Yu bɔdi in yon difens sistɛm de ple trik pan yu? Lɛ wi lan bɔt Autoimmune Pancreatitis insay wan simpul we!

Wi gɛt wan wɔndaful difens sistɛm na wi bɔdi, nɔto so? Na dat wi kin kɔl di imyun sistɛm. I de protɛkt wi bay we i de fɛt di jem, baktri, ɛn vayrɔs dɛn we de mek wi gɛt sik. Bɔt imajin, wetin go apin if sɔntɛnde dis sem difɛns sistɛm we wi gɛt kin kɔnfyus wit di gud sɛl dɛn na wi yon bɔdi ɛn bigin fɔ atak dɛn? Na da tɛm de i kin apin, we dɛn kɔl ``Autoimmune Pancreatitis''. Fɔ tɔk am simpul wan, yu yon imyun sistɛm kin bigin fɔ wok agens yu pankrias.

Wetin na ``Autoimmune Pancreatitis''? Fɔ tɔk am simpul wan...

Tink bɔt yu bɔdi in imyun sistɛm lɛk ami we de protɛkt wan kɔntri. Di wok we dis ami de du na fɔ protɛkt di kɔntri frɔm ɛnimi dɛn we de na do (lɛk jem ɛn vayrɔs). Bɔt insay `(Autoimmune Pancreatitis)`, dis ami kin mek mistek ɛn atak inosɛnt sitizin dɛn na in yon kɔntri (dat na, wɛlbɔdi sɛl dɛn na di pankrias) tink se dɛn na ɛnimi. Dis kin mek di pankrias kin inflam, i kin wund, ɛn i nɔ kin wok fayn. Dis na wetin wi kɔl ɔtoimyun pankriaytis .

Aw dis sik kin bɔku?

Fɔ tru, `(Autoimmune Pancreatitis)` na sik we nɔ kin bɔku . Bɔku tɛm, i kin apin to lɛk wan pan ɔl wan ɔndrɛd tawzin pipul dɛn. if wi tek lכng tεm inflammatory kכndishכn dεm na di pankrias (`chronic pancreatitis`), na כnli lεk 2% pan dεm de fכl insay dis `(Autoimmune Pancreatitis)` kεtכgכri. So, dis nɔto sik we de ambɔg ɔlman.

Yu tink se kayn `(Autoimmune Pancreatitis)` de?

Yes, na tu kayn `(Autoimmune Pancreatitis)` de. Lɛ wi si wetin dɛn bi.

1. Tayp 1 Ɔtoimyun Pankriaytis

Dis na di kayn we we dɛn kin yuz mɔ . insay dis, wi gεt mכr pan wan protin we dεn kכl `(Immunoglobulin G4)` כ `(IgG4)` insay wi bכdi. dis `(IgG4)` na wan kayn antibodi. we swel כ inflameshn de enisay na di bכdi, di lεvεl fכ dis `(IgG4)` de inkrεs.

Bɔt insay dis fɔs kayn, di prɔblɛm nɔto jɔs wit di pankrias. I kin afɛkt ɔda pat dɛn bak na wi bɔdi. Fɔ ɛgzampul:

• di bayl dakt dεm: dis na tכb dεm we lεk tכb we de kכri bayl frכm di liva to di sכmכl intestin.
• di rεnal tכb dεm: Na di tכb dεm we de insay di kidni dεm.
• Liva
• Lɔng
• Galblad we de na di bɔdi
• Saliva gland dɛn
• Tayrɔyd gland we dɛn kɔl

Swel ɛn damej kin apin bak na say dɛn lɛk dis.

2. Tayp 2 Ɔtoimyun Pankriaytis

Dis kayn we de afɛkt di pankrias nɔmɔ . wetin de apin ya na dat wan kayn wayt bכdi sεl we dεn kכl ``nyutrofil`` de damej di pankrias εn pankrεas dakt dεm. Dɛn kin si dis sik mɔr pan yɔŋ pipul dɛm.Dɛn kin gɛt inflammatory bowel disease (IBD) bak.

Wetin na di tin dɛm we kin mek pɔsin gɛt `(Autoimmune Pancreatitis)`? Ɛnitin de we kin mek pɔsin gɛt prɔblɛm?

