Wetin yu nid fɔ no bɔt Castleman Disease

Yu dɔn ɛva gɛt wan lump, we wi kɔl "lump," na yu nɛk, armpit, ɔ groin? Sɔmtɛm, lumps lɛk dis kin swel we yu gɛt kɔmɔn kol ɔ sɔm kayn infekshɔn. Dat na nɔmal tin. Bɔt if yu gɛt swɛlin swɛlin lɛk dis fɔ natin, fɔ lɔng tɛm, ɛn yu de fil bak taya ɛn yu de lɔs yu wet, yu fɔ wɔri smɔl. Tide, wi go tɔk bɔt wan rare kɔndishɔn we pɔsin kin sɔprayz pan dɛn kayn tɛm ya. Dat na di sik we dɛn kɔl Castleman.

Fɔ tɔk am simpul wan, wetin na Castleman Disease?

Imajin se wi bɔdi tan lɛk kɔntri. Dɔn wi imyun sistɛm na di ami we de protɛkt da kɔntri de. We wan jem (ɛnimi) kam insay di bɔdi frɔm do, dis ami kin go fɛt ɛn win da ɛnimi de. We di fɛt dɔn, di ami go bak na di barɔk ɛn nɔ tɔk natin. Dis na wetin kin apin na pɔrsin wae gɛt wɛl bɔdi in bɔdi.

Bɔt wit pɔsin we gɛt di sik we dɛn kɔl Castleman, i difrɛn. Wetin kin apin ya na dat di ami we bin go fɛt wɔ, di imyun sistɛm, nɔ kin kol ivin afta di fɛt dɔn. Dɛn kin kɔntinyu fɔ du sɔntin. I tan lɛk se dɛn rɛdi fɔ fɛt wɔ ɔltɛm. Dis kin mek di bɔdi inflamɛns fɔ lɔng tɛm. Dis kin pwɛl wi ɔgan dɛn.

Dis tɛm ya, wi limf no dɛm, dɛn smɔl smɔl tin dɛn de, tan lɛk sojaman dɛn ples. Dɛn kin du bɔku wok, lɛk fɔ filta di jem dɛn ɛn fɔ kip di imyun sɛl dɛn. Naw, bikɔs di imyun sistɛm de wok ɔltɛm, dɛn limf no dɛn ya de wok bak ɔltɛm. Dis kin mek di sɛl dɛn we de insay dɛn kin bigin fɔ gro pasmak. Na dat mek di limf no dɛm kin swel pan di sik we dɛn kɔl Castleman. I nɔ jɔs de swel, i kin ivin mek chenj dɛn na di tisu na dɛn limf no dɛn de.

Wetin na di men kayn sik we dɛn kɔl Castleman disease?

Dɛn sheb di sik we dɛn kɔl Casselman to tu men kayn. Di sayn dɛm ɛn di tritmɛnt fɔ ɛni wan pan dɛn rili difrɛn. So, i impɔtant fɔ ɔndastand dɛn tu kayn ya gud gud wan.

Sɔbtayp dɛn de fɔ multicentric Castleman disease (MCD)?

Yes, dεn sheb MCD fכs to sεvεra sכbtayp dεm. Dɛn kin du dis klas bay di kɔz ɛn ɔda kɔndishɔn dɛn we kin apin wit am.

• MCD we gɛt fɔ du wit POEMS: POEMS na wan sik we nɔ kin apin na di blɔd we nɔ kin apin so ɔltɛm. Sɔntɛnde MCD kin apin togɛda wit POEMS.
• MCD we gɛt fɔ du wit HHV-8: Dis kin kam we pɔsin gɛt wan vayrɔs we dɛn kɔl Human Herpes Virus-8 (HHV-8). Dis kayn tin kin apin mɔ to pipul dɛn we gɛt HIV ɔ we nɔ gɛt bɛtɛ imyun fɔ ɔda rizin.
• Idiopathic MCD (iMCD): Di mεdikal tεm " idiopathic " min "dεn nכ fכnshכn kכz." Bɔku pan di wan dɛn we gɛt MCD gɛt dis kayn. Dis min se dɛn nɔ no yet di rayt tin we mek i apin.

Dɛn sheb dis kayn iMCD mɔ to tri smɔl smɔl kategori dɛm:

1. iMCD we gɛt fɔ du wit TAFRO: TAFRO na nem we dɛn pul frɔm wan kɔmbaynshɔn pan sɔm simptom dɛm. Dat min se, Thrombocytopenia (di blɔd pletlɛt dɛn we nɔ de bɔku), Anasarca (we di bɔdi de swel wit wata), Fiva (fiva), Renal dysfunction (we di kidni nɔ de wok fayn) ɛn Organomegaly (we di liva ɔ di splin big) na di sayn dɛm we yu kin si pan dis.

2. iMCD wit idiopathic plasmacytic lymphadenopathy (iMCD-IPL): Insay dis kayn, di pletlet kכnt kin εlevεt. I kin bi bak se di wayt blɔd sɛl dɛn kin mek antibodi dɛn pasmak.

