Prɔblɛm de wit di limf sɛl dɛn na yu bɔdi? Lɛ wi tɔk bɔt Limfoproliferativ Disɔda (LPD)!

Yu dɔn ɛva yɛri se smɔl sojaman dɛn de na wi bɔdi we de protɛkt wi frɔm sik? Dɛn kɔl dɛn sojaman dɛn de wayt blɔd sɛl. Pan dɛn wayt blɔd sɛl ya, wan spɛshal kayn de we dɛn kɔl limfosayt . Dɛn men wok na fɔ mek wi imyun sistɛm strɔng bay we dɛn de fɛt ɛnimi dɛn lɛk vayrɔs ɛn baktri dɛm we de kam insay wi bɔdi, ɛn ivin pwɛl di kansa sɛl dɛm. Bɔt sɔntɛnde dɛn limfosayt ya kin stɔp fɔ wok fayn, ɔ dɛn kin bigin fɔ bɔku tumɔs. Na da tɛm de wi kin kɔl wan grup fɔ sik dɛn we dɛn kɔl Lymphoproliferative Disorders (LPDs) . Dis na tin we nɔ kin apin so ɔltɛm. Lɛ wi tɔk mɔ bɔt dis, nɔto so?

Wetin na di Limfoproliferativ Disɔda (LPD)? Yu tink se difrɛn kayn dɛn de?

Fɔ tɔk am simpul wan, LPD na grup fɔ sik dɛn we kin apin we wi limf sɛl dɛn we dɛn kɔl limfosayt nɔ de wok fayn ɔ gro we wi nɔ ebul fɔ kɔntrol. Wi kin sheb dɛn tin ya to tu men grup dɛn.

1. LPD dεm (Immunologic Disorders) we riliyt to di imyun sistεm

dis kayn LPD dεm de ambɔg di we aw wi imyun sistεm de ansa to fכrin invayda dεm. Pipul wae gɛt dis sik kin gɛt mɔr risk fɔ gɛt kansa lɛk lymphoma .

• X-linked lymphoproliferative disorder (XLP): If pɔsin we gɛt dis sik gɛt di Epstein-Barr vayrɔs , i kin go bifo to limfoma.
• Autoimmune lymphoproliferative syndrome (ALPS): Dis na we bɔku bɔku limfosayt dɛn kin gɛda na say dɛn lɛk wi limf no dɛn, splin, ɛn liva, ɛn dis kin mek dɛn ɔgan dɛn de swel. I tan lɛk se wi yon sɛl dɛn jɔs de gɛda na say dɛn we wi nɔ ebul fɔ kɔntrol.
• Pɔst-transplant lymphoproliferative disorders (PTLD): Dis na tin we nɔ kin apin so ɔltɛm bɔt we kin rili siriɔs. i kin apin afta dεn transplant כgan (e.g., kidni, liva) כ allogeneic stεm sεl transplant. Dis kin bi mɔ if yu ɔ di pɔsin we gi di ɔgan ɔ stem sɛl dɛn dɔn gɛt di Epstein-Barr vayrɔs, we kin afɛkt di B-sɛl dɛn.

2. Limfoyd Blɔd Kansa

Dɛn sik ya na di siriɔs sik dɛn we wi kin yɛri bɔt bɔku tɛm, lɛk Lukimia ɛn Limfoma . wetin de apin ya na di wayt bכdi sεl dεm na wi bon mכro εn bכdi, dat na di B-sεl dεm, T-sεl dεm εn Natural kil sεl dεm (NK sεl dεm), dεn dכn pwεl.Muteshon, abnכmal sεl dεm we de mכltiply we dεn nכ de kכntro. Dɛn nɔmal sɛl dɛn ya kin krawd di wɛlbɔdi blɔd sɛl dɛn. Pan ɔl we sɔntɛnde dɛn kin mɛn dɛn tin ya, dɛn na siriɔs sik dɛn we kin mek pɔsin in layf de pan denja.

