Yu kin sik bɔku tɛm? Dis kin bi di rizin: Lɛ wi lan bɔt hypogammaglobulinemia.

Bɔku tɛm yu kin gɛt kol, flu, ɛn kɔf? Ɔ yu smɔl pikin kin gɛt infɛkshɔn na in yes ɔ i kin gɛt prɔblɛm wit in sayn? Sɔntɛnde wi kin tink se dɛn sik ya na nɔmal sik, bɔt if dɛn sik ya kin kɔntinyu fɔ kam bak, ɔda tin kin de we kin mek wi gɛt dis sik. Wan sik we dɛn kin sɔprayz pan dɛn kayn tɛm ya na di hypogammaglobulinemia. Pan ɔl we na lɔng nem smɔl, lɛ wi ɔndastand am simpul wan.

Wetin na haypogammaglobulinemia?

Fɔ tɔk am simpul wan, haypogammaglobulinemia na wan sik we yu bɔdi gɛt smɔl smɔl antibodi dɛm. Wan ɔda nem fɔ dɛn antibodi ya na immunoglobulins. Naw imajin se wi bɔdi tan lɛk fɔt. Di ɛnimi dɛn we kin kam na dis fɔt na jem, lɛk vayrɔs ɛn baktri. So di sojaman dɛn we de protɛkt wi frɔm dɛn ɛnimi dɛn ya na wi imyun sistɛm .

Dis imyun sistεm gεt wan spεshal kayn sεl we dεn kכl B-sεl dεm . Dɛn tan lɛk kɔmando dɛn we dɛn tren spɛshal wan. We wan jεm go insay di bכdi, dεn B-sεl dεm ya de mek antibodi dεm we dεn kכl imyunoglobulin. Dɛn antibodi ya kin go ɛn kech di jem ɛn pwɛl am. Na da tɛm de wi nɔ kin sik, ɔ wi kin wɛl kwik kwik wan frɔm di sik.

Yu go jɔs no bɔt dis sik we yu du blɔd tɛst.

Lɛ wi brok dɛn wɔd ya so dat wi go ɔndastand dɛn:

• Hypo: min se i de dɔŋ di nɔmal.
• Gama globulin: Dis na di kayn imyunoglobulin we kכmכn pas כl.
• Emia: min insay di blɔd.

So, we di lɛvɛl fɔ dis imyunoglobulin na yu blɔd go dɔŋ, yu bɔdi in difɛns sistɛm kin wik. Dɔn, i izi fɔ mek smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl smɔl. So , yu kin gɛt infɛkshɔn ɛn gɛt ɔda sik dɛn.

Yu tink se kayn tin dɛn de we kin apin to dis?

Yɛs, wan sik we dɛn kɔl haypogammaglobulinemia kin afɛkt pikin ɛn big pipul dɛn. Tu men kayn dɛn de:

1. Praymari (congenital) hypogammaglobulinemia: Dis kin kכz fכ sכm jεnεtik sik dεm we nכ kin apin. Wi kin kɔl dɛn tin ya Praymari Immunodeficiency Diseases (PIDD) . Fɔ tɔk am simpul wan, we dɛn bɔn yu, dɛn bɔn yu wit wan patikyula mistek (muteshɔn) na yu jin dɛn. na dεn jin dεm ya de sho di imyun sistεm aw fכ wok. So we mistek de na da instrɔkshɔn de, di imyuniti de ridyus. Bɔku tɛm dɛn kin pas dɛn jenɛtik mistek ya frɔm wan jɛnɛreshɔn to ɔda jɛnɛreshɔn.

2. Sεkכnd (akwyayz) haypogammaglobulinemia: Dis naDi kayn we we kɔmɔn pas ɔl. Dis sik kin kam bikɔs ɔf difrɛn kayn mɛrɛsin ɔr as sayd ɛfɛkt fɔ sɔm mɛrɛsin dɛn. Dis min se dɛn bɔn yu wit wɛl bɔdi ɛn afta dat yu kin gɛt dis sik leta na yu layf.

Aw dis sik nɔ kin apin so ɔltɛm?

Hypogammaglobulinemia na wan pan di kɔmɔn praymari imyunodefisiɛns sik dɛm (PIDD) we wi bin dɔn tɔk bɔt. Bɔt, PIDD nɔto sik we kin rili kɔmɔn in jɛnɛral. Fɔ ɛgzampul, dɛn se na lɛk af milyɔn pipul dɛn na Amɛrika de liv wit PIDD.

Wetin na di sayn dɛm fɔ dis?

