"Dɔkta, i dɔn te we a bigin fɔ tek mɛrɛsin fɔ dis kɔlɔstrel. A de kɔntrol mi it bak fayn fayn wan. Bɔt mi kɔlɔstrel lɛvɛl stil nɔ kam dɔŋ..." Yu fil sɔntin lɛk dis bak? Ɔ sɔmbɔdi na yu famili gɛt dis prɔblɛm? Infakt, fɔ kɔntrol kɔlɔstrel na big prɔblɛm fɔ sɔm pipul dɛn. Pan ɔl we bɔku pipul dɛn kin gɛt gud rizɔlt frɔm ‘statin’ tayp drɔgs, sɔm nɔ kin gɛt am. So, dɛn dɔn kam wit wan nyu mɛrɛsin we dɛn kɔl Leqvio fɔ ɛp dɛn kayn pipul ya. Lɛ wi tɔk bɔt dis ditayli ɛn jɔs tide.
Wetin na dis ay kɔlɔstrel (Hyperlipidemia)?
Fɔ tɔk am simpul wan, Hyperlipidemia na we yu gɛt tumɔs kayn fat (wi kɔl dɛn lipid) na yu blɔd. Wi ɔl nid sɔm fat na wi bɔdi. Dɛn kin du bɔku impɔtant wok dɛn. Bɔt na we dɛn tu ay na in di prɔblɛm dɛn kin bigin. If dɛn fat ya bɔku as tɛm de go, di risk fɔ gɛt siriɔs sik lɛk at sik, strok, ɛn at atak kin bɔku.
Bɔku tɛm wi kin tɔk bɔt tu pan di men kayn fat dɛn.
| Fat tayp | Fɔ tɔk am simpul wan... |
|---|---|
| LDL (Low-Density Lipoprotein) we gɛt kɔlɔstrel | dis na wetin wi kin kכ l "bad kכlestכl" biכs i kin gεt dεposit na di wכl dεm na di bכdi in bכdi, sכmtεm i kin kכl dεm sכmtεm εn mek i gεt at sik. |
| HDL (High-Density Lipoprotein) we gɛt kɔlɔstrel | dεn kכl dis "gud kכlestכl" biכs i de εp fכ kכri bad kכlestכl (LDL) to di liva εn pul am kכmכt na di bכdi. |
Apat frɔm dat, ɔda kayn fat de we dɛn kɔl triglisɛrɛyd. I nɔ fayn fɔ gɛt bɔku pan dɛn.
Wetin na di tin dɛn we kin mek pɔsin gɛt bɔku kɔlɔstrel?
Bɔrku tɛm, dis kin kam bikɔs ɔf wi layf, it, ɛn sɔm sik dɛn we wi kin gɛt togɛda.
- Fɔ it ɛn drink: Rɛd mit, sosish, bekin, ɛn it dɛn we gɛt ɔyl (fried rays, kebab, paratha) gɛt bɔku sɛtyuret fat. If yu it dɛn tin ya bɔku tɛm, dat kin mek yu kɔlɔstrel bɔku.
- Di we aw pipul dɛn de liv:Tin dɛn lɛk fɔ smok, fɔ drink pasmak, fɔ strɛs, ɛn fɔ nɔ du ɛksɛsayz kin rili afɛkt di kɔlɔstrel we de bɔku.
- Ɔda tin dɛn we kin apin to pɔsin: Sɔm kayn sik lɛk dayabitis, liva ɔ kidni prɔblɛm, haypo tayroyd, ɛn slip apnɛa kin mek bak yu gɛt bɔku kɔlɔstrel.
di men gol fכ tritmεnt na fכ ridyus di lεvεl fכ dεn "bad" fεt dεm na di bכdi. Dis kin ridyus de risk fɔ gɛt siriɔs tin lɛk at atak ɛn strok.
Aw di drɔg we dɛn kɔl Leqvio de wok?
Statin na di men mɛrɛsin fɔ kɔlɔstrel. Bɔt sɔm pipul dɛn nɔ kin gɛt dɛn kɔlɔstrel lɛvɛl smɔl lɛk aw dɛn go want pan ɔl we dɛn de tek dɛn mɛrɛsin ya ɛn fala wɛlbɔdi it. Pipul dεm wae gεt jεnεtik kכndyushכn wae dεn kכl "primary hyperlipidemia" kin nid mכr dan wan mεdikeshכn.
Leqvio na nyu drɔg wae dɔn kam fɔ ɛp dɛn pipul ya. Di aktif ingridiɛnt we de insay am na Inclisiran. i de pan wan klas fכ dכg dεm we dεn kכl `smכl intafεring RNA (siRNA)`.
Fɔ tɔk am simpul wan, dis drɔg de mek di liva ebul fɔ tek "bad kɔlɔstrel" (LDL) frɔm di blɔd. Mɔ spesifik wan, i de ɛp di liva fɔ no di LDL patikyula dɛn. Afta di liva dɔn tek dɛn LDL patikyula dɛn ya, i kin yuz dɛn ɔ pul dɛn kɔmɔt na di bɔdi. Dis kin ridyus di lɛvɛl we di LDL de na di blɔd bad bad wan.
Dis na kɔmplit difrɛn we pas aw statin drɔgs de wok.
Yu tink se ɛnibɔdi we gɛt kɔlɔstrel kin yuz Leqvio?
Nɔ, dis nɔto mɛrɛsin fɔ ɔlman. Dɛn dɔn gri fɔ gi Leqvio fɔ pipul dɛn we dɔn ɔlrɛdi de it ɛn tek di maksimal doz fɔ wan statin, bɔt stil gɛt ay kɔlɔstrel lɛvɛl .
Dɛn kin advays dis mɛrɛsin, mɔ fɔ pipul dɛm wae gɛt wan jenɛtik kɔndishɔn we dɛn kɔl `Heterozygous Familial Hypercholesterolemia (HeFH).` If yu gɛt ay kɔlɔstrel ɛn yu lɛvɛl nɔ de kam dɔŋ pan ɔl we yu de tek statin ɛn fala wɛl bɔdi it, yu dɔktɔ kin tɔk to yu bɔt Leqvio. Na yu dɔktɔ nɔmɔ go disayd if dis fayn fɔ yu.
Aw a go gɛt dis vaysin?
Leqvio nɔto pil, na shot . Na injɛkshɔn we dɛn kin put ɔnda di bɔdi. Yu nɔ go ebul fɔ gi am na os. Na wɛlbɔdi biznɛs pɔsin (dɔktɔ ɔ nɔs) we de na ɔspitul ɔ klinik de gi am.
Di schedule fɔ gi di vaksin na dis:
1. Fɔs vaksin: Dɛn go gi yu wan vaksin fɔs.
2. Sɛkɔn vaksin:Dɛn kin gi di sɛkɔn vaysin 3 mɔnt afta di fɔs wan.
3. Afta dat: Afta dat, yu nid fɔ gɛt wan injɛkshɔn ɛvri 6 mɔnt .
Dɛn kin injekt dis vaysin na di shɔl, bɛlɛ, ɔ bak na di ɔp an. I rili impɔtant fɔ gɛt yu vaysin di rayt tɛm ɛn nɔ mis ɛni apɔntinmɛnt.
Wetin yu no bɔt di sakrifays we Leqvio bin gɛt?
Dɛn dɔn du tri men stɔdi fɔ si aw Leqvio wok fayn ɛn sef. Dɛn bin du dɛn stɔdi ya fɔ 18 mɔnt.
- Tu stɔdi: Di wan dɛn we tek pat bin gɛt pipul dɛn we gɛt at sik we nɔ bin ebul fɔ lɛf dɛn kɔlɔstrel lɛvɛl pan ɔl we dɛn bin de yuz statin.
- insay di כda stכdi, di wan dεm we tek pat na di wan dεm we gεt jεnεtik kכlestכl kכndishכn we dεn kכl `HeFH`.
Insay dɛn stɔdi ya, dɛn bin gi wan grup di Leqvio vaysin ɛn di ɔda grup bin gi wan plesibo vaysin we nɔ bin gɛt ɛni ɛfɛkt. Di tin dɛn we bin apin bin rili klia.
| Tim | di chenj na di "bad" (LDL) kכlestכl lεvεl afta 18 mכnt |
|---|---|
| Di wan dɛn we bin gɛt Leqvio | pan avrej, i dכn dכn bay 40% - 51% . |
| Di wan dɛn we bin gɛt plasɛbo (fak mɛrɛsin) . | Di avrej inkris na 1% - 8% . |
Dɛn rizɔlt ya sho se Leqvio na drɔg we kin ridyus di LDL kɔlɔstrel lɛvɛl we statin nɔ kin kɔntrol bad bad wan. di kכlestכl lεvεl kin bigin fכ dכn insay di fכs 3 mכnt dεm.
Dis mɛrɛsin de ridyus di risk fɔ gɛt at atak ɛn strok?
Dis na kwɛstyɔn we rili impɔtant. Dɛn dɔn sho se statin drɔgs kin ridyus LDL kɔlɔstrel ɛn ridyus di risk fɔ gɛt at atak ɛn strok. Bɔt Leqvio na drɔg we de wok difrɛn we.
stכdi dεm we dεn de du naw sho se Leqvio kin ridyus LDL kכlestכl bכku bכku wan. Bɔt dɛn bin du dɛn stɔdi ya fɔ shɔt tɛm, we na lɛk 18 mɔnt so. So, da tɛm de nɔ go du fɔ si if di mɛrɛsin rili de ridyus di risk fɔ gɛt at atak ɛn strok.
Bɔt we di LDL kɔlɔstrel dɔn ridyus dis kayn big wan, dat de sho se dis risk kin ridyus tumara bambay. Dɛn de du mɔ lɔng tɛm stɔdi fɔ kɔnfɔm dis.
Sayd ɛfɛkt ɛn aw fɔ mɛn dɛn?
Lɛk ɛni mɛrɛsin, Leqvio kin mek smɔl smɔl sayd ɛfɛkt dɛn. di wan dεm we kכmכn pas כl na di riakshכn dεm na di say we dεn injεkt .
- Rɛdnɛs na di say we dɛn injɛkshɔn
- I de it
- Pen
Fɔ dis rizin, di wɛlbɔdi biznɛs pɔsin we gi di vaysin nɔ go gi di vaysin na say we di san dɔn bɔn, we gɛt rash, ɔ we gɛt di sik. If yu dɔn gɛt injɛkshɔn bifo ɛn yu dɔn gɛt mɔ pen, tɛl di dɔktɔ ɔ nɔs. Dɔn dɛn kin pik difrɛn sayt.
Apat frɔm dɛn tin ya, ɔda bad bad tin dɛn kin apin. If yu gɛt ɛni ɔda sayn we nɔ kɔmɔn, tɔk to yu dɔktɔ wantɛm wantɛm.
Naw, dɛn nɔ ripɔt ɛni intarakshɔn bitwin Leqvio ɛn ɔda mɛrɛsin dɛn. Bɔt i impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn, vaytamɛn dɛn, ɛn ɛbul prɔdak dɛn we yu de tek.
Mɛsej we dɛn kin kɛr go na os
- Leqvio na nyu vaysin fɔ kɔntrol kɔlɔstrel.
- Dis kin fayn fɔ pipul dɛm wae gɛt ay kɔlɔstrel lɛvɛl wae nɔr kin ebul fɔ kɔntrol wit statin mɛrɛsin ɛn it.
- Dis na vaysin we pɔsin we sabi kia fɔ wɛlbɔdi biznɛs kin gi ɛvri 6 mɔnt (afta di fɔs tu dos).
- stכdi dεn sho se dis kin rili wok fכ ridyus di "bad" LDL kכlestכl lεvεl.
- Na yu dɔktɔ nɔmɔ go disayd if dis mɛrɛsin fayn fɔ yu, so tɔk to yu dɔktɔ bɔt dis.
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