Kansa dɛn we gɛt fɔ du wit B-sɛl

Sɔm ɔda kayn nɔ-Hɔdgkin limfoma dɛm we de insay dis kategori na:

• Difεs big B-sεl limfoma
• Fɔlikul limfoma
• Mantɛl sɛl limfoma

Sɔm kayn B-sɛl lukimiya de bak:

• Chronic lymphocytic leukemia (CLL): Na ya, di nכmal B-sεl dεm na di bon mכro de mכltiply pasmak, we de krawd di hεlty bכdi sεl dεm εn pletlεt dεm.
• B-sεl prolymphocytic leukemia: Na ya bak, abnכmal B-sεl dεm de bil insay di bon mכro, we de krawd di hεlty sεl dεm.
• Hairy cell leukemia: As di nem sho, dɛn gi dɛn abnɔmal wayt blɔd sɛl ya in nem bikɔs dɛn tan lɛk ia we dɛn si am wit maykroskɔp. Dɛn kin fɔm bak na di bon mɛro ɛn dɛn kin bɔku pasmak.

Kansa dɛn we gɛt fɔ du wit T-sɛl

di sik dεm we de kכmכt frכm di T-sεl dεm, dεn kin mεnshכn dεm to tu kεtכgrεf:

• Systemic T-cell lymphomas: Dɛn tin ya kin afɛkt yu limf no dɛm, splin, bon mɛro, blɔd, ɛn ɔda ɔgan dɛm na di bɔdi.
• Cutaneous T-cell lymphomas: Dɛn kin afɛkt di skin mɔ, bɔt sɔm tɛm dɛn kin afɛkt di limf no dɛm, blɔd, bon mɛro, ɛn insay ɔgan dɛm.

difrεn tכp dεm de fכ di sistεmik T-sεl limfoma dεm. Sɔm pan di kayn dɛn we dɛn kin yuz mɔ na:

• Pεrifεral T-sεl limfoma, we dεn nכ spεsifiket כda we (PTCL NOS) .
• Angioimyunoblastik T-sεl limfoma (AITL) .
• Anaplastik big sɛl limfoma

Sɔm kayn we dɛn de bak we nɔ bɔku:

• Epatosplenik T-sεl limfoma (HSTCL) .
• Ɛnteropati-asɔsiet T-sɛl limfoma (EATL) .

sכm sistεmik T-sεl limfoma dεm dεn kכl dεm bak krεse T-sεl lukimiya . Ɛgzampul dɛn:

• T-sεl prolimfosaytik lukimiya (T-PLL) .
• T-sεl big granul limfosaytik lukimiya (T-LGL) .

Tu men sכbtayp dεm de fכ di kכtan T-sεl limfoma:

• Maykɔsis fungoides we de na di bɔdi
• Di sik we dɛn kɔl Sézary syndrome

NK-sεl rilayt dizכrd dεm

dis dεm de rili rεs εn de afekt NK sεl dεm.

• Ekstranodal NK T-sεl limfoma nos tayp
• Agresiv NK-sεl lukimiya (AKNL) .
• NK-sεl big granul limfosaytik lukimiya (NK-LGL) .

Naw yu kin si aw bɔku difrɛn kɔndishɔn dɛn de kɔba ɔnda LPD dɛn. Yu nɔr nid fɔ go dip bɔt ɛni wan pan dɛn, bɔt i impɔtant fɔ no se dis sik de.

Wetin na di sayn dɛm fɔ LPD? Aw yu no dɛn?

Di sayn dɛm fɔ dɛn LPD ya kin difrɛn bad bad wan, i kin dipen pan di kayn LPD we yu gɛt. Bɔt sɔm kɔmɔn sayn dɛn de we yu kin si. Lɛ wi tek wan luk pan wetin dɛn bi:

• Fɔ swet pasmak na nɛt: Nɔto jɔs fɔ swet, bɔt fɔ swet sote di sheet dɛn wet.
• Di limf no dɛm, liva, ɔ splin dɔn swɛla: If yu notis se swɛlin de na say dɛm lɛk yu nɛk, yu an, ɔ yu bɔdi, ɔ if yu gɛt sɔntin we nɔ kɔmɔn na yu bɛlɛ, yu fɔ wɔri.
• Blɔd ɛn brus we nɔ kɔmɔn ɔ we pasmak: If yu blɔd bɔku ivin frɔm smɔl injuri, ɔ if yu jɔs gɛt blu-tin brus na ples dɛn na yu bɔdi.
• Taya ɔltɛm: Fɔ fil taya ilɛksɛf yu slip bɔku.
• Fiva ɔltɛm: If yu gɛt fiva we nɔ de dɔn fɔ natin.
• Vayral infɛkshɔn ɔltɛm: Bikɔs yu nɔ gɛt bɛtɛ imyuniti, yu kin gɛt sik dɛn lɛk kol ɛn flu bɔku tɛm.
• Anorexia: Na di filin wae yu nɔr want fɔ it.
• Fɔ lɔs yu wet we yu nɔ ɛksplen: If yu lɔs yu wet wantɛm wantɛm we yu nɔ de it ɔ ɛksesaiz, dat na sayn bak we yu fɔ tek tɛm wit.

