Yu pikin in bɛlɛ de at bad bad wan? I kin bi Ɛmolaytik Yurɛmik Sindrom (HUS)!

Yu smɔl pikin dɔn gɛt dayarɛa wit bɛlɛ we de at fɔ sɔm dez? Yu kin ivin si blɔd insay. Na nɔmal tin fɔ mek yu, as mama ɔ papa, wɔri bad bad wan we dat apin. We yu gɛt sɔm kayn sik dɛn lɛk dis, i kin pas jɔs fɔ jɔs pen na yu bɛlɛ. Tide wi go tɔk bɔt wan sik we kin siriɔs, bɔt i kin rili trit if dɛn no am kwik. Dat na (Hemolytic Uremic Syndrome) , ɔ (HUS) fɔ shɔt tɛm.

Wetin na Ɛmolaytik Yuremik Sindrom (HUS)? Lɛ wi ɔndastand am simpul wan.

Okay, naw mek wi luk wetin dis (HUS) bi. Fɔ tɔk am simpul wan, na sik we di smɔl smɔl blɔd vesel dɛn na wi kidni kin blok . Tink bɔt am lɛk se wata paip de blok ɛn di wata stɔp fɔ flɔ. Dis blɔk de mek tri men tin dɛn apin:

1. Yu rɛd blɔd sɛl dɛn kin pwɛl: Insay mɛrɛsin, dɛn kin kɔl dis ɛmolaytik anemia . Rɛd blɔd sɛl dɛn na di tin dɛn we de kɛr ɔksijɛn go ɔlsay na wi bɔdi. So we dɛn dɔn pwɛl dɛn, di ɔksijɛn we di bɔdi nid kin go dɔŋ.

2. di nכmba fכ di pletlet dεm na di bכdi de dכn: Dεn kכl dis kכndyushכn trombocytopenia . Plɛtlɛt na smɔl smɔl sɛl dɛn we de ɛp wi blɔd fɔ klɔt we wi de blɔd. We dɛn tin ya dɔn go dɔŋ, i kin at fɔ lɛ pɔsin stɔp fɔ blɔd, ɛn brus kin apin ɔlsay na di bɔdi.

3. Kidni damej: Dis na di tin we denja pas ɔl. We di kidni dɛn nɔ de wok fayn, dɛn nɔ kin ebul fɔ pul dɔti tin dɛn we kin gɛda na di bɔdi. Dɛn kin kɔl dis bak (Acute Kidney Injury - AKI) .

Pan ɔl we HUS kin afɛkt ɛnibɔdi, bɔku tɛm na baktriyal infɛkshɔn , mɔ Escherichia coli , we dɛn kin kɔl E. coli . Dis baktri de mek yu gɛt dayarɛa, mɔ di dayarɛa we gɛt blɔd. Bɔt, sindrom na wan kɔlekɛshɔn fɔ di simptom dɛm, ɛn HUS kin apin bak bikɔs ɔf ɔda tin dɛm pas E. coli.

Dis kכndyushכn (HUS) kin afekt nכto di kidni dεm nכmכ, bכt sכmtεm כda כgan dεm lεk di at εn bren. Bɔt i kin afɛkt di kidni dɛn mɔ.

Di tin we impɔtant pas ɔl: If yu ɔ yu pikin gɛt blɔd dayarɛa ɔ i gɛt dayarɛa fɔ pas tri dez, mek shɔ se yu go to dɔktɔ. If dɛn nɔ trit am, HUS kin rili bad ɛn ivin kin mek pɔsin in layf de pan denja.

Difrɛn kayn HUS dɛn de?

Yes, sɔm men kayn (HUS) de. Lɛ wi lan smɔl bɔt dɛn:

1. "Typical" (HUS): Dis na di kayn we we dɛn kin yuz mɔ . Bɔku tɛm, na baktri infɛkshɔn, mɔ E. coli, we kin afɛkt wi smɔl intestinal ɛn kɔlon.

