Ivin we wi yɛri di wɔd kansa, wi ɔl kin gɛt big fred na wi maynd. Bɔt tide, mɛrɛsin sayɛns dɔn go bifo bɔku. Dɛn dɔn si se wɔndaful we dɛn fɔ trit pɔsin fɔ fɛt di kansa sɛl dɛn. Tide wi go tɔk bɔt wan pan dɛn kayn spɛshal tritmɛnt we dɛn de. Fɔ tɔk am simpul wan, dɛn kin yuz dɛn tin ya fɔ ambɔg di it we di kansa tɔŋ dɛn de it, dat na di blɔd we dɛn de gi ɛn fɔ mek dɛn slo fɔ gro.
Wetin na dɛn Angiogenesis Inhibitors ya rili?
Fɔ ɔndastand dis, lɛ wi tek wan smɔl ɛgzampul. Imajin, fɔ mek ɛni tik gro big, i nid fɔ gɛt wata ɛn tin dɛn we de mek i gɛt tin fɔ it ɔltɛm. Semweso, fɔ mek tumbu big ɛn go na ɔda pat dɛn na di bɔdi, i impɔtant fɔ gɛt gud blɔd.
Kansa tumbu kin rili smɔl fɔs. Da tɛm de, i kin tek di tin dɛn we i nid frɔm di wɛlbɔdi tisu we de rawnd am. bכt we di tכmכro gro to lεk 1-2 milimita, i gεt fכ divεlכp nyu bכdi vεsεl sistεm fכ in yon. Jɔs lɛk aw plant kin gro nyu branch dɛn. Na frɔm dɛn nyu blɔd vesel ya di kansa tɔŋ de ‘fid’, gro ivin big, ɛn bigin fɔ skata.
Dɛn spɛshal mɛrɛsin ya we dɛn kɔl Angiogenesis Inhibitors , de wok bay we dɛn de stɔp di kansa sɛl dɛn fɔ mek nyu blɔd vesel dɛn. Dis kin mek di kansa sɛl dɛn nɔ gro kwik kwik wan, ɛn sɔntɛnde di sɛl dɛn kin ivin smɔl. Pan ɔl we dis tritmɛnt nɔ go ebul fɔ mɛn di kansa ɔltogɛda, i kin kɔntrol aw di kansa de gro ɛn mek yu de wit di wan dɛn we yu lɛk fɔ smɔl tɛm.
Aw dis mɛrɛsin de wok?
dis dכg dεm de blכk wan prכsεs we dεn kכl Angiogenesis we de apin na wi bכdi. Nɔmal wan, dis na tin we rili impɔtant fɔ wi bɔdi. Imajin se yu gɛt wund na yu an. afta dat dεn sεl dεm we inju de mek wan spεshal signal (SOS signal) we se, ‘εp wi!’. Bikɔs ɔf dis signal, nyu blɔd kapilari dɛn kin kɔmɔt frɔm di blɔd vesel dɛn we de rawnd di wund, we kin mek di wund gɛt di blɔd we i nid ɛn mɛn am.
Naw di tin we bad pas ɔl na ya na dat di kansa sɛl dɛn bak de yuz dis gud prɔses na wi bɔdi fɔ dɛn bɛnifit. Dɛn kin sɛn di sem sayn dɛn bak ɛn mek nyu blɔd vesel dɛn fɔ it dɛnsɛf.
wetin di Angiogenesis Inhibitors de du na fכ disrupt dat signal sistεm.
- di men signal we de insay dis signal sistεm na wan protin we dεn kכl VEGF (Vascular Endothelial Growth Factor) .
- we dis protin, VEGF, de tay pan di rεsεpכta dεm we de na di sεl dεm, i de sεnd di mεsej fכ nyu bכdi vεsul dεm fכ fכm.
- Dɛn mɛrɛsin ya kin stɔp dis prɔses difrɛn we dɛn.
| Aw i de wok | Ɛgzampul dɛn bɔt di kayn drɔgs dɛn |
|---|---|
| i de tay pan di VEGF protin εn i de stכp am fכ biεn to di rεsεpכta dεm. | Monoklonal antibodi dεm lεk Bevacizumab (Avastin®). |
| i de blכk signal frכm di VEGF rεsεpכta dεm dεn wan dεm. | Tayrosin kinaz Inhibitor dεm lεk Sorafenib (Nexavar®) εn Sunitinib (Sutent®). |
| i de blכk כda signal sistεm dεm we de involv fכ fכm di bכdi vεsul dεm na di kεnsar tכmכro dεm. | Imyunmodulεtכr dεm lεk Thalidomide εn Lenalidomide (Revlimid®). |
Us kɔndishɔn dɛn kin yuz dis mɛrɛsin fɔ?