Di men sayn fɔ haypogammaglobulinemia pan pikin ɛn big pipul na we dɛn kin gɛt infɛkshɔn ɔltɛm ɔ we kin tek lɔng tɛm. Di sayn dɛm de dipen pan di kayn infekshɔn we de apin. Di infεkshכn εn simptom dεm we kin kכmכn wit haypogammaglobulinemia na:

• Infεkshכn na yu yes: yu yes de at, yu yes dεm de injuri (sכmtεm i de skata), fiva. (Imajin se sɔm pikin dɛn kin gɛt infɛkshɔn na dɛn yes we nɔ de dɔn, we kin kam bak bak ɛn bak pan ɔl we dɛn de tek mɛrɛsin.)
• Sayn infεkshכn: Nos de rכn כ yu nos stכf, taya, fiva. (Sɔm pipul dɛn kin wek na mɔnin ɛn fil se dɛn stɔf ɛn dɛn ed kin ebi, nɔto so? If i kɔntinyu fɔ de, yu fɔ wɔri.)
• Bronchitis: Kɔf we de kɔntinyu fɔ kɔf, we yu nɔ de blo fayn, fiva.
• Nyumonia: Chɛst tayt ɔ pen, i nɔ izi fɔ blo, fiva.
• Bɛlɛ flu: dayarɛa, nɔs, vɔmit, fiva.
• Meningitis: Stif nɛk, ed we de at, fiva. (Dis denja smɔl, yu nid fɔ fɛn am kwik kwik wan.)
• Infεkshכn na di skin: skin lεsin, swεla, it, fiva.

כlso, di simptom dεm kin difrεn dipכnt pan di כndalayn kכndyushכn we mek di imyunoglobulin lεvεl dεm lכw. Fɔ ɛgzampul, pikin we gɛt sɔm kayn PIDD kin gɛt alɛji. Ɔda kayn dɛn kin ivin mek i delay fɔ gro ɛn divɛlɔp.

Wetin kin mek dis apin?

Tu tin dɛn de we kin mek i apin. Ɔ yu imyun sistɛm nɔ de mek inof imyunoglobulin, ɔ di wan dɛn we i de mek de pwɛl fɔ sɔm rizin. Di tin dɛm wae kin mek yu gɛt dis sik kin difrɛn difrɛn wan wae yu gɛt praymari ɔr sɛkɔndari lupus.

Di tin dɛn we kin mek pɔsin gɛt praymari haypogammaglobulinemia

Sɔm pan di kayn `PIDD` dɛm we kin gɛt fɔ du wit dis na:

• Kɔmɔn Variable Immunodeficiency (CVID): Na di jenɛtik difrɛns we de mek di bɔdi nɔ ebul fɔ mek inof imyunoglobulin. dis na di mכst kכmכn kכz fכ praymar haypogammaglobulinemia pan big pipul dεm.
• X-linked Agammaglobulinemia (XLA): wan jεnεtik difεkt na di X kromozom de mek di bכdi nכ de mek inof B-sεl כ immunoglobulin. dis kin mεntal afekt man pikin dεm (biכs na wan X kromozom nכmכ dεn gεt). XLA na wan kɔmɔn tin we kin mek pikin dɛn gɛt haypogammaglobulinemia.
• Transient Hypogammaglobulinemia of Infancy (THI): dis kin apin we di pikin in immunoglobulin lεvεl bigin fכ dכn arawnd 3 mכnt. Bebi dεm we gεt THI kin gεt infεkshכn, bכt bכku tεm dεn nכ kin sho di sayn dεm. Dis sik kin dɔn fɔ insɛf we i ol 3 ia.
• sεlektiv IgA dεfisiεns: Dis na we di bכdi nכ de mek inof fכ wan spεshal tכp imyunoglobulin we dεn kכl Immunoglobulin A.
• haypa-IgM sεndrכm dεm: pan dis, sכm kayn imyunoglobulin dεm de prodyuz nכmal כ pasmak, bכt כda wan dεm nכ de prodyuz in inof amoun.

Apat frɔm dis, ɔda kayn PIDD de we kin mek pɔsin gɛt praymari haypogammaglobulinemia:

• Ataxia-telangiectasia we pɔsin kin gɛt
• Ɔtosɔmal rɛsɛsiv agammaglobulinemia (ARA) .
• Gud sindrom (GS) .
• Isolεt nכn-IgG imyunoglobulin dεfisiεns dεm
• Sivεr kכmbayn imyun dεfisiεns (SCID) .
• Spesifi k antibodi dεfisiεns (SAD) .
• Di sik we dɛn kɔl Wiskott-Aldrich (WAS) .