Impɔtant: Nɔ panik if yu gɛt wan ɔ tu pan dɛn sayn ya. Dɛn kin kam bak bikɔs ɔf ɔda tin dɛn we nɔ izi fɔ du. Bɔt if dɛn sik ya kɔntinyu, i go fayn ɔltɛm fɔ go to dɔktɔ fɔ advays.

Wetin na di tin dɛn we kin mek pɔsin gɛt LPD?

I at fɔ no wan tin we kin mek bɔku pan di LPD dɛn, bɔt difrɛn tin dɛn kin ɛp fɔ mek dɛn gɛt dis sik.

• Infεkshכn: Sכm kayn LPD kin kכz fכ infεkshכn lεk di Epstein-Barr vayrus כ di H. pylori baktri . Imajin, dɛn kayn maykroɔganism ya we de kam insay wi bɔdi de ambɔg wi sɛl sistɛm.
• Sɔm sik dɛn we pɔsin kin gɛt we i de fɛt insɛf: Rimatɔyd at, lupusPipul dεm we gεt sכm sik dεm de pan risk fכ gεt sכm kayn LPD dεm (e.g. marginal zone lymphomas). Dis na we di imyun sistεm na wi bכdi de atak wi כwn sεl dεm.
• Mεdikeshכn: sכ m imyun supεrshכn drog dεm (e.g., dכg dεm we dεn gi fכ sכpres di imyun sistεm afta dεn transplant כgan) kin mek kכndyushכn lεk hεpatosplenic T-sεl limfoma.
• Sכm jεnεtik mכtεshכn dεm: Na sכm tεm we yu kin gεt jεnεtik mכtεshכn we de mek dis kayn LPD. fכ egzampl, pipul dεm we gεt X-linked lymphoproliferative disorder (XLP) gεt mכtεshכn na tu jin dεm. dis kin mek dεn kin gεt wan כnusual siriכs rispכns to di Epstein-Barr vayrus εn dεn kin gεt limfoma. di jεnεtik mכtεshכn dεm we de afekt di growth fכ di wayt blכd sεl dεm de kכl bak wit limfoma εn lukimiya.

Aw dɔktɔ dɛn kin no if pɔsin gɛt LPD? (Diagnosis) .

Bikɔs bɔku kayn LPD de, we dɛn de du diagnosis, dɔktɔ dɛn kin luk fɔs fɔ no us kayn LPD de mek yu gɛt di sik.

Fɔ du dis, dɔktɔ go tink bɔt yu sik dɛn lɛk di limf no dɛm we dɔn swel, sayn dɛm we de sho se yu liva ɔ yu splin big pas aw i fɔ bi, ɛn aks bɔt yu past mɛdikal histri ɛn if ɛnibɔdi na yu famili dɔn gɛt dis kayn sik.

Dɔn i pɔsibul fɔ du tɛst dɛn lɛk dis:

• Bayopsi: Dɛn kin du bon mɛro bayɔpsi fɔ luk fɔ sayn dɛm fɔ blɔd kansa lɛk lukimiya ɔ limfoma. Dis min se yu fɔ tek smɔl smɔl bon mɛrɔ ɛn tɛst am. Sɔntɛnde dɛn kin tek smɔl pat pan di limf node we dɔn swel bak.
• Blɔd tɛst: Kɔmplit blɔd kɔnt (CBC) , Kɔmprɛhɛnsif mɛtabolik panɛl (CMP) , Epstein-Barr antibodi tɛst, ɛpatitis tɛst, HIV tɛst, Lactate dehydrogenase (LDH) tɛst, ɛn ɔda tin dɛn Dɛn tin ya kin tɛl yu bɔku tin bɔt di chenj dɛn we de apin na di blɔd sɛl, infɛkshɔn, ɛn di liva ɛn kidni we de wok.
• Imej tɛst: Dɛn kin du tɛst lɛk kɔmpyuta tomografi (CT) skan ɛn positron emission tomography (PET) skan . dis kin luk tin dεm lεk di כgan dεm we de insay di bכdi, di kכndishכn fכ di limf no dεm, εn if di kεnsar sεl dεm dכn spre. I tan lɛk se yu tek pikchɔ fɔ di insay pat pan di bɔdi.
• Lab tεst dεm: spεshal tεst dεm lεk fכ fכlכ saytכmetri kin εp fכ no di spεsifi k tכp fכ LPD.

