Yu mama, yu anti, yu sista, ɔ yu fambul we de nia yu dɔn ɛva gɛt bɔdi kansa? We dat apin, na nɔmal tin fɔ fil bɔku fred ɛn wɔri, de wɔnda se, "A go gɛt am bak?" Bɔku tɛm, dɛn kayn kansa ya kin gɛt fɔ du wit wan risk we pɔsin kin gɛt frɔm in mama ɛn papa. Tide, wi go tɔk bɔt wan spɛshal tɛst we de luk fɔ da ɛritaj risk de. Dat na di BRCA jin tɛst.
Fɔ tɔk am simpul wan, wetin na dis BRCA tɛst?
Okay, mek wi put am dis we. Wi ɔl gɛt tu kayn jin dɛn na wi bɔdi we dɛn kɔl BRCA1 ɛn BRCA2 . Di men wok we dɛn de du na fɔ mek di DNA na wi bɔdi in sɛl dɛn fayn ɛn stɔp di kansa sɛl dɛn fɔ gro we wi nɔ ebul fɔ kɔntrol. I tan lɛk di bɔdi in yon gad dɛn. Na dat mek wi kin kɔl dɛn tumor suppressor genes ya bak.
Naw imajin, wetin go apin if sɔntin de we nɔ fayn, ɔ chenj chenj, na dɛn jin ya we de protɛkt wi? Dɔn di prɔses we de stɔp di kansa sɛl dɛn fɔ gro kin wik. Dis kin rili mek di chans fɔ gɛt kansa na yu bɔdi, ovarian kansa , ɛn bɔku ɔda kayn kansa dɛn.
di imכtant tin na dat dεn BRCA jin mכtεshכn dεm ya na ɛritayt . Dat min se dɛn kin pas frɔm mama to pikin. Di BRCA tɛst de tek wan sɛmpul pan yu blɔd ɛn chɛk fɔ si if yu gɛt risk muteshon na di BRCA1 ɔ BRCA2 jin dɛm.
Yu tink se ɔlman fɔ gɛt dis BRCA tɛst?
Nɔ, nɔto so atɔl. Dɛn BRCA jin difrɛns ya nɔ kin rili kɔmɔn na sosayti. So, dɔktɔ dɛn nɔ kin se yu fɔ du dis tɛst pas yu gɛt sɔm tin dɛn we kin mek yu gɛt dis sik. Dis nɔto tɛst we jɔs de fɔ mek pɔsin want fɔ no mɔ.
So, us kayn pipul dɛn dɔktɔ go tɛl yu fɔ du dis tɛst? Mek wi si.
| Risk factor | Wan simpul ɛksplen |
|---|---|
| Pɔsin in yon kansa istri | If yusɛf dɔn gɛt bɔdi kansa, mɔ if i bin dɔn gɛt bifo yu ol 50. Ɔ if yu dɔn gɛt bɔdi ɛn ovarian kansa. |
| Famili kansa istri | If wan ɔ mɔ pipul dɛn na yu famili (lɛk yu mama, yu sista, yu gyal pikin, yu anti) dɔn gɛt bɔdi kansa, mɔ if man dɔn gɛt bɔdi kansa, dat na strɔng tin bak. |
| Wan BRCA difrɛns we dɛn dɔn ɔlrɛdi no | If dɛn dɔn ɔlrɛdi kɔnfyus pɔsin na yu famili se i gɛt BRCA jin dɛfɛkt. |
| Ɔda kayn kansa dɛn | If pɔsin na yu famili dɔn gɛt kansa lɛk ovarian kansa, pankrias kansa, ɔ prɔstat kansa. |
| Sik dɛn we nɔ kin bɔku we pɔsin kin gɛt frɔm in mama ɛn papa | If ɛnibɔdi na yu famili gɛt ɔda sik dɛn we yu kin gɛt frɔm yu mama ɛn papa we kin mek yu gɛt kansa, lɛk Cowden syndrome ɔ Li-Fraumeni syndrome. |
Di tin we impɔtant pas ɔl na dat yu nɔ fɔ disayd fɔ yusɛf if yu fɔ du dis tɛst ɔ nɔ fɔ du am. I bɛtɛ fɔ mek yu tɔk bɔt dis wit yu dɔktɔ ɛn disayd fɔ du sɔntin bay di advays we i gi yu.
Wetin wi kin lan frɔm BRCA tɛst?
If dis tɛst kɔnfyus se yu gɛt BRCA jin dɛfekt, dat min se yu gɛt ay pas nɔmal risk fɔ gɛt sɔm kayn kansa.
Tink bɔt dis: Pɔsin we gɛt BRCA jin muteshɔn kin gɛt siks tɛm mɔ risk fɔ gɛt bɔdi kansa we i ol 80 ia we yu kɔmpia am to di jenɛral pipul dɛn. Di kansa kin apin bak we i yɔŋ ɛn i kin afɛkt ɔl tu di bɔdi.
Apat frɔm di kansa na di bɔdi, dis prɔblɛm we de na di jɛnɛtiks kin mek pɔsin gɛt bɔku ɔda kayn kansa:
- Ovarian kansa : Dɔn bak we gɛt fɔ du wit am na fallopian tube kansa ɛn peritoneal kansa.
- Prɔstat kansa : Fɔ man dɛn.
