Ɛnibɔdi na yu famili, mɔ we yu yɔŋ, dɔn gɛt kansa na yu kɔlon? Ɔ dɔktɔ dɔn tɛl yu se yu gɛt bɔku bɔku polip na yu kɔlon? Sɔntɛm dis na bikɔs ɔf wan jenɛtik kɔndishɔn we de rɔn na famili. Tide wi go tɔk bɔt wan pan dɛn kayn tin ya we nɔ kin apin so ɔltɛm bɔt we rili impɔtant. Na FAP, ɔ Famili Adenomatous Polipɔsis. Pan ɔl we di nem kɔmplikt smɔl, lɛ wi ɔndastand am simpul wan.
Fɔ tɔk am simpul wan, wetin na FAP?
FAP na jεnεtik kכndishכn we dεn kin pas dכn frכm jεnereshכn to jεnereshכn. Pipul dεm wae gεt dis kכndyushכn kin gεt bכku tכmכro dεm we dεn kכl adenomas , we kin bi kεnsar, na dεn kכlon εn rεktum.
Naw yu kin de tink se, "I nɔmal fɔ gɛt sist na yu kɔlon?" Yes, na nɔmal tin fɔ mek sɔm pipul dɛn gɛt wan ɔ tu pan dɛn sist ya as dɛn de ol. Bɔt pɔsin we gɛt FAP kin gɛt bɔku bɔku, sɔntɛm ivin bɔku bɔku pan dɛn sist ya. Ɛn i kin bigin we i rili yɔŋ , sɔntɛm i kin yɔŋ lɛk 15 ɔ 16 ia.
Dɛn polip ya nɔ kin gɛt kansa fɔs. Bɔt dɛn kɔl dɛn ‘precancerous’. Dis min se if dɛn nɔ trit am, i rili big fɔ mek wan ɔ mɔ pan dɛn polip ya go bi kɔlorektal kansa .
Imajin aw i go at fɔ pul bɔku bɔku pan dɛn tumbu ya wan bay wan. I nɔ pɔsibul fɔ du am. Na dat mek fɔ mek dɛn ebul fɔ kɔntrol dis big big prɔblɛm, dɔktɔ dɛn kin se dɛn fɔ du ɔpreshɔn fɔ pul di wan ol big intestin, we na wan tɔtal kɔlektɔmi . sכmtεm, dεn kin pul di rεktum bak (proctocolectomy).
If dɛn nɔ du dis ɔpreshɔn, bɔku pipul dɛn we gɛt FAP go gɛt kansa we dɛn ol. Dɔn bak, pipul dɛn we gɛt FAP nɔ kin jɔs gɛt tumbu na dɛn kɔlon bɔt na ɔda pat dɛn na dɛn bɔdi (fɔ ɛgzampul, dɛn bɛlɛ, smɔl intestinal, skin, ɛn bon dɛn). So, ivin afta dɛn dɔn pul di kɔlon, dɛn go nid fɔ de chɛk dɛn ɔltɛm wit dɔktɔ ɔlsay na dɛn layf.
Wetin na di risk fɔ gɛt kansa wit FAP?
If dɛn nɔ trit am, FAP gɛt nia 100% chans fɔ gɛt kɔlon kansa. Dis na wan sik we rili siriɔs. Pipul wae gɛt FAP kin gɛt kansa wae dɛn dɔn ol pasmak ɛn kin gɛt kansa kwik pas di avɛrej pɔrsin. So, if yu no se famili histri de fɔ FAP, yu pikin fɔ gɛt kɔlon skɔpi ɛvri ia we i ol 10 ia.
Apat frɔm di kɔlon kansa, pipul dɛm wae gɛt FAP kin gɛt ɔda kayn kansa bak.
| Di kayn kansa we yu gɛt | Risk fɔ apin (bay chans ) . |
|---|---|
| Duodenal kansa we de na di bɔdi | ~8% |
| Papillary tayroyd kansa | ~2% |
| Kansa na di pankrias | ~2% |
| Liva kansa (Hepatoblastoma) - mɔ pan pikin dɛn | ~1.5% ɛn . |
| Bɛlɛ kansa | ~1% |
| Bren ɛn spɛshal tɔŋ dɛn | I nɔ rich 1% . |
Difrɛn kayn FAP dɛn de?