Aw dɛn kin trit LPD dɛn?

Di tritmɛnt fɔ LPD dɛn dipen pan di patikyula kayn LPD we yu gɛt. Nɔto ɔlman gɛt di sem tritmɛnt. Fɔ ɛgzampul, if yu gɛt lukimiya ɔ lymphoma, yu kin gɛt tritmɛnt dɛn lɛk dɛn wan ya:

• Kimotɛrapi: Na drɔgs we dɛn kin gi fɔ pwɛl di kansa sɛl dɛn.
• Immunotherapy: Na tritmɛnt we de mek yu yon imyun sistɛm ebul fɔ fɛt di kansa sɛl dɛn.
• Radieshɔn tɛrapi: Fɔ pwɛl di kansa sɛl dɛn we yu de yuz ay ɛnaji rayt.
• stεm sεl (bon mכro) transplant: fכ transplant hεlty stεm sεl dεm fכ riples di bon mכro we dεn dכn pwεl.
• Targeted therapy: Na Drug wae de target spεshal mכlikul dεm wae de εp di kεnsar sεl dεm fכ gro εn liv.

Mɛmba se na yu dɔktɔ go disayd di bɛst tritmɛnt fɔ yu. Na in sabi yu kɔndishɔn pas ɔlman.

Aw di ɛkspiriɛns tan lɛk fɔ pɔsin we gɛt LPD? Yu tink se i kin mɛn?

Dis na smɔl kwɛstyɔn wae nɔr kin izi fɔ ansa bikɔs bɔrku kayn LPD de, ɛn bɔrku tin lɛk yu wɛl bɔdi, ej, ɛn stej wae de sik kin afɛkt de autkam.

Sɔm kayn LPD dɛn kin wɛl ɔl. Fɔ ɛgzampul, kemo-imyunotɛrapi kin mɛn sɔm kayn limfoma, lɛk big B-sɛl limfoma ɛn Bɔkit limfoma. Pɔsin we gɛt X-linked lymphoproliferative disorder (XLP) kin wɛl wit stem sɛl transplant.

Bɔt sɔmtɛm, tritmɛnt kin put sɔm limfoma dɛn na remission , we min se di sayn dɛn kin dɔn ɛn tɛst nɔ kin ebul fɔ no di sik igen. Bɔt di sik nɔ kin wɛl ɔl. Sɔm LPD kin kam bak mɔnt ɔr ia afta di tritmɛnt dɔn.

If yu gɛt LPD, yu go mɔs de wɔnda if i kin mɛn ɛn aw lɔng yu kin liv. Di bɛst ples fɔ gɛt infɔmeshɔn bɔt dis na frɔm yu dɔktɔ. I sabi yu ɛn yu kɔndishɔn pas ɔlman. So nɔ fred fɔ aks am ɛni kwɛstyɔn we yu gɛt.

Aw a kin kia fɔ misɛf? (Fɔ kia fɔ yusɛf) .

LPD na siriɔs mɛdikal kɔndishɔn. Pan ɔl we tritmɛnt kin ridyus di sayn dɛm ɛn ivin mek yu gɛt mɛrɛsin, yu kin stil gɛt prɔblɛm dɛn we yu de du tritmɛnt. Na sɔm advays dɛn we go ɛp yu:

