Wetin na di sik we dɛn kɔl Leptomeningeal Disease? Lɛ wi tɔk bɔt am!

I at fɔ put insay wɔd dɛn de fred ɛn wɔri we yu kin fil we yu kam fɔ no se yu gɛt kansa. We yu de fɛt kansa, wi ɔl dɔn yɛri se i kin go ɔda pat na yu bɔdi. Tide, wi go tɔk bɔt wan we aw kansa kin afɛkt wi bren, di mɛmbran dɛm we de rawnd wi spayna, ɛn wi sɛribrospaynal fluid. Dɔktɔ dɛn kin kɔl dis Leptomeningeal Disease , sɔm tɛm dɛn kin kɔl dis LMD ɔ LM .

Fɔ tɔk am simpul wan, wetin na Leptomeningeal Disease?

Okay, mek wi brok dis dɔŋ smɔl. Tri tin dɛn de we de protɛkt wi bren ɛn wi spɛnal kɔd. Wi kin kɔl dɛn tin ya di meninges. di tu tin mεmbran dεm we de insay dεn mεninge dεm ya dεn kכl dεm di lεptomeninges . Lɛk di kɔva dɛn na buk, dɛn mɛmbran ya de protɛkt dɛn tu impɔtant pat dɛn ya na wi nervɔs sistɛm.

Neks, wan spɛshal wata de we de flɔ insay wi bren ɛn rawnd wi spɛnal kɔd. Dɛn kɔl dis sɛribrospaynal fluid (CSF) . Dis wata de gi di bren ɛn di spɛnal kɔd it, i de protɛkt am, ɛn i de pul dɔti tin dɛn.

Naw, lɛptomeningeal sik (LMD) na we kansa we de ɔdasay na di bɔdi, lɛk brɔst kansa ɔ lɔng kansa, de skata ɛn go insay dɛn lɛptomeningeal mɛmbran dɛn we wi bin tɔk bɔt ɛn di sɛribrospinal fluid (CSF). Dat min se di kansa sɛl dɛn kin bigin fɔ flɔt insay dis wata, lɛk dɔti we de flɔt insay wata. Dɛn kin tek dis as wan kayn kansa we rili bad.

Aw kɔmɔn sik na lɛptomeningeal disease (LMD)?

Leptomeningeal disease (LMD) nɔr kin rili bɔku. Bɔt bikɔs dɛn dɔn go bifo pan mɛrɛsin we de mek pipul dɛn ebul fɔ liv lɔng wit kansa, i de kam mɔ ɛn mɔ. Na avrej, LMD kin apin pan lɛk 5% pan di wan dɛn we gɛt kansa.

Dis LMD kכndyushכn dεn kin si am mכst pan pipul dεm wae gεt dεn kayn kεnsar dεm ya:

• Brest kansa: Brest kansa na di kayn brɔst kansa we kin gɛt fɔ du wit LMD. I kin afɛkt 3% to 5% pan uman dɛn we gɛt bɔdi kansa. stכdi dεn sho se uman dεm we gεt di tכp we dεn kכl ``Triple negative breast cancer'' εn di sכbtayp ``Lobular breast cancer'' de pan hכy risk fכ gεt LMD.
• di lכng kεnsar: כl tu di nכn sכm sכl lכng kεnsar (NSCLC) εn sכm sכm lכng kεnsar (SCLC) kin spre to di lεptomeninges εn sεribrospεnal fכluid. Dɔktɔ dɛn se bitwin 4% ɛn 7% pan di pipul dɛn we gɛt NSCLC kin gɛt LMD. Dis rεt de inkrεs to lεk 11% pan di pipul dεm wae gεt SCLC.
• Melanoma: Dis na siriɔs kayn kansa na yu skin. Na lɛk 5% pan di pipul dɛm wae gɛt melanomaLMD kin divɛlɔp.
• Acute lymphocytic leukemia (ALL): Dis na kansa we de na di blɔd. Bitwin 1% ɛn 10% pan pipul dɛm wae gɛt ALL kin gɛt LMD.
• Nɔn-Hɔdgkin limfoma (NHL): Dis na kansa bak na di limfatik sistɛm. Bitwin 5% ɛn 10% pan pipul dɛm wae gɛt NHL kin gɛt NHL.

Wetin na di difrɛns bitwin di mɛtastas na di bren ɛn di sik we dɛn kɔl leptomeningeal disease (LMD)?

Dɛn tu tin ya kin apin we di kansa skata, bɔt smɔl difrɛns de.

di bren mεtastas na we di kεnsar sεl dεm de travul dayrekt insay di bren tisu εn fכm tכmכro dεm de.

כltu, lεptomeningeal disease (LMD) na we di kεnsar sεl dεm de travul insay di sεribrospεnal fכluid (CSF) εn di lεptomeningeal mεmbran dεm we de rawnd di bren εn spεnal kכd . na ya, di kεnsar sεl dεm kin de fכt insay di wata כ dεn kin spre kכs di sεf fכ di mεmbran dεm.

Sɔmtɛm dɛn tu tin ya kin apin togɛda, ɔr dɛn kin apin wan bay wan.

Wetin na di sayn dɛm fɔ dis sik?

Bɔrku sayn dɛm kin de fɔ lɛptomeningeal disease (LMD), bikɔs i kin afɛkt di bren ɛn spɛshal kɔd, we na wi ɔl nervɔs sistɛm. Bɔt, na sɔm pan di sayn dɛm wae kin kam pan pɔrsin wae gɛt dis sik:

• Ed pen: Dis na di men sayn wae bɔrku pipul kin gɛt. I nɔr tan lɛk nɔmal ed pen, i kin tranga smɔl, ɛn sɔmtɛm i kin wɔs na mɔnin.
• Nɔs ɛn vɔmit: Nɔs ɛn vɔmit kin apin, mɔ na mɔnin.
• Chenj we yu de waka: Yu kin fil lɛk se yu nɔ ebul fɔ kɔntrol yusɛf ɛn yu kin stɔp we yu de waka.
• Yu nɔ de yɛri fayn: I kin apin wantɛm wantɛm, ɛn yu kin bigin fɔ yɛri difrɛn sawnd dɛn na yu yes.
• Prɔblɛm fɔ si: yu kin si tu tɛm ɛn yu nɔ kin si fayn.
• Seizures : Yu kin lɔs yu kɔnshɛns wantɛm wantɛm ɛn yu kin gɛt kɔnvulshɔn.
• Kɔnfyushɔn ɛn chenj na di kɔnshɛns, di we aw pɔsin de fil, ɔ di we aw i de biev: I nɔ kin izi fɔ pe atɛnshɔn, i kin mek i nɔ mɛmba, i kin vɛks, ɛn i kin mek i vɛks.
• Bak ɛn leg pen: Pen kin apin na di bak ɛn along di leg.
• Yu leg ɔ yu bɔdi kin swɛla ɔ wik: Yu leg kin fil lɛk se yu nɔ gɛt layf ɛn yu nɔ gɛt layf.
• Prɔblɛm dɛn we yu kin gɛt we yu de pis ɔ we yu de pul dɔti: I kin at fɔ kɔntrol yu urine ɛn stɔl.
• Ɔda nyu nyurolɔjik prɔblɛm dɛn: Apat frɔm dis, nyu nyurolɔjik simptom dɛn kin apia, lɛk we i nɔ kin izi fɔ tɔk ɛn wan pat pan di fes kin swɛ.

Di tin we impɔtant pas ɔl na dat, if yu gɛt kansa, tɛl yu dɔktɔ wantɛm wantɛm if yu gɛt ɛni nyu sayn lɛk dis.

Wetin mek di sik we dɛn kɔl leptomeningeal disease (LMD) kin apin?

Fɔ tɔk am simpul wan, LMD kin apin we di kansa sɛl dɛn kin brok kɔmɔt na di say we di kansa bin de na di bɔdi (e.g., di bɔdi, di lכng), travul tru di blɔd ɔ di limfatik sistɛm, ɛn go insay di sɛribrospaynal fluid (CSF) ɛn di lɛptomeninges we wi bin dɔn tɔk bɔt bifo tɛm. Dis de sho aw fa di kansa dɔn skata.

nכmal wan, di sεribrospεnal fכluid (CSF) kin kכmכt na wi bren, dεn kin travul rawnd di bren εn spεnal kכd, εn i kin kכmכt bak insay di bכdi. Dis kin apin insay wan saykl. Bɔt we di kansa sɛl dɛn go insay dis CSF, dɛn kin ambɔg di nɔmal flɔ we dis wata de flɔ. Dɔn di CSF kin gɛda, we kin mek di prɛshɔn we de insay di bren go ɔp. Na dat mek bɔku sayn dɛn kin apin. כlso, we di kεnsar sεl dεm spre to di lεptomeningeal mεmbran dεm, dεn kin pwεl dεn mεmbran dεm εn di nεv dεm we kכnεkt to dεm.

Aw dɔktɔ dɛn kin no dis?

If yu sɔspɛkt se yu gɛt LMD, dɔktɔ dɛn go du tu men tɛst dɛn:

.

2. lכmba pankshכn / Spinal Tap: Insay dis tεst , dεn de put wan tin nidul insay yu lכw bכk, fכ tek kia fכ nכ damej yu spεnal kכd, fכ pul sכm sכm sכm sכm sכm sεribrospεnal fכluid (CSF). Dɔn dɛn kin tɛst di sampul na lab fɔ si if ɛni kansa sɛl de.

Sɔntɛnde, if di we aw di kansa sɛl dɛn de skata rili klia (maykroskɔpik), dɛn nɔ kin no am pan MRI skan. Insay dɛn kayn tin ya, fɔ no di sik kin tranga smɔl. Na dat mek i impɔtant fɔ tɛl yu dɔktɔ di rayt tin bɔt yu sik dɛn.

Yu tink se kɔmplit mɛrɛsin de fɔ dis?

Bɔt i sɔri fɔ no se naw, no mɛrɛsin nɔ de fɔ lɛptomeningeal disease (LMD). Bikɔs na siriɔs kansa we de ɔlsay, di men gol fɔ tritmɛnt na fɔ kɔntrol aw di kansa de skata, fɔ ridyus di sayn dɛm ɛn ɛp yu fɔ liv fayn fayn wan, ɛn fɔ mek yu gɛt kwaliti layf.

Di tritmɛnt we dɛn kin pik kin dipen pan tin dɛn lɛk di kayn kansa we yu bin gɛt fɔs, aw fa di kansa dɔn skata, ɛn yu ɔl wɛl bɔdi. Sɔm pan di tritmɛnt dɛm wae dɛn kin yuse pas ɔl na:

• Rεdyushכn tεrapi: Dɛn kin gi rεdyushכn tεrapi to di pat dεm na di bren כ spεnal kכd we di sik afɛkt. dis kin ridyus sכm simptom dεm (e.g., pen, nεv wik) εn impruv sכm nεv fכnshכn.
• Kimotɛrapi: .Dɛn kin gi drɔgs fɔ kil di kansa sɛl dɛn. Dɛn kin tek dɛn mɛrɛsin ya as pils, gi dɛn as injɛkshɔn na wan vein, ɔ sɔm tɛm dɛn kin injekt dɛn dairekt insay di sɛribrospaynal fluid (CSF). dis dεn kכl am ``Intrathecal chemotherapy.'' dεn kin du dis tru wan sכm sכm tכb we dεn put insay di bren we dεn kכl ``ventricular access device.''

Yu tink se we dɛn de fɔ mek dis nɔ apin?

Infakt, naw, no patikyula we nɔ de fɔ mek LMD nɔ gro, bikɔs i kin apin bikɔs ɔf di prɛd we di kansa we dɔn ɔlrɛdi de na di bɔdi de skata.

Aw lɔŋ yu kin liv wit dis sik?

A no se dis na kwɛstyɔn we at fɔ aks. LMD na wan advans stej fɔ kansa. Dis min se we dis kכndyushכn apin, di sikman de na di mכst siriכs stej fכ di kansa.

Na avrej, di wan dɛn we gɛt tritmɛnt kin tink se dɛn go liv fɔ tri to siks mɔnt afta dɛn dɔn no se dɛn gɛt di sik . Fɔ di wan dɛn we nɔ de gɛt tritmɛnt, dis tɛm kin tek lɛk wan mɔnt so.

Bɔt dis kin difrɛn frɔm wan pɔsin to ɔda pɔsin. E kin dipen pan bɔrku tin, lɛk di kayn kansa wae yu gɛt ɛn aw yu bɔdi de du tritmɛnt. Yu dɔktɔ na di bɛst pɔsin fɔ gi yu infɔmeshɔn bɔt dis.

Aw a kin kia fɔ misɛf? A fɔ tink bɔt aw fɔ kia fɔ pipul dɛn we de na os?

If yu gɛt LMD, i impɔtant fɔ ɔndastand yu kɔndishɔn klia wan. LMD na wan prɔblɛm we kin mek pɔsin gɛt kansa we nɔ go mɛn. Aks yu dɔktɔ wetin fɔ ɛkspɛkt bay aw yu sik. Da we de, yu kin ebul fɔ kɔntrol yu sik dɛn, yu kin fil fayn, ɛn put di tin dɛn we impɔtant to yu fɔs.

Dɛn tin ya nɔ kin izi fɔ tɔk bɔt, ilɛksɛf na yu ɔ yu dɔktɔ. Bɔt dɛn rili impɔtant. Yu dɔktɔ kin ɛp yu fɔ ɔndastand wetin de apin to yu bɔdi ɛn wetin kin apin tumara bambay. I kin ɛp yu bak fɔ tink bɔt di tin dɛn we yu go ebul fɔ du ɛn if nid de, i kin rifer yu to sɔpɔt savis.

Hospice care na savis wae de ɛp pipul dɛm wae gɛt dis sik wae de mɛk pɔrsin nɔr de liv fayn, liv dɛn las de fayn fayn wan, wit rɛspɛkt, ɔnda dɛn kɔntrol, ɛn wit ay kwaliti layf. We wi de fɛt siriɔs sik, bɔku pan wi tɛm ɛn trɛnk de fɔ tritmɛnt. We yu de tink bɔt aw fɔ kia fɔ pipul dɛn we de na os, dɛn kin pe atɛnshɔn pan aw fɔ spɛn di tɛm we lɛf, pas fɔ tink bɔt di sik insɛf. We yu tɔk to yu dɔktɔ bɔt aw LMD go afɛkt yu layf, us tritmɛnt dɛn de fɔ yu kayn kansa, ɛn wetin fɔ ɛkspɛkt frɔm dɛn tritmɛnt dɛn de, yu kin disayd fɔ du di bɛst fɔ yu.

If yu gɛt LMD, yu go mɔs de liv wit wan siriɔs kansa we dɔn skata ɔlsay na yu bɔdi pan ɔl we dɛn dɔn trit yu. We yu kam fɔ no se yu gɛt siriɔs prɔblɛm we yu nɔ go ebul fɔ mɛn, yu go sɔprayz, vɛks, ɛn fred. Yu go de wɔnda se, “Wetin mek dis de apin to mi?” Nɔto yu wan de pan dis kayn tin. Aks yu dɔktɔ fɔ ɛp yu. Dɛn ɔndastand wetin yu de go tru, ɛn dɛn go ɛp yu ɛni we we dɛn ebul.

Di tin dɛn we impɔtant pas ɔl fɔ mɛmba (Take-Home Message) .

• lεptomeningeal disease (LMD) na we di kεnsar de spre to di mεmbran dεm we de kכba di bren εn spεnal kכd εn insay di sεribrospεnal fכluid.
• Dis na siriɔs sik we dɛn nɔ go ebul fɔ mɛn.
• Nyurolɔjik simptom dɛm lɛk ed we de at, nɔs, i nɔ izi fɔ waka, prɔblɛm wit yu si/yɛri, ɛn kɔnfyushɔn kin apin.
• Dɛn kin no di sik bay we dɛn de du MRI skan ɛn we dɛn kin pank am na di bɔdi.
• Di gol fɔ tritmɛnt na fɔ kɔntrol di sayn dɛm ɛn fɔ mek yu gɛt kwaliti layf.
• Nɔr frayd fɔ tɔk opin wan wit yu dɔktɔ bɔt yu sik, yu tumara bambay, ɛn opshɔn dɛm lɛk fɔ kia fɔ yu na hospice. Gɛt di sɔpɔt we yu ɛn yu famili nid fɔ go tru dis tranga tɛm.

` Leptomeningeal Disease, Kansa, Bren, Spinal Kɔd, Sɛribrospinal Fluid, Simptom dɛm, Kansa Spread