Yes, wan men kayn FAP de ɛn sɔm sɔb-tayp dɛn we difrɛn smɔl ɛn we nɔ kin rili bad. Lɛ wi si wetin dɛn bi.
| FAP tayp | Tɔk bɔt |
|---|---|
| Klasik FAP (Klasik FAP) . | Dis na di kayn we we pipul dɛn kin gɛt mɔ. i pas 100, i kin bi se na tawzin tawzin polip dεm de divεlכp na di kכlon. |
| FAP we dɛn dɔn atɛnd (AFAP) . | Dis na tin we nɔ siriɔs smɔl. di nכmba fכ di sist dεm we de divεlכp na di intestinal de bitwin 20 εn 100. |
| Gardner sindrom we gɛt di sik | dis lεk Klasik FAP, we min se pas 100 tכmכro dεm de divεlכp. Apat frɔm dat, ɔda kayn tumbu dɛn kin kam bak na ɔda pat dɛn na di bɔdi, fɔ ɛgzampul, na di skin, di sɔft tisu dɛn, ɛn di bon dɛn. |
| Turcot sindrom we gɛt di sik | dis kin mek bכku tכmכro dεm fכm na di intestines, εn wan kansa tכmכro de fכm na di bren. |
Wetin na di difrɛns bitwin FAP ɛn Lynch Syndrome?
Lynch syndrome na ɔda jɛnɛtik kɔndishɔn we kin pas dɔŋ to jɛnɛreshɔn ɛn i kin mek pɔsin gɛt kansa na in kɔlon. Bɔt wan impɔtant difrɛns de bitwin dɛn tu. Pipul wae gɛt Lynch syndrome nɔr kin gɛt ɔndrɛd polyp, lɛk aw dɛn kin du na FAP. Sɔntɛnde, wan ɔ tu polip kin kam, ɛn dɛn kin gɛt kansa kwik kwik wan. Na dat mek sɔmtɛm dɛn kin kɔl di Lynch syndrome "nonpolyposis" kɔndishɔn. di tu kכndyushכn dεm de kכz fכ difεkt dεm na difrεn jin dεm.
Wetin na di sayn dɛm fɔ FAP?
insay FAP, di tכmכro dεm na di kכlon kin bigin fכ divεlכp bכku bכku wan pas di jεnarכl pכpulεshכn, bכku tεm we dεn yכng. Bɔku tɛm, dɛn tumbu ya nɔ kin mek pɔsin gɛt ɛni sayn te dɛn big we denja. Na dat mek i rili impɔtant fɔ mek dɛn chɛk pɔsin.
Bɔt bikɔs di nɔmba fɔ di sist dɛn bɔku ɛn dɛn kin gro kwik kwik wan, sɔntɛnde di sayn dɛn kin sho. Dɛn kayn sayn ya na:
- Blɔd we de kɔmɔt na di rɛktɔ
- Dayarɛa we nɔ de dɔn
- Pɔsin we de fil pen na di bɛlɛ we nɔ de dɔn
Apat frɔm dis, pipul dɛm wae gɛt FAP kin gɛt ɔda sik dɛm bak wae dɔktɔ kin si izi wan.
- Dεrmatofibromas: Na di wan dεm we at, we lεk ska we de fכm כnda di skin.
- Epidamal sist: sfεri lכmp dεm we fulכp wit kεratin we de fכm כnda di skin.
- Ɔstioma dɛn: .Tכmכro dεm we nכ de fכm na di bon dεm. Bɔku tɛm dɛn kin si dɛn tin ya na di skel ɔ di bɛlɛ.
- Ekstra tit ɔ tit we gɛt impak: Dɛn kin no dɛn tin ya wit dɛnt ɛkstrem rayt.
- Pigmented retinal spots (CHRPE): yu kin si dis we yu de egzam yu yay. Bɔt bɔku tɛm, dɛn nɔ kin afɛkt di we aw pɔsin de si.