3. iMCD, we dɛn nɔ tɔk ɔda we (iMCD-NOS): Di wan dɛn we gɛt iMCD we nɔ gɛt natin fɔ du wit TAFRO ɛn we dɛn nɔ go ebul fɔ fɛn ɔda patikyula kɔz fɔ dɛn, de insay dis kategori.

Wetin kin bi di sayn dɛm fɔ dis sik?

Di sayn dɛm kin difrɛn difrɛn wan fɔ di kayn sik wae yu gɛt pan Castleman.

Di sik we dɛn kɔl Unicentric Casselman disease (UCD) nɔ kin gɛt ɛni sayn . di onli sayn na di limf node we swel (adenoid). sכmtεm, di simptom dεm (e.g., pen, sכt brith) kin כnli apin we di no we swεla prεs pan כda כgan.

Bɔt pan di sik we dɛn kɔl multicentric Castleman disease (MCD), di sayn dɛm kin klia mɔ. Apat frɔm di gland dɛn we swel, yu kin gɛt:

• Fiva we kin kam ɔltɛm
• Fɔ fil taya pasmak ɛn taya fɔ natin (dis kin bi bak bikɔs ɔf anemia) .
• Fɔ swet pasmak na nɛt
• Nɔs ɛn vɔmit
• We yu nɔ bin de ɛkspɛkt fɔ lɔs yu wet
• Di leg, anklɛ, ɔ bɛlɛ kin swel
• di splin we big (splenomegaly) ɔ di liva we big (hepatomegaly) .
• Di an ɛn fut dɛn kin swɛla (peripheral neuropathy) .

Wetin mek dis sik kin apin? Ɛnitin de we kin mek pɔsin gɛt prɔblɛm?

Infakt, sayɛnsman dɛn nɔ dɔn fɛn wan patikyula tin yet we kin mek pɔsin gɛt wan sik we dɛn kɔl unicentric Castleman disease (UCD) .

Multicentric Castleman disease (MCD) gɛt fɔ du wit di HHV-8 vayrɔs we wi bin dɔn tɔk bɔt . Bɔt di wan dɛn we de du risach stil de chɛk if ɔda infɛkshɔn, jin muteshɔn, ɔ ɔtoimyun rεspכns kin bi rispansabl fɔ di kayn iMCD we wi nɔ no.

We i kam pan di risk factor dɛm, dɛn nɔr no risk factor dɛm fɔ UCD ɛn iMCD. Bɔt if yu gɛt HIV ɔ ɔda wikɛd imyun sistɛm, yu de pan ay risk fɔ gɛt HHV-8-associated MCD.

Pan ɔl we dis sik kin kam pan pipul dɛn we ol ɛni ej, i kin kam pan pipul dɛn we ol bitwin 30 ɛn 60 ia .

Wetin na de prɔblɛm wae kin kam wit dis sik?

Castleman disease kin mek yu gɛt ɔda kayn sik smɔl smɔl, mɔr lɛk kansa , lɛk limfoma, we na kansa na di limfatik sistɛm.

Apat frɔm dat, pipul dɛn we gɛt UCD kin gɛt wan sik we nɔ kin apin so ɔltɛm bɔt we kin rili siriɔs we dɛn kɔl paraneoplastic pemphigus (PNP). Pipul wae gɛt MCD kin gɛt bɔrku risk fɔ gɛt difrɛn kayn infεkshɔn. If dɛn nɔ trit dɛn sik ya, i kin mek di ɔgan dɛn pwɛl ɛn ivin day.

Bɔt nɔ wɔri, yu dɔktɔ go de wach dis sik ɔltɛm ɛn tek di step dɛn we nid fɔ ɛp fɔ mek dɛn nɔ gɛt dɛn prɔblɛm ya as i pɔsibul.

Aw dɔktɔ kin no kɔrɛkt wan bɔt dis sik?

Bikɔs di sayn dɛm fɔ Castleman in sik tan lɛk ɔda sik dɛm lɛk kɔmɔn kol ɔ flu, dɔktɔ go fɔs chɛk fɔ kɔmɔn sik dɛm. Na da tɛm de nɔmɔ dɛn go sɔprayz se dɛn gɛt Castleman in sik ɛn du sɔm patikyula tɛst dɛn.

Dɛn kin du dɛn tɛst ya mɔ:

• Lab test: Dɛn go chɛk yu blɔd ɔnda maykroskɔp fɔ chɛk fɔ si if yu blɔd sɛl nɔ de wok fayn ɛn ɔda tin dɛn we nɔ fayn. If dɛn sɔprayz se MCD gɛt fɔ du wit HHV-8, dɛn kin du HIV tɛst bak.
• imej tεst: CT skan εn PET skan kin εp fכ no usay di limf no dεm we swεla de na di bכdi. Dɛn kin chɛk bak fɔ si if di ɔgan dɛn lɛk di liva ɛn di splin dɔn big.
• Limf node bayɔpsi: Dis na di wangren ɛn mɔs difinitiv we fɔ kɔnfɔm di sik . dis involv fכ tek wan rili sכm pat pan di tisu frכm di limf node we swel εn egzamin am כnda maykroskכp. afta dat dis kin no fכ sכri if eni spεshal sεl chenj dεm de we kכnεkt wit Kasεlman sik.

