Yu bɔdi gɛt asid tumɔs? Lɛ wi lan bɔt laktik asid!

Yu dɔn ɛva fil taya, pen, ɔ nɔ de blo fayn we yu taya smɔl? Dɛn tin ya kin bi bikɔs ɔf bɔku rizin dɛn. Bɔt tide wi go tɔk bɔt wan kɔndishɔn we kin apin we wan kemikal we dɛn kɔl laktik asid gɛda na wi bɔdi. Dis na wetin dɔktɔ dɛn kin kɔl laktik asid . Nɔ wɔri, lɛ wi tɔk bɔt dis simpul wan.

Wetin na Laktik Asidɔsis?

Fɔ tɔk am simpul wan, laktik asid na wan sik we de bɔku bɔku laktik asid na yu blɔd. Dis kin apin we yu bɔdi de mek tumɔs laktik asid, ɔ we yu bɔdi nɔ ebul fɔ pul di laktik asid we i de mek fayn fayn wan.

Nɔmal wan, na wi liva ɛn kidni dɛn de pul di laktik asid we pasmak na wi bɔdi. Bɔt if di laktik asid tu bɔku, ɔ if sɔm wikɛd tin de na dɛn ɔgan ya lɛk di liva ɛn di kidni, dɛn nɔ kin ebul fɔ du dis wok fayn fayn wan. Na da tɛm de laktik asid kin bigin fɔ gɛda na di blɔd.

We di lɛvɛl we di laktik asid de na yu blɔd go ɔp smɔl, wi kin kɔl am hyperlactatemia . כltu, if dis inkrεs mכr εn di bכdi in pH (i.e. asid-bεys bεlε) tu asid, dεn kכl dat laktik asidכsis .

Wetin mek laktik asid kin fɔm na wi bɔdi?

Laktik asid, we sɔm pipul dɛn kin kɔl laktat , na wan natura bayprodukt we de mek di sɛl dɛn mɛtabolism. Wi sɛl dɛn de yuz glukɔs (shuga) fɔ mek ɛnaji. dis prכsεs dεn kכl am anaerobik glycolysis . dis kin apin we di sεl dεm nid εnεji kwik kwik wan, bכt dεn nכ gεt inof כksijεn fכ du dat.

Nɔmal wan, wi kin gɛt ɛnaji tru wan prɔses we de yuz ɔksijɛn. Dɛn kɔl dis aerobik mɛtabolism . כltu, anaerobic glycolysis lεk εnεji sכs we wi de yuz we imejensi. Imajin, we yu rɔn tranga wan wantɛm wantɛm ɔ es ebi ebi wet, yu mɔsul dɛn nɔ gɛt ɔksijɛn wantɛm wantɛm. Na da tɛm de dɛn kin yuz dis we. semweso, we wi tisu dεm nכ de gεt כksijεn bikoz fכ sכm sik dεm, dεn de mek laktik asid bak dis we.

Wetin kin apin we laktik asid de apin?

Wetin kin apin we yu gɛt laktik asid de dipen pan aw i siriɔs. Sɔm pipul dɛn kin gɛt dis sik fɔ sɔm tɛm, mɔ afta dɛn dɔn du bɔku ɛksesaiz. I kin mek yu bɔdi pen fɔ sɔm dez. Bɔt if yu liva ɛn yu kidni dɛn gɛt gud wɛlbɔdi, di laktik asid go dɔn insay sɔm dez.

Bɔt if yu bɔdi kɔntinyu fɔ mek bɔku bɔku laktik asid, ɔ if yu liva ɛn yu kidni nɔ ebul fɔ prosɛs am fayn, di tin kin rili siriɔs. Bɔrku tɛm dis kin apun wit sɔm kayn sik. as di laktat lεvεl na yu bכdi de kכntinyu fכ go כp, di pH lεvεl de dכn, εn di kadyak autput de dכn sכmtεm. Dis kin mek ɔda ɔgan dɛn nɔ wok ɛn ivin day. So i impɔtant fɔ no bɔt dis.

Wetin na di sayn dɛm fɔ Lactic Acidosis?

De sayn dɛm fɔ dis sik kin difrɛn wae de fɔs ɛn wae de sik kin kam tranga.

Di sayn dɛm we kin kam fɔs

Fɔs, yu kin fil tin dɛn lɛk dis:

• Nɔs ɛn vɔmit.
• Taya pasmak ɛn taya pasmak.
• di brith kwik, dip (dεn kכl dis respiratory compensation , we dεn de tray fכ ridyus di asid na di bכdi tru di brith).
• Mɔsul dɛn de twitch ɛn bɔdi de pen.

Simptom dɛm wae de sik kin kam siriɔs

As de sik de wɔs, dɛn tin ya kin apin bak:

• Wiknɛs ɛn slip mɔ ɛn mɔ.
• Delirium ɛn kɔnfyushɔn.
• I nɔ kin izi fɔ kɔntrol di muvmɛnt, lɛk we yu de waka ( ataxia ).
• Di urine autput we de dכn ( Oliguria ).

Ɔda sayn dɛn we de sho se yu gɛt dis sik

Yu kin gɛt sayn bak fɔ wan ɔndalayn mɛdikal kɔndishɔn we de mek yu gɛt laktik asid . Fɔ ɛgzampul, tin dɛn lɛk sepsis ( blɔd infɛkshɔn), shɔk ( strok), ɔ liva we nɔ de wok fayn . Di sayn dɛm fɔ dis kin bi:

• Lɔw bɔdi tɛmpracha.
• Lɔw blɔd prɛshɔn.
• Fiva.
• Jaundice (we de yɔlɔ na di skin ɛn di wayt na di yay).

Wetin na di men tin we kin mek pɔsin gɛt laktik asid?

Bɔku rizin dɛn kin de fɔ dis. Di tin we kin mek yu nɔ gɛt bɛtɛ ɔksijɛn na yu blɔd (hypoxemia) ɔ ɔksijɛn nɔ de na yu tisu dɛn (hypoxia). Bɔrku tɛm, dis kin kam bikɔs ɔf wan sik wae de mɛk pɔrsin gɛt dis sik.

Dɔktɔ dɛn dɔn sheb dis sik we de mek pɔsin gɛt laktik asid to sɔm kayn tin dɛn bay di tin dɛn we kin mek i gɛt am:

Tayp A

Tayp A laktik asidכsis kin apin we yu tisu dεm nכ gεt inof כksijεn. Bɔrku tɛm dɛn kin si am pan siriɔs mɛrɛsin. I kin bi bak fɔ sɔm tɛm, we kin kam bikɔs i de du ɛksɛsayz pasmak.

Sɔm kɔndishɔn dɛn we kin mek dɛn prodyuz laktat pasmak na:

• Pulmonary disorder kin mek di blɔd nɔ gɛt inof ɔksijɛn.
• di dizayd we de mek di blɔd nɔ de rɔn sloslo ɛn di ɔksijɛn nɔ de go na di tisu dɛn.
• Di prɔblɛm dɛn we gɛt fɔ du wit ɛmoglobin kin afɛkt di we aw di rɛd blɔd sɛl dɛn kin ebul fɔ kɛr ɔksijɛn.
• Shok kɔndishɔn lɛk sɛptik shɔk , haypovolemik shɔk, ɔ kadiɔjɛnik shɔk .
• Intestinal ischemic sindrom we de na di bɔdi .
• Fɔ lɔng tɛm we yu kin gɛt sik ɛn kɔnvulshɔn.
• Pɔyzin we dɛn kɔl kabon monoksayd .

Tayp B

Tayp B laktik asidכsis de apin witout haypoksimia כ haypoksia . Tri sɔbtayp dɛn de.

Tayp B1

dis kin kכz fכ di כndalayn sik dεm we de intafεr di abiliti fכ mεtabolayz laktat.

Dɛn kin bi:

• Liva sik .
• Kidni sik .
• Thiamine (vitamin B1) we nɔ de.
• Kansa.
• HIV/AIDS stetmɛnt.
• Di sik dɛn we de na di maytochondrial .
• Dayabitis- we gɛt fɔ du wit ketoacidosis.
• Adikshɔn pan rɔm ( Alcohol use disorder ).

Tayp B2

Dis kin apin as sayd ɛfɛkt fɔ sɔm mɛrɛsin ɛn pɔyzin. Ɛgzampul dɛn:

• Saynayd pɔyzin.
• Pɔyzin we dɛn kɔl kabon monoksayd .
• Pɔyzin we pɔsin kin drink rɔm .
• Yuz kɔkɛyn .
• Sɔm mɛrɛsin fɔ HIV ( Nyukliɔsayd rivas transkriptayz inhibito dɛn (antiretroviral tɛrapi) ).
• Sɔm kayn inhala dɛn we dɛn kin yuz fɔ sik dɛn lɛk asma ( Beta-adrenergic agonist inhalers ).
• Epinephrine injection fɔ siriɔs alɛji.
• Di antibayɔtik we dɛn kɔl linezolid .
• Propofol fɔ anestezi.
• Metformin, na wan mɛrɛsin we dɛn kin yuz fɔ dayabitis (dɛn kin yuz dis bɔku bɔku wan na Sri Lanka, so yu fɔ no bɔt dis mɔ).

Tayp B3

dis de kכz fכ di kכnεkshכn dεfisit dεm fכ spεsifi k εnzym dεm we nid fכ mεtabolayz laktat. Dɛn tin ya nɔ kin apin so ɔltɛm. Ɛgzampul dɛn:

• Di sik we dɛn kin gɛt we dɛn kin kip glaykojen .
• Fruktoz-1,6-difosfataz dεfisiεns .
• Piruvat kabɔksilayz dɛfisiɛns .
• Pyruvate dehydrogenase we nɔ de wok fayn .
• Oksidativ fכsfכrayleshכn dεfisiεns .
• Mɛtilmalɔnik asidyuria .

D-laktik asidכsis

di kayn A εn B we wi bin tכk bכt, de riliyt to di akyumyulesh כn fכ L-laktat na yu bכdi. dis L-laktat na wan kayn laktik asid we nכmal fכ prodyuz εn mεtabolayz insay di mכtalman bכdi.

Bɔt ɔda kayn laktik asid de we nɔ kin bɔku, we kin apin bikɔs di D-laktat kin gɛda . Dis kayn laktik asid na wan kayn baktri we de na yu big intestin de mek am. D-laktat de prodyuz as bayprodukt we dεn baktri dεm ya de mεtabolayz di kכbaidret dεm we dεn de digεst.

D-laktik asidכsis de apin we dεn baktri dεm ya de gro pasmak. afta dat di D-laktat we pasmak de kכmכt frכm di intestines insay di bכdi. D-lactate nכ kin mεtabolayz bay wi kidni כ liva. So i kin kɔntinyu fɔ gɛda na di blɔd. Bɔku tɛm dɛn kin si dis as kɔmplikeshɔn fɔ wan sik we dɛn kɔl shɔt gut sindrom .

Aw dɛn kin no se pɔsin gɛt Laktik Asid?

Dɔktɔ dɛn kin no if yu gɛt laktik asid bay dɛn tin ya:

• di blכd laktat lεvεl dεm we pas 4 mmol/L (milimכl pan wan lita).
• Blɔd pH smɔl pas 7.35.

Dɛn kin mɛzhɔ dɛn valyu ya bay we dɛn tek blɔd sɛmpul frɔm yu ɛn tɛst am.

Us tɛst dɛn kin du fɔ dis?

Dɛn kin du dɛn tɛst ya fɔ no if pɔsin gɛt laktik asid :

• Comprehensive metabolic panel (CMP) : Dis na simpul blɔd tɛst we de mɛzhɔ difrɛn tin dɛn na yu blɔd fɔ gɛt di bɛsis infɔmeshɔn bɔt yu wɛlbɔdi.
• Blɔd laktat tɛst : Apat frɔm di tin dɛn we dɛn kin mɛzhɔ na di CMP, dɛn kin mɛzhɔ di laktat lɛvɛl na yu blɔd spɛshal wan.
• Aniɔn gap blɔd tɛst : Dis tɛst de mɛzhɔ di pH ɛn ilɛktrɔlayt balans na yu blɔd.
• di atεrial bכdi gas tεst : Dis de mכsu di כksijεn satεrayshכn na yu atεri dεm, εn bak di pH εn εlektrolayt bεlε.

Aw dɛn kin trit Laktik Asidɔsis?

If yu gɛt laktik asid bikɔs ɔf sɔntin fɔ sɔm tɛm, lɛk fɔ du ɛksɛsayz pasmak, fɔ shek, ɔ fɔ gɛt sik, i go ɔltɛm sɔlv as tɛm de go. Yu kin gɛt fridɔm bay we yu de na os ɛn gɛt wata we de na yu bɔdi.

Bɔt we dɛn de na ɔspitul, dɛn kin trit laktik asid wantɛm wantɛm wit wata we dɛn kin put insay di bɛlɛ ( IV fluid , na dat wi kin kɔl salin) ɛn ɔda tritmɛnt dɛn we kin mek pɔsin gɛt layf bak, lɛk ɔksijɛn tɛrapi , if nid de.

Dɔn dɛn go no di tritmɛnt bay di tin we mek dɛn du am. Dipen pan yu sik, yu mɛdikal tim go wok fɔ trit di ɔndalayn mɛdikal kɔndishɔn ɔ pɔyzin we de mek yu gɛt di laktik asid .

If yu de sho sayn dɛm fɔ low ɔksijɛn lɛvɛl, di mɛdikal tim go sɔspɛkt Tayp A kɔz – lɛk aw yu at ɔr yu nɔr de blo fayn, sepsis , ɔr shɔk – ɛn trit dɛn imejensi dɛm fɔs.

Insay kes dɛm we dɛn nɔ sho se ɔksijɛn lɛvɛl smɔl, dɛn kin tink bɔt di difrɛn tin dɛm we kin mek pɔsin gɛt tayp B ɛn trit dɛm spɛshal wan.

Us kayn rizɔlt pɔrsin wae gɛt laktik asid kin ɛkspɛkt?

Di rizulyt de dipen pan de kɔz ɛn aw i siriɔs. Tayp A laktik asid – we gɛt fɔ du wit sɛpsis , shɔk, ɛn/ɔ ridyus ɔksijɛn we de gi di blɔd – na mɔ siriɔs. Ɔda kayn laktik asid kin smɔl ɛn kin divɛlɔp sloslo, we kin gi mɔ tɛm ɛn chans fɔ trit.

in jεnarכl, as di bכdi laktat lεvεl de inkrεs, di rεt fכ day kin inkrεs. Bɔt, i pɔsibul fɔ mek yu wɛl ful wan if yu gɛt tritmɛnt kwik ɛn fayn.

Laktik asidכsis na wan pan difrεn kכndyushכn dεm we dεn kכl mεtabolik asidכsis, we asid de bכku na yu bכdi. insay mεtabolik asidכsis , di bכdi in nכmal mεtabolik prכsεs dεm we de prodyuz εn mεnεj asid de disrupt insay sכm we. Nɔmal wan, yu liva ɛn kidni kin filta di asid we pasmak. Bɔt we dɛn ɔgan dɛn de nɔ de wok fayn, dɛn nɔ kin ebul fɔ kɔntrol asid. So, fɔ kia fɔ yu liva ɛn kidni bay we yu de drink bɔku wata, nɔ rɔm ɛn tek mɛrɛsin dɛn we de ambɔg yu, dat kin ɛp yu fɔ mek yu gɛt wɛlbɔdi fɔ lɔng tɛm.

Smɔl pɔynt dɛn we wi fɔ mɛmba

Okay, so lɛ wi mɛmba yu bɔt sɔm pan di impɔtant tin dɛn we wi tɔk bɔt tide:

• Laktik asid na we di laktik asid de go ɔp na di blɔd.
• Bɔku rizin dɛn kin de fɔ dis. Di men rizin na bikɔs di bɔdi nɔ de gɛt bɛtɛ ɔksijɛn.
• Di fɔs sayn dɛm kin bi wae yu taya pasmak, yu kin vɔmit, ɛn yu kin blo kwik kwik wan.
• Dɛn kin du blɔd tɛst fɔ no if pɔsin gɛt dis sik.
• Di tritmɛnt dipen pan di tin we mek i apin. Sɔntɛnde, rɛst ɛn wata kin du fɔ yu, sɔm tɛm dɛn kin nid fɔ go na ɔspitul.
• If dɛn no se i gɛt am ɛn trit am kwik, i kin mɛn.
• Fɔ kip di liva ɛn kidni dɛn wɛl kin ɛp fɔ protɛkt yusɛf frɔm tin dɛn lɛk dis.

So, if yu gɛt ɛni wan pan dɛn sik ya, ɔ if yu want fɔ no mɔ bɔt dis, nɔ fɔgɛt fɔ go to dɔktɔ. Stay wit wɛlbɔdi!

` Laktik asidכsis, laktik asidכsis, laktat, bכdi asid, bכdi asid bεlε, εksεsayz, hεlth