktɔ dɛn kin tink bɔt ɔda tritmɛnt dɛn lɛk:

• Rituximab - Dis na wan monoklonal antibodi tayp vaksin.
• Cyclophosphamide - Dɛn kin yuz dis bak as kemotɛrapi mɛrɛsin.

Wetin fɔ du if tumbu de?

If dɛn no se yu gɛt tumbu, yu mɛdikal tim kin tɛl yu fɔ du ɔpreshɔn fɔ pul am ɛn/ɔ tek kimotɛrapi . Dis kin ɛp fɔ mek yu AE kɔndishɔn wɛl kwik kwik wan.

Manejmɛnt fɔ di simptom dɛn

Yu kin nid ɔda mɛrɛsin fɔ kɔntrol di sayn dɛm fɔ AE:

• Mɛrɛsin dɛn we de mek pɔsin nɔ gɛt sik- Ridyus ɔ protɛkt di epileptic seizures.
• Mɛrɛsin fɔ mɛn wɔri ɛn pwɛl hat. Sɔm ɛgzampul dɛn na mɛrɛsin wae de mek pɔrsin fil bad ɛn mɛrɛsin wae de mek pɔrsin nɔr de wɔri.
• If mental dizayd de (`saykosis`), den dεn kin gi mεdikeshכn fכ dat (`Antipsychotic mεdikeshכn`).

Apat frɔm dat, fizik tritmɛnt, wok tɛrapi, ɛn/ɔ tɔk tritmɛnt kin rili ɛp fɔ mek yu wɛl kwik kwik wan.

Ustɛm dɛn go ebul fɔ mɛn dis sik?

Di sakses fɔ tritmɛnt fɔ ɔtoimyun ɛnsɛfalaytis (AE) kin difrɛn frɔm wan pɔsin to ɔda pɔsin. Sɔm pipul dɛn kin du wɛl pan di fɔs dez wae dɛn de trit dɛn. Ɔda pipul dɛn kin nid fɔ tek tritmɛnt fɔ sɔm wik ɔ mɔnt.

I nɔ kin izi fɔ mek dɔktɔ dɛn tɔk klia wan aw yu bɔdi go biev we dɛn gɛt tritmɛnt. Bɔt dɛn go wach yu kɔndishɔn gud gud wan ɛn tɛl yu. Trɔst se di dɔktɔ dɛn go ɛp yu.

Wetin na de prognosis fɔ pɔrsin wae gɛt dis sik?

In jɛnɛral, if dɛn no ɛn trit ɔtoimyun ɛnsɛfalaytis kwik, di risk fɔ gɛt lɔng tɛm kɔmplikeshɔn ɛn fɔ kam bak kin ridyus.

Bɔt AE nɔto di sem fɔ ɔlman. If yu gɛt ɔda sik dɛn lɛk kansa, dat kin afɛkt di we aw yu de si tin bak. Yu mɛdikal tim kin gi yu gud aidia bɔt wetin fɔ ɛkspɛkt.

Yu tink se dis na sik we pɔsin kin gɛt fɔ ɔl in layf?

Bɔrku tɛm, ɔtoimyun ɛnsɛfalaytis kin ansa fayn to tritmɛnt ɛn i kin bɛtɛ. Bɔt fɔ sɔm pipul dɛn, dis kin tek lɔng tɛm. Dɔn bak, AE kin kam bak (rilaps), mɔ if yu kansa nɔ de ansa fayn to tritmɛnt.

Autoimmune encephalitis na siriɔs sik we nid fɔ go to dɔktɔ wantɛm wantɛm. Bikɔs difrɛn kayn dɛn de, di sayn dɛm kin difrɛn, ɛn fɔ no if yu gɛt dis sik kin tek sɔm tɛm. Bɔt mɛmba se yu mɛdikal tim go wok togɛda fɔ no di sik ɛn bigin fɔ trit am kwik kwik wan.

Fɔ dɔn, tin dɛn we wi fɔ mɛmba

Di nem Autoimmune Encephalitis kin mek yu fred smɔl, bɔt fɔ no bɔt am kin ɛp yu fɔ tek akshɔn kwik if di sayn dɛn de sho.

• Wetin kin apin pan dis na dat yu yone imyun sistεm de atak yu bren.
• Sɔm kayn sik lɛk wae yu nɔr de mɛmba fayn fayn wan, yu kɔnfyus, yu gɛt ɛpilepshi, yu de muv ɔda kayn we, yu nɔr kin ebul fɔ tɔk, ɛn yu kin chenj yu maynd.
• If yu gɛt dɛn sik ya, yu go mɔs go to dɔktɔ.
• I rili impɔtant fɔ no di sik ɛn bigin fɔ trit am kwik.
• Tritmɛnt de, ɛn bɔku pipul dɛn kin wɛl.
• Sɔntɛnde, di sik kin kam bak, so i impɔtant fɔ fala di advays we dɔktɔ gi yu.

If yu ɔ pɔsin we yu sabi gɛt ɛni ɔda kwɛstyɔn bɔt dis, nɔ fred fɔ tɔk to dɔktɔ. Dɛn kin gladi pasmak fɔ ɛp yu.

` Awtoimyun Ɛnsɛfalaytis, Inflameshɔn na di bren, Imyun sistɛm, Mɛmori lɔs, Epilepsy, Mental sik