Wetin na di sik we dɛn kɔl Gorlin Syndrome? Nɔ wɔri, lɛ wi tɔk bɔt am ditayli!

Yu dɔn ɛva notis nyu spat ɔ lumps we de fɔm ɔltɛm na yu skin? Ɔ yu dɔn yɛri bɔt tin dɛn we nɔ gɛt pen na yu jawbon? Dɛn tin ya kin bi nɔmal tin. Bɔt, sɔm tɛm dɛn we nɔ kin apin so ɔltɛm, dɛn sik ya kin gɛt fɔ du wit wan sik we nɔ kin apin so ɔltɛm. Na da sik de wi go tɔk bɔt tide, we dɛn kɔl Gorlin Syndrome. Nɔ fred we yu yɛri dis nem. Lɛ wi tɔk bɔt am simpul wan, di we we yu go ɔndastand.

Wetin rili na Gorlin Syndrome?

Fɔ tɔk am simpul wan, di sik we dɛn kɔl Gorlin syndrome na wan sik we nɔ kin apin so ɔltɛm . dεn kin kכl am כda nem dεm bak, lεk `(Basal Cell Nevus Syndrome)`, `(Nevoid Basal Cell Carcinoma Syndrome - NBCCS)` εn `(Gorlin-Goltz Syndrome)`. Pɔsin wae gɛt dis sik kin gɛt bɔrku risk fɔ gɛt ɔl tu di kansa ɛn nɔr kin gɛt kansa (we min se i nɔ kin du bɔku bad tin to di bɔdi) tumbu. sכmtεm, di risk de fכ gεt wan kayn kεnsar na di skin we dεn kכl `(Basal Cell Carcinoma)` . Dis na di kayn kansa wae kin kam pan yu skin.

Imajin, sɔm jin dɛn de na wi bɔdi, we dɛn men wok na fɔ kɔntrol di we aw di sɛl dɛn de sheb we nɔ nid fɔ de ɛn di we aw di tumbu dɛn de mek. wi kin kכl dεn ya bak ``tכmכro sכpreshכn jin dεm``. so, insay Gorlin sεndrכm, wetin de apin na dat chenj de, dat na ``mכtεshכn``, insay wan pan dεn jin dεm ya. Dis na di rizin we mek di risk fɔ gɛt tumbu kin bɔku lɛk aw wi bin dɔn tɔk.

De tin wae impɔtant pas ɔl na dat nɔr patikyula mɛrɛsin nɔr de yet fɔ Gorlin syndrome . Bɔt nɔ wɔri! If yu fala yu dɔktɔ in instrɔkshɔn fayn fayn wan, ɛn if dɛn no tin lɛk kansa ɛn trit am kwik , pɔsin we gɛt dis sik kin liv nɔmal layf. I nɔ nid fɔ afɛkt yu layf ɔr kwaliti layf.

Aw dis sik kin kɔmɔn?

Gorlin syndrome na wan sik we nɔ kin apin so ɔltɛm . Masta sabi bukman dɛn se ivin na kɔntri lɛk Amɛrika, dis sik nɔ pas 50,000 pipul dɛn. Bɔt dis nɔmba kin pas dat fa fawe. De rizin na wae sɔm pipul kin gɛt sɔm kayn sik wae nɔr kin ivin no se dɛn gɛt dis sik. Bɔku tɛm, di sayn dɛn kin sho pan di titi ɔ yɔŋ pipul dɛn .

Wetin na di sayn dɛm wae de sho se pɔrsin gɛt Gorlin Syndrome?