Wetin na di tritmɛnt dɛm fɔ dis?

Di we aw dɛn kin trit am kin difrɛn ɔlsay fɔ di kayn sik.

Tritmɛnt fɔ Yunisɛntrik Kasɛlman Disizin (UCD) .

di men εn di mכst saksesful tritmεnt fכ UCD na כ pεrayshכn fכ pul di limf node we afekt . Bɔrku tɛm, di sik kin wɛl ɔl afta dis ɔpreshɔn.

Sɔntɛnde, if di tumbu big, dɛn kin gi am redyushɔn tɛrapi ɔ imyunotɛrapi bifo dɛn du di ɔpreshɔn fɔ mek i smɔl ɛn mek i izi fɔ pul am.

If di lump de na say we dɛn nɔ go ebul fɔ pul am wit ɔpreshɔn, ɛn yu nɔ gɛt ɛni sayn, yu dɔktɔ go disayd nɔ fɔ trit am ɛn jɔs wach am. Bɔt fɔ pɔsin we nɔto kandidet fɔ ɔpreshɔn ɛn stil gɛt di sayn dɛn, dɛn kin gi di sem tritmɛnt we dɛn kin gi fɔ MCD.

Tritmɛnt fɔ di sik we dɛn kɔl multicentric Casselman disease (MCD) .

Bikɔs MCD na wan sik we kin skata to bɔku pat dɛn na di bɔdi, dɛn nɔ kin ebul fɔ mɛn am wit ɔpreshɔn ɔ redyushɔn tɛrapi. So, dɛn kin yuz ɔda tritmɛnt dɛn. Di tritmɛnt dipen pan if yu gɛt HHV-8 ɛn aw di sik bad.

Dɛn tritmɛnt ya mɔ na dɛn kin gi:

• Kɔtikosterɔyd: Dɛn mɛrɛsin ya kin ɛp fɔ kɔntrol di sik dɛn bay we dɛn de ridyus di inflamɛns na di bɔdi.
• Kεmothεrapi dεm: dεn ya de wok bay we dεn de kכntro di rεt we di sεl dεm na di limf sistεm de gro tu kwik. Rituximab na tin we dɛn kin yuz fɔ HHV-8-asɔsiet MCD.
• Immunotherapy: Dɛn tritmɛnt ya de wok bay we dɛn de mek yu bɔdi in imyun sistɛm we de wok pasmak kol. Siltuximab (Sylvant®) na di wan ol mɛrɛsin we dɛn dɔn gri fɔ fɔ iMCD.
• Antivayral drɔgs: If yu gɛt HHV-8-associated MCD, dɛn kin gi yu dɛn drɔgs ya fɔ kɔntrol HIV ɔ HHV-8 infɛkshɔn.

Ustɛm a fɔ go to dɔktɔ?

If yu notis se yu nɛk, yu armpit, ɔ yu groin gɛt wan bɔmp ɔ bɔmp we yu kin fil, mek shɔ se yu tɛl yu dɔktɔ bɔt dat.

Dɔn bak, if di sayn dɛn we wi tɔk bɔt na dis atikul, lɛk fiva we yu nɔ ɛksplen, we yu de lɔs yu wet, ɛn we yu taya pasmak, de fɔ sɔm wiks, mek shɔ se yu go to dɔktɔ.

I pɔsibul fɔ liv wit dis sik?

Di ansa to dis kweshon dipen pan di kayn Casselman we yu get.

Pɔsin we gɛt UCD kin ɛkspɛkt fɔ gɛt rili gud autkam . We dɛn du ɔpreshɔn fɔ pul di tumbu, bɔku tɛm di sik kin wɛl kpatakpata. Afta tritmɛnt, dis nɔ go afɛkt di nɔmal layf we yu de liv.

Di prɔgnosis fɔ pipul dɛn we gɛt MCD kin kɔmplikt smɔl . I kin difrɛn fɔ di kayn sik ɛn aw i siriɔs. Fɔ sɔm pipul dɛn, di sayn dɛn kin rili bad wantɛm wantɛm ɛn dat kin mek dɛn layf de pan denja. Fɔ ɔda pipul dɛn, di sik kin te fɔ lɔng tɛm, bɔt op de. Bitwin 65% ɛn 75% pan di pipul dɛn we dɛn no se gɛt MCD de liv fɔ pas fayv ia . Dis de impɔtant wit nyu tritmɛnt dɛn.

Nɔr simpul, wan saiz-fit-ɔl ansa nɔr de fɔ Casselman sik. E go dipen pan yu ɛkspiriɛns, di kayn sik wae yu gɛt, ɛn if yu gɛt ɔda sik, lɛk HIV, TAFRO, ɔr POEMS. Sɔntɛnde, ɔpreshɔn ɛn fɔ de wach di dɔktɔ ɔltɛm go du fɔ am. Ɔ yu kin nid fɔ gɛt bɔku tritmɛnt dɛn ɔlsay na yu layf. So e fayn fɔ tɔk to yu dɔktɔ opin wan bɔt yu sik, yu tritmɛnt, ɛn yu tumara bambay.