Risach pipul dɛn stil de tray fɔ no di rayt tin we kin mek i apin , bɔt i kin apin to pipul dɛn we ol bitwin 50 ɛn 60 ia. Bɔt i kin apin bifo tɛm. Man dɛn kin gɛt dis sik tu tɛm pas uman dɛn.

Sɔntɛnde, dɛn kin tink se na di riakshɔn we di bɔdi in imyun sistɛm kin du to baktriyal infɛkshɔn. Apat frɔm dat, pipul dɛm wae gɛt ɔda ɔtoimyun disɔda kin gɛt bɔrku risk fɔ gɛt dis. Fɔ ɛgzampul:

• (Hashimoto in tayroyd): Dis kin mek di tayroyd gland nɔ de wok bɛtɛ (haypothyroidism).
• (Inflammatory bowel disease - IBD): εspεshali kכndishכn dεm lεk `(ulcerative colitis)`.
• (Praymari biliary cholangitis) we gɛt di sik.
• retroperitoneal fibrosis: na di fכmeshכn fכ tisu we lεk ska na di layn na di bak pat na di bכdi.
• Rimatɔyd at: Na inflamɛns na di jɔyn dɛn.
• (Sarkoidosis) we dɛn kɔl .
• (Sjögren in sik we dɛn kɔl Sjögren in sindrom)

If yu gɛt ɔda ɔtoimyun kɔndishɔn lɛk dis, i fayn fɔ mek yu wɔri smɔl bɔt Ɔtoimyun Pankriaytis bak.

Wetin na di sayn dɛm fɔ `(Autoimmune Pancreatitis)`?

We dis sik bigin , nɔr kin si ɛni sayn . Bɔt as di sik de go bifo, di pankrias dakt dɛn kin bigin fɔ smɔl, ɛn dis kin mek di ɛnzaym dɛn we di pankrias kin pul nɔ ebul fɔ pas fayn fayn wan.

If di pankrias dakt blok, i kin mek yu gɛt sɔm sayn dɛn lɛk:

• Di pen we de na di ɔp pat na di bɛlɛ
• Midul bak pen
• Rɔnbɛlɛ
• Nɔs/vomit we pɔsin kin gɛt
• We yu de lɔs yu wet

Impɔtant: Sɔm pan dɛn sayn ya kin si bak pan pankrias kansa. So if yu gɛt dɛn sik ya, i go fayn fɔ mek yu nɔ fred ɛn go to dɔktɔ wantɛm wantɛm fɔ no wetin na di prɔblɛm . Fɔ gɛt `(Autoimmune Pancreatitis)` nɔ min se yu gɛt kansa.

apat frכm dat, כtoimyun pankrεas kin mek i swel, i kin mek i gro we nכ de gro kεnsar, εn sist dεm we fulכp wit wata na di pankrias. If dɛn swel, lumps, ɔ sist ya apin na di ed pan yu pankrias, dɛn kin blok di bayl dakt, we kin mek di bayl nɔ flɔ fayn fayn wan insay di smɔl intestinal. Bayl gɛt wan tin we dɛn kɔl bilirubin. We dis bilirubin gɛda na di blɔd, i kin mek pɔsin gɛt janda.Di skin ɛn di wayt na di yay kin bi yɔlɔ (jaundice), ɛn yu kin fil taya. We bilirubin go ɔp na di urine , di urine kin dak . We dɛn pul bilirubin na di intestinal , di stɔl kin gɛt pale kɔlɔ .

Wetin na di poshubul komplikashכn dεm fכ `(Autoimmune Pancreatitis)`?

If di pankrias inflamɛns fɔ lɔng tɛm, i kin mek yu nɔs, yu nɔ gɛt bɔku bɔku bɔdi, ɛn i kin mek yu gɛt pen ɔltɛm na yu bɛlɛ we de ɔp ɛn bak. Dɔn bak, if di sɛl dɛn we de mek insulin na di pankrias pwɛl , dayabitis kin kam.

di IgG4 antibodi dεm kin atak nכto di pankrias nכmכ, bכt כda כgan dεm, spεshal wan na Tayp 1. dεn kayn כgan dεm ya inklud:

• Bayl dakt dɛn
• Saliva gland dɛn
• Gland dɛn we de mek pɔsin kray
• Tayrɔyd gland (`Tayrɔyd`) .
• Kidni dɛn
• At
• di lכng dεm εn di pleura (layn na di lכng dεm) .