Bɔku tɛm, dɔktɔ dɛn kin tɛl dɛn dis tritmɛnt fɔ kansa dɛn we dɔn go bifo ɔ we dɔn kam bak afta dɛn dɔn trit am. Fɔ ɛgzampul:
- Bren kansa
- Brɔst kansa
- Kansa na di sɛvikal
- Kansa na di kɔlon
- Kidni kansa
- Kansa na di liva
- Kansa na di lɔng
- Limfoma ɛn Mɔltipɛl Mayloma
- Kansa na di pankrias
- Bɛlɛ kansa
- Tayrɔyd kansa
- Kansa na di uterin
Apat frɔm dat, dɛn kin yuz dis kayn mɛrɛsin we dɛn kɔl VEGF inhibitors bak fɔ trit sɔm sik dɛn we kin apin na di yay we di blɔd vesel dɛn nɔ de gro fayn na di yay.
Wetin kin apin we dɛn de trit am?
Dɛn nɔ kin gi dɛn mɛrɛsin ya dɛn wan. Bɔku tɛm dɛn kin gi dɛn togɛda wit ɔda tritmɛnt dɛn fɔ kansa, lɛk kemotɛrapi ɔ imyunotɛrapi. Fɔ tɔk am simpul wan, di wan dɛn we de mek di angiogenesis inhibitors de mek di kansa angri bay we dɛn de mek i nɔ gɛt in it, ɛn ɔda tritmɛnt dɛn de kil di kansa sɛl dɛn dairekt wan.
Dipen pan di kayn mɛrɛsin we dɛn gi yu, dɛn kin gi yu am as pil wan ɔ tu tɛm insay di de, ɔ dɛn kin gi yu am insay yu bɛlɛ (IV) wit salin wan tɛm ɛvri sɔm dez.
Aw lɔng di tritmɛnt go dipen pan di kayn mɛrɛsin we dɛn gi yu ɛn di sik we yu gɛt. Sɔm pipul dɛn kin kɔntinyu fɔ tek di mɛrɛsin as lɔng as i de wok. Ɔda pipul dɛn kin gɛt fɔ stɔp we dɛn nɔ kin ebul fɔ bia wit di sayd ɛfɛkt dɛn. Dis ɔl kin disayd bay we yu tɔk to yu dɔktɔ ɛn wej di gud ɛn bad tin dɛn we di tritmɛnt gɛt.
Wetin na di risk ɛn sayd ɛfɛkt dɛm?
I rili impɔtant fɔ mek yu no di bad tin dɛn ɛn di bad tin dɛn we kin apin we yu yuz dis mɛrɛsin bifo tɛm, so dat yu go no ɛni chenj we de apin na yu bɔdi kwik kwik wan.
Sɔm pan de sayd ɛfɛkt dɛm wae dɛn mɛrɛsin ya kin gɛt kin denja, so i impɔtant fɔ no bɔt dis.
| Sayd ɛfɛkt/risk | Wetin fɔ no |
|---|---|
| Di ay blɔd prɛshɔn | I impɔtant fɔ wach yu blɔd prɛshɔn ɔltɛm we yu de trit yu. |
| Blɔd we de kɔmɔt insay pɔsin in bɔdi | Yu fɔ no bɔt di sayn dɛm lɛk fɔ brus ɛnisay na di bɔdi ɛn blɔd na di stɔl. |
| Dilay we wund de wɛl | Di dɔktɔ kin tek tɛm mɔ fɔ gi dɛn mɛrɛsin ya bifo ɔ afta di ɔpreshɔn. |
| Pɔrfɔreshɔn na di bɛlɛ | Pan ɔl we dis nɔ kin apin so ɔltɛm, if yu gɛt bɛlɛ pen wantɛm wantɛm, tɛl yu dɔktɔ wantɛm wantɛm. |
| Blɔd we de klɔt | Dis na wan sik wae de mek yu denja pasmak ɛn kin mek yu gɛt tin dɛm lɛk at atak ɔr strok. |
| Ɔda sayd ɛfɛkt dɛn | Di tayroyd we nɔ de wok fayn ɛn di liva we de pwɛl kin apin bak. |
Dɛn tin ya kin tan lɛk se yu de mek yu fred, bɔt yu dɔktɔ go de wach yu wɛlbɔdi ɛn blɔd tɛst ɔltɛm, so dɛn kin no ɛn kɔntrol dɛn bad bad tin ya.