De sayn dɛm fɔ dis sik kin difrɛn frɔm wan pɔrsin to ɔda pɔrsin, bɔt sɔm kɔmɔn sayn dɛm de:

Di men tin dɛn we pɔsin kin si

• Multiple basal cell carcinomas: Dis kayn skin kansa kin de pan say dεm we di san de pan lεk di fes εn nεk. Bɔt pan pipul dɛm wae gɛt Gorlin syndrome, dis kin kam wae dɛn yɔŋ, wae dɛn dɔn rich twɛnti ia .
• Odontogenik kεratosist dεm:Dis na tin dεm we nכ de mek yu fil pen, we nכ de kכnεs we de fכm na di jawbone. Dɛn kin bɔrku pan pikin ɛn yɔŋ pipul dɛm wae gɛt Gorlin syndrome.
• sכm sכm pit dεm כ diprεshכn dεm na di palm dεm εn di sכl dεm na di fut dεm: Dis fכm dεn kin si am mכst insay di 20s. Dɛn tin ya kin de sote go.
• di skel chenj dεm: yu kin si sכm chenj dεm na di we aw di rib dεm εn di spayna de fכm.

Di sayn dɛm we nɔ kin bɔku

Nɔto ɔlman go gɛt dɛn kayn sik ya, bɔt sɔm pipul dɛn kin gɛt:

• di tכmכro dεm na di bren: Dis kin bi kεnsar (medulloblastoma) כ nכn kansa (meningioma).
• di fibroma dεm na di at כ ovaria dεm: Dis na tכmכro dεm we nכ de kכnεs, we nכ de du bad.
• Prɔblɛm na di yay: tin dɛn lɛk strabismus, nystagmus, ɛn katarakt.
• siriכs chenj dεm na di bon dεm: fכ egzampl, di spayna nכ de kכmplit (spina bifida).
• di fכs tin dεm we nכ nכmal: di distans bitwin di yay dεm de bכku (hypertelorism), we dεn bכn wit sכm lip/palate, εn sכm sכm wayt spat dεm (milia) na di fes.
• ed we big pas nכmal (macrocephaly).
• Disabiliti dɛn we gɛt fɔ du wit intɛlektual.
• Epileptic stet dεm `(Seizures)`.

Wetin kin mek pɔsin gɛt Gorlin Syndrome?

As wi bin dɔn tɔk, dis sik kin kam bikɔs wi jin dɛn chenj. fכ bi prεsis, tri jin dεm de na wi bכdi we de stכp di fכmeshכn fכ tכmכro dεm (tumor suppressor genes). na di jin dεm we dεn kכl ``PTCH1`` (dis na di wan we de involv mכst), ``PTCH2`` εn ``SUFU``. we dεn jin dεm ya nכ de wok fayn, sכm sεl dεm kin bigin fכ gro bכku bכku wan. Na dat kin mek yu gɛt sɔm kayn sik lɛk tumor.

Bɔku pipul dɛn kin gɛt dis jin muteshɔn frɔm dɛn mama ɛn papa. Bɔt sɔm tɛm dɛn de, dis jin muteshon kin apin randomly bifo dɛn bɔn am, we nɔ gɛt ɛni famili histri.

dis jεnεtik mכtεshכn de inhεrit insay wan "autosomal dominant" patεn . Fɔ tɔk am simpul wan, yu kin gɛt nɔmal jin frɔm wan mama ɔ papa ɛn wan jin we dɔn chenj frɔm di ɔda wan. yu nid fכ gεt εither di PTCH כ SUFU jin mכtεshכn fכ divεlכp Gorlin sεndrכm.

Sayɛnsman dɛn se pɔsin we gɛt Gorlin syndrome kin jɔs gɛt kansa if dɛn chenj di nɔmal kɔpi fɔ di tumor suppressor jin sɔm we dɛn. Fɔ ɛgzampul, di damej we di san de gi kin mek di gud jin chenj. Dɔn, dɛn tu jin ya nɔ de wok fayn, ɛn dɛn nɔ kin ebul fɔ stɔp di tumbu dɛn. Dis na wetin kin mek pɔsin gɛt kansa na di skin. Ɛn if ɔda sɛl dɛn na di bɔdi pwɛl dis kayn we, ɔda kayn kansa kin kam.

Aw dɔktɔ dɛn kin no bɔt dis sik?