Aw dɛn kin no se pɔsin gɛt Autoimmune Pancreatitis?

Fɔ no dis sik kɔrɛkt wan ɛn mek shɔ se nɔto pankrias kansa, dɛn go nid fɔ du bɔku tɛst dɛn. Yu go nid fɔ gɛt tɛst dɛn lɛk dɛn wan ya:

• Blɔd tɛst: Dɛn tin ya de chɛk fɔ si if di IgG4 gɛt abnɔmal ay lɛvɛl, ɛn bak fɔ di liva we de wok ɛn di lɛvɛl we sɔm kayn blɔd sɛl dɛn de.
• Imej tɛst: Dɛn tin ya de chɛk di sayz fɔ di pankrias, if ɛni skata de, ɔ if di dakt dɛn dɔn smɔl. εgzampl fכ dεn tεst ya na `(CT skan)` εn `(MRI skan)`.
• Bayopsi: Dis na fɔ tek wan smɔl pat pan yu pankrias ɛn chɛk am ɔnda maykroskɔp. dis kin bi tru wan minimally invasive endoscopic prosidur we dεn kכl Endoscopic Ultrasound (EUS). We yu de du dis, yu dɔktɔ kin put wan lɔng tiub we kin chenj (we gɛt layt ɛn ɔltra saund divays na wan ɛnd) insay yu bɛlɛ ɛn yu insay fɔ luk yu pankrias. Dɔn dɛn kin tek bayɔpsi sɛmpul tru yu bɛlɛ ɔ yu insay. Sɔntɛnde, dɔktɔ we de du ɔpreshɔn kin nid fɔ mek smɔl say na yu skin (laparoskopi) fɔ tek bayɔpsi sɛmpul.
• Kɔtikosterɔyd trayal: Dis kin ɛp bak fɔ kɔnfɔm di diagnosis. Dɛn kin gi yu stɛroyd fɔ shɔt tɛm fɔ si if yu IgG4 lɛvɛl go dɔŋ ɛn yu imej tɛst dɛn go bɛtɛ.

Aw dɛn kin trit `(Autoimmune Pancreatitis)`?

I sɔprayz fɔ no se fɔ smɔl pipul dɛn, dis sik kin dɔn fɔ insɛf we dɛn nɔ gɛt ɛni tritmɛnt . Bɔt fɔ bɔku pipul dɛn, dɛn nid fɔ gɛt tritmɛnt .

Dɛn kin trit ɔtoimyun Pankriaytis mɔ wit kɔtikosterɔyd.Wan kayn mɛrɛsin we dɛn kɔl stɛroyd. Fɔ ɛgzampul, wan mɛrɛsin lɛk `(prednisone)` ɔ `(prednisolone)`. Dɛn mɛrɛsin ya de wok bay we dɛn de ridyus di swel ɛn mek di imyun sistɛm we de wok pasmak kol. Bɔrku tɛm, di tritmɛnt kin bigin wit ay doz ɔf stɛroyd. afta dat di doz de ridyus sכmtεm (`tapered`).

If yu nɔ gɛt prɔblɛm, bɔku tɛm yu nɔ kin nid ɛni ɔda tritmɛnt. Di tritmɛnt we dɛn nid de dipen pan di kayn kɔmplikeshɔn. if di pankrεas dakt sכmtεm sכmtεm (`duct narrowing`), dεn kin du wan prכsidכs fכ opin di dakt εn strכng am wit wan olo mεsh divays (`stent`).

A kin mek a nɔ gɛt `(Autoimmune Pancreatitis)`?

Fɔ tru, natin nɔ de we yu go du fɔ mek dis sik nɔ kam bikɔs na prɔblɛm wit wi yon imyun sistɛm.

Wetin na de luk fɔ pipul dɛm wae gɛt `(Autoimmune Pancreatitis)`?

Bɔrku pipul dɛn kin wɛl fayn fayn wan afta dɛn dɔn trit kɔtikosterɔyd , ɛn nɔr kin gɛt prɔblɛm wit dɛn. We yu gɛt ɔtoimyun pankriaytis nɔ de afɛkt di we aw yu de liv yu layf .