Di tin dɛn we kin mek pɔsin gɛt sɛkɔndari haypogammaglobulinemia

Dis na di rizin dɛn we mek dis tin kin apin leta:

• Mɛrɛsin: Sɔm mɛrɛsin kin mek di imyunoglobulin lɛvɛl smɔl. Fɔ ɛgzampul, mɛrɛsin dɛn we de mek pɔsin nɔ ebul fɔ fɛt di sik, mɛrɛsin dɛn we de mek pɔsin nɔ gɛt sik, kɔtikosterɔyd, ɛn mɛrɛsin dɛn we de tek kimotɛrapi.
• Nεfrotik sεndrכm: Insay dis kכndyushכn, yu kidni dεm de kכl tu mכch protin na yu urine. di imyunoglobulin dεm we na protin dεm bak kin kכmכt dis we.
• Protein-losing enteropathy: Dis na we tu mכch protin de lכs frכm yu bכdi tru yu gεstrointestinal sistεm.
• Kansa:Kansa we de afɛkt yu B-sɛl dɛn kin mek di imyunoglobulin lɛvɛl smɔl. Fɔ ɛgzampul, kansa lɛk kronik lymphocytic leukemia, lymphoma, ɛn multiple myeloma.
• HIV: HIV na wan sik we pɔsin kin gɛt we i du mami ɛn dadi biznɛs wit ɔda pɔsin (STI). I kin mek bak hapogammaglobulinemia ɛn ɔda prɔblɛm dɛn wit di imyun sistɛm.

Us prɔblɛm dɛn dis kin mek?

If dɛn nɔ trit am, di haypogammaglobulinemia kin mek pɔsin gɛt siriɔs infɛkshɔn ɛn ivin prɔblɛm dɛn we kin mek pɔsin in layf de pan denja . Wan prɔblɛm we kin apin na di brɔnkiɛktasis . Dis na wan sik we di lɔng dɛn kin pwɛl fɔ ɔltɛm. Dis kכndyushכn kin mכr pan pipul dεm wae gεt כp rεspiretכri trakt infεkshכn plεnti tεm.

Imajin pɔsin we gɛt prɔblɛm wit in lɔng we i de kɔf ɛn gɛt blɔd ɔltɛm. We dɛn lɔng dɛn de kɔntinyu fɔ pwɛl, i kin bi wan sik we go de sote go.

Apat frɔm dat, di haypogammaglobulinemia kin mek di risk fɔ:

• Awtoimyun sik dɛm: Dis na tin dɛm wae yu yone imyun sistɛm kin atak yu yone bɔdi in sɛl dɛm.
• Damej to di insay ɔgan dɛn.
• Kansa.
• Sepsis: Dis na bad bad infεkshכn we de spre כlsay na di bכdi.

Aw yu no dis?

Dɔktɔ dɛn go du blɔd tɛst fɔ no aw yu imyunoglobulin de. If yu lɛvɛl smɔl pas aw i fɔ bi, dɛn kin no se yu gɛt haypogammaglobulinemia. Dɔn yu dɔktɔ go put yu sik na difrɛn say dɛn we yu nɔ gɛt bɛtɛ wɛlbɔdi, we nɔ de mek yu sik, ɔ we rili bad .

Fɔ no gud gud wan wetin de mek dis lɔw lɛvɛl, di dɔktɔ go tink bɔt dɛn tin ya:

• Yu sayn dɛm: Ɛspɛshali if yu kin gɛt infɛkshɔn bɔku tɛm.
• Yu famili mɛdikal histri: Ɛnibɔdi na yu famili gɛt PIDD?
• Di mɛrɛsin dɛn we yu de tek: Ɛspɛshali di mɛrɛsin dɛn we kin mek pɔsin gɛt haypogammaglobulinemia as sayd ɛfɛkt.

Yu kin nid fɔ du ɔda tɛst dɛn bak, we kin inklud:

• Ɔda blɔd tɛst: Fɔ ɛgzampul, fɔ kɔmplit blɔd kɔnt, tɛst fɔ antibodi, ɛn tɛst fɔ si aw yu ɔgan dɛn de wok.
• di we aw dεn de tek imej: fכ chεk fכ di tisu dεm we dεn dכn pwεl bikoz fכ infεkshכn כ tכmכro (e.g. X-ray, CT scan)
• Jɛnɛtik tɛst: Chɛk fɔ di jenɛtik difrɛns dɛn we gɛt fɔ du wit PIDD.
• Bayɔpsi tɛst: .Fɔ tek wan tisu sɛmpul ɛn tɛst am fɔ si if kansa sɛl dɛn de.