2. "Atypical" (HUS) (aHUS): Dis na smɔl tin we nɔ kin apin.Bɔku tɛm dis kin bi bikɔs ɔf di jɛnɛtik rizin, we min se i kin kɔmɔt frɔm mama ɛn papa to pikin dɛn.

3. "Sεkɔndari" (HUS): Dis kayn kin apin wit ɔda mεdikal kכndyushכn dεm. Fɔ ɛgzampul, i kin kam bikɔs ɔf sɔm mɛrɛsin dɛn, ɔda sik dɛn, ɔ we uman gɛt bɛlɛ.

Mek wi lan smɔl mɔ bɔt "Atypical" (HUS) (aHUS)

(aHUS) na wan sik we nɔ kin apin so ɔltɛm. I kin mek bak yu gɛt di sem sayn dɛm lɛk di wan we bin dɔn de bifo:

• Di rεd blɔd sɛl lεvεl dεm we de dכn.
• Di pletlɛt dɛn we dɛn kin gɛt kin go dɔŋ.
• Sudden kidney failure (akyu kidni failure) .
• Ay blɔd prɛshɔn (haypa prɛshɔn) ɔ nɔ ebul fɔ kɔntrol blɔd prɛshɔn.

Dis kכndyushכn (aHUS) kin bi wan jεnεtik dizayd . Dat min se na sɔm chenj (muteshɔn) dɛn we de na wi jin dɛn kin mek i apin. Bɔt ivin if dis jenɛtik kɔndishɔn de, sɔm infekshɔn, sik, ɔ tin we de na di say we i de na di say kin mek i apin.

Aw kɔmɔn tin (HUS)?

Bitwin 5% ɛn 15% pan di pipul dɛm we gɛt dayarɛa we di baktri (E. coli) kɔz go gɛt HUS . Di kayn we dɛn kɔl (aHUS) nɔ kin bɔku. I kin apin to lɛk wan pan ɛvri milyɔn pipul dɛn.

Wetin na di men sayn dɛm fɔ (HUS)?

I rili impɔtant fɔ mek yu no bɔt dɛn sik ya.

Fɔs sayn dɛn we pɔsin kin si:

• Daya: Bɔku tɛm, blɔd kin kam wit am.
• Pɔsin we de fil pen na di bɛlɛ.
• Nɔs ɛn vɔmit.
• Ed de at .
• Chil ɛn fiva.

Ɔda tin dɛn we pɔsin kin si:

• I izi fɔ mek pɔsin brus.
• Pale skin (pallor): Di insay pat na di nos ɛn ivin di insay pat na di mɔt kin bi pale.
• Kɔnfyus.
• Gɛt fit.
• Kɔndishɔn dɛn we tan lɛk strok.
• Hat rit kwik kwik wan (arithmia).

If di kɔndishɔn fɔ (HUS) kam tranga, di rɛd blɔd sɛl dɛm we dɔn pwɛl kin mek blɔd klɔt ɛn pwɛl ɔgan dɛm lɛk di kidni dɛm. Dɔn di kidni dɛn nɔ kin ebul fɔ filta di dɔti tin dɛn fayn fayn wan. Dis na wetin wi kin kɔl (Acute Kidney Injury - AKI) . Na di sayn dɛm fɔ am:

• Blɔd we de na di urine (hematuria).
• Di pɔyzin we de na di blɔd kin bɔku: Dis kin mek i nɔ fil fayn ɛn i kin mek i fil se i sik.
• Di ay blɔd prɛshɔn.
• I nɔ izi fɔ blo (dyspnea).
• Ɛdima: I kin swel, mɔ na di leg ɛn anklɛ.
• di urine we de kכmכt dכn dכn (oliguria).

Wetin na di men tin dɛm wae kin mek pɔrsin gɛt (HUS)?

Mɔs pan di kes dɛm fɔ HUS kin kɔmɔt frɔm sɔm kayn E. coli baktri dɛm. Dɛn baktri ya kin mek wan pɔyzin we dɛn kɔl Shiga pɔyzin . Dis pɔyzin de pwɛl di layn na wi smɔl intestin ɛn mek wi gɛt dayarɛa. Dis pɔyzin kin go insay di blɔd bak, ɛn i kin pwɛl di rɛd blɔd sɛl dɛn ɛn pwɛl di kidni dɛn.

