Yu skin ɛn di wayt tin dɛn na yu yay de tɔn yɔlɔ? Lɛ wi lan mɔ bɔt Dubin-Johnson Syndrome!

Yu dɔn ɛva notis se yu skin kɔlɔ ɔ di wayt na yu yay tan lɛk se i yɔlɔ smɔl? Ɔ yu dɔn ɛva notis se yu urine dɔn dak yɔlɔ pas aw i kin bi? If yu de gɛt dɛn tin ya, wan tin we kin mek yu gɛt dis sik na wan sik we nɔ kin apin so ɔltɛm bɔt we nɔ kin rili siriɔs we dɛn kɔl Dubin-Johnson syndrome . So, lɛ wi tɔk bɔt dis ditayli, rili simpul wan.

Wetin na Dubin-Johnson Syndrome?

Fɔ tɔk am simpul wan, Dubin-Johnson syndrome na wan sik we de ambɔg wi liva . Wetin kin apin pan dis na dat wan yɔlɔ tin we dɛn kɔl bilirubin we dɛn kin mek na wi bɔdi kin gɛda instead fɔ kɔmɔt na di bɔdi fayn fayn wan. Naw yu go de wɔnda wetin na bilirubin. Afta sɔm tɛm, we dɛn layf dɔn, di rɛd blɔd sɛl dɛn na wi bɔdi kin brok. Na da tɛm de dis bilirubin kin kɔmɔt. nכmal wan, dis bilirubin fכ kכmכt frכm wi liva wit bayl εn kכmכt frכm di bכdi as west. Bɔt dis prɔses nɔ kin apin fayn fayn wan na pɔsin in bɔdi we gɛt Dubin-Johnson syndrome. So, bilirubin kin gɛda na di liva ɛn blɔd, ɛn dis kin mek pɔsin gɛt sɔm sayn dɛn lɛk janda . Na da tɛm de di skin ɛn di wayt tin dɛn na di yay kin tɔn yɔlɔ.

Udat dɛn dis kayn tin kin afɛkt mɔ?

Dubin-Johnson syndrome na wan jenɛtik kɔndishɔn , so i kin afɛkt ɛnibɔdi, pan ɛni ej. Fɔ mek yu gɛt di sik, yu mama ɛn papa ɔl tu fɔ pas di jin to yu. dis dεn kכl am כ tosom rεsεsiv inhεritεns. Fɔ ɛgzampul, if na wan pan yu mama ɛn papa nɔmɔ yu gɛt di jin, yu nɔ go sho di sik, bɔt yu go gɛt di jin. Dis min se yu kin pas di jin to yu pikin dɛn.

Aw kɔmɔn tin dis kin apin?

Nɔr ɛksaktɔl statystik nɔr de fɔ aw dis kin kɔmɔn, bɔt i kin mɔs pan pipul dɛm wae de liv na kɔntri dɛm lɛk Iran, Iraq, Morocco, ɛn Japan. Dɛn se na lɛk wan pan ɛvri 1,300 pipul dɛn na dɛn kɔntri dɛn de kin gɛt dis sik.

Aw di sik we dɛn kɔl Dubin-Johnson syndrome kin afɛkt mi bɔdi?

Dubin-Johnson syndrome kin kam bikɔs di yɔlɔ sɔbstans bilirubin kin gɛda na yu liva. Dis na wetin de mek yu skin ɛn di wayt pat na yu yay luk yɔlɔ. Sɔntɛnde, we yu de insay os ɛn na smɔl layt, yu nɔ go notis dis yɔlɔ. Bɔt, na ples we gɛt layt, lɛk na di san, dis yɔlɔnɛs kin kam fɔ no mɔ. Bɔku tɛm, di fɔs tin we yu kin notis bɔt dis yɔlɔ na di fes.. Dɔn i kin skata to ɔda pat dɛn na di bɔdi, lɛk di chɛst ɛn di bɛlɛ. We yu luk na miro, if yu opin yu mɔt ɛn luk ɔnda yu tɔŋ, yu go si se i dɔn tɔn yɔlɔ de bak.

Wetin na di sayn dɛm fɔ dis?

Bɔrku pipul dɛm wae dɛn kin no se gɛt Dubin-Johnson syndrome gɛt di men sayn dɛm fɔ janda, wae kin kam wae bilirubin kin gɛda na dɛn liva. Dis min se:

• Yu skin de yɔlɔ ɛn yu yay wayt.
• Wan chenj na di kɔlɔ na yu urine (we de tɔn to dak yɔlɔ ɔ brawn).

Sɔntɛnde, we di bɔdi gɛt sɔm strɛs, fɔ ɛgzampul, we yu gɛt ɔda sik, we yu gɛt bɛlɛ, ɔ if yu de yuz bɔn kɔntrol pils (we yu kin tek fɔ mek yu nɔ gɛt bɛlɛ), dis yɔlɔ kɔlɔ kin bɔku.