Fɔ no if yu gɛt Gorlin syndrome, yu dɔktɔ go du dɛn tin ya:

• Fɔ chɛk yu bɔdi: Chɛk fɔ si if yu gɛt kansa na yu skin.
• imej tεst: Chεk fכ tכmכro, fibroma, כ skel prכblεm na di jawbon (e.g., X-ray, CT skan, MRI skan).
• Bayopsi: Na we dɛn kin pul smɔl tisu na di skin ɔ wan lump ɛn chɛk am ɔnda maykroskɔp fɔ si if i gɛt kansa sɛl dɛn.
• Jɛnɛtik tɛst: Dɛn kin tek blɔd sɛmpul fɔ chɛk if yu gɛt jɛnɛtik muteshɔn we gɛt fɔ du wit Gorlin sindrom.

Wetin na di tritmɛnt fɔ Gorlin Syndrome?

Pan ɔl we nɔr patikyula tritmɛnt nɔr de fɔ Gorlin syndrome insɛf, if yu gɛt tumor wae gɛt kansa ɔr de kɔz ɔda prɔblɛm, yu kin nid fɔ trit dɛm. Fɔ ɛgzampul:

• Dɛn kin pul kansa na di skin ɔ di jawbone tumor if dɛn du ɔpreshɔn .
• Ɔda tritmɛnt dɛn fɔ kansa, lɛk krim we dɛn kin put pan pɔsin in bɔdi ɔ fɔ yuz fotodaynamik tɛrapi bak fɔ pwɛl di kansa sɛl dɛn.

Bikɔs yu gɛt mɔ chans fɔ gɛt kansa, yu dɔktɔ go tɛl yu fɔ yuz gud tin fɔ protɛkt yusɛf frɔm di san, wɛr klos we gɛt lɔng sliv, ɛn wɛr hat we yu de na di san. Dɔn bak, dɛn kin jɔs du tɛst dɛn lɛk ɛkstrem rayt we i rili nid fɔ du am. Jɛnɛral wan, ɔnkɔlɔjis dɛn nɔ kin gi redyushɔn tɛrapi as kansa tritmɛnt fɔ pipul dɛn we gɛt Gorlin syndrome. Dis na bikɔs redyushɔn kin mek pɔsin gɛt kansa mɔ.

Yu tink se dɛn kin ebul fɔ avɔyd di sik we dɛn kɔl Gorlin Syndrome?

Wi nɔ go ebul fɔ kɔntrol di jin dɛn we dɛn bɔn wi wit. So, no we nɔ de fɔ mek yu nɔ gɛt di sik we dɛn kɔl Gorlin syndrome. Bɔt yu kin ridyus di chans fɔ gɛt kansa na yu skin if yu du tin dɛn fɔ mek yu nɔ gɛt am . Dɔn bak, if yu de du dɔktɔ chɛk-ap ɔltɛm, yu kin no kansa kwik kwik wan. Dɔn i kin izi fɔ mɛn am.

If yu gɛt Gorlin syndrome (ɔ if sɔmbɔdi na yu famili gɛt am) ɛn yu de plan fɔ bɔn pikin ɛn yu de wɔri se yu pikin go gɛt am, go to pɔsin we de advays yu bɔt yu jɛnɛtiks . Dɛn go ɛksplen di prɔblɛm dɛn we kin apin to yu ɛn yu patna.

Aw di tumara bambay go tan lɛk fɔ pɔsin we gɛt dis sik? (Autluk) .

Bɔrku pipul dɛn kin mɛna Gorlin syndrome bay wae dɛn kin tek step fɔ mek dɛn nɔ gɛt kansa na dɛn skin ɛn dɛn kin gɛt dɔktɔ chɛk-ap ɔltɛm. If yu de chɛk yu kansa ɔltɛm lɛk aw yu dɔktɔ tɛl yu, yu kin kech ɛni prɔblɛm kwik kwik wan . Pipul wae gɛt Gorlin syndrome kin liv lɔng ɛn lɛk di wan dɛm wae nɔr gɛt dis sik lɛk pipul dɛm wae nɔr gɛt dis sik.

Dɔn bak, di tin we impɔtant pas ɔl fɔ mɛmba na dat nɔto ɔlman we gɛt Gorlin syndrome go gɛt kansa ɔ gɛt di sem prɔblɛm. I kin difrɛn frɔm wan pɔsin to ɔda pɔsin. Yu dɔktɔ go advays yu bɔt yu sik bay di sayn dɛm we yu gɛt.

