Yu dɔn ɛva yɛri se wan, sɔntɛm tu ɔ tri pipul dɛn na yu famili dɔn gɛt kansa na yu kɔlon? Ɔ yu de fred smɔl bikɔs yu gɛt kansa na yu famili? Infakt, sɔm kayn kansa kin pas frɔm wan jɛnɛreshɔn to ɔda jɛnɛreshɔn. Tide wi go tɔk bɔt wan spɛshal kayn kɔlon kansa we de pas tru wi jin dɛm. Wi de kɔl dis HNPCC.
Wetin na HNPCC?
Fɔ tɔk am simpul wan, HNPCC (Hereditary Nonpolyposis Colorectal Cancer) na wan kayn kɔlon kansa we kin kɔmɔt frɔm sɔm chenj (muteshɔn) dɛn na di jin dɛn we kin pas tru jɛnɛreshɔn. Dis na kansa we de apin na wi big intestinal (colon).
So dis na di sem tin wit Lynch Syndrome?
Yu go dɔn yɛri Lynch Syndrome bɔku tɛm pas HNPCC. Dɛn tu tin ya gɛt tayt padi biznɛs, bɔt nɔto di sem. Tink bɔt am dis we. Lynch Syndrome na wan jenɛtik dɛfekt na wi bɔdi. Na wan jenɛtik kɔndishɔn we de mek di risk fɔ gɛt kansa bɔku.
HNPCC na di nem we dɛn kin gi to wan kɔndishɔn we pɔsin we gɛt Lynch Syndrome kin gɛt kɔlon kansa ɔ ɔda kansa dɛn we gɛt fɔ du wit am (lɛk uterin ɔ smɔl bɔdi kansa), mɔ bifo i ol 50. HNPCC kansa kin apin mɔ na di rayt say na di big intestinal.
Fɔ sɔmtin, Lynch Syndrome na di jenɛtik kɔz fɔ dis sik. HNPCC na di kansa kכndyushכn we de kכmכt frכm da kכz de.
Aw kɔmɔn tin fɔ HNPCC? Wetin na di sayn dɛm we de sho se yu gɛt dis sik?
HNPCC de mek bitwin 2% ɛn 4% pan ɔl di kɔlorektal kansa dɛn we dɛn ripɔt ɔlsay na di wɔl. Pan ɔl we dis sik kin apin pan ɛni ej, bɔku tɛm dɛn kin no am pan pipul dɛn we nɔ rich 50 ia yet.
HNPCC nɔ kin gɛt ɛni patikyula simptom na di fɔs stej, bɔt as di kansa de go bifo, dɛn simptom ya kin apia.
| Di sayn we de sho se di sik de | Fɔ ɛksplen am simpul wan |
|---|---|
| Bɛlɛ de at ɔ blo | Di bɛlɛ nɔ kin fil fayn ɔltɛm, i kin fil pen, ɔ i kin fil lɛk se i de blo. |
| Fil fɔ it | Di apɛtit we de go dɔŋ. |
| Blɔd we de na di stɔl | Blɔd na di stɔl ɔ blak stɔl we yu de go na tɔylɛt. |
| Fɔ fil taya fɔ natin | Fɔ fil so taya dat yu nɔ ebul fɔ ivin du nɔmal wok dɛn. |
| We yu de lɔs yu wet we yu nɔ gɛt rizin | We yu de lɔs yu wet wantɛm wantɛm we yu nɔ de it ɔ ɛksesaiz. |
Wetin mek HNPCC de divɛlɔp? Yu tink se i kin pas?
Di men rizin fɔ dis na wi jin dɛn. Tink bɔt wi bɔdi lɛk bildin we dɛn bil akɔdin to big plan. Di buk we gɛt da plan de na wi DNA. Wi kin kɔl di instrɔkshɔn dɛn we de insay dis DNA jin dɛn.
Pipul dεm we gεt Lynch Syndrome gεt difεkt na sεvεra spεsifi k jin dεm (`MLH1`, `MSH2`, `MSH6`, `PMS2` εn `EPCAM`) we de ripεr mistek dεm na DNA. we dεn jin dεm ya nכ de wok fayn, mistek dεm na DNA (`DNA rεplikshכn mistek`) we de apin we wi sεl dεm de divayd nכ de kכrekt. As tɛm de go, dɛn mistek ya kin gɛda ɛn wan nɔmal sɛl kin bi kansa sɛl.