Wetin na di men tin we kin mek pɔsin gɛt FAP?
As wi bin dɔn tɔk, FAP na bikɔs ɔf wan jin we de chenj. di jin we de afekt dis dεn kכl am di APC (Adenomatous Polyposis Coli) jin.
Na jin dɛn de kɔntrol ɔltin na wi bɔdi, lɛk kɔmpyuta program. dis APC jin na ‘tכmכro sכpreshכn jin'. dat min se di men wok we dis jin de du na fכ stכp di sεl dεm fכ divayd we dεn nכ ebul fכ kכntrכl εn fכ mek tכmכro. I tan lɛk di brek dɛn we de na motoka.
Pɔsin we gɛt FAP gɛt wan mutated APC jin, we min se i nɔ fayn. Dɔn, lɛk motoka we in brek brok, di sɛl dɛn kin sheb we dɛn nɔ ebul fɔ kɔntrol ɛn dɛn kin mek bɔku bɔku tumbu dɛn.
Dis jenɛtik dɛfɛkt na tin we dɛn kin gɛt frɔm dɛn mama ɛn papa. if wan pan di mama εn papa gεt dis APC jin mכtεshכn, di pikin gεt 50% chans fכ gεt am . Dis min se ɛni pikin kin gɛt am ɔ i nɔ kin gɛt am. Bɔt lɛk 30% pan di pipul dɛn we dɛn no se gɛt FAP nɔ gɛt famili histri. dis min se dis jεnεtik dεfεkt dεn dכn kam na dεn bכdi sכm tεm dεm (original mutation).
Wetin na di prɔblɛm dɛn we kin apin to FAP?
di mכst imכtant εn denja kכmplikεshכn fכ mεnεj wit FAP na kכlon kεnsar . Dis risk kin ridyus bad bad wan we dɛn du ɔpreshɔn fɔ pul di kɔlon. Bɔt sɔm prɔblɛm dɛn de we pɔsin kin gɛt we i nɔ gɛt kɔlon. di we aw di bכdi de muv di bכdi de chenj. fכ dis, dεn kin yuz ileostomy pouch כ ileal pouch .
biכs di APC jin dεfekt de insay εvri sεl na di bכdi, tכmכro dεm kin fכm bak ausayd di intestinal. Sɔm pan dɛn tin ya kin gɛt kansa.
- Duodenal polyps: Dɛn wan ya de divɛlɔp insay ɔlmost ɔlman we gɛt FAP. sכm nכmba pan dεm kin bi kεnsar na di duodenum, bayl dakt, כ pankrεas dakt.
- Bɛlɛ polip: kin apin pan lɛk 90% pan pipul dɛm, bɔt na smɔl pasɛnt nɔmɔ, lɛk 1%, kin gɛt kansa.
- Desmoid tumors: Dɛn tin ya nɔto kansa. Bɔt dɛn kin rili agresiv ɛn dɛn kin skata to ɔgan ɛn blɔd vesel dɛn we de nia dɛn, ɛn pwɛl dɛn. I at fɔ pul dɛn ɛn dɛn kin kam bak.
- Tayroyd kansa: Dis kin apin pan lɛk 2% pan pipul dɛm wae gɛt FAP. Bɔku tɛm, dɛn kin mɛn dɛn tin ya kpatakpata.
- Liva kansa: ɛpatoblastoma, mɔ pan pikin dɛn we gɛt FAPSmɔl risk de fɔ gɛt wan kayn liva kansa we nɔ kin bɔku we dɛn kɔl.
Aw dɛn kin trit am ɛn manej am?
Dɛn kin sheb di tritmɛnt plan fɔ FAP to tu pat: ɔpreshɔn ɛn tɛst fɔ ɔl yu layf.
1. Ɔpreshɔn
כl di pipul dεm we gεt klas FAP go nid fכ gεt tכtal kolεktomi, we involv fכ pul di כl kכlon, we dεn ol 20 כ ali 30 ia. Yu dɔktɔ go disayd ustɛm ɛn aw fɔ du dis ɔpreshɔn, bay wetin yu gɛt.