Yu kin gɛt E. coli infɛkshɔn frɔm:

• Mit dɛn we nɔ kuk fayn: mɔ bif, bif we dɛn dɔn grɔn.
• Milk ɛn frut drink dɛn we nɔ pastɔrayz: Pastɔrayz na we dɛn kin ɔt saful saful we kin kil bad tin dɛn lɛk baktri.
• Frut ɛn vɛjitebul dɛn we dɛn nɔ was, we dɔti.

Dɛn kin kɔl dɛn E. coli strayn ya we de mek pɔyzin bak Shiga toxin-producing E. coli (STEC) . di STEC strain we kכmכn pas כl na Nɔt Amɛrika na E. coli O157:H7 .

Na smɔl tɛm nɔmɔ, sɔm mɛrɛsin ɛn tin dɛn kin mek bak "sɛkɔndari (HUS)". Ɛgzampul dɛn:

• Di mɛrɛsin dɛn we de agens kansa (Kɛmotɛrapi drɔgs): lɛk (bleomycin), (cisplatin), (gemcitabine).
• Immunosuppressant drɔgs: lɛk (sayklɔspɔrin), (takrolimus).
• Kwinin: Na mɛrɛsin fɔ malaria.
• Sɔm drɔgs : (ɔksimɔfon), (ɛkstasi), (kɔkɛyn).

Yu tink se (HUS) kin pas?

Nɔ, HUS nɔto pɔsin we kin pas.

Bɔt dɛn kin pas di E. coli baktri dɛm. Dis baktri kin pas tru it ɔ drink we gɛt dɔti, ɔ we i kam nia pɔsin ɔ animal we gɛt dayarɛa we gɛt E. coli in fes. So, i impɔtant fɔ rili tek tɛm we wi de klin.

Udat kin gɛt mɔ sik (HUS)?

Pan ɔl we ɛnibɔdi kin gɛt HUS, dɛn pipul ya kin gɛt mɔ risk:

• Fɔ yɔŋ pikin dɛn we nɔ rich 5 ia yet.
• Fɔ di wan dɛn we gɛt wik imyun sistɛm (immunocompromised).
• If pɔsin na yu famili dɔn gɛt HUS bifo (especially aHUS).
• If yu gɛt E. coli infɛkshɔn: Ɛspɛshali frɔm tin dɛn lɛk mit we nɔ kuk fayn ɛn milk we nɔ pasteurized.
• Dairekt kɔntakt wit pɔsin we gɛt dayarɛa we (E. coli) kɔz.

Aw yu go no if yu gɛt (HUS)? (Diagnosis) .

We yu go to dɔktɔ, i go du dɛn tin ya:

• Aks bɔt yu mɛdikal istri .
• Aks bɔt yu famili mɛdikal istri .
• Dɛn kin du wan ɛgzam pan pɔsin in bɔdi .

If dɛn tin ya mek pipul dɛn sɔprayz pan wan sik we dɛn kɔl (HUS), di dɔktɔ go ɔda fɔ mek dɛn du sɔm ɔda tɛst dɛn.

Us kayn tɛst dɛn kin du?

• Urinalysis: Dɛn kin tek wan sampul pan yu urine ɛn chɛk fɔ si if i gɛt prɔtin ɔ blɔd.
• Blɔd tɛst: Dɛn kin tek blɔd sɛmpul fɔ chɛk tin dɛn lɛk di rɛd blɔd sɛl, di pletlɛt lɛvɛl, ɛn aw yu kidni ɛn liva de wok fayn.
• Stɔl tɛst: Dɛn kin tek wan stɔl sɛmpul ɛn chɛk fɔ si if baktri dɛm we de mek HUS, lɛk E. coli O157.
• Jɛnɛtik tɛst: Sɔntɛnde, dɛn kin sɛn wan sɛmpul pan yu blɔd fɔ mek dɛn tɛst yu jɛnɛtiks. Dis kin ɛp fɔ no if yu gɛt jɛnɛtik kɔndishɔn lɛk aHUS ɛn us tritmɛnt bɛtɛ fɔ yu.
• Kidni bayɔpsi: Dis na fɔ tek smɔl pat pan di kidni ɛn chɛk am ɔnda maykroskɔp fɔ si ɔmɔs damej dɔn apin to di kidni ɛn wetin mek i apin. Nɔto ɔlman nid dis.