Di impɔtant tin na dat HNPCC nɔto sik we pɔsin kin gɛt. Dat min se i nɔ de skata frɔm wan pɔsin to ɔda pɔsin lɛk kol. Bɔt di fɔlt jin we de mek i gɛt am kin pas frɔm wan jɛnɛreshɔn to ɔda jɛnɛreshɔn. Dat min se if ɛni wan pan dɛn mama ɛn papa gɛt Lynch Syndrome, pikin gɛt 50% chans fɔ gɛt da jin de. If dɛn gɛt da jin de, da pikin de gɛt ay risk fɔ gɛt HNPCC ɔ ɔda kansa dɛn we gɛt fɔ du wit am tumara bambay.
Aw dɔktɔ kin no dis?
If yu gɛt di sayn dɛn we wi dɔn tɔk bɔt, mɔ if pɔsin na yu famili dɔn gɛt kansa na yu kɔlon, yu fɔ rili go to dɔktɔ.
Di dɔktɔ go chɛk yu fɔs. Dɔn, if dɛn tink se gɛt kansa na di kɔlon, di tɛst we dɛn kin du mɔ na fɔ kɔlon skɔpi . dis involv fכ put wan tin tכb tru di anus εn yuz kεmεra fכ egzamin di insay pat pan di big intestin.
Fɔ kɔnfirm if yu gɛt HNPCC, yu dɔktɔ go luk fɔ dɛn tin ya bak:
- Famili kansa istri:Dɛn go mɔs aks yu if ɛnibɔdi na yu fambul we de nia yu, lɛk yu mama, papa, ɔ brɔda ɛn sista dɛn, dɔn ɛva gɛt kɔlon kansa ɔ ɔda kansa we gɛt fɔ du wit Linch Sindrom bifo i ol 50 ia.
- Jɛnɛtik Tɛst: Dɛn kin se yu fɔ du spɛshal blɔd tɛst fɔ no if yu gɛt di jɛnɛtik muteshon we de mek yu gɛt HNPCC.
- Fɔ pul ɔda tin dɛn we de apin: Lɛk HNPCC, ɔda kayn kɔlon kansa we pɔsin kin gɛt frɔm in mama ɛn papa de we dɛn kɔl FAP (Familial Adenomatous Polyposis) . Bikɔs difrɛns de bitwin di tu, dɛn go du tɛst bak fɔ kɔnfɔm se yu gɛt HNPCC ɛn nɔto FAP.
Wetin na di difrɛns bitwin HNPCC ɛn FAP?
Pan ɔl we dɛn ɔl tu na tin dɛn we pɔsin kin gɛt we i gɛt kansa na in kɔlon, di jin dɛn we kin mek dɛn gɛt am difrɛn. di men difrεns na di nכmba fכ di polip dεm we de divεlכp na di kכlon.
| Di kwaliti we pɔsin gɛt | HNPCC (Lynch Sindrom) we gɛt di sik. | FAP we dɛn kin yuz |
|---|---|---|
| Sayz fɔ di polip dɛn | Na smɔl frut dɛn nɔmɔ dɛn kin mek ɔ dɛn nɔ kin mek dɛn (bɔku tɛm i nɔ kin rich 10). | Ɔndrɛd, sɔntɛm tawzin, nat dɛn kin fɔm. |
| Fɔ bi pɔsin we gɛt kansa | Sɔm tin dɛn we kin gro kin bi kansa kwik kwik wan. | If dɛn nɔ trit am, 100% chans de fɔ mek wan pan dɛn tɔŋ ya bi kansa. |
Wetin na di tritmɛnt dɛm fɔ HNPCC?
Di men tritmɛnt fɔ HNPCC na ɔpreshɔn (kɔlektɔmi) . Dis min se dɛn fɔ ɔpreshɔn di pat ɔ ɔl di kɔlon usay di kansa de. Dɛn kin du dis difrɛn difrɛn we dɛn.
- Patɛl kɔlektɔmi: Dɛn kin pul di pat nɔmɔ na di kɔlon usay di kansa de.
- Total colectomy: Dɛn kin pul di wan ol big intestinal.
- Proctectomy: Dɛn kin pul ɔl tu di big intestinal ɛn di rεktum.
If di kansa dɔn skata (metastasized) to ɔda pat dɛn na di bɔdi, yu dɔktɔ kin tɛl yu fɔ du ɔda tritmɛnt dɛn apat frɔm ɔpreshɔn.