2. Fɔ de screen ɔltɛm
Yu go gɛt fɔ du difrɛn tɛst dɛn bifo ɛn afta dɛn du yu ɔpreshɔn, ɛn ɔlsay na yu layf. Dis na di bɛst we fɔ protɛkt yu layf.
| Test tayp | Plan | Jɛnɛral wan we dɛn kin rɛkɔmɛnd fɔ tek tɛm |
|---|---|---|
| Kolonoskopi we dɛn kin du | fכ chεk fכ tכmכro dεm na di kכlon εn rεktum. | Fɔ di wan dɛn we de pan denja, ɛvri ia frɔm we dɛn ol 10 ia te dɛn du di ɔpreshɔn. |
| Sigmoidoskopi we dɛn kin du | fכ egzamin di rεmεnεnt rεktum כ ileal pauch afta dεn כpεrayshכn. | Afta di ɔpreshɔn, ɛvri 6-12 mɔnt ɔ ɛvri 1-4 ia. |
| Ɛndoskopi we de ɔp | fכ chεk fכ tכmכro dεm na di bεlε εn sכmכl intestכn (kכlon). | Na ɔltɛm lɛk aw dɔktɔ se. |
| Ultrasound skan we dɛn kin yuz | Fɔ tayroyd ɔ liva kansa. | Na dɔktɔ in advays. |
| CT ɔ MRI skan | Fɔ chɛk fɔ dismoid tumor dɛn. | Na dɔktɔ in advays. |
Aw layf de wit FAP?
Na nɔmal tin fɔ fil bad ɛn shɔk we yu kam fɔ no se yu gɛt jenɛtik kɔndishɔn lɛk dis. Bɔt fɔ no bɔt dis sik kwik kwik wan na di bɛst we fɔ kɔntrol yu kansa risk.
If pɔrsin wae gɛt FAP de kia fɔ am fayn fayn wan ɛn de chɛk am ɔltɛm, i kin liv nɔrmal, lɔng, wɛl bɔdi layf . afta dεn dכn pul di kכlon, di big risk de kכmכt frכm כda kεnsar dεm na di gεstrointestinal trakt כ desmoid tכmכro dεm. Bɔt dɛn tin ya nɔ kin bɔku pas kansa na di kɔlon.
Pan ɔl we ɔpreshɔn na big chenj na yu layf, wit di advans tɛknɔlɔji tide, laparoscopic ɔpreshɔn kin ɛp yu fɔ wɛl kwik kwik wan.
Di tin we impɔtant pas ɔl na fɔ no se nɔto yu wangren de. Dɔktɔ, fambul, ɛn padi dɛn de we go gayd ɛn sɔpɔt yu pan dis waka. So, if yu gɛt ɛni kwɛstyɔn ɔ tin we de mɔna yu, tɔk to yu dɔktɔ bɔt am opin wan.
Mɛsej we dɛn kin kɛr go na os
- FAP na siriɔs jɛnɛtik sik we kin pas tru jɛnɛreshɔn ɛn i kin mek bɔku bɔku tɔŋ dɛn fɔm na di kɔlon.
- If dɛn nɔ trit am, di risk fɔ gɛt kɔlon kansa de nia 100%.
- If pɔsin na yu famili dɔn gɛt kɔlon kansa ɔ bɔku bɔku tumbu dɛn we i yɔŋ, tɔk to yu dɔktɔ bɔt fɔ mek dɛn du di jenɛtik tɛst.
- Fɔ no am kwik kwik wan ɛn fɔ chɛk am ɔltɛm na impɔtant tin fɔ sev pipul dɛn layf. Pikin dɛn we de pan denja fɔ bigin fɔ chɛk dɛn we dɛn ol 10 ia.
- Di men tritmɛnt fɔ mek yu nɔ gɛt kansa na fɔ ɔpreshɔn di big intestin (colectomy).
- If yu gɛt di rayt mɛrɛsin ɛn supavayshɔn, yu kin liv ful ɛn wɛlbɔdi layf ivin wit FAP.
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