Aw a kin kia fɔ misɛf? (Fɔ kia fɔ yusɛf) .

If yu gɛt Gorlin syndrome, yu fɔ tek dɛn spɛshal step ya fɔ mek yu nɔ gɛt kansa na yu skin:

• Nɔ yuz bed fɔ tan.
• Stay insay os as yu ebul di tɛm we di san kin bɔku (10 a.m. to 4 p.m.).
• Wear brayt-spɛktrum sanskrin wit at le SPF 30 ɛvride. Ri-aplay ɔltɛm.
• We yu de go na do, wɛr klos we de protɛkt yu frɔm UV ɛn hat we gɛt wayd brim.

Yu go nid bak fɔ go to difrɛn dɔktɔ dɛn fɔ chɛk if yu gɛt kansa ɛn ɔda tin dɛn. Aw ɔltɛm yu nid fɔ go go dipen pan if dɛn fɛn ɛni tumbu ɔ ɔda tin we nɔ fayn. Dɛn dɔktɔ visit ya kin gɛt fɔ du wit:

• Mek dɔktɔ we de mɛn yu skin chɛk yu skin.
• Dɛnt ɛgzam ɛn imej tɛst fɔ chɛk fɔ si if di tɔŋ de na di jawbon.
• Imej tɛst fɔ chɛk fɔ fibromas, bren tumor, ɔr yu gɛt prɔblɛm wit yu yay.

Ustɛm a fɔ go to dɔktɔ?

If yu tink se yu ɔ yu pikin gɛt basal cell carcinoma, go to dɔktɔ wantɛm wantɛm . Dis na di sayn wae de sho se yu gɛt Gorlin syndrome. Jɔs lɛk ɔda kayn kansa na yu skin, no bɔt ɛni nyu, we de kɔntinyu fɔ de, ɔ we de gro ɔ gɛt spat.

Bɔku tɛm, kansa na di skin nɔ kin gɛt ɛnitin fɔ du wit di sik we dɛn kɔl Gorlin syndrome, bɔt ilɛk wetin mek dɛn gɛt am, i impɔtant fɔ mek dɛn du tɛst.

Us kwɛstyɔn dɛn yu fɔ aks di dɔktɔ?

If dɛn no se yu gɛt Gorlin syndrome, yu kin aks yu dɔktɔ dɛn kwɛstyɔn ya:

• Us kansa simptom dɛm a fɔ no bɔt?
• Aw ɔltɛm a go nid fɔ gɛt kansa skrinin?
• Wetin a go du fɔ mek a nɔ gɛt bɔku kansa?
• A go nid tritmɛnt fɔ di tumbu dɛn we nɔ gɛt kansa?
• Wetin na di chans fɔ mek a gɛt pikin we gɛt Gorlin syndrome?

Gorlin syndrome kin kam wit sɔm kayn prɔblɛm wae pipul dɛm wae nɔr gɛt dis sik nɔr kin gɛt. If yu gɛt NBCCS, yu ɛn yu mɛdikal tim fɔ de wach mɔ fɔ no ɛn trit ɛni basal sɛl kansa we de divɛlɔp.

Faynal Mɛsej fɔ Tek-Hom

di gud nyus na dat, di basal sel kansa kin kכmplit if dεn trit am kwik. Dɔn bak, bɔku tɛm, di tumbu dɛn we nɔ gɛt kansa nɔ kin mek prɔblɛm. If dɛn du dat, dɔktɔ kin pul dɛn ɔ tɛl yu fɔ du ɔda tritmɛnt dɛn. Yu kin liv lɔng, ful layf wit Gorlin syndrome. So, nɔ panik, bɔt tek tɛm. Fɔ fala di rayt advays we dɔktɔ gi yu, ɛn ɔltin go fayn!

` Gorlin sindrom, NBCCS, basal sel kansa, jenɛtik sik, skin kansa, dɛmatɔlɔji