- Kimotɛrapi: Na mɛrɛsin we de pwɛl di kansa sɛl dɛn.
- Immunotherapy: I de mek wi bɔdi in yon imyun sistɛm fɔ fɛt di kansa sɛl dɛn.
Bɔrku tɛm, imyunotɛrapi kin bi mɔ sakrifays fɔ HNPCC kansa.
Wetin na di fiuja fɔ pɔsin we gɛt HNPCC?
Lynch Syndrome na wan sik wae de kam wit jεnεtiks wae nɔr kin ebul fɔ mɛn. Na tin we pɔsin kin gɛt fɔ ɔl in layf. Bɔt ɔpreshɔn kin mɛn HNPCC kansa ɛn mek dɛn nɔ gɛt kansa na di kɔlon tumara bambay.
Pɔsin we gɛt HNPCC de pan denja fɔ gɛt ɔda kayn kansa apat frɔm kɔlon kansa. Na dat mek yu dɔktɔ go tɛl yu fɔ de chɛk yu ɔltɛm.
- Kansa we de na di ɛndometrial
- Kansa na ovarian
- Bɛlɛ kansa
- Kidni, bren, liva ɛn skin kansa
Di tin we impɔtant pas ɔl na fɔ no am kwik kwik wan . If dɛn du tɛst yu di rayt tɛm, dɛn kin no ɛni wan pan dɛn kansa ya kwik kwik wan ɛn dɛn kin trit yu fayn fayn wan.
Na avrej, lɛk 60% pan di pipul dɛm we dɛn no se gɛt HNPCC kin liv fɔ 5 ia. Ɛn bitwin 70% ɛn 88% pan di pipul dɛm wae gɛt bɔdi kansa bikɔs ɔf di Lynch Syndrome kin liv fɔ pas 10 ia. Dɛn statystik ya de sho aw impɔtant fɔ no am kwik kwik wan ɛn fɔ trit am.
Wetin dɛn kin du fɔ avɔyd ɛn kɔntrol dis risk?
No we nɔ de fɔ mek di jenɛtik chenj we de mek dis nɔ apin. Na sɔntin we wi gɛt frɔm wisɛf. Bɔt bɔku tin dɛn de we yu kin du fɔ mek yu nɔ gɛt kansa ɔ fɔ no am kwik.
- Yu fɔ no bɔt yu famili histri: If pɔsin na yu famili gɛt Lynch Syndrome ɔ HNPCC, tɔk to yu dɔktɔ bɔt am ɛn aks if yu nid fɔ gɛt jenɛtik tɛst bak.
- Start fɔ screen kwik: If dɛn no se yu gɛt Lynch Syndrome, yu dɔktɔ go se yu fɔ bigin fɔ gɛt kɔlon kansa skrinin (colonoscopy) we yu ol 20 ia.
- Fɔ liv fayn layf: Dɛn tin ya kin ɛp bɔku fɔ mek yu nɔ gɛt kansa:
- Nɔ smok kpatakpata.
- Limit fɔ drink rɔm.
- It fayn it we gɛt bɔku vɛjitebul ɛn frut.
- Ɛksesaiz ɔltɛm.
- Mek yu gɛt wɛlbɔdi bɔdi wet.
- Yu fɔ no bɔt di sayn dɛm: If yu gɛt ɛni nyu sayn, nɔr ignore dɛm ɛn go to dɔktɔ kwik kwik wan.
Mɛsej we dɛn kin kɛr go na os
- HNPCC na wan kɔlon kansa we dɛn kin gɛt frɔm dɛn mama ɛn papa we dɛn kin gɛt frɔm wan jenɛtik difrɛns we dɛn kɔl Lynch Syndrome.
- If wan ɔ mɔ pan yu famili dɔn gɛt kɔlon kansa bifo dɛn ol 50 ia, tɔk to dɔktɔ fɔ si if yusɛf de pan denja.
- dis kכndyushכn nכ de pas, bכt 50% chans de fכ pikin dεm go gεt di jin we de mek di risk.
- If yu de du skrinin ɔltɛm, dɛn kin no kansa kwik kwik wan ɛn dɛn kin sev pipul dɛn layf.
- Dɛn kin trit HNPCC fayn fayn wan wit ɔpreshɔn ɛn ɔda tritmɛnt dɛn.
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