Apat frɔm dɛn tin ya, ɔda smɔl smɔl sayn dɛn kin apin, bɔt bɔku tɛm dɛn nɔ kin rili bad:

• Fɔ fil taya na `(Fatigue)`.
• Smɔl pen na di bɛlɛ we de dɔŋ (Abdominal Pain).

De impɔtant tin na dat, Dubin-Johnson syndrome na wan kayn sik wae nɔr de fayn. Dis min se i nɔ go mek ɛni big damej pan yu layf.

If yu du sɔm tɛst dɛn, yu go si tin dɛn lɛk dis:

• yu liva gεt sכm tin dεm we de bכku, we de mek i tan lεk blak (dεn de chεk dis bay we dεn tek sכm sכm tisu frכm di liva - dεn kכl am `Liver Biopsy` ).
• di liva kin big sכmtεm ( `Hepatomegaly` ).

Wetin kin mek pɔsin gɛt di sik we dɛn kɔl Dubin-Johnson syndrome?

di men kכz fכ Dubin-Johnson sεndrכm na di mכtεshכn na di `ABCC2` jin. dis `ABCC2` jin de rispansabl fכ mek wan protin we de εp wi sεl dεm fכ pul west prodakt dεm. spεshal wan, dis protin de εp di liva sεl dεm fכ pul bilirubin (di yכlכ tin we lεf we di rεd bכdi sεl dεm brok) εn kכmכt am as bayl (wan wata we de εp fכ digεst it).

So, if yu gɛt Dubin-Johnson syndrome, yu bɔdi nɔ go ebul fɔ pul dis dɔti tin we dɛn kɔl bilirubin fayn fayn wan frɔm yu sɛl dɛn. dis kin mek tin dεm lεk bilirubin de bכku na yu bכdi (dεn kכl dis haypa bilirubinemia ). Na dat mek sɔm kayn sik lɛk janda kin apia.

Aw dɛn kin no se pɔsin gɛt di sik we dɛn kɔl Dubin-Johnson syndrome?

Yu dɔktɔ go fɔs chɛk yu, aks yu bɔt yu sik, ɛn no if ɛnibɔdi na yu famili dɔn gɛt dis kayn sik bifo (famili mɛdikal istri).

Dɔn, dɛn go ɔda fɔ mek dɛn du sɔm ɔda tɛst dɛn fɔ mek dɛn no se dɛn dɔn no di sik. Dɛn tin ya kin bi:

• Imej tɛst (fɔ ɛgzampul , ɛkstrem rayt , ɔltra saund skan ) fɔ luk yu liva.
• Blɔd tɛst (espɛshali di bilirubin tɛst ) .wan).
• Test fɔ urine .
• Sɔntɛm na tɛst usay dɛn tek wan smɔl pat pan di liva ( `Liver Biopsy` ).

If di bilirubin tɛst sho se yu blɔd bilirubin lɛvɛl tu ay, dat min se yu gɛt wan sik we dɛn kɔl hyperbilirubinemia (we bilirubin bɔku na di blɔd). If yu sik nɔ de chenj, yu dɔktɔ kin tɛl yu fɔ du di jenɛtik blɔd tɛst fɔ no di jin we de mek yu gɛt di sik. Dis na di onli we fɔ kɔnfirm se yu gɛt Dubin-Johnson syndrome.

Wetin na di tritmɛnt dɛm fɔ dis?

Di gud nyus na dat, bɔrku pipul dɛm wae dɛn dɔn no se gɛt Dubin-Johnson syndrome nɔr nid ɛni tritmɛnt. Dis na bikɔs i nɔto siriɔs sik. Bɔt if dɛn nid tritmɛnt, i kin bi fɔ ɔda kɔndishɔn ɔ prɔses we de mek yu bilirubin lɛvɛl go ɔp. Fɔ ɛgzampul, if yu gɛt kol, yu dɔktɔ kin tɛl yu fɔ drink bɔku wata ɛn rɛst. Ɔ, if wan mɛrɛsin we yu de tek de mek yu sik wɔs, yu dɔktɔ kin advays yu fɔ stɔp fɔ tek da mɛrɛsin de.

Wetin kin mek di sayn dɛm fɔ Dubin-Johnson syndrome wɔs?

Di sayn dɛm wae kin kam wit jaundice wae kin kam wit Dubin-Johnson syndrome kin teik yu layf. Bɔt dɛn sik ya kin wɔs if yu:

• If yu de drink rɔm.
• If yu de tek bɔn kɔntrol pils.
• If infekshɔn de.
• If yu gɛt bɛlɛ.