- Kansa na di pankrias
- Fanconi anemia : Na kansa we nɔ kin apin so ɔltɛm we kin apin we i smɔl.
Wetin kin apin bifo, di tɛm ɛn afta di tɛst?
Dis prɔses nɔr kɔmplikt lɛk aw yu go tink.
Bifo di tɛst
Bɔku tɛm dɛn go sɛn yu to pɔsin we de advays yu bɔt yu jɛnɛtiks . Dis na pipul dɛm wae gɛt ɛkspɛriɛns pan jin dɛm, ɛriti, ɛn kansa risk. I go ɛksplen to yu dɛn tin ya:
- Wetin i min if di tɛst rizɔlt na `Positive` ɔ `Negative`?
- Aw di rizɔlt kin afɛkt di risk we yu gɛt fɔ gɛt kansa?
- Aw dis rizɔlt go afɛkt di ɔda pipul dɛm na yu famili (pikin dɛm, brɔda ɛn sista dɛm)?
We dɛn de du di tɛst
I rili simpul. I jɔs de tek blɔd sɛmpul frɔm wan vein na yu an. Jɔs lɛk aw dɛn kin gi blɔd fɔ mek dɛn du blɔd tɛst ɔltɛm. Pan ɔl we yu kin fil smɔl pen we dɛn put di nidul, di wan ol tin we dɛn kin du nɔ kin tek fayv minit.
Afta di tɛst
I kin tek sɔm wiks fɔ mek di rizɔlt kam bak. Afta di rizɔlt kam bak, yu fɔ mit wit yu jenɛtik kɔlnɔ bak. I go ɛp yu fɔ ɔndastand di tin dɛn we go apin ɛn tɔk bɔt wetin yu nid fɔ du nɛks.
Wetin di tin dɛn we kin apin kin min?
Tri kayn tin dɛn de we kin apin. Lɛ wi tɔk bɔt dɛn klia wan wan bay wan.
| Rizult tayp | Wetin dat min? |
|---|---|
| 1. Di rizulyt na gud tin. | |
| Minin | Dis min se yu gɛt wan muteshon na yu BRCA1 ɔ BRCA2 jin we de mek yu gɛt kansa mɔ. Bɔt dis nɔ min se yu gɛt kansa ɔ yu go mɔs gɛt am. I jɔs min se yu risk de bɔku. |
| Wetin fɔ du nɛks? | Naw yu kin tek step fɔ ridyus yu risk. Afta yu dɔn tɔk bɔt dis wit yu dɔktɔ, yu kin tink bɔt tin dɛn lɛk:
|
| 2. Di rizulyt na negatif. | |
| Minin | I min se yu nɔ gɛt BRCA jin dɛfekt na yu bɔdi. Dat min se yu pikin dɛn nɔ go gɛt BRCA jin dɛfɛkt frɔm yu. |
| Bɔt... | Dis nɔ de gi garanti se yu nɔ go ɛva gɛt kansa. I jɔs min se yu risk tan lɛk di wan we pɔsin we de na di jenɛral pipul dɛn gɛt. Bɔt if yu gɛt strɔng famili histri bɔt kansa, yu kin gɛt difrɛn jin muteshɔn we kin mek yu gɛt kansa mɔ. Tɔk to yu jenɛtik advaysa bɔt dis. |
| 3. Di rizulyt nɔ shɔ (Uncetain / VUS) . | |
| Minin | Dis na tin we kɔmplikt smɔl. Dis min se chenj (`variant`) de na yu BRCA jin, bɔt sayɛnsman dɛn nɔ shɔ yet if di chenj de ambɔg, i de mek di risk fɔ gɛt kansa go ɔp, ɔ na nɔmal, chenj we nɔ de du bad. Dɛn kɔl dis `Variant of Unknown Significance (VUS).` |
| Wetin fɔ du nɛks? | Nɔ panik na dis tɛm. Yu jenɛtik advaysa go ɛksplen dis to yu mɔ. Yu kin nid fɔ mek dɛn tɛst ɔda pipul dɛn na yu famili ɔ dɛn go tɛl yu tumara bambay if nyu infɔmeshɔn kam. Fɔ naw, dɛn kin tek dis kayn rizɔlt as bad rizɔlt. |
Mɛsej we dɛn kin kɛr go na os
- di BRCA tεst na spεshal jεnεtik tεst we de luk fכ ɛritayt risk fכ brεst, ovarian, εn sεvεra כda kayn kεnsar.
- Dis nɔto tɛst we ɔlman fɔ gɛt. Dɔktɔ dɛn kin jɔs tɛl pipul dɛn we gɛt sɔm tin dɛn we kin mek dɛn gɛt kansa, lɛk we dɛn famili gɛt kansa.
- If yu gɛt gud rizɔlt nɔ min se yu gɛt kansa. E min se yu risk de pasmak ɛn yu kin tek step fɔ manej da risk de.
- I rili impɔtant fɔ tɔk bɔt dis wit dɔktɔ ɛn pɔsin we de advays yu bɔt di jɛnɛtiks bifo ɛn afta yu gɛt di rizɔlt.
- No na pawa. Fɔ no bɔt di prɔblɛm dɛn we yu kin gɛt na impɔtant tin fɔ protɛkt yu ɛn yu famili fɔ gɛt wɛlbɔdi tumara bambay.
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