Aw a go tek kia ɔf misɛf? Ustɛm a fɔ kɔl di dɔktɔ?
Di impɔtant tin we yu kin du na fɔ no gud gud wan bɔt di sayd ɛfɛkt dɛn we yu kin gɛt bifo yu bigin dis mɛrɛsin. Dɔn, if yu notis ɛni chenj na yu bɔdi, yu kin no am kwik kwik wan ɛn tɛl yu dɔktɔ. Yu dɔktɔ kin gi yu ɔda mɛrɛsin fɔ kɔntrol dɛn sayd ɛfɛkt dɛn de, ɔ chenj di doz fɔ di mɛrɛsin we yu de tek.
Go to dɔktɔ wantɛm wantɛm if yu gɛt ɛni sayn we nɔ kɔmɔn wantɛm wantɛm. Ɛspɛshali if yu gɛt sɔm sayn dɛm fɔ strok ɔ at atak (e.g., yu chɛst de pen bad bad wan, i nɔ izi fɔ blo, yu fes ɔ yu bɔdi nɔ de fil fayn), go na di ɔspitul we de nia yu in Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm.
Tin dɛn de we kin stɔp dis prɔses fɔ insɛf?
yes, sכm it dεm gεt kכmpawnd dεm we kin blכk sכm pan di signal dεm we de involv insay dis angiojεnεsis prכsεs. Bɔku tɛm, dɛn kin si dɛn it ya na di Mɛditarenian it dɛn. Fɔ ɛgzampul:
- Grin ti
- Ɔliv ɔyl
- Rɛd greps dɛn
- Pinat dɛn we dɛn kin yuz fɔ mek tin dɛn
- Asparagus we dɛn kɔl Asparagus
Dɔktɔ dɛn de du risach bɔt nyu mɛrɛsin dɛn we dɛn de yuz dɛn natura l kɔmpawnd dɛn ya, bɔt da risach de stil bigin.
I impɔtant fɔ mɛmba sɔntin we impɔtant na ya. If yu it dɛn it ya, i nɔ go mɛn kansa ɔ stɔp di kansa tumbu dɛn we de gro. Dɛn tin ya nɔ kin ɛva tek ples fɔ di mɛrɛsin dɛn we dɔktɔ kin gi pɔsin fɔ gɛt kansa.
Bɔt fɔ it tin dɛn we gɛt fayn fayn tin dɛn kin ɛp fɔ mek pɔsin we de go tru kansa tritmɛnt strɔng. So, mek shɔ se yu it tin dɛn we gɛt balans.
Mɛsej we dɛn kin kɛr go na os
- di angiogenesis inhibitors na wan kayn dכg we de stכp di fכmeshכn fכ di bכdi vεsul dεm we de gi blכd to kansa tכmכro dεm, we de kכntro dεn growth.
- Pan ɔl we dɛn tin ya nɔ kin ebul fɔ mɛn kansa ɔltogɛda, dɛn kin ɛp fɔ kɔntrol aw di sik de go bifo ɛn mek i liv lɔng.
- Bɔku tɛm dɛn kin gi dɛn mɛrɛsin ya togɛda wit ɔda tritmɛnt dɛn lɛk kemotɛrapi.
- As denja sayd ɛfɛkt lɛk ay blɔd prɛshɔn ɛn blɔd klɔt kin apin, tɛl yu dɔktɔ wantɛm wantɛm bɔt ɛni ɔda kayn sayn we nɔ kɔmɔn we de apin we yu de trit yu.
- Nɔ ɛva yuz natura l it sɔpɔtmɛnt as sɔbstityuyt fɔ mɛrɛsin. Ɔltɛm fala yu dɔktɔ in advays.
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