If yu fil lɛk se yu sik de wɔs, tɔk to yu dɔktɔ bɔt di tritmɛnt we go ɛp yu fɔ gɛt fridɔm.

Yu tink se dɛn go ebul fɔ protɛkt di sik we dɛn kɔl Dubin-Johnson syndrome?

Bikɔs na wan sik we pɔsin kin gɛt we i kam pan jɛnɛtiks, wi nɔ go ebul fɔ mek di sik we dɛn kɔl Dubin-Johnson syndrome nɔ kam. Bɔt if yu de plan fɔ bɔn pikin ɛn yu want fɔ no di risk fɔ mek yu pikin gɛt dis jenɛtik sik, yu kin tɔk to yu dɔktɔ bɔt aw fɔ tɛst yu jɛnɛtiks ɔ aw fɔ advays yu jɛnɛtiks .

If a gɛt Dubin-Johnson syndrome, wetin a fɔ ɛkspɛkt?

De luk fɔ pipul dɛm wae dɛn dɔn no se gɛt Dubin-Johnson syndrome kin rili fayn. Nɔr mɛrɛsin nɔr de, ɛn bɔrku tɛm nɔr kin nid tritmɛnt, ɛn dɛn kin kɔntrol di sayn dɛm. Di tin wae impɔtant pas ɔl na dat, de sik nɔr kin afɛkt pɔrsin in layf.

Ustɛm a fɔ go to mi dɔktɔ?

If yu Dubin-Johnson syndrome de wɔs, mɔ if yu janda de mek yu gɛt sayn dɛm we tan lɛk flu, go to yu dɔktɔ. Fɔ ɛgzampul:

• Pɔsin we de fil pen na di bɛlɛ .
• Fiva .
• Taya .
• Nɔs ɔ vɔmit .

Us kwɛstyɔn dɛn a fɔ aks mi dɔktɔ?

Yu kin aks yu dɔktɔ kwɛstyɔn dɛn lɛk dɛn wan ya:

• Yu tink se di sik dɛn we a kin gɛt kin nid fɔ gɛt tritmɛnt?
• Yu tink se mi pikin go gɛt dis sik?
• Wetin a fɔ du if a nɔ fil fayn bikɔs ɔf di sik dɛn we a gɛt?

Wetin na di difrɛns bitwin Dubin-Johnson syndrome ɛn Rotor syndrome?

Dubin-Johnson syndrome ɛn Rotor syndrome na ɔl tu di jenɛtik kɔndishɔn dɛn. Dɛn ɔl tu gɛt di sem sayn dɛn lɛk janda. Bɔt di men difrɛns bitwin dɛn tu tin ya na di tin we kin mek dɛn gɛt am.

Dubin-Johnson sεndrכm de kכz bay wan mכtεshכn na di `ABCC2` jin. כltu, di Rotor sεndrכm de kכz bay wan mכtεshכn na di `SLCO1B1` εn `SLCO1B3` jin dεm .

Wan ɔda impɔtant tin fɔ no na dat, di sik we dɛn kɔl Rotor Syndrome kin rili afɛkt di we aw pɔsin in bɔdi de tek sɔm mɛrɛsin dɛn. So, if yu ɔ yu pikin gɛt Rotor Syndrome, i rili impɔtant fɔ tɛl yu dɔktɔ bifo yu gi yu sɔm mɛrɛsin dɛn.

Apat frɔm dat, di Rotor Syndrome nɔ de mek di liva in kɔlɔ chenj. Bɔt di liva fɔ pipul dɛn we gɛt Dubin-Johnson Syndrome kin tan lɛk blak .

I nɔmal fɔ fil wɔri we yu ɔ yu pikin in skin tɔn yɔlɔ. Pan ɔl we janda kin bɔku pan pikin dɛn we dɛn jɔs bɔn, di jaundice we Dubin-Johnson syndrome kin kam wit na wan sik we kin kɔntinyu fɔ de, we kin de fɔ ɔl dɛn layf.

Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .

So, yu no bɔku tin naw bɔt Dubin-Johnson syndrome. Nɔ wɔri, i nɔto siriɔs kɔndishɔn. Yu dɔktɔ go ɛksplen us tritmɛnt yu nid fɔ mek yu yay ɛn yu skin nɔ yɔlɔ, ɔ if yu gɛt ɔda sayn dɛn. De tin wae impɔtant pas ɔl na fɔ tɔk to yu dɔktɔ bɔt yu sik ɔltɛm ɛn mek shɔ se yu gɛt wɛl bɔdi. Yu kin liv nɔrmal, gladi gladi layf wit dis sik.

` Dubin-Johnson syndrome, yɔlɔ fiva, liva, bilirubin, jɛnɛtik sik, yɔlɔ na di skin, janda