כltu, `(Autoimmune Pancreatitis)` kin kam bak (rilaps) . dis kin kכmכn spεshal pan pipul dεm we gεt di fכs tכyp (`Type 1`). Di sik kin kam bak insay di fɔs tri ia afta dɛn dɔn no se i gɛt am. Pɔsin wae gɛt dis sik kin kam bak kin gɛt prɔblɛm bak.

Wetin kin apin if di sik kam bak?

If dɛn mɛn am fayn fayn wan, ivin di wan dɛn we gɛt sik we de kam bak kin liv aktif, wɛlbɔdi layf .

Yu kin nid fɔ bigin yuz kɔtikosterɔyd bak. Sɔm pipul dɛn kin kɔntinyu fɔ gɛt stɛroyd tritmɛnt fɔ sɔm ia fɔ mek dɛn nɔ gɛt di sik bak. Dɔktɔ dɛn kin tray ɔda mɛrɛsin dɛn bak we de trit wan imyun sistɛm we de wok pasmak (immunomodulating ɛn immunosuppressive drugs).

Aw a go fil we dɛn de trit mi?

Sɔm sayd ɛfɛkt kin apin we yu de yuz stɛroyd. Fɔ ɛgzampul, di bɛlɛ kin at, i kin want fɔ it mɔ, i nɔ kin rɛst, ɛn i nɔ kin izi fɔ slip. Dɛn sayd ɛfɛkt ya kin ambɔg smɔl layf ɛvride, bɔt dɛn kin de fɔ shɔt tɛm . Fɔ mek yu gɛt di bɛst pan yu Autoimmune Pancreatitis tritmɛnt, i impɔtant fɔ kɔntinyu fɔ tek di sterɔyd dɛn lɛk aw yu dɔktɔ tɛl yu .

If di sayd ɛfɛkt dɛn tu de mɔna yu fɔ bia, mek shɔ se yu tɛl yu dɔktɔ bifo yu stɔp di tritmɛnt. I kin gi yu ɔda tritmɛnt fɔ ɛp yu fɔ gɛt rilif, ɔ chenj yu tritmɛnt plan.

Ustɛm a kin go bak to nɔmal aktiviti afta tritmɛnt fɔ `(Autoimmune Pancreatitis)`?

stεroyd tritmεnt kin gi rilif frכm di simptom dεm fכ `(Autoimmune Pancreatitis)` insay fכ wik.Bɔrku pipul kin kam bak to dɛn nɔrmal tin wae dɛn kin du afta dɛn sik dɔn dɔn.

Awtoimyun Pankrias na wan sik we nɔ kin apin so ɔltɛm we kin afɛkt di wok we di pankrias de du. We yu go to dɔktɔ we sabi bɔt pankrias sik dɛn, dat kin ɛp yu fɔ gɛt di bɛst kia we yu nid. Bɔku pipul dɛn kin wɛl afta dɛn dɔn tek stɛroyd . Sɔm pipul dɛn kin nid ɔda tritmɛnt fɔ Autoimmune Pancreatitis fɔ mek dɛn gɛt rilif fɔ lɔng tɛm.

Fɔ dɔn, mɛmba dis (Take-Home Message) .

• Awtoimyun Pankrias na wan sik we nɔ kin apin so ɔltɛm we yu yon imyun sistɛm kin atak yu pankrias.
• If yu gɛt sɔm sayn dɛn lɛk bɛlɛ pen, yu wet, ɔ yu gɛt janda , mek shɔ se yu go to dɔktɔ .
• Dis nɔto pankrias kansa, bɔt di sayn dɛn we de sho se i gɛt di sem tin, so i impɔtant fɔ no di rayt we .
• Di men tritmɛnt na kɔtikosterɔyd.
• Bɔrku pipul dɛn kin wɛl fayn fayn wan wit tritmɛnt, bɔt dis sik kin kam bak.
• I rili impɔtant fɔ fala di dɔktɔ in instrɔkshɔn dɛn di rayt we fɔ mek yu wɛl kwik kwik wan .

Mɛmba se nɔto yu wangren de. Na nɔmal tin fɔ gɛt bɔku tin dɛn we de rɔn na yu maynd pan tin lɛk dis. So, tɔk to yu dɔktɔ ɛn aks yu kwɛstyɔn dɛn. Dɛn de ya fɔ ɛp yu.

` Awtoimyun Pankrεas, Pankrεas, Awtoimyuniti, IgG4, Pankrεas hεlth, Pankrεas Sinhala, Dijestiv hεlth