Aw dɛn kin trit dis?

Di tritmɛnt dipen pan wetin mek yu gɛt di haypogammaglobulinemia ɛn aw i tranga. Dɛn kin sɛn yu bak to dɔktɔ we de stɔdi bɔt aw yu bɔdi de fɛt sik.

If di sik na sɛkɔndari to wan mɛdikal kɔndishɔn , bɔku tɛm dɔktɔ dɛn go trit di sik we de ɔnda am. Fɔ ɛgzampul, if yu immunoglobulin lɛvɛl smɔl bikɔs ɔf wan sayd ɛfɛkt we wan mɛrɛsin we yu de tek gɛt, dɛn kin chenj di mɛrɛsin.

If yu gɛt praymari haypogammaglobulinemia , yu go nid fɔ de ɔnda dɔktɔ fɔ di res ɔf yu layf fɔ protɛkt yusɛf frɔm siriɔs infɛkshɔn. Di tritmɛnt we dɛn kin pik kin bi:

• Wachful wet: If yu smɔl imyunoglobulin lɛvɛl nɔ de mek yu gɛt big prɔblɛm wit yu wɛlbɔdi, yu dɔktɔ kin wach yu sik. di kכndyushכn dεm we de sכlv fכ dεn wan, lεk transient hypogammaglobulinemia of infancy (THI), we wi bin dכn tכk bכt, kin nכ nid fכ tritmεnt.
• Antibayɔtik: Dɛn kin gi yu antibayɔtik fɔ mɛn baktriyal infɛkshɔn ɔ fɔ mek yu nɔ gɛt di sik.
• Immunoglobulin (IgG) riplesmɛnt tɛrapi: If yu immunoglobulin lɛvɛl rili smɔl, dɛn kin gi yu imyunoglobulin frɔm pɔsin we gi yu. dis dεn kin gi am as injεkshכn insay wan vein (IV) כ כnda di skin (subcutaneously). Pipul wae gɛt PIDD wae nid dis tritmɛnt kin nid fɔ tek dis tritmɛnt fɔ di res ɔf dɛn layf.
• Stem sel transplant: If yu bɔdi nɔ ebul fɔ mek wɛlbɔdi imyun sɛl, yu kin gɛt stem sɛl transplant frɔm pɔsin we gi yu. leta dεn stεm sεl dεm ya go divεlכp to hεlty bכdi sεl dεm, inklud B-sεl dεm.

Yu tink se dis na siriɔs tin?

Hypogammaglobulinemia kin bi siriɔs tin. I dipen pan di kɔz ɛn aw yu imyunoglobulin lɛvɛl smɔl. Immunoglobulin dɛn tan lɛk sojaman dɛn na wi bɔdi we de fɛt bad bad sik dɛn lɛk vayrɔs, baktri, parasayt, ɛn fɛns. So we dɛn sojaman ya nɔ de igen fɔ protɛkt wi, wi kin gɛt siriɔs sik dɛn ɔltɛm. If dɛn nɔ trit am, siriɔs infɛkshɔn kin mek di tisu dɛn pwɛl fɔ lɔng tɛm ɛn ivin day.

So, wi nɔ fɔ tek dis kɔndishɔn as sɔntin we nɔ impɔtant. If yu gɛt sɔm sayn dɛn, i impɔtant fɔ go to dɔktɔ wantɛm wantɛm.

Wetin kin apin if dɛn nɔ trit am?

I impɔtant fɔ mek dɔktɔ no wetin mek pɔsin gɛt di sik we dɛn kɔl hypogammaglobulinemia. If yu bigin tritmɛnt kwik, yu gɛt bɛtɛ chans fɔ gɛt wɛl bɔdi ɛn fɔ mek yu nɔ gɛt prɔblɛm dɛn we kin apin afta sɔm ia. If yu gɛt wan sik we de put yu pan denja fɔ gɛt haypogammaglobulinemia, yu dɔktɔ go de wach yu immunoglobulin lɛvɛl ɔltɛm. Dɛn go rikomɛnd wan tritmɛnt plan fɔ ɛp fɔ mek yu nɔ gɛt siriɔs infɛkshɔn.

Yu tink se dɛn go ebul fɔ stɔp dis?

