Wi nɔ kin pe atɛnshɔn tumɔs to sɔm pan di smɔl smɔl chenj dɛn we kin apin na wi bɔdi, nɔto so? Bɔt sɔntɛnde, dɛn smɔl smɔl chenj dɛn de, fɔ ɛgzampul, sɔntin lɛk we yu urine de luk, kin bi sayn fɔ se yu gɛt siriɔs wɛlbɔdi prɔblɛm pas aw yu tink. Tide wi go tɔk bɔt wan pan dɛn kayn sik ya we nɔ kin bɔku, bɔt we kin rili wɔri bɔt kidni. Dɛn kɔl dis Kɔmplimɛnt 3 Glomerulopathy, ɔ C3G fɔ shɔt tɛm.
Fɔ tɔk am simpul wan, wetin na C3G?
Tink bɔt yu kidni dɛn lɛk wan supa filta we de klin di blɔd na yu bɔdi. insay dis filta dεn gεt rili fayn, mεsh lεk strכkchכ dεm we dεn kכl glomeruli. Dɛn tin ya kin filta di dɔti tin dɛn we de kɔmɔt na di blɔd ɛn afta dat dɛn kin pul dɛn as urine.
Wi ɔl gɛt wan imyun sistɛm na wi bɔdi. I tan lɛk difens ami we de fɛt di jem dɛn we de kam insay wi bɔdi. Wan spɛshal fɔs na dis ami na wetin wi kɔl di kɔmplimɛnt sistɛm. nכmal wan, dis fכs de εp wi, bכt insay di bכdi fכ pכsin we gεt C3G sik, di fכnshכn fכ dis kompliment sistεm de disrupt. Fɔ tɔk am simpul wan, dis difɛns ami gɛt mistek, ɛn dɛn kin bigin fɔ atak di dilik filta we de na wi yon kidni.
dis atak de pwεl di filta mεsh, εn tin dεm lεk protin εn rεd bכdi sεl dεm we nכmal fכ de na di bכdi de bigin fכ kכlכm na di urine. As tɛm de go, dis damej kin bɔku ɛn di wok we di kidni dɛn kin du kin stɔp smɔl smɔl, ɛn dis kin mek di kidni nɔ wok fayn ɛn i kin nid fɔ dayalaysis.
Wetin na di sayn dɛm fɔ dis sik?
Nɔto ɔlman wae gɛt C3G sik go gɛt di sem kayn sik. Sɔm pipul dɛn kin gɛt sɔm pan dɛn sik ya, ɛn ɔda wan dɛn kin jɔs gɛt wan ɔ tu.
| Di sayn we de sho se di sik de | Dis min se... |
|---|---|
| Chenj na di we aw di urine de luk | If yu urine tan lɛk klawd, fom, ɔ dak kɔlɔ (rɛd, pink, ɔ brawn), dis na bikɔs prɔtin ɛn blɔd sɛl dɛn de na di urine. |
| Di bɔdi we de swel | Swel kin apin, mɔ na di leg, anklɛ, an, ɔ rawnd di yay. Dis kin apin we di bɔdi nɔ gɛt bɔku prɔtin. |
| Pen na di jɔyn dɛn | Jɔyn pen kin apin bikɔs di bɔdi in imyun sistɛm nɔ de wok fayn. |
| Di ay blɔd prɛshɔn | We di kidni dɛn pwɛl, i kin afɛkt bak fɔ kɔntrol di blɔd prɛshɔn. |
| Fɔ taya ɔltɛm | We di kidni dɛn nɔ de wok fayn, dɔti tin dɛn kin gɛda na di bɔdi, ɛn dis kin mek yu fil taya ɛn wik ɔltɛm. |
| Infekshɔn dɛn we kin kam bɔku tɛm | if di kompliment sistεm nכ de wok fayn i kin mek di bכdi in ebul fכ fכt di jεm dεm bak. |
| Prɔblɛm dɛn we gɛt fɔ du wit di yay | Sɔm pipul dɛn kin gɛt prɔblɛm wit dɛn yay bak. |
Lɛ wi lan bɔt di nyu mɛrɛsin we dɛn kɔl Fabhalta (Iptacopan) .
As tritmɛnt fɔ C3G sik, dɔktɔ dɛn kin gi mɛrɛsin dɛn we de kɔntrol blɔd prɛshɔn ɛn ridyus di prɔtin we de kɔmɔt na di urine (lɛk ACE inhibitors, ARBs). Dɛn kin gi mɛrɛsin bak fɔ mek pɔsin gɛt bɔku kɔlɔstrel. Sɔntɛnde, dɛn kin yuz mɛrɛsin dɛn bak we de kɔntrol di wok we di imyun sistɛm de du (glucocorticoids, mycophenolate mofetil).
Bɔt Fabhalta spɛshal bikɔs na di fɔs drɔg we dɛn dɔn gri fɔ ridyus di prɔtin we de kɔmɔt na di urine fɔ big pipul dɛn we gɛt C3G sik.
Aw dis mɛrɛsin de wok?
Yu mɛmba da kɔnfyus difens sistɛm de na wi bɔdi (kɔmplimɛnt sistɛm) we a bin dɔn tɔk bɔt? Di drɔg we dɛn kɔl Fabhalta de blok di wok we wan spɛshal prɔtin we de na da ami de we dɛn kɔl Factor B. Fɔ tɔk tru, i de mek di ami we kɔnfyus we de atak in yon kidni dɛn, kol. dis de ridyus di damej we di kidni dεm de pwεl εn i de kכntrכl di protinuria.