Aw tɛst go kɔnfirm se yu gɛt HUS?

• Frɔm urine test: If blɔd ɔ protin de na di urine.
• Blɔd tɛst: If di rɛd blɔd sɛl ɛn pletlɛt lɛvɛl nɔ bɔku, ɔ if di valyu dɛn we de sho se di kidni de wok (lɛk kriaytinin) go ɔp.
• Stɔl tɛst: If dɛn fɛn baktri dɛm lɛk (E. coli O157).
• Kidni bayɔpsi: Yu kin si spɛshal damej pan di kidni dɛn.

Aw dɛn kin trit (HUS)?

If dɛn no se yu gɛt HUS, yu go nid fɔ go na ɔspitul ɛn trit yu. Di tritmɛnt dɛn we yu kin gɛt na:

• intravenous (IV) fluid dεm εn/כ tכb fכ it (enteral nyutrishכn): Dis de εp fכ mek yu nכ gεt wata εn gi yu nyutrishכn we i nid.
• Di mɛrɛsin dɛn we dɛn kin yuz:
• Dɛn kin tray fɔ ridyus di damej we di kidni dɛn kin gɛt bay we dɛn kin gi dɛn mɛrɛsin dɛn we de mek di blɔd prɛshɔn go dɔŋ (antihypertensives) .
• Dɛn kin gi pipul dɛn we gɛt aHUS sɔm patikyula mɛrɛsin dɛn lɛk eculizumab ɔ ravulizumab . Bifo yu bigin fɔ tek dɛn mɛrɛsin ya, i impɔtant fɔ gɛt di vaksin agens di sik dɛn we de na di mɛningɔkɔk ɛn nyumokɔk , bikɔs dɛn mɛrɛsin ya kin mek yu gɛt dɛn sik dɛn de.
• Yu kin nid fɔ tek antibayɔtik fɔ at le tu wiks.
• Blɔd transfyushɔn: Fɔ gi rɛd blɔd sɛl ɛn pletlɛt to pɔsin we gɛt (HUS) rili impɔtant. Rɛd blɔd sɛl dɛn kin ridyus di sayn dɛn we de sho se pɔsin nɔ gɛt bɛtɛ blɔd, lɛk we i nɔ de blo fayn ɛn di at kin bit kwik kwik wan. Plɛtlɛt dɛn kin ɛp di blɔd fɔ klot fayn fayn wan, ɛn dis kin mek di blɔd nɔ bɔku ɛn i nɔ kin gɛt bɔku bɔku brus.

If di kidni dɛn dɔn pwɛl bad bad wan, dɛn kin nid fɔ du dayalaysis fɔ klin di blɔd te di kidni dɛn kam bak. If di kidni dεm fεl kכmplit wan biכs fכ HUS, i kin nid fכ transplant di kidni .

Yu tink se HUS kin wɛl ɔltogɛda?

Yes, bɔrku pipul dɛn kin wɛl frɔm HUS ɛn nɔr kin pwɛl dɛn wɛl bɔdi fɔ ɔltɛm.

Bɔt sɔm pipul dɛn, mɔ yɔŋ pikin dɛn, kin gɛt mild kronik kidni sik (CKD) pan 20% to 50%. εnd-stej kidni sik (ESK) kin divεlכp insay 3% to 5%. Stɔdi dɔn sho se CKD kin afɛkt lɛk 45% pan di big pipul dɛn.

Mɔ pas 85% pan di pipul dɛm wae gɛt HUS kin fulɔp dɛn kidni fɔ wok bak. Bɔt ivin if dɛn wɛl ɔl, smɔl chans de fɔ mek dɛn gɛt ay blɔd prɛshɔn ɔ ɔda prɔblɛm dɛn na dɛn kidni tumara bambay.

Yu tink se dɛn kin ebul fɔ stɔp HUS?

Na sɔm tin dɛm wae yu kin du fɔ ɛp fɔ mek yu nɔ gɛt E. coli infɛkshɔn, we na wan men tin we kin mek yu gɛt HUS. Dɛn tin ya rili impɔtant fɔ yu ɛn yu famili:

• Nɔ swim na dɔti ples (lek, riva), mɔ if yu tink se di wata gɛt bɔku bɔku bɔdi.
• If yu gɛt dayarɛa, nɔ go swim.
• Nɔ drink drink dɛn we nɔ pastɔrayz (raw) (milk, frut jus).
• Ɔltɛm, klin di tin dɛn we yu kin yuz na di kichin gud gud wan (naif, fɔk, spun) ɛn di say dɛn we yu kin pripia it (kɔnta, kɔt bod, dish).
• Kuk eg ɛn grɔn mit fayn fayn wan te di intanɛnt tɛmpracha we at le 71 digri sɛlshiɔs (160 digri F), ɛn bɔd dɛn to di insay tɛmpracha we go pas 74 digri sɛlshiɔs (165 digri Fahrenheit).
• We yu de pul di frɔst fɔ mit, put am na maykrowev ɔ frij. Nɔ defrɔst am na say we dɛn de pripia it ɔ insay ɔt wata.
• Kip raw ɛn kuk it dɛn separet.
• Was yu an fayn fayn wan wit sop ɛn ɔt wata bifo yu it, afta yu dɔn yuz di bafa, afta yu dɔn chenj smɔl pikin dɛn nɛpi, ɛn afta yu dɔn tɔch animal dɛn we de na fam.

Jɔs tink bɔt, if yu fala dɛn simpul tin ya, yu go ebul fɔ protɛkt yusɛf frɔm siriɔs tin lɛk dis.

Wetin yu kin ɛkspɛkt if yu gɛt (HUS)?

If dɛn no di sik ɛn tritmɛnt fayn fayn wan, bɔrku pipul dɛm wae gɛt HUS kin wɛl bak ɛn nɔr kin pwɛl dɛn wɛl bɔdi fɔ ɔltɛm. Bɔt, risk de fɔ mek yu gɛt ay blɔd prɛshɔn ɔ ɔda tin dɛn we go afɛkt di kidni dɛn tumara bambay.

Di bad bad kes dɛm fɔ HUS, mɔ if i afɛkt ɔda ɔgan dɛm lɛk di bren, kin kil pɔsin if dɛn nɔ trit am.

Wetin na di chans fɔ liv (HUS)?

If dɛn no di sik ɛn tritmɛnt fayn fayn wan, pas 90% pan pipul dɛn kin sev frɔm HUS. So i impɔtant fɔ mek yu nɔ fred ɛn go to dɔktɔ kwik kwik wan if yu gɛt sɔm sayn dɛn.

Aw a kin kia fɔ misɛf?

If yu ɔ yu pikin gɛt bad bad dayarɛa, i rili impɔtant fɔ tray fɔ mek yu bɔdi gɛt wata bak.Rihaydreshɔn drink, lɛk Jeevani, kin ɛp fɔ tek ples fɔ di ilɛktrɔlayt dɛn we dɔn lɔs. Bebi ɛn smɔl pikin dɛn kin nid fɔ gi dɛn mama in milk ɔ fɔmula. Aks dɔktɔ bɔt di bɛst we fɔ mek yu pikin gɛt wata.

Ustɛm a fɔ go to dɔktɔ?

Si dɔktɔ wantɛm wantɛm if yu gɛt dɛn sayn ya:

• Dayrɛa we gɛt blɔd.
• Dayarɛa we kin las pas tri dez.
• Di bɔdi we de swel.
• Skin we kin brus izi wan.
• I kin taya bad bad wan.

Us kwɛstyɔn dɛn a fɔ aks di dɔktɔ?

Yu kin aks di dɔktɔ dɛn kwɛstyɔn ya:

• Aw yu go kɔnfɔm if a gɛt Ɛmolaytik Yuremik Sindrom?
• Aw a bin gɛt di sik we dɛn kɔl Hemolytic Uremic Syndrome?
• If a nɔ gɛt Hemolytic Uremic Syndrome, us ɔda mɛrɛsin a go gɛt?
• Us tritmɛnt dɛn yu kin advays?
• Yu tink se mi kidni dɛn go pwɛl sote go?
• A go gɛt ay blɔd prɛshɔn ɔ ɔda prɔblɛm dɛn na mi kidni tumara bambay?

Wetin na di triad fɔ Ɛmolaytik Yuremik Sindrom?

Triad na tri men sayn dɛm we de sho se pɔsin gɛt sɔm kayn mɛrɛsin.

Di triad we dɛn kɔl Hemolytic Uremic Syndrome inklud:

1. Damej pan yu rεd blɔd sɛl dεm (microangiopathic hemolytic anemia) .

2. Di nɔmba fɔ di pletlɛt dɛn we de na yu blɔd de go dɔŋ smɔl smɔl (thrombocytopenia) .

3. Akyu kidni injuri.

If a gɛt dayarɛa, dat min se a gɛt Ɛmolaytik Yurɛmik Sindrom?

Jɔs bikɔs yu gɛt dayarɛa nɔ min se yu gɛt Ɛmolaytik Yurɛmik Sindrom. Bɔt if yu gɛt blɔd dayarɛa, ɔ if yu dayarɛa bad bad wan (to di say we wata de dayarɛa ɔ i go las pas tri dez), yu fɔ rili go to dɔktɔ.

Wetin na di difrεns bitwin (Hεmolytic Uremic Syndrome) εn (Thrombotic Thrombocytopenic Purpura - TTP)?

Hεmolytic Uremic Syndrome (HUS) εn Thrombotic Thrombocytopenic Purpura (TTP) na tu kayn kכndyushכn dεm we fiba. insay TTP, bכdi kכlכt dεm de fכm insay sכm sכm bכdi vεsul dεm. Pan ɔl we dɔktɔ dɛn bin de grup HUS ɛn TTP togɛda, naw dɛn kin tek dɛn as difrɛn kɔndishɔn dɛn.

Fɔ dɔn, tin dɛn fɔ mɛmba (Take-Home Message) .

Bɔrku tɛm, dayarɛa na sik wae de kam fɔ shɔt tɛm, bɔt nɔr kin fayn fɔ yu. Bɔku tɛm, i kin bɛtɛ insay wan ɔ tu dez. Bɔt if yu gɛt dayarɛa we gɛt blɔd, ɔ if yu gɛt dayarɛa fɔ pas tri dez, wit fɔ fil taya, yu nɔ de fil fayn, ɔ yu nɔ de pas bɛtɛ urine we yu go na di bafa, na tɛm fɔ go to dɔktɔ wantɛm wantɛm.

Wan sik wae dɛn kɔl Hemolytic Uremic Syndrome kin pwɛl yu kidni bad bad wan ɛn i kin afɛkt ɔda ɔgan dɛm.Di kwik we yu gɛt tritmɛnt fɔ dis, na di mɔ yu nɔ go gɛt prɔblɛm wit yu kidni fɔ lɔng tɛm. So, no bɔt di sayn dɛn we de sho se yu gɛt dis sik, klin yu fayn fayn wan, ɛn go to dɔktɔ if yu gɛt ɛnitin fɔ wɔri bɔt. Yu wɛlbɔdi rili impɔtant to yu!

` Ɛmolaytik Yuremik Sindrom, HUS, Kidni Sik, Dayarɛa, E. coli, Rɛd Blɔd Sɛl, Plɛtlɛt, Pikin Wɛlbɔdi