Wi nɔ kin ebul fɔ stɔp di kɔndishɔn (lɛk di jenɛtik dɛfɛkt) we kin mek pɔsin gɛt haypogammaglobulinemia. Bɔt yu dɔktɔ kin tɛl yu fɔ du tritmɛnt fɔ ɛp fɔ mek yu nɔ gɛt prɔblɛm dɛn , lɛk fɔ gɛt infɛkshɔn ɔltɛm ɛn fɔ pwɛl yu lɔng.

Aw a go tek kia ɔf misɛf? Wetin a kin du fɔ mek a nɔ gɛt di sik?

Di tin we impɔtant pas ɔl na fɔ fala wetin yu dɔktɔ tɛl yu fɔ du. Dɛn tin ya kin ɛp fɔ mek yu nɔ gɛt di sik:

• Wash yu an fayn fayn wan: Wash yu an wit sop ɛn wata fɔ at le 20 sɛkɔn. Mek shɔ se yu was yu an afta yu dɔn go na do, bifo yu it, ɛn afta yu dɔn yuz di bafa.
• We yu de wɛr fes mask we nid de fɔ mek di jem dɛn we de na di briz nɔ go skata: Dis impɔtant mɔ we yu de go na say dɛn we pipul dɛn kin bɔku ɛn di tɛm we sik kin bɔku.
• Nɔ de fa frɔm pipul dɛn we sik ɛn ples dɛn we pipul dɛn kin bɔku as yu ebul: di jem kin skata izi wan na dɛn kayn ples dɛn de.
• Fɔ gɛt ɔl di vaysin dɛn di rayt tɛm: Bɔt aks yu dɔktɔ bɔt if sɔm layf vaysin dɛn rayt fɔ yu, bikɔs sɔm layf vaysin dɛn nɔ kin fayn fɔ pipul dɛn we gɛt wikɛd imyun sistɛm.

Wetin a fɔ aks di dɔktɔ?

We yu lan bɔt dis sik, yu kin gɛt bɔku kwɛstyɔn dɛn. Nɔ fred. Tɔk to yu dɔktɔ ɛn mek dɛn no klia wan bɔt dɛn tin ya:

• Wetin de mek mi immunoglobulin lɛvɛl de drɔp?
• Us tɛst a go nid fɔ gɛt fɔ no/monitor mi kɔndishɔn?
• Us tritmɛnt dɛn yu kin advays?
• Ɛni bad tin de we kin apin to di tritmɛnt? Wetin na dɛn?
• Us chenj dɛn na mi layf fɔ mek a nɔ gɛt di sik?
• Us sayn dɛn a fɔ go to dɔktɔ wantɛm wantɛm fɔ? Ɔ a fɔ go na imejensi rum (ETU) ?

We yu kam fɔ no se yu immunoglobulin lɛvɛl nɔ bɔku, yu kin fil se yu nɔ gɛt bɛtɛ trɛnk ɛn yu wik. Yu kin tink se, "O, wetin if a nɔ gɛt inof sojaman dɛn fɔ protɛkt mi?"

Bɔt nɔ wɔri. Fɔ tɔk to yu dɔktɔ na di fɔs tin fɔ no mɔ bɔt yu sik, wetin kin mek yu gɛt am, ɛn aw tritmɛnt dɛn kin ɛp. Wok wit yu dɔktɔ fɔ mɛn yu sik ɛn gɛt di kia we yu nid.

Fɔ dɔn, tin dɛn we wi fɔ mɛmba

Hypogammaglobulinemia na wan sik we di bɔdi in imyun sistɛm nɔ gɛt bɛtɛ antibodi (immunoglobulins), we de fɛt di jem dɛn. Dis kin mek pɔsin sik ɔltɛm.

Di tin we impɔtant pas ɔl na fɔ go to dɔktɔ if yu de gɛt infɛkshɔn ɔltɛm, mɔ di sem kayn infɛkshɔn, pas fɔ dismis am as nɔmal.

• Dis sik kin de we dɛn bɔn am, ɔ i kin kam leta bikɔs ɔf ɔda sik ɔ mɛrɛsin.
• If yu fɛn di kɔz ɛn gɛt di rayt tritmɛnt, yu kin avɔyd prɔblɛm ɛn liv fayn layf.
• I rili impɔtant fɔ fala di advays we dɔktɔ gi yu, liv fayn layf, ɛn tek step fɔ protɛkt yusɛf frɔm infɛkshɔn.

Nɔto yu wan, dɔktɔ ɛn wɛl bɔdi wokman dɛn de we go ɛp yu fɔ dil wit dis tin. Nɔ fred fɔ tɔk to dɛn.

` Hypogammaglobulinemia, Antibodi, Immunoglobulin, Imyun Sistem, Infεkshכn, PIDD