Aw a fɔ yuz di mɛrɛsin?
Fabhalta na kapsul we yu de tek wit yu mɔt. Yu kin tek am tu tɛm insay di de, wit it ɔ yu nɔ it am. Di tin we impɔtant pas ɔl na fɔ swɛla di kapsul ɔl. Nɔ brok, krɔs, ɔ chew di kapsul. If yu mis wan doz, tek am as yu mɛmba ɛn tek di ɔda doz dɛm lɛk aw yu kin tek am.
stכdi dεm we dεn du pan di effektiv we Fabhalta de wok dεn sho se pipul dεm we de tek dis mεdisin dεn dכn rεdכks di protin we de kכmכt na dεn urine bay lεk 35% insay 6 mכnt. I dɔn ɛp bak fɔ mek di kidni dɛn kɔntinyu fɔ wok ɔ fɔ mek i wok fayn.
Sayd ɛfɛkt ɛn aw fɔ mɛn dɛn?
Lɛk ɛni mɛrɛsin, Fabhalta kin gɛt sayd ɛfɛkt. Di sayd ɛfɛkt dɛm we kin apin pas ɔl na di sayn dɛm fɔ kol, lɛk we yu nos kin stɔp, yu nos kin rɔn , yu kin kɔf, yu kin sniz, ɛn yu trot kin at.
Bɔt wan siriɔs tin de we wi nid fɔ rili tek tɛm wit dis mɛrɛsin. Dat min se bikɔs dis mɛrɛsin de kɔntrol pat pan di kɔmplimɛnt sistɛm, risk de fɔ gɛt siriɔs infɛkshɔn we sɔm kayn baktri dɛm (Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae type B) kin mek. Dɛn infɛkshɔn ya kin ivin mek pɔsin in layf de pan denja.
So, yu fɔ de no ɔl di vaysin dɛn we yu nid (especially meningitis ɛn nyumonia vaysin) at le tu wiks bifo yu bigin dis mɛrɛsin. Yu dɔktɔ go advays yu bɔt dis.
| If yu gɛt dɛn sik ya, go to dɔktɔ wantɛm wantɛm! | |
|---|---|
| Fiva (wit ɔ nɔ gɛt kol), chɛst pen, kɔf, at fɔ blo, at bit kwik kwik wan. | |
| Bɔdi de at ɛn sɔm sayn dɛn we tan lɛk flu. | |
| Skin we gɛt klem. | |
| Ed we de at ɔltɛm, fiva, nɔs, vɔmit, nɛk ɔ bak we de stif. | |
| Fɔ fil taya pas aw yu kin fil, fɔ kɔnfyus, ɛn fɔ chenj yu yay. | |
Mɛmba se nɔto ɔl dɛn bad tin ya kin apin. Tɔk to yu dɔktɔ bɔt ɛni sayn we de mɔna yu.
Test ɛn ɔda tin dɛn we dɛn nid fɔ du we dɛn de trit am
- Blɔd tɛst: We yu de tek dis mɛrɛsin, yu dɔktɔ go du blɔd tɛst ɔltɛm fɔ chɛk aw yu bɔdi de du di mɛrɛsin. Fabhalta kin mek yu kɔlɔstrel ɛn triglisrayd lɛvɛl go ɔp, so yu go nid fɔ mek dɛn chɛk dɛn tin ya ɔltɛm.
- Intarakshɔn wit ɔda mɛrɛsin dɛm: Sɔm ɔda mɛrɛsin dɛm we yu de tek kin afɛkt di we aw Fabhalta de wok. So, i rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek, lɛk vaytamɛn ɛn ɛbul mɛrɛsin dɛn. Dɔn i kin disayd di bɛst tritmɛnt fɔ yu.
- Speshal Sefty Program: Bikɔs ɔf di risk fɔ mek pɔsin gɛt siriɔs infɛkshɔn wit dis mɛrɛsin, dɛn kin gi am ɔnda spɛshal sefty program (REMS program). Yu dɔktɔ go tɛl yu bɔt am ɛn gi yu sefty kad. I impɔtant fɔ kip di kad wit yu ɔl di tɛm we yu de trit yu ɛn fɔ tu wiks afta yu dɔn stɔp di mɛrɛsin.
Mɛsej we dɛn kin kɛr go na os
- C3G na sik we nɔ kin bɔku bɔt we kin pwɛl di kidni dɛn bikɔs di imyun sistɛm nɔ de wok fayn.
- Fabhalta (Iptacopan) na wan nyu, tכgεt tεrapi we dεn apruv fכ ridyus di protin we de kכmכt na di urine fכ C3G pasεnshכn dεm.
- Risk de fɔ gɛt siriɔs infɛkshɔn we yu de yuz dis mɛrɛsin. So, i impɔtant fɔ gɛt di vaysin dɛn we yu nid bifo yu bigin fɔ tek di tritmɛnt.
- Notis yu dɔktɔ wantɛm wantɛm bɔt ɛni ɔda kayn sayn ɔ sayd ɛfɛkt we nɔ kɔmɔn. Yu fɔ no mɔ bɔt sayn dɛn we de sho se yu gɛt di sik, lɛk fiva ɛn ed we de at bad bad wan.
- Yu nɔ fɔ ɛva bigin, stɔp, ɔ chenj di doz fɔ yu mɛrɛsin if yu dɔktɔ nɔ advays yu.
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