• Aks bɔt palliativ kia: Sɔmbɔdi wae gɛt LPD kin nid ɛp fɔ kɔntrol di sayn dɛm ɛn di sayd ɛfɛkt dɛm wae di tritmɛnt kin gɛt. Palliative care na spɛshal kayn kia wae de ɛp fɔ mek pɔrsin in kwaliti layf bɛtɛ ɛn fɔ ridyus pen ɛn ɔda diskɔmfɔt, pas fɔ tray fɔ mɛn di sik. Yu palliativ kia tim kin gi yu gud advays.
• It fayn: Yu nɔ go want fɔ it we yu sik ɔ we yu de du tritmɛnt. If na so i bi, go to pɔsin we sabi bɔt it . I go advays yu bɔt di rayt it ɛn drink fɔ yu.
• Gɛt sɔm ɛksesaiz: Lɛt ɛksesaiz kin ɛp fɔ ridyus di strɛs we kin kam wit siriɔs sik. Bɔt mek shɔ se yu tɔk to dɔktɔ bifo yu bigin fɔ du nyu ɛksɛsayz.
• Protɛkt yusɛf frɔm infɛkshɔn: Yu imyun sistɛm kin wik bikɔs yu sik ɔr tritmɛnt. So aks yu dɔktɔ bɔt aw fɔ mek yu nɔ gɛt vayrɔs infɛkshɔn. I impɔtant fɔ avɔyd fɔ de na say dɛn we pipul dɛn kin bɔku ɛn fɔ was yu an ɔltɛm.

Ustɛm a fɔ go to di dɔktɔ?

If dɛn de trit yu fɔ LPD, aks yu dɔktɔ us sayn dɛn we de sho se yu sik de wɔs (e.g., fiva we nɔ de dɔn) so dat yu go no ustɛm fɔ kɔntakt am.

We dɔktɔ yuz di mɛrɛsin wɔd "lymphoproliferation" ɔ "lymphoproliferative disorders (LPDs)," dɛn de tɔk bɔt wan grup fɔ sik dɛn we gɛt fɔ du wit sɔm patikyula wayt blɔd sɛl dɛn we kin afɛkt yu imyun sistɛm ɔ gɛt kansa.

If yu gɛt dis sik, yu kin want fɔ no di patikyula tin dɛn bɔt yu sik pas di wɔd dɛn we dɛn kin yuz fɔ mɛn pipul dɛn. Bɔt we yu sik, no na pawa. If na so i bi, if yu no di minin bihayn di nem, dat kin ɛp yu fɔ ɔndastand gud gud wan bɔt wetin de apin insay yu bɔdi.

Fɔ ɛgzampul, LPD dɛn gɛt kɔmɔn sayn ɛn tritmɛnt dɛn. Bɔt dɛn ɔl nɔto di sem. Dɔn bak, yu ɛkspiriɛns kin difrɛn frɔm ɔda pipul dɛn. If yu dɔktɔ yuz di wɔd "lymphoproliferative disorder (LPD), aks fɔ mɔr ditel bɔt yu patikyula sik. Dɛn go gladi fɔ ansa yu kwɛstyɔn dɛm.

Fɔ dɔn, mɛsej we yu kin kɛr go na os:

di limfoproliferativ Dizכrd (LPD) na wan grup we kכmpleks, we kin bi siriכs kכndyushכn dεm we kin kכz fכ abnכmaliti fכ di wok we di limfosayt dεm, we na wi bכdi in difεns sεl dεm, de du.

• Yu fɔ no bɔt di sayn dɛm: Nɔ les if yu gɛt fiva we nɔ de dɔn, yu taya pasmak, yu de lɔs yu wet, ɔ yu limf no dɛm swel.
• I impɔtant fɔ go to dɔktɔ: If yu gɛt dawt, go to dɔktɔ kwik kwik wan fɔ mek dɛn chɛk yu. Di mɔ we dɛn no di sik kwik kwik wan, na di mɔ i go izi fɔ mek dɛn trit am fayn.
• Nɔto ɔl di LPD dɛn na di sem: difrɛn kayn dɛn de, ɛn ɛni wan pan dɛn gɛt difrɛn tritmɛnt. Yu dɔktɔ go disayd di tritmɛnt we go fayn fɔ yu.
• Nɔto yu wangren de: We yu gɛt prɔblɛm lɛk dis, di sɔpɔt we yu fambul, padi dɛn, ɛn di wan dɛn we de wok na di dɔktɔ dɛn kin gi yu rili impɔtant.

Di tin we impɔtant pas ɔl na fɔ nɔ fred, fɔ kɔntinyu fɔ strɔng, ɛn fɔ fala di advays we di dɔktɔ dɛn gi. If yu trit yu fayn ɛn yu gɛt gud trɛnk na yu maynd, yu go ebul fɔ